Michael Robert Horsman

2024

Author Correction: Combination of proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers (Scientific Reports, (2024), 14, 1, (11569), 10.1038/s41598-024-62272-z)

Rykkelid, A. M., Sinha, P. M., Folefac, C. A., Horsman, M. R., Sørensen, B. S., Søland, T. M., Schreurs, O. J. F., Malinen, E. & Edin, N. F. J., 3 Jul 2024, In: Scientific Reports. 14, 1, 15311.

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Open Access

Combination of proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers

Rykkelid, A. M., Sinha, P. M., Folefac, C. A., Horsman, M. R., Sørensen, B. S., Søland, T. M., Schreurs, O. J. F., Malinen, E. & Edin, N. F. J., 2024, In: Scientific Reports. 14, 1, 8 p., 11569.

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Open Access

Targeting the Tumor Vascular Supply to Enhance Radiation Therapy Administered in Single or Clinically Relevant Fractionated Schedules

Horsman, M. R., Aug 2024, In: International Journal of Molecular Sciences . 25, 15, 8078.

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Open Access

2023

A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Ademaj, A., Veltsista, P. D., Marder, D., Hälg, R. A., Puric, E., Brunner, T. B., Crezee, H., Gabrys, D., Franckena, M., Gani, C., Horsman, M. R., Krempien, R., Lindner, L. H., Maluta, S., Notter, M., Petzold, G., Abdel-Rahman, S., Richetti, A., Thomsen, A. R. & Tsoutsou, P. & 4 others, Fietkau, R., Ott, O. J., Ghadjar, P. & Riesterer, O., May 2023, In: Strahlentherapie und Onkologie. 199, 5, p. 436-444 9 p.

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Open Access

In Vitro Characterization of the Bacteria-derived Hypoxia-selective Cytotoxin BE-₄₃₅₄₇

Busk, M., Eggertsen, P. P., Overgaard, J., Horsman, M. R., Tørring, T., Jacobsen, K. M. & Poulsen, T. B., Dec 2023, In: Anticancer Research. 43, 12, p. 5319-5329 11 p.

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Open Access

Radiation-Induced Immunoediting of Cancer

Tubin, S., Horsman, M. R., Sørensen, B. S., Gupta, S. & M.M., K., Jan 2023, Handbook of Cancer and Immunology. Cham: Springer, p. 1-20 20 p.

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education › peer-review

Open Access

The effect of single bout and prolonged aerobic exercise on tumor hypoxia in mice

Elming, P. B., Busk, M., Wittenborn, T. R., Bussink, J., Horsman, M. R. & Lønbro, S., Mar 2023, In: Journal of Applied Physiology. 134, 3, p. 692-702 11 p.

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Using immunotherapy to enhance the response of a C3H mammary carcinoma to proton radiation

Nielsen, S., Sitarz, M. K., Sinha, P. M., Folefac, C. A., Høyer, M., Sørensen, B. S. & Horsman, M. R., Nov 2023, In: Acta oncologica (Stockholm, Sweden). 62, 11, p. 1581-1586 6 p.

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Open Access

2021

Does the combination of hyperthermia with low LET (linear energy transfer) radiation induce anti-tumor effects equivalent to those seen with high LET radiation alone?

Elming, P. B., Sørensen, B. S., Spejlborg, H., Overgaard, J. & Horsman, M. R., 2021, In: International Journal of Hyperthermia. 38, 1, p. 105-110 6 p.

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Open Access

Refinement of an established procedure and its application for identification of hypoxia in prostate cancer xenografts

Elming, P. B., Wittenborn, T. R., Busk, M., Sørensen, B. S., Thomsen, M. B. H., Strandgaard, T., Dyrskjøt, L., Nielsen, S. & Horsman, M. R., Jun 2021, In: Cancers. 13, 11, 2602.

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Open Access

Therapeutic Modification of Hypoxia

Horsman, M. R., Sørensen, B. S., Busk, M. & Siemann, D. W., Nov 2021, In: Clinical Oncology. 33, 11, p. e492-e509 18 p.

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2020

Dose response modifiers in radiation therapy

Horsman, M. R., Lindegaard, J. C., Grau, C., Nordsmark, M., Alsner, J. & Overgaard, J., 15 Feb 2020, Gunderson and Tepper's Clinical Radiation Oncology 5th Edition. Gundersen, L. & Tepper, J. (eds.). 5 ed. Philadelfia, PA, USA: Elsevier, p. 48-60

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research

Imaging of Tumor Hypoxia for Radiotherapy: Current Status and Future Directions

Busk, M., Overgaard, J. & Horsman, M. R., Nov 2020, In: Seminars in Nuclear Medicine. 50, 6, p. 562-583 22 p.

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2 Citations (Scopus)

In vitro hypoxia responsiveness of [¹⁸F] FDG and [¹⁸F] FAZA retention: influence of shaking versus stagnant conditions, glass versus polystyrene substrata and cell number down-scaling

Busk, M., Horsman, M. R., Overgaard, J. & Jakobsen, S., 1 Dec 2020, In: EJNMMI Radiopharmacy and Chemistry. 5, 1, 14.

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Open Access

Molecular and biological rationale of hyperthermia as radio- and chemosensitizer

Oei, A. L., Kok, H. P., Oei, S. B., Horsman, M. R., Stalpers, L. J. A., Franken, N. A. P. & Crezee, J., 2020, In: Advanced Drug Delivery Reviews. 163-164, p. 84-97 14 p.

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3 Citations (Scopus)

Proton scanning and X-ray beam irradiation induce distinct regulation of inflammatory cytokines in a preclinical mouse model

Nielsen, S., Bassler, N., Grzanka, L., Swakon, J., Olko, P., Horsman, M. R. & Sørensen, B. S., Oct 2020, In: International Journal of Radiation Biology. 96, 10, p. 1238-1244 7 p.

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Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

Sørensen, B. S. & Horsman, M. R., 2020, In: Frontiers in Oncology. 10, 11 p., 562.

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Open Access

Tumors resistant to checkpoint inhibitors can become sensitive after treatment with vascular disrupting agents

Horsman, M. R., Wittenborn, T. R., Nielsen, P. S. & Elming, P. B., Jul 2020, In: International Journal of Molecular Sciences . 21, 13, p. 1-14 14 p., 4778.

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Open Access

2019

Dual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes

Busk, M., Horsman, M. R., Overgaard, J. & Jakobsen, S., 2019, In: Acta Oncologica. 58, 10, p. 1476-1482 7 p.

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1 Citation (Scopus)

Hyperthermia: The optimal treatment to overcome radiation resistant hypoxia

Elming, P. B., Sørensen, B. S., Oei, A. L., Franken, N. A. P., Crezee, J., Overgaard, J. & Horsman, M. R., 2019, In: Cancers. 11, 1, 20 p., 60.

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Open Access

5 Citations (Scopus)

Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running

Lønbro, S., Wiggins, J. M., Wittenborn, T., Elming, P. B., Rice, L., Pampo, C., Lee, J. A., Siemann, D. W. & Horsman, M. R., 2019, In: PLOS ONE. 14, 5, 15 p., e0215584.

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Open Access

The oxygen effect and therapeutic approaches to tumour hypoxia

Horsman, M. R., Brown, J. M., van der Kogel, A. J., Wouters, B. G. & Overgaard, J., 2019, Basic clinical radiobiology . Van der Kogel, A. J. & Joiner, M. C. (eds.). 5 ed. Boca Raton: CRC Press, p. 188-205

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review

2018

APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells

Jacobsen, K. M., Villadsen, N. L., Tørring, T., Nielsen, C. B., Salomón, T., Nielsen, M. M., Tsakos, M., Sibbersen, C., Scavenius, C., Nielsen, R., Christensen, E. I., Guerra, P. F., Bross, P., Pedersen, J. S., Enghild, J. J., Johannsen, M., Frøkiær, J., Overgaard, J., Horsman, M. R. & Busk, M. & 1 others, Poulsen, T. B., Nov 2018, In: Cell Chemical Biology. 25, 11, p. 1337-1349.e12 13 p.

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2017

Enhancing the radiation response of tumors but not early or late responding normal tissues using a vascular disrupting agent

Horsman, M. R., Nov 2017, In: Acta Oncologica. 56, 11, p. 1634-1638 5 p.

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FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach

Busk, M., Munk, O. L., Jakobsen, S., Frøkiær, J., Overgaard, J. & Horsman, M. R., May 2017, In: Acta Oncologica. 56, 5, p. 706-712 7 p.

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Hypoxia positron emission tomography imaging: combining information on perfusion and tracer retention to improve hypoxia specificity

Busk, M., Munk, O. L., Jakobsen, S. S. & Horsman, M. R., Nov 2017, In: Acta Oncologica. 56, 11, p. 1583-1590 8 p.

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Realizing the Potential of Vascular Targeted Therapy: The Rationale for Combining Vascular Disrupting Agents and Anti-Angiogenic Agents to Treat Cancer

Siemann, D. W., Chaplin, D. J. & Horsman, M. R., 14 Sept 2017, In: Cancer Investigation. 35, 8, p. 519-534 16 p.

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Relative biological effectiveness (RBE) and distal edge effects of proton radiation on early damage in vivo

Sørensen, B. S., Bassler, N., Nielsen, S., Horsman, M. R., Grzanka, L., Spejlborg, H., Swakoń, J., Olko, P. & Overgaard, J., Nov 2017, In: Acta Oncologica. 56, 11, p. 1387-1391 5 p.

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Results from (11)C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly

Iversen, A. B., Horsman, M. R., Jakobsen, S., Jensen, J. B., Garm, C., Jessen, N., Breining, P., Frøkiær, J. & Busk, M., 25 Aug 2017, In: Scientific Reports. 7, 1, p. 9436 13 p., 9436.

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Open Access

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Targeting therapy-resistant cancer stem cells by hyperthermia

Oei, A. L., Vriend, L. E. M., Krawczyk, P. M., Horsman, M. R., Franken, N. A. P. & Crezee, J., 2017, In: International Journal of Hyperthermia. 33, 4, p. 419-427 12 p.

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Open Access

The potential of hyperpolarized (13)C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents

Iversen, A. B., Busk, M., Bertelsen, L. B., Laustsen, C., Munk, O. L., Nielsen, T., Wittenborn, T. R., Bussink, J., Lok, J., Stødkilde-Jørgensen, H. & Horsman, M. R., 2017, In: Acta Oncologica. 56, 11, p. 1-8 8 p.

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Vascular targeting agents

Horsman, M. R. & Siemann, D. W., 2017, Encyclopedia of Cancer. Schwaub, M. (ed.). 4 ed. Berlin, Tyskland: Springer, p. 3897-3900 4 p.

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2016

Hypoxia as a Biomarker and for Personalized Radiation Oncology

Vordermark, D. & Horsman, M. R., 20 Jun 2016, Recent Results in Cancer Research. Baumann, M., Krause, M. & Cordes, N. (eds.). Springer Berlin, Heidelberg, Vol. 198. p. 123-42 20 p. (Recent Results in Cancer Research).

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Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms

van den Tempel, N., Horsman, M. R. & Kanaar, R., Jun 2016, In: International Journal of Hyperthermia. 32, 4, p. 446-54 9 p.

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Open Access

Pathophysiological Basis for the Formation of the Tumor Microenvironment

Horsman, M. R. & Vaupel, P., 12 Apr 2016, In: Frontiers in Oncology. 6, APR, 12 p., 66.

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Open Access

Realistic biological approaches for improving thermoradiotherapy

Horsman, M. R., 2016, In: International Journal of Hyperthermia. p. 1-9 9 p.

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Simulation of heterogeneous molecular delivery in tumours using μCT reconstructions and MRI validation

Wittenborn, T. R., Nielsen, T., Thomsen, J. S., Horsman, M. R. & Nygaard, J. V., 26 Aug 2016, In: Microvascular Research. 108, p. 69-74 6 p.

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The impact of hypoxia and its modification of the outcome of radiotherapy

Horsman, M. R. & Overgaard, J., 16 Aug 2016, In: Journal of Radiation Research. 57, 1, p. 90-98 9 p.

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Open Access

2015

A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo

Sun, M., Wang, M., Chen, M., Dagnaes-Hansen, F., Le, D. Q. S., Baatrup, A., Horsman, M. R., Kjems, J. & Bünger, C., May 2015, In: Acta Biomaterialia. 18, p. 21-29 9 p.

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Dose-response modifiers in radiation therapy

Horsman, M. R., Lindegaard, J. C., Grau, C., Nordsmark, M., Alsner, J. & Overgaard, J., 9 Sept 2015, Clinical radiation oncology. Gundersen, L. & Tepper, J. (eds.). 4 ed. Philadelphia, PA, USA: Elsevier, p. 51-62 12 p.

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research

Hyperpolarized magnetic resonance spectroscopy for assessing tumor hypoxia

Iversen, A. B., Ringgaard, S., Laustsen, C., Stødkilde-Jørgensen, H., Bentzen, L., Busk, M. & Horsman, M. R., 4 Sept 2015, In: Acta Oncologica. p. 1393-1398 6 p.

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Modulation of the tumor vasculature and oxygenation to improve therapy

Siemann, D. W. & Horsman, M. R., Sept 2015, In: Pharmacology & Therapeutics. 153, 9, p. 107-24 18 p.

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Photoelectron Spectra and Electronic Structures of the Radiosensitizer Nimorazole and Related Compounds

Feketeová, L., Plekan, O., Goonewardane, M., Ahmed, M., Albright, A. L., White, J., O'Hair, R. A. J., Horsman, M. R., Wang, F. & Prince, K. C., 1 Oct 2015, In: Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory. 119, 39, p. 9986-95 10 p.

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Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model

Sørensen, B. S., Horsman, M. R., Alsner, J., Overgaard, J., Durante, M., Scholz, M., Friedrich, T. & Bassler, N., 21 Oct 2015, In: Acta Oncologica. 54, 9, p. 1623-1630 8 p.

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Open Access

30 Citations (Scopus)

Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model

Sørensen, B. S., Horsman, M. R., Alsner, J., Overgaard, J., Durante, M., Scholz, M., Friedrich, T. & Bassler, N., 2015, In: Acta Oncologica. 54, 9, p. 1623-1630 8 p.

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Open Access

Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro

Sørensen, B. S., Busk, M., Overgaard, J., Horsman, M. R. & Alsner, J., 2015, In: PLOS ONE. 10, 8, 14 p., e0134955.

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Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L

Parker, E. N., Song, J., Kishore Kumar, G. D., Odutola, S. O., Chavarria, G. E., Charlton-Sevcik, A. K., Strecker, T. E., Barnes, A. L., Sudhan, D. R., Wittenborn, T. R., Siemann, D. W., Horsman, M. R., Chaplin, D. J., Trawick, M. L. & Pinney, K. G., 1 Nov 2015, In: Bioorganic & Medicinal Chemistry. 23, 21, p. 6974-6992 19 p.

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Michael Robert Horsman

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