Michael Robert Horsman

  1. 2021
  2. Published

    Refinement of an established procedure and its application for identification of hypoxia in prostate cancer xenografts. / Elming, Pernille B.; Wittenborn, Thomas R.; Busk, Morten; Sørensen, Brita S.; Thomsen, Mathilde Borg Houlberg; Strandgaard, Trine; Dyrskjøt, Lars; Nielsen, Steffen; Horsman, Michael R.

    In: Cancers, Vol. 13, No. 11, 2602, 06.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    Does the combination of hyperthermia with low LET (linear energy transfer) radiation induce anti-tumor effects equivalent to those seen with high LET radiation alone? / Elming, Pernille B.; Sørensen, Brita S.; Spejlborg, Harald; Overgaard, Jens; Horsman, Michael R.

    In: International Journal of Hyperthermia, Vol. 38, No. 1, 2021, p. 105-110.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. 2020
  5. Published

    Imaging of Tumor Hypoxia for Radiotherapy : Current Status and Future Directions. / Busk, Morten; Overgaard, Jens; Horsman, Michael R.

    In: Seminars in Nuclear Medicine, Vol. 50, No. 6, 11.2020, p. 562-583.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  6. Published

    Proton scanning and X-ray beam irradiation induce distinct regulation of inflammatory cytokines in a preclinical mouse model. / Nielsen, Steffen; Bassler, Niels; Grzanka, Leszek; Swakon, Jan; Olko, Pawel; Horsman, Michael R.; Sørensen, Brita Singers.

    In: International Journal of Radiation Biology, Vol. 96, No. 10, 10.2020, p. 1238-1244.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Tumors resistant to checkpoint inhibitors can become sensitive after treatment with vascular disrupting agents. / Horsman, Michael R.; Wittenborn, Thomas R.; Nielsen, Patricia S.; Elming, Pernille B.

    In: International Journal of Molecular Sciences, Vol. 21, No. 13, 4778, 07.2020, p. 1-14.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    Dose response modifiers in radiation therapy. / Horsman, Michael Robert; Lindegaard, Jacob Christian; Grau, Cai; Nordsmark, Marianne; Alsner, Jan; Overgaard, Jens.

    Gunderson and Tepper's Clinical Radiation Oncology 5th Edition. ed. / LL Gundersen; JE Tepper. 5. ed. Philadelfia, PA, USA : Elsevier, 2020. p. 48-60.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearch

  9. Published

    Molecular and biological rationale of hyperthermia as radio- and chemosensitizer. / Oei, A. L.; Kok, H. P.; Oei, S. B.; Horsman, M. R.; Stalpers, L. J.A.; Franken, N. A.P.; Crezee, J.

    In: Advanced Drug Delivery Reviews, Vol. 163-164, 2020, p. 84-97.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Tumor Hypoxia : Impact on Radiation Therapy and Molecular Pathways. / Sørensen, Brita Singers; Horsman, Michael R.

    In: Frontiers in Oncology, Vol. 10, 562, 2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  11. 2019
  12. Published

    Dual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes. / Busk, Morten; Horsman, Michael R.; Overgaard, Jens; Jakobsen, Steen.

    In: Acta Oncologica, Vol. 58, No. 10, 2019, p. 1476-1482.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Hyperthermia : The optimal treatment to overcome radiation resistant hypoxia. / Elming, Pernille B.; Sørensen, Brita S.; Oei, Arlene L.; Franken, Nicolaas A.P.; Crezee, Johannes; Overgaard, Jens; Horsman, Michael R.

    In: Cancers, Vol. 11, No. 1, 60, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  14. Published

    Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running. / Lønbro, Simon; Wiggins, Jennifer M.; Wittenborn, Thomas; Elming, Pernille Byrialsen; Rice, Lori; Pampo, Christine; Lee, Jennifer A.; Siemann, Dietmar W.; Horsman, Michael R.

    In: PLOS ONE, Vol. 14, No. 5, e0215584, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    The oxygen effect and therapeutic approaches to tumour hypoxia. / Horsman, Michael Robert; Brown, J. Martin; van der Kogel, Albert J.; Wouters, B.G.; Overgaard, Jens.

    Basic clinical radiobiology . ed. / Albert J. Van der Kogel; Michael C. Joiner. 5. ed. Boca Raton : CRC Press, 2019. p. 188-205.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  16. 2018
  17. Published
  18. 2017
  19. Published

    Enhancing the radiation response of tumors but not early or late responding normal tissues using a vascular disrupting agent. / Horsman, Michael R.

    In: Acta Oncologica, Vol. 56, No. 11, 11.2017, p. 1634-1638.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Hypoxia positron emission tomography imaging: combining information on perfusion and tracer retention to improve hypoxia specificity. / Busk, Morten; Munk, Ole L; Jakobsen, Steen S; Horsman, Michael R.

    In: Acta Oncologica, Vol. 56, No. 11, 11.2017, p. 1583-1590.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    Relative biological effectiveness (RBE) and distal edge effects of proton radiation on early damage in vivo. / Sørensen, Brita Singers; Bassler, Niels; Nielsen, Steffen; Horsman, Michael R; Grzanka, Leszek; Spejlborg, Harald; Swakoń, Jan; Olko, Paweł; Overgaard, Jens.

    In: Acta Oncologica, Vol. 56, No. 11, 11.2017, p. 1387-1391.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    Realizing the Potential of Vascular Targeted Therapy: The Rationale for Combining Vascular Disrupting Agents and Anti-Angiogenic Agents to Treat Cancer. / Siemann, D W; Chaplin, D J; Horsman, M R.

    In: Cancer Investigation, Vol. 35, No. 8, 14.09.2017, p. 519-534.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Results from (11)C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly. / Iversen, Ane B; Horsman, Michael R; Jakobsen, Steen; Jensen, Jonas B; Garm, Christian; Jessen, Niels; Breining, Peter; Frøkiær, Jørgen; Busk, Morten.

    In: Scientific Reports, Vol. 7, No. 1, 9436, 25.08.2017, p. 9436.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach. / Busk, Morten; Munk, Ole L; Jakobsen, Steen; Frøkiær, Jørgen; Overgaard, Jens; Horsman, Michael R.

    In: Acta oncologica (Stockholm, Sweden), Vol. 56, No. 5, 05.2017, p. 706-712.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Targeting therapy-resistant cancer stem cells by hyperthermia. / Oei, A L; Vriend, L E M; Krawczyk, P M; Horsman, M R; Franken, N A P; Crezee, J.

    In: International Journal of Hyperthermia, Vol. 33, No. 4, 2017, p. 419-427 .

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    The potential of hyperpolarized (13)C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents. / Iversen, Ane B; Busk, Morten; Bertelsen, Lotte B; Laustsen, Christoffer; Munk, Ole L; Nielsen, Thomas; Wittenborn, Thomas R; Bussink, Johan; Lok, Jasper; Stødkilde-Jørgensen, Hans; Horsman, Michael R.

    In: Acta oncologica (Stockholm, Sweden), Vol. 56, 2017, p. 1-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    Vascular targeting agents. / Horsman, Michael Robert; Siemann, Dietmar W.

    Encyclopedia of Cancer. ed. / Manfred Schwaub. 4. ed. Berlin, Tyskland : Springer, 2017. p. 3897-3900.

    Research output: Contribution to book/anthology/report/proceedingEncyclopedia entryResearchpeer-review

  28. 2016
  29. Published

    Simulation of heterogeneous molecular delivery in tumours using μCT reconstructions and MRI validation. / Wittenborn, Thomas Rea; Nielsen, Thomas; Thomsen, Jesper Skovhus; Horsman, Michael Robert; Nygaard, Jens Vinge.

    In: Microvascular Research, Vol. 108, 26.08.2016, p. 69-74.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    The impact of hypoxia and its modification of the outcome of radiotherapy. / Horsman, Michael R; Overgaard, Jens.

    In: Journal of Radiation Research, Vol. 57, No. 1, 16.08.2016, p. 90-98.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Hypoxia as a Biomarker and for Personalized Radiation Oncology. / Vordermark, Dirk; Horsman, Michael R.

    Molecular Radio-Oncology. ed. / Michael Baumann; Metchild Krause; Nils Cordes. Vol. 198 Springer Verlag, Berlin, Heidelberg, 2016. p. 123-42 (Recent Results in Cancer Research).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  32. Published

    Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms. / van den Tempel, Nathalie; Horsman, Michael R; Kanaar, Roland.

    In: International Journal of Hyperthermia, Vol. 32, No. 4, 06.2016, p. 446-54.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  33. Published

    Pathophysiological Basis for the Formation of the Tumor Microenvironment. / Horsman, Michael R; Vaupel, Peter.

    In: Frontiers in Oncology, Vol. 6, 66, 12.04.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  34. Published

    Realistic biological approaches for improving thermoradiotherapy. / Horsman, Michael R.

    In: International Journal of Hyperthermia, 2016, p. 1-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  35. 2015
  36. Published

    Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. / Parker, Erica N; Song, Jiangli; Kishore Kumar, G D; Odutola, Samuel O; Chavarria, Gustavo E; Charlton-Sevcik, Amanda K; Strecker, Tracy E; Barnes, Ashleigh L; Sudhan, Dhivya R; Wittenborn, Thomas R; Siemann, Dietmar W; Horsman, Michael R; Chaplin, David J; Trawick, Mary Lynn; Pinney, Kevin G.

    In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 21, 01.11.2015, p. 6974-6992.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. Published

    Photoelectron Spectra and Electronic Structures of the Radiosensitizer Nimorazole and Related Compounds. / Feketeová, Linda; Plekan, Oksana; Goonewardane, Mayanthi; Ahmed, Marawan; Albright, Abigail L; White, Jonathan; O'Hair, Richard A J; Horsman, Michael R; Wang, Feng; Prince, Kevin C.

    In: Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, Vol. 119, No. 39, 01.10.2015, p. 9986-95.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    Dose-response modifiers in radiation therapy. / Horsman, Michael Robert; Lindegaard, Jacob Christian; Grau, Cai; Nordsmark, Marianne; Alsner, Jan; Overgaard, Jens.

    Clinical radiation oncology. ed. / LL Gundersen; JE Tepper. 4. ed. Philadelphia, PA, USA : Elsevier, 2015. p. 51-62.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearch

  39. Published

    Hyperpolarized magnetic resonance spectroscopy for assessing tumor hypoxia. / Iversen, Ane B; Ringgaard, Steffen; Laustsen, Christoffer; Stødkilde-Jørgensen, Hans; Bentzen, Lise; Busk, Morten; Horsman, Michael R.

    In: Acta Oncologica, 04.09.2015, p. 1393-1398.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    Modulation of the tumor vasculature and oxygenation to improve therapy. / Siemann, Dietmar W; Horsman, Michael R.

    In: Pharmacology & Therapeutics, Vol. 153, No. 9, 09.2015, p. 107-24.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. Published

    The usability of a 15-gene hypoxia classifier as a universal hypoxia profile in various cancer cell types. / Sørensen, Brita Singers; Knudsen, Anders Bisgård; Wittrup, Catja Foged; Nielsen, Steffen; Aggerholm-Pedersen, Ninna; Busk, Morten; Horsman, Michael; Høyer, Morten; Bouchelouche, Pierre Nourdine; Overgaard, Jens; Alsner, Jan.

    In: Radiotherapy & Oncology, Vol. 116, No. 3, 09.2015, p. 346-51.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  42. Published

    A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo. / Sun, Ming; Wang, Miao; Chen, Muwan; Dagnaes-Hansen, Frederik; Le, Dang Quang Svend; Baatrup, Anette; Horsman, Michael R; Kjems, Jørgen; Bünger, Cody.

    In: Acta Biomaterialia, Vol. 18, 05.2015, p. 21-29.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. Published

    Therapeutic potential of using the vascular disrupting agent OXi4503 to enhance mild temperature thermoradiation. / Horsman, Michael R.

    In: International Journal of Hyperthermia, Vol. 31, No. 5, 05.2015, p. 453-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    Uniform Combretastatin-induced Effect on Monocytes and Neutrophils in Peripheral Blood but Not in Tumors. / Bohn, Anja B; Brems-Eskildsen, Anne S; Møller, Bjarne K; Horsman, Michael R.

    In: Anticancer Research, Vol. 35, No. 5, 05.2015, p. 2559-64.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model. / Sørensen, Brita Singers; Horsman, Michael Robert; Alsner, Jan; Overgaard, Jens; Durante, Marco; Scholz, Michael; Friedrich, Thomas; Bassler, Niels.

    In: Acta Oncologica, Vol. 54, No. 9, 2015, p. 1623-1630.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro. / Sørensen, Brita Singers; Busk, Morten; Overgaard, Jens; Horsman, Michael R; Alsner, Jan.

    In: PLOS ONE, Vol. 10, No. 8, e0134955, 2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. Published

    Targeting tumour hypoxia to improve outcome of stereotactic radiotherapy. / Wittenborn, Thomas R; Horsman, Michael R.

    In: Acta Oncologica, Vol. 54, No. 9, 2015, p. 1385-92.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  48. 2014
  49. Published

    Effect of radiation on cell proliferation and tumor hypoxia in HPV-positive head and neck cancer in vivo models. / Sørensen, Brita Singers; Busk, Morten; Horsman, Michael R; Alsner, Jan; Overgaard, Jens; Kyle, Alastair H; Minchinton, Andrew I.

    In: Anticancer Research, Vol. 34, No. 11, 11.2014, p. 6297-304.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published

    In vivo bio-distribution and homing of endothelial outgrowth cells in a tumour model. / Bertelsen, Lotte B; Hagensen, Mette; Busk, Morten; Zhang, Rui; Knudsen, Anne S; Nielsen, Nathalie; Falborg, Lise; Møller, Bjarne K; Horsman, Michael R; Stødkilde-Jørgensen, Hans.

    In: Nuclear Medicine and Biology, 01.08.2014, p. 848-855.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  51. Published

    Tumor Hypoxia. / Nordsmark, M.; Busk, M.; Petersen, J. B.; Alsner, J.; Overgaard, J.; Horsman, M. R.

    Comprehensive Biomedical Physics: Radiation Therapy Physics and Treatment Optimization. Vol. 9 Elsevier, 2014. p. 205-222.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  52. Published

    Formation of radical anions of radiosensitizers and related model compounds via electrospray ionization. / Feketeová, Linda; Albright, Abigail L; Sørensen, Brita Singers; Horsman, Michael Robert; White, Jonathan; O'Hair, Richard A J; Bassler, Niels.

    In: International Journal of Mass Spectrometry, Vol. 365-366, 15.05.2014, p. 56-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  53. Published

    Accumulation of nano-sized particles in a murine model of angiogenesis. / Wittenborn, Thomas R; Larsen, Esben K U; Nielsen, Thomas; Rydtoft, Louise M; Hansen, Line; Nygaard, Jens V; Vorup-Jensen, Thomas; Kjems, Jørgen; Horsman, Michael R; Nielsen, Niels Christian.

    In: Biochemical and Biophysical Research Communications, Vol. 443, No. 2, 10.01.2014, p. 470-6.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. Published

    A combretastatin-mediated decrease in neutrophil concentration in peripheral blood and the impact on the anti-tumor activity of this drug in two different murine tumor models. / Bohn, Anja Bille; Wittenborn, Thomas; Brems-Eskildsen, Anne Sofie; Laurberg, Tinne; Bertelsen, Lotte Bonde; Nielsen, Thomas; Stødkilde-Jørgensen, Hans; Møller, Bjarne Kuno; Horsman, Michael R.

    In: PLOS ONE, Vol. 9, No. 10, 2014, p. e110091.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  55. Published

    Clinical Imaging of Hypoxia. / Horsman, Michael Robert; Busk, Morten; Nielsen, Thomas; Nordsmark, Marianne; Overgaard, Jens.

    Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities. ed. / Giovanni Melilo. New York : Humana Press, 2014. p. 179-204 (Cancer Drug Discovery and Development).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  56. Published

    Electrochemical analysis of miRNA deregulated during the hypoxia conditions. / de Almeida Campos, Rui César; Horsman, Michael Robert; Ferapontova, Elena.

    2014. Abstract from 12th Topical Meeting of the International Society of Electrochemistry. Bioelectrochemistry 2013., Bochum, Germany.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  57. Published

    Hypoxia and radiation therapy. / Nordsmark, Marianne; Alsner, Jan; Busk, Morten; Overgaard, Jens; Horsman, Michael Robert.

    Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities. ed. / Giovanni Melilo. New York : Humana Press, 2014. p. 265-81 (Cancer Drug Discovery and Development).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  58. Published

    Hypoxia, Metastasis, and Antiangiogenic Therapies. / Siemann, Dietmar W; Dai, Yau; Horsman, Michael Robert.

    Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities. ed. / Giovanni Melilo. New York : Humana Press, 2014. p. 205-228 (Cancer Drug Discovery and Development).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  59. Published

    Sustained Drug Delivery Device for Treatment of Breast Cancer and Bone Metastases. / Sun, Ming; Wang, Miao; Chen, Muwan; Dagnæs-Hansen, Frederik; Le, Dang Quang Svend; Baatrup, Anette; Horsman, Michael Robert; Kjems, Jørgen; Bünger, Cody.

    2014. #1167 Poster session presented at Orthopedic Research Society annual meeting 2014, New Orleans, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  60. Published

    Treatment with a vascular disrupting agent does not increase recruitment of indium labelled human endothelial outgrowth cells in an experimental tumour model. / Bertelsen, Lotte B; Bohn, Anja B; Shen, Yuan Yuan; Falborg, Lise; Stødkilde-Jørgensen, Hans; Horsman, Michael R.

    In: B M C Cancer, Vol. 14, 2014, p. 903.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  61. 2013
  62. Published

    Induction of hypoxia by vascular disrupting agents and the significance for their combination with radiation therapy. / Iversen, Ane B; Busk, Morten; Horsman, Michael R.

    In: Acta Oncologica, Vol. 52, No. 7, 10.2013, p. 1320-6.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  63. Published

    Relevance of hypoxia in radiation oncology: pathophysiology, tumor biology and implications for treatment. / Busk, Morten; Horsman, M R.

    In: Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 57, No. 3, 09.2013, p. 219-234.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  64. Published

    Ultra-high field (1)H magnetic resonance imaging approaches for acute hypoxia. / Nielsen, Thomas; Nielsen, Niels Christian; Holm, Thomas Hellesøe; Ostergaard, Leif; Horsman, Michael R; Busk, Morten.

    In: Acta oncologica (Stockholm, Sweden), Vol. 52, No. 7, 30.08.2013, p. 1287-1292.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  65. Published

    Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells. / Sørensen, Brita Singers; Busk, Morten; Olthof, Nadine; Speel, Ernst-Jan; Horsman, Michael R; Alsner, Jan; Overgaard, Jens.

    In: Radiotherapy & Oncology, Vol. 108, No. 3, 13.08.2013, p. 500-505.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  66. Published

    The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis. / Østergaard, Leif; Tietze, Anna; Nielsen, Thomas; Drasbek, Kim R; Mouridsen, Kim; Jespersen, Sune N; Horsman, Michael R.

    In: Cancer Research, Vol. 73, No. 18, 13.06.2013, p. 5618-5624.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  67. Published

    Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo. / Horsman, Michael Robert; Christensen, Kent L; Overgaard, Jens.

    In: International Journal of Hyperthermia, Vol. 5, No. 2, 04.2013, p. 123-36.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  68. Published

    Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model. / Nawroth, Isabel; Alsner, Jan; Deleuran, B.W.; Dagnæs-Hansen, Frederik; Yang, Chuanxu; Horsman, Michael Robert; Overgaard, Jens; Howard, Ken; Kjems, Jørgen; Gao, Shan.

    In: Acta Oncologica, Vol. 52, No. 8, 01.01.2013, p. 1730-1738.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  69. Published

    PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice. / Busk, Morten; Mortensen, Lise Saksø; Nordsmark, M; Overgaard, J; Jakobsen, S; Hansen, K V; Theil, J; Kallehauge, Jesper; D'Andrea, F P; Steiniche, T; Horsman, M R.

    In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 40, No. 2, 01.2013, p. 186-97.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  70. Published

    PET imaging of tumor hypoxia using 18F-labeled pimonidazole. / Busk, Morten; Jakobsen, Steen; Horsman, Michael R; Mortensen, Lise S; Iversen, Ane Bundsbæk; Overgaard, Jens; Nordsmark, Marianne; Ji, Xiaosheng; Lee, David Y; Raleigh, James R.

    In: Acta Oncologica, Vol. 52, No. 7, 2013, p. 1300-1307.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  71. 2012
  72. Published

    Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in preclinical studies of antivascular treatments. / Nielsen, Thomas; Wittenborn, T.; Horsman, M.R.

    In: Pharmaceutics, Vol. 4, No. 4, 01.12.2012, p. 563-589.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  73. Published

    Tumour microenvironment and radiation response in sarcomas originating from tumourigenic human mesenchymal stem cells. / D'Andrea, Filippo Peder; Safwat, Akmal Ahmed; Burns, Jorge S.; Kassem, Moustapha; Horsman, Michael Robert; Overgaard, Jens.

    In: International Journal of Radiation Biology, Vol. 88, No. 6, 06.2012, p. 457-465.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  74. Published

    Combretastatin A-4 phosphate affects tumor vessel volume and size distribution as assessed using MRI-based vessel size imaging. / Nielsen, Thomas; Bentzen, Lise; Pedersen, Michael Nygaard; Tramm, Trine; Rijken, Paul F J W; Bussink, Johan; Horsman, Michael R; Østergaard, Leif.

    In: Clinical Cancer Research, Vol. 18, No. 23, 2012, p. 6469-77.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  75. Published

    Dose-reponse modifiers in radiation therapy. / Horsman, Michael Robert; Lindegaard, Jacob Christian; Grau, Cai; Nordsmark, Marianne; Overgaard, Jens.

    Clinical Radiation Oncology. ed. / Leonard L. Gunderson; Joel E. Tepper. 3. ed. Philadelphia, USA : W. B. Saunders Company, 2012. p. 53-64.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  76. Published

    Imaging hypoxia to improve radiotherapy outcome. / Horsman, Michael R; Mortensen, Lise Saksø; Petersen, Jørgen B; Busk, Morten; Overgaard, Jens.

    In: Nature Reviews. Clinical Oncology, Vol. 9, No. 12, 2012, p. 674-87.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  77. Published

    Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L. / Chavarria, Gustavo E; Horsman, Michael R; Arispe, Wara M; Kumar, G D Kishore; Chen, Shen-En; Strecker, Tracy E; Parker, Erica N; Chaplin, David J; Pinney, Kevin G; Trawick, Mary Lynn.

    In: European Journal of Medicinal Chemistry, Vol. 58, 2012, p. 568-72.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  78. Published

    Radiosensitizers investigated using electrospray ionization mass spectrometry. / Feketeová, Linda; Bassler, Niels; Sørensen, Brita Singers; Horsman, Michael Robert; White, Jonathan; O'Hair, Richard A. J.

    2012. Poster session presented at International Mass Spectrometry Conference, Kyoto, Japan.

    Research output: Contribution to conferencePosterResearch

  79. Published

    The vascular-disrupting agent, combretastatin-A4-phosphate, enhances neurogenic vasoconstriction in rat small arteries. / Su, Junjing; Laursen, Britt E; Eskildsen-Helmond, Yvonne; Horsman, Michael R; Simonsen, Ulf.

    In: European Journal of Pharmacology, 2012, p. 104-111.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  80. Published

    Treatment with the vascular disrupting agent Combretastatin is associated with impaired AQP2 trafficking and increased urine output. / Bohn, Anja Bille; Norregaard, Rikke; Stødkilde-Jørgensen, Lene; Wang, Yan; Bertelsen, Lotte B; Fenton, Robert A; Matchkov, Vladimir V; Bouzinova, Elena V; Horsman, Michael R; Frokiaer, Jorgen; Stødkilde-Jørgensen, Hans.

    In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2012, p. R186-R198.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  81. Published

    Tumourigenicity and radiation resistance of mesenchymal stem cells. / D'Andrea, Filippo Peder; Horsman, Michael Robert; Kassem, Moustapha; Overgaard, Jens; Safwat, Akmal Ahmed.

    In: Acta Oncologica, Vol. 51, No. 5, 2012, p. 669-679.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  82. Published

    Ultra-High-Field DCE-MRI of Angiogenesis in a Novel Angiogenesis Mouse Model. / Wittenborn, Thomas; Nielsen, Thomas; Nygaard, Jens Vinge; Larsen, Esben Kjær Unmack; Thim, Troels; Rydtoft, Louise Munk; Vorup-Jensen, Thomas; Kjems, Jørgen; Nielsen, Niels Christian; Horsman, Michael Robert; Falk, Erling.

    In: Journal of Magnetic Resonance Imaging, Vol. 35, No. 3, 2012, p. 703-710.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  83. 2011
  84. Published

    Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation. / Bertelsen, Lotte B; Shen, Yuan Yuan; Nielsen, Thomas; Stødkilde-Jørgensen, Hans; Lloyd, G Kenneth; Siemann, Dietmar W; Horsman, Michael R.

    In: International Journal of Radiation Biology, Vol. 87, No. 11, 11.2011, p. 1126-1134.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  85. Published

    Dose-Response Modifiers in Radiation Therapy. / Horsman, Michael R.; Lindegaard, Jacob C.; Grau, Cai; Nordsmark, Marianne; Overgaard, Jens.

    Clinical Radiation Oncology: Third Edition. Elsevier Inc, 2011. p. 53-64.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  86. Published

    Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. / D'Andrea, Filippo Peder; Safwat, Akmal Ahmed; Kassem, Moustapha; Gautier, Laurant; Overgaard, Jens; Horsman, Michael Robert.

    In: Radiotherapy & Oncology, Vol. 99, No. 3, 06.2011, p. 373-378.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  87. Published

    In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors. / Busk, Morten; Toustrup, Kasper; Soerensen, Brita S; Alsner, Jan; Horsman, Michael R; Jakobsen, Steen; Overgaard, Jens.

    In: B M C Cancer, Vol. 11, No. 1, 09.02.2011, p. 63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  88. Published

    Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study. / Mortensen, Lise Saksø; Busk, Morten; Nordsmark, Marianne; Jakobsen, Steen; Theil, Jørn; Overgaard, Jens; Horsman, Michael R.

    In: Radiotherapy & Oncology, Vol. 99, No. 3, 2011, p. 418-23.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  89. Published

    Combretastatin-induced hypertension and the consequences for its combination with other therapies. / Busk, Morten; Bohn, Anja Bille; Skals, Marianne; Wang, Tobias; Horsman, Michael R.

    In: Vascular Pharmacology, Vol. 54, No. 1-2, 2011, p. 13-17.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  90. Published

    Exploitation of tumor hypoxia in tumor therapy. / Osinsky, Sergey; Horsman, Michael Robert.

    Tumor hypoxia in the clinical setting. ed. / Sergey Osinsky; Helmut Friess; Peter Vaupel. Kyiv Akademperiodyka, Kiev : National Academy of Sciences Ukraine, 2011. p. 232-243.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  91. Published

    Impact on radiotherapy. / Horsman, Michael Robert; Overgaard, Jens; Siemann, Dietmar W.

    Tumor Microenvironment. ed. / Dietmar W. Siemann. 1. ed. Chichester, West Sussex, UK : John Wiley & Sons Ltd, 2011. p. 353-376.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  92. Published

    Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment. / Busk, Morten; Walenta, Stefan; Mueller-Klieser, Wolfgang; Steiniche, Torben; Jakobsen, Steen; Horsman, Michael Robert; Overgaard, Jens.

    In: Radiotherapy & Oncology, 2011, p. 404-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  93. Published

    Tumor hypoxia and the response to therapy. / Horsman, Michael Robert; Vaupel, Peter.

    Tumor hypoxia in the clinical setting. ed. / Sergey Osinsky; Helmut Friess; Peter Vaupel. Kyiv Akademperiodyka, Kiev : National Academy of Sciences Ukraine, 2011. p. 69-92.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  94. Published

    Tumour hypoxia in the clinical setting: Conclusions. / Osinsky, Sergey; Molls, Michael; Horsman, Michael Robert; Vaupel, Peter.

    Tumor hypoxia in the clinical setting. ed. / Sergey Osinsky; Helmut Friess; Peter Vaupel. Kyiv Akademperiodyka, Kiev : National Academy of Sciences Ukraine, 2011. p. 265-268.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  95. 2010
  96. Published

    Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival. / Offersen, Birgitte V; Knap, Marianne M; Horsman, Michael R; Verheijen, Jan; Hanemaaijer, Roeland; Overgaard, Jens.

    In: Acta Oncologica, Vol. 49, No. 8, 01.11.2010, p. 1283-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  97. Published

    Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro. / Sørensen, Brita Singers; Toustrup, Kasper; Horsman, Michael Robert; Overgaard, Jens; Alsner, Jan.

    In: Acta Oncologica, Vol. 49, No. 7, 10.2010, p. 895-905.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  98. Published

    Prospective evaluation of angiogenic, hypoxic and EGFR-related biomarkers in recurrent glioblastoma multiforme treated with cetuximab, bevacizumab and irinotecan. / Hasselbalch, Benedikte; Eriksen, Jesper Grau; Broholm, Helle; Christensen, Ib Jarle; Grunnet, Kirsten; Horsman, Michael R; Poulsen, Hans Skovgaard; Stockhausen, Marie-Thérése; Lassen, Ulrik.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 118, No. 8, 01.08.2010, p. 585-94.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  99. Published

    Tumour perfusion and associated physiology: characterization and significance for hyperthermia. / Vaupel, Peter; Horsman, Michael R.

    In: International Journal of Hyperthermia, Vol. 26, No. 3, 01.01.2010, p. 209-10.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  100. Published

    A novel angiogenesis mouse model for screening functionalized nano-particles. / Wittenborn, Thomas; Nygaard, Jens Vinge; Larsen, E. K. U.; Nielsen, T.; Thim, Troels; Horsman, Michael Robert; Vorup-Jensen, Thomas; Kjems, Jørgen; Falk, Erling.

    2010. Abstract from Ph.d-dag , Aarhus, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  101. Published

    Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET. / Busk, Morten; Munk, Ole Lajord; Jakobsen, Steen; Wang, Tobias; Skals, Marianne; Steiniche, Torben; Horsman, Michael Robert; Overgaard, Jens.

    In: Acta Oncologica, Vol. 49, No. 7, 2010, p. 922-33.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  102. Published

    Biodistribution of 99mTc-HYNIC-lactadherin in mice - a potential tracer for visualizing apoptosis in vivo. / Falborg, Lise; Waehrens, Lasse N; Alsner, Jan; Bluhme, Henrik; Frøkiaer, Jørgen; Heegaard, Christian W; Horsman, Michael R; Rasmussen, Jan T; Rehling, Michael.

    In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 70, No. 3, 2010, p. 209-16.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  103. Published

    Imaging tumour physiology and vasculature to predict and assess response to heat. / Hokland, Steffen; Nielsen, Thomas; Busk, Morten; Horsman, Michael R.

    In: International Journal of Hyperthermia, Vol. 26, No. 3, 2010, p. 264-72.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  104. Published

    NPI-2358 Rapidly Inhibit the Blood Flow in Tumour Treatment by Analyzing Dynamic Contrast Enhanced Magnetic Resonance Imaging Parameters. / Shen, Yuan Yuan; Liu, Cheng-Xia; Bertelsen, Lotte Bonde; Nielsen, Thomas; Horsman, Michael Robert; Stødkilde-Jørgensen, Hans.

    In: China Journal of Cancer Prevention and Treatment, Vol. 7, 2010, p. 488-490.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  105. Published

    Non-invasive imaging of combretastatin activity in two tumor models: Association with invasive estimates. / Nielsen, Thomas; Murata, Rumi; Maxwell, Ross J; Stødkilde-Jørgensen, Hans; Østergaard, Leif; Ley, Carsten D; Kristjansen, Paul E G; Horsman, Michael R.

    In: Acta Oncologica, Vol. 49, No. 7, 2010, p. 906-13.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  106. Published

    Time and dose dependent vascular effects of NPI-2358 in mouse tumour models. / Bertelsen, Lotte Bonde; Shen, Yuan Yuan; Bohn, Anja Bille; Nielsen, Thomas; Loyd, GK; Stødkilde-Jørgensen, Hans; Siemann, DW; Horsman, Michael Robert.

    2010. Poster session presented at   Time and dose dependent vascular effects of NPI-2358 in mouse tumour models, .

    Research output: Contribution to conferencePosterResearch

  107. Published

    Vascular targeting therapy: potential benefit depends on tumor and host related effects. / Horsman, M R; Bohn, Anja Bille; Busk, Morten.

    In: Experimental Oncology, Vol. 32, No. 3, 2010, p. 143-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  108. 2009
  109. Published

    Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast? / Busk, Morten; Horsman, Michael Robert; Jakobsen, Steen; Hansen, Kim V; Bussink, Johan; van der Kogel, Albert; Overgaard, Jens.

    In: Radiotherapy & Oncology, Vol. 92, No. 3, 09.2009, p. 429-436.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  110. Published

    A Novel in Vivo Angiogenesis Mouse Model. / Wittenborn, Thomas; Nygaard, Jens Vinge; Horsman, Michael Robert; Vorup-Jensen, Thomas; Kjems, Jørgen; Thim, Troels; Nielsen, Thomas; Larsen, Esben Kjær Unmack; Falk, Erling.

    In: Arteriosclerosis, Thrombosis, and Vascular Biology, No. 7, 2009.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference articleResearchpeer-review

  111. Published

    Assessing Thermal Damage Using Dynamic Contrast Enhanced MRI. / Hokland, Steffen; Nielsen, Thomas; Moonen, Chrit; Stødkilde-Jørgensen, Hans; Horsman, Michael Robert; Pedersen, Michael.

    2009. Abstract from ISMRM, Honolulu, Haiti.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  112. Published

    Effect of Vascular Targeting on Tumor Vessel Volume and Size Distribution. / Nielsen, Thomas; Bentzen, Lise Nørgaard; Pedersen, Michael; Horsman, Michael Robert; Østergaard, Leif.

    2009. Abstract from ISMRM, Honolulu, Haiti.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  113. Published

    Imaging tumor hypxia: The need to combine techniques. / Horsman, Michael Robert; Nielsen, T; Østergaard, L; Tramm, Trine; Busk, Morten.

    2009. Poster session presented at ECCO 15 and 34th ESMO Multidisciplinary Congress, Berlin, Germany.

    Research output: Contribution to conferencePosterResearch

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