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Michael Hans Willi Lappe

Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy. / Viuff, Mette Hansen; Just, Jesper; Brun, Sara et al.
In: The Journal of clinical endocrinology and metabolism, Vol. 107, No. 7, 07.2022, p. 1983-1993.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Viuff, MH, Just, J, Brun, S, Dam, TV, Hansen, M, Melgaard, L, Hougaard, DM, Lappe, M & Gravholt, CH 2022, 'Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy', The Journal of clinical endocrinology and metabolism, vol. 107, no. 7, pp. 1983-1993. https://doi.org/10.1210/clinem/dgac167

APA

Viuff, M. H., Just, J., Brun, S., Dam, T. V., Hansen, M., Melgaard, L., Hougaard, D. M., Lappe, M., & Gravholt, C. H. (2022). Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy. The Journal of clinical endocrinology and metabolism, 107(7), 1983-1993. https://doi.org/10.1210/clinem/dgac167

CBE

Viuff MH, Just J, Brun S, Dam TV, Hansen M, Melgaard L, Hougaard DM, Lappe M, Gravholt CH. 2022. Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy. The Journal of clinical endocrinology and metabolism. 107(7):1983-1993. https://doi.org/10.1210/clinem/dgac167

MLA

Viuff, Mette Hansen et al. "Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy". The Journal of clinical endocrinology and metabolism. 2022, 107(7). 1983-1993. https://doi.org/10.1210/clinem/dgac167

Vancouver

Viuff MH, Just J, Brun S, Dam TV, Hansen M, Melgaard L et al. Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy. The Journal of clinical endocrinology and metabolism. 2022 Jul;107(7):1983-1993. doi: 10.1210/clinem/dgac167

Author

Viuff, Mette Hansen ; Just, Jesper ; Brun, Sara et al. / Women With Turner Syndrome Are Both Estrogen and Androgen Deficient : The Impact of Hormone Replacement Therapy. In: The Journal of clinical endocrinology and metabolism. 2022 ; Vol. 107, No. 7. pp. 1983-1993.

Bibtex

@article{49dceb4b8f154592b487a718c6a175d8,
title = "Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy",
abstract = "CONTEXT: Women with Turner syndrome (TS) suffer from hypergonadotropic hypogonadism, causing a deficit in gonadal hormone secretion. As a consequence, these women are treated with estrogen from the age of 12 years, and later in combination with progesterone. However, androgens have been given less attention.OBJECTIVE: To assess sex hormone levels in women with TS, both those treated and those nontreated with hormone replacement therapy (HRT), and investigate the impact of HRT on sex hormone levels.METHODS: At Aarhus University Hospital, 99 women with TS were followed 3 times from August 2003 to February 2010. Seventeen were lost during follow-up. Control group 1 consisted of 68 healthy age-matched control women seen once during this period. Control group 2 consisted of 28 young, eumenorrheic women sampled 9 times throughout the same menstrual cycle. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-estradiol, estrone sulfate, DHEAS, testosterone, free androgen index, androstenedione, 17-OH progesterone, and sex hormone-binding globulin (SHBG) were analyzed.RESULTS: All androgens, 17-OH progesterone, and sex hormone-binding globulin (SHBG) were 30% to 50% lower in TS compared with controls (P < 0.01). FSH, LH, and estrone sulfate were more than doubled in women with TS compared with controls (P < 0.02). Using principal component analysis, we describe a positive correlation between women with TS receiving HRT, elevated levels of SHBG, and decreased levels of androgens.CONCLUSION: The sex hormone profile in TS reveals a picture of androgen deficiency, aggravated further by HRT. Conventional HRT does not normalize estradiol levels in TS.",
keywords = "Androgens/deficiency, Estradiol, Estrogens/deficiency, Female, Follicle Stimulating Hormone, Gonadal Steroid Hormones/therapeutic use, Hormone Replacement Therapy, Humans, Luteinizing Hormone, Progesterone/therapeutic use, Sex Hormone-Binding Globulin/analysis, Sex hormones, Testosterone, Turner Syndrome/drug therapy",
author = "Viuff, {Mette Hansen} and Jesper Just and Sara Brun and Dam, {Tine Vrist} and Mette Hansen and Lars Melgaard and Hougaard, {David M} and Michael Lappe and Gravholt, {Claus H{\o}jbjerg}",
note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2022",
month = jul,
doi = "10.1210/clinem/dgac167",
language = "English",
volume = "107",
pages = "1983--1993",
journal = "The Journal of clinical endocrinology and metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Women With Turner Syndrome Are Both Estrogen and Androgen Deficient

T2 - The Impact of Hormone Replacement Therapy

AU - Viuff, Mette Hansen

AU - Just, Jesper

AU - Brun, Sara

AU - Dam, Tine Vrist

AU - Hansen, Mette

AU - Melgaard, Lars

AU - Hougaard, David M

AU - Lappe, Michael

AU - Gravholt, Claus Højbjerg

N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022/7

Y1 - 2022/7

N2 - CONTEXT: Women with Turner syndrome (TS) suffer from hypergonadotropic hypogonadism, causing a deficit in gonadal hormone secretion. As a consequence, these women are treated with estrogen from the age of 12 years, and later in combination with progesterone. However, androgens have been given less attention.OBJECTIVE: To assess sex hormone levels in women with TS, both those treated and those nontreated with hormone replacement therapy (HRT), and investigate the impact of HRT on sex hormone levels.METHODS: At Aarhus University Hospital, 99 women with TS were followed 3 times from August 2003 to February 2010. Seventeen were lost during follow-up. Control group 1 consisted of 68 healthy age-matched control women seen once during this period. Control group 2 consisted of 28 young, eumenorrheic women sampled 9 times throughout the same menstrual cycle. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-estradiol, estrone sulfate, DHEAS, testosterone, free androgen index, androstenedione, 17-OH progesterone, and sex hormone-binding globulin (SHBG) were analyzed.RESULTS: All androgens, 17-OH progesterone, and sex hormone-binding globulin (SHBG) were 30% to 50% lower in TS compared with controls (P < 0.01). FSH, LH, and estrone sulfate were more than doubled in women with TS compared with controls (P < 0.02). Using principal component analysis, we describe a positive correlation between women with TS receiving HRT, elevated levels of SHBG, and decreased levels of androgens.CONCLUSION: The sex hormone profile in TS reveals a picture of androgen deficiency, aggravated further by HRT. Conventional HRT does not normalize estradiol levels in TS.

AB - CONTEXT: Women with Turner syndrome (TS) suffer from hypergonadotropic hypogonadism, causing a deficit in gonadal hormone secretion. As a consequence, these women are treated with estrogen from the age of 12 years, and later in combination with progesterone. However, androgens have been given less attention.OBJECTIVE: To assess sex hormone levels in women with TS, both those treated and those nontreated with hormone replacement therapy (HRT), and investigate the impact of HRT on sex hormone levels.METHODS: At Aarhus University Hospital, 99 women with TS were followed 3 times from August 2003 to February 2010. Seventeen were lost during follow-up. Control group 1 consisted of 68 healthy age-matched control women seen once during this period. Control group 2 consisted of 28 young, eumenorrheic women sampled 9 times throughout the same menstrual cycle. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-estradiol, estrone sulfate, DHEAS, testosterone, free androgen index, androstenedione, 17-OH progesterone, and sex hormone-binding globulin (SHBG) were analyzed.RESULTS: All androgens, 17-OH progesterone, and sex hormone-binding globulin (SHBG) were 30% to 50% lower in TS compared with controls (P < 0.01). FSH, LH, and estrone sulfate were more than doubled in women with TS compared with controls (P < 0.02). Using principal component analysis, we describe a positive correlation between women with TS receiving HRT, elevated levels of SHBG, and decreased levels of androgens.CONCLUSION: The sex hormone profile in TS reveals a picture of androgen deficiency, aggravated further by HRT. Conventional HRT does not normalize estradiol levels in TS.

KW - Androgens/deficiency

KW - Estradiol

KW - Estrogens/deficiency

KW - Female

KW - Follicle Stimulating Hormone

KW - Gonadal Steroid Hormones/therapeutic use

KW - Hormone Replacement Therapy

KW - Humans

KW - Luteinizing Hormone

KW - Progesterone/therapeutic use

KW - Sex Hormone-Binding Globulin/analysis

KW - Sex hormones

KW - Testosterone

KW - Turner Syndrome/drug therapy

U2 - 10.1210/clinem/dgac167

DO - 10.1210/clinem/dgac167

M3 - Journal article

C2 - 35302622

VL - 107

SP - 1983

EP - 1993

JO - The Journal of clinical endocrinology and metabolism

JF - The Journal of clinical endocrinology and metabolism

SN - 0021-972X

IS - 7

ER -