Morten Schallburg Nielsen

2024

Endo- and transcytotic pathways at the brain barriers

Erickson, M. A. & Nielsen, M. S., 6 May 2024, In: Frontiers in Drug Delivery. 4

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research

The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B., Nielsen, M. S., Neuhaus, W., Bell, R. D., Letoha, T. & Meyer, A. H. & 7 others, Leparc, G., Lenter, M., Lesuisse, D., Cader, Z. M., Buckley, S. T., Loryan, I. & Pietrzik, C. U., Jun 2024, In: European Journal of Cell Biology. 103, 2, 151406.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2023

Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

Nielsen, S. S. E., Holst, M. R., Langthaler, K., Christensen, S. C., Bruun, E. H., Brodin, B. & Nielsen, M. S., Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 2.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

Ozgür, B., Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, M., Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Brodin, B., Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 96.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device

Hudecz, D., McCloskey, M. C., Vergo, S., Christensen, S., McGrath, J. L. & Nielsen, M. S., Mar 2023, In: International Journal of Molecular Sciences . 24, 6, 5624.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

SorLA in astrocytes regulates blood-brain barrier integrity

Toth, A. E., Klepe, A., Lipka, D. V., Goldeman, C., Brodin, B. & Nielsen, M. S., Jan 2023, In: Frontiers in Drug Delivery. 2, 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Sortilins in the blood-brain barrier: impact on barrier integrity

Toth, A. E. & Nielsen, M. S., Mar 2023, In: Neural Regeneration Research. 18, 3, p. 549-550 2 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Holst, M. R., de Wit, N. M., Ozgür, B., Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Brodin, B. & Nielsen, M. S., Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 82.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2022

Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers

Alam, P., Holst, M. R., Lauritsen, L., Nielsen, J., Nielsen, S. S. E., Jensen, P. H., Brewer, J. R., Otzen, D. E. & Nielsen, M. S., 2022, In: Fluids and Barriers of the CNS. 19, 1, 12 p., 37.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Sortilin regulates blood-brain barrier integrity

Toth, A. E., Helms, H. C., Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Brodin, B. & Nielsen, M. S., Feb 2022, In: FEBS journal. 289, 4, p. 1062-1079 18 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2021

Basigin Antibodies with Capacity for Drug Delivery Across Brain Endothelial Cells

Christensen, S. C., Hudecz, D., Jensen, A., Christensen, S. & Nielsen, M. S., Sept 2021, In: Molecular Neurobiology. 58, 9, p. 4392-4403 12 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Cyclic hypoxia conditioning alters the content of myoblast-derived extracellular vesicles and enhances their cell-protective functions

Yan, Y., Gu, T., Christensen, S. D. K., Su, J., Lassen, T. R., Hjortbak, M. V., Lo, I., Venø, S. T., Tóth, A. E., Song, P., Nielsen, M. S., Bøtker, H. E., Blagoev, B., Drasbek, K. R. & Kjems, J., Sept 2021, In: Biomedicines. 9, 9, 20 p., 1211.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Mapping Receptor Antibody Endocytosis and Trafficking in Brain Endothelial Cells

Holst, M. R., Nielsen, S. S. E. & Nielsen, M. S., 2021, Methods in Molecular Biology: Methods and Protocols. 2. ed. Springer, p. 193-205 13 p. (Methods in molecular biology (Clifton, N.J.), Vol. 2367).

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review

Two peptides targeting endothelial receptors are internalized into murine brain endothelial cells

Hudecz, D., Sigurdardóttir, S. B., Christensen, S. C., Hempel, C., Urquhart, A. J., Andresen, T. L. & Nielsen, M. S., Apr 2021, In: PLOS ONE. 16, 4 , 20 p., e0249686.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2020

Characterization of basigin monoclonal antibodies for receptor-mediated drug delivery to the brain

Christensen, S. C., Krogh, B. O., Jensen, A., Andersen, C. B. F., Christensen, S. & Nielsen, M. S., 2020, In: Scientific Reports. 10, 1, 13 p., 14582.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

Kristensen, M., Kucharz, K., Felipe Alves Fernandes, E., Strømgaard, K., Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, A., Ulrikkaholm Tofte-Hansen, M., Irene Aldana Garcia, B., Lauritzen, M. & Brodin, B., 2020, In: Pharmaceutics. 12, 7, p. 1-24 24 p., 661.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development

Amoushahi, M., Steffensen, L. L., Galieva, A., Agger, J., Heuck, A., Siupka, P., Ernst, E., Nielsen, M. S., Sunde, L. & Lykke-Hartmann, K., Jun 2020, In: Journal of Assisted Reproduction and Genetics. 37, 6, p. 1355-1365 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Transport of a peptide from bovine α_s1-casein across models of the intestinal and blood–brain barriers

Christensen, B., Toth, A. E., Nielsen, S. S. E., Scavenius, C., Petersen, S. V., Enghild, J. J., Rasmussen, J. T., Nielsen, M. S. & Sørensen, E. S., Oct 2020, In: Nutrients. 12, 10, 14 p., 3157.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model

Hudecz, D., Khire, T., Chung, H. L., Adumeau, L., Glavin, D., Luke, E., Nielsen, M. S., Dawson, K. A., McGrath, J. L. & Yan, Y., Jan 2020, In: ACS Nano. 14, 1, p. 1111-1122 12 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Vesicular Transport Machinery in Brain Endothelial Cells: What We Know and What We Do Not

Toth, A. E., Holst, M. R. & Nielsen, M. S., 2020, In: Current Pharmaceutical Design. 26, 13, p. 1405-1416 12 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

2019

HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA

Madsen, P., Isaksen, T. J., Siupka, P., Tóth, A. E., Nyegaard, M., Gustafsen, C. & Nielsen, M. S., 2019, In: Scientific Reports. 9, 13 p., 611.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier

Leduc-Galindo, D., Qvist, P., Tóth, A. E., Fryland, T., Nielsen, M. S., Børglum, A. D. & Christensen, J. H., 2019, In: Microvascular Research. 122, p. 131-135 5 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells

Toth, A. E., Nielsen, S. S. E., Tomaka, W., Abbott, N. J. & Nielsen, M. S., May 2019, In: Fluids and Barriers of the CNS. 16, 1, 14.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2018

Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy

Tóth, A. & Nielsen, M. S., 12 Sept 2018, In: Neural Regeneration Research. 13, 11, p. 1883 1884 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Johnsen, K. B., Bak, M., Kempen, P. J., Melander, F., Burkhart, A., Thomsen, M. S., Nielsen, M. S., Moos, T. & Andresen, T. L., 2018, In: Theranostics. 8, 12, p. 3416-3436 21 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner

Højland, A., Richner, M., Mølgaard, S., Dieu, R. S., Eskelund, A., Nykjær, A., Nyengaard, J. R., Lykkesfeldt, J., Glerup, S. & Nielsen, M. S., 1 Aug 2018, In: Behavioural Brain Research. 348, p. 90-100 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro

Toth, A. E., Siupka, P., P Augustine, T. J., Venø, S. T., Thomsen, L. B., Moos, T., Lohi, H. T., Madsen, P., Lykke-Hartmann, K. & Nielsen, M. S., Nov 2018, In: Molecular Neurobiology. 55, 11, p. 8522-8537 16 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2017

Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

Siupka, P., Hersom, M. N., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J., Brodin, B. & Nielsen, M. S., 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 7, p. 2598-2613 16 p., 271678X17700665.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells

Nielsen, S. S. E., Siupka, P., Georgian, A., Preston, J. E., Tóth, A. E., Yusof, S. R., Abbott, N. J. & Nielsen, M. S., 24 Sept 2017, In: Journal of Visualized Experiments. 2017, 127, e56277.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Maternally Contributed Folate Receptor 1 Is Expressed in Ovarian Follicles and Contributes to Preimplantation Development

Strandgaard, T., Foder, S., Heuck, A., Ernst, E., Nielsen, M. S. & Lykke-Hartmann, K., 2017, In: Frontiers in Cell and Developmental Biology. 5, SEP, 11 p., 89.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Johnsen, K. B., Burkhart, A., Melander, F., Kempen, P. J., Vejlebo, J. B., Siupka, P., Nielsen, M. S., Andresen, T. L. & Moos, T., 4 Sept 2017, In: Scientific Reports. 7, 1, p. 10396 10396.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2016

Aldehyder og ketoner

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. Systime

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education

Alkener, alkyner og isomeri

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. Systime

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education

Alkoholer, phenoler, ethere og thioler

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. Systime

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education

Aminer og amider

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. Systime

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education

Bindinger og molekylestruktur

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. Systime

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education

Carboxylsyrer og carboxylsyrederivater

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. Systime

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education

Cytokine-like factor-1 (CLF-1): An essential facilitator of cardiotrophin-like cytokine: CNTFRα (CLC:CNTFRα) signalling and sorLA mediated turnover

Larsen, J. V., Kristensen, A. M., Pallesen, L. T., Bauer, J., Vægter, C. B., Nielsen, M. S., Madsen, P. & Petersen, C. M., 2016, In: Molecular and Cellular Biology.

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Open Access

Morten Schallburg Nielsen

Research output

Search results