Marianne Gerberg Skals

2024

ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats

Skals, M., Broch-Lips, M., Skov, M. B., Riisager, A., Ceelen, J., Nielsen, O. B., Brull, S. J., de Boer, H. D. & Pedersen, T. H., Dec 2024, In: Nature Communications. 15, 1, 9289.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2 Citations (Scopus)

2020

Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium

Christensen, I. B., Wu, Q., Bohlbro, A. S., Skals, M. G., Damkier, H. H., Hübner, C. A., Fenton, R. A. & Praetorius, J., 2020, In: Fluids and Barriers of the CNS. 17, 1, 18 p., 2.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

10 Citations (Scopus)

Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis

Christensen, M. G., Johnsen, N., Skals, M., Hamilton, A. D. M., Rubak, P., Hvas, A. M. & Praetorius, H., 2 Aug 2020, In: International Journal of Molecular Sciences . 21, 16, p. 1-18 18 p., 5652.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

6 Citations (Scopus)

2019

P2X₁ receptor blockers reduce the number of circulating thrombocytes and the overall survival of urosepsis with haemolysin-producing Escherichia coli

Skals, M., Greve, A. S., Fagerberg, S. K., Johnsen, N., Christensen, M. G. & Praetorius, H. A., Jun 2019, In: Purinergic Signalling. 15, 2, p. 265-276 12 p.

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Open Access

8 Citations (Scopus)

α-Haemolysin production, as a single factor, causes fulminant sepsis in a model of Escherichia coli-induced bacteraemia

Johnsen, N., Hamilton, A. D. M., Greve, A. S., Christensen, M. G., Therkildsen, J. R., Wehmöller, J., Skals, M. & Praetorius, H. A., 2019, In: Cellular Microbiology. 21, 6, 11 p., e13017.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

20 Citations (Scopus)

2017

Loop Diuretics Diminish Hemolysis Induced by α-Hemolysin from Escherichia coli

Söderström, C. M., Fagerberg, S. K., Brogaard, M. B., Leipziger, J., Skals, M. & Praetorius, H. A., Jun 2017, In: Journal of Membrane Biology. 250, 3, p. 301-313 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

3 Citations (Scopus)

P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli

Greve, A.-S., Skals, M., Fagerberg, S. K., Tonnus, W., Ellermann-Eriksen, S., Evans, R. J., Linkermann, A. & Praetorius, H. A., 6 Apr 2017, In: Frontiers in cellular and infection microbiology. 7, APR, 14 p., 113.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

38 Citations (Scopus)

2016

Inhibition of P2X receptors protects human monocytes against damage by leukotoxin from Aggregatibacter actinomycetemcomitans and α-hemolysin from Escherichia coli

Fagerberg, S. K., Jakobsen, M. R., Skals, M. & Praetorius, H. A., 15 Nov 2016, In: Infection and Immunity. 84, 11, p. 3114-3130 17 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

22 Citations (Scopus)

2015

[Ca2+]i oscillations and IL-6 release induced by alpha-hemolysin from Escherichia coli require P2 receptor activation in renal epithelia

Christensen, M., Fagerberg, S. K., de Bruijn, P. I. A., Bjælde, R. G., Jakobsen, H., Leipziger, J. G., Skals, M. G. & Prætorius, H., 2015, In: Journal of Biological Chemistry. 290, 23, p. 14776-84 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

12 Citations (Scopus)

2014

Bacterial RTX Toxins Allow Acute ATP Release from Human Erythrocytes Directly through the Toxin Pore

Skals, M., Bjaelde, R. G., Reinholdt, J., Poulsen, K., Vad, B. S., Otzen, D., Leipziger, J. & Praetorius, H. A., 4 Jul 2014, In: Journal of Biological Chemistry. 289, p. 19098-19109 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

45 Citations (Scopus)

Sialic acid residues are essential for cell lysis mediated by leukotoxin from Aggregatibacter actinomycetemcomitans

Munksgaard, P. S., Skals, M. G., Reinholdt, J., Poulsen, K., Jensen, M. R., Yang, C., Leipziger, J., Vorup-Jensen, T. & Praetorius, H. A., Jun 2014, In: Infection and Immunity. 82, 6, p. 2219-28 10 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

18 Citations (Scopus)

2013

Mechanisms of cytolysin-induced cell damage -- a role for auto- and paracrine signalling

Skals, M. G. & Prætorius, H., 2013, In: Acta Physiologica (Print). 209, 2, p. 95 113 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

12 Citations (Scopus)

P2X receptor-dependent erythrocyte damage by α-hemolysin from Escherichia coli triggers phagocytosis by THP-1 cells

Fagerberg, S. K., Skals, M. G., Leipziger, J. G. & Prætorius, H., 2013, In: Toxins. 5, p. 472 487 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

16 Citations (Scopus)

P2X receptor stimulation amplifies complement-induced haemolysis

Hejl, J. L., Skals, M., Leipziger, J. & Praetorius, H. A., Apr 2013, In: Pflügers Archiv - European Journal of Physiology. 465, 4, p. 529-41 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

P2X receptor stimulation amplifies complement-induced haemolysis

Hjel, J. L., Skals, M. G., Leipziger, J. G. & Prætorius, H., 2013, In: Pflügers Archiv - European Journal of Physiology. 465, p. 529-41 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

20 Citations (Scopus)

2012

Leukotoxin from Aggregatibacter actinomycetemcomitans causes shrinkage and P2X receptor-dependent lysis of human erythrocytes

Munksgaard, P. S., Vorup-Jensen, T., Reinholdt, J., Söderström, C. M., Poulsen, K., Leipziger, J., Praetorius, H. A. & Skals, M., 2012, In: Cellular Microbiology. 14, 12, p. 1904-20 17 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

41 Citations (Scopus)

Purinergic signalling and volume regulation in erythrocytes induced by bacterial toxins

Skals, M. G., 2012, Århus Universitet.

Research output: Types of Thesis › PhD thesis

2011

Combretastatin-induced hypertension and the consequences for its combination with other therapies

Busk, M., Bohn, A. B., Skals, M., Wang, T. & Horsman, M. R., 2011, In: Vascular Pharmacology. 54, 1-2, p. 13-17 5 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

16 Citations (Scopus)

Haemolysis induced by α-toxin from Staphylococcus aureus requires P2X receptor activation

Skals, M. G., Leipziger, J. G. & Prætorius, H., 2011, In: Pflügers Archiv - European Journal of Physiology. 462, p. 669-679 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

45 Citations (Scopus)

Python Erythrocytes Are Resistant to α-Hemolysin from Escherichia coli

Larsen, C. K., Skals, M. G., Nielsen, T. W., Cheema, M. U., Leipziger, J. G. & Prætorius, H., 8 Nov 2011, In: Journal of Membrane Biology. 244, 3, p. 131-140

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24 Citations (Scopus)

2010

Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET

Busk, M., Munk, O. L., Jakobsen, S., Wang, T., Skals, M., Steiniche, T., Horsman, M. R. & Overgaard, J., 2010, In: Acta Oncologica. 49, 7, p. 922-33 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

34 Citations (Scopus)

Escherichia coli α-hemolysin triggers shrinkage of erythrocytes via K(Ca)_3.1 and TMEM16A channels with subsequent phosphatidylserine exposure.

Skals, M. G., Jensen, U. B., Ousingsawat, J., Kunzelmann, K., Leipziger, J. G. & Prætorius, H., 2010, In: Journal of Biological Chemistry. 285, p. 15557-15565 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Escherichia coli α-hemolysin triggers shrinkage of erythrocytes via K_Ca3.1 and TMEM16A channels with subsequent phosphatidylserine exposure

Skals, M., Jensen, U. B., Ousingsawat, J., Kunzelmann, K., Leipziger, J. & Praetorius, H. A., 14 May 2010, In: Journal of Biological Chemistry. 285, 20, p. 15557-15565 9 p.

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Open Access

54 Citations (Scopus)

2009

α-hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis

Skals, M. G., Jørgensen, N. R., Leipziger, J. G. & Prætorius, H., 2009, In: Proceedings of the National Academy of Sciences (PNAS). 106, p. 4030-4035 6 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

113 Citations (Scopus)

2006

Cardiovascular changes under normoxic and hypoxic conditions in the air-breathing teleost Synbranchus marmoratus: importance of the venous system

Skals, M. G., Skovgaard, N., Taylor, E. W., Leite, C. A. C., Abe, A. S. & Wang, T., 2006, In: Journal of Experimental Biology. 209, Pt 20, p. 4167-73 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

33 Citations (Scopus)

Evidence for a respiratory component, similar to mammalian respiratory sinus arrhythmia, in the heart rate variability signal from the rattlesnake, Crotalus durissus terrificus

Campbell, H. A., Leite, C. A. C., Wang, T., Skals, M. G., Abe, A. S., Egginton, S., Rantin, F. T., Bishop, C. M. & Taylor, E. W., Jul 2006, In: Journal of Experimental Biology. 209, Pt 14, p. 2628-36 9 p.

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41 Citations (Scopus)

2005

Venous tone and cardiac function in the South American rattlesnake Crotalus durissus: mean circulatory filling pressure during adrenergic stimulation in anaesthetised and fully recovered animals

Skals, M. G., Skovgaard, N., Abe, A. S. & Wang, T., 2005, In: Journal of Experimental Biology. 208, Pt 19, p. 3747-59 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

29 Citations (Scopus)

2004

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

Nakayama, K., Frew, I. J., Hagensen, M., Skals, M. G., Habelhah, H., Bhoumik, A., Kadoya, T., Erdjument-Bromage, H., Tempst, P., Frappell, P. B., Bowtell, D. D. & Ronai, Z., 25 Jun 2004, In: Cell. 117, 7, p. 941-52 12 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

360 Citations (Scopus)

Marianne Gerberg Skals

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