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Development and degeneration of dorsal root ganglia in th...
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Michaela Miehe
Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
- Eva Sonnenberg-Riethmacher, Germany
- Michaela Miehe
- Claus C. Stolt, Germany
- Derk E. Goerich, Germany
- Michael Wegner, Germany
- Dieter Riethmacher, Germany
Abstract
The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.
The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.
| Original language | English |
|---|---|
| Journal | Mechanisms of Development |
| Volume | 109 |
| Issue | 2 |
| Pages (from-to) | 253 |
| Number of pages | 265 |
| ISSN | 0925-4773 |
| Publication status | Published - Dec 2001 |
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