Martin Roelsgaard Jakobsen

Professor

Profile photo

Martin Roelsgaard Jakobsen

Professor

  • Department of Biomedicine - Forskning og uddannelse, Skou-bygningen
Postal address:
Høegh-Guldbergs Gade 10
1115, 220
8000
Aarhus C
Denmark

Email: mrj@biomed.au.dk

Mobile: +4526153369

Employment

Professor

Department of Biomedicine - Forskning og uddannelse, Skou-bygningen

Aarhus University

Aarhus C, Denmark

2 Sep 2021 → present

CSO, STipe Therapeutics

STipe Therapeutics

Aarhus C, Denmark

1 Sep 2018 → …

Lundbeck Fellow

Lundbeck Fonden, Pulje til Sundhedsfaglig Forskning

1 Oct 2017 → …

Prizes

  1. 23rd SSAC congress Poster Award

    Jakobsen, Martin Roelsgaard (Recipient), 20 Oct 2006

  2. 23th Scandinavian Society for Antimicrobial Chemotherapy

    Jakobsen, Martin Roelsgaard (Recipient), 26 Oct 2006

  3. Alfred Benzon Postdoc Fellowship: Adaptive changes in HIV-1 subtype C envelope glycoproteins contributing to pathogenicity

    Jakobsen, Martin Roelsgaard (Recipient), 1 Dec 2008

  4. Ung Eliteforskerpris Sapere Aude trin 1: Modtager Januar 2011

    Jakobsen, Martin Roelsgaard (Recipient), 27 Jan 2011

  5. Lundbeck Foundation Fellowship

    Jakobsen, Martin Roelsgaard (Recipient), 2017

  6. Anders Jahre's Award for Medical Research - Young Scientists

    Jakobsen, Martin Roelsgaard (Recipient), 2018

Research outputs

Plasmacytoid Dendritic Cells as a Novel Cell-Based Cancer Immunotherapy

Hernández, S. S., Jakobsen, M. R. & Bak, R. O., Sep 2022, In: International Journal of Molecular Sciences . 23, 19, 11397.

Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer

Sokac, M., Ahrenfeldt, J., Litchfield, K., Watkins, T. B. K., Knudsen, M., Dyrskjøt, L., Jakobsen, M. R. & Birkbak, N. J., Aug 2022, In: Cancer Research Communications. 2, 8, p. 762-771 10 p.

Increased Soluble PD-1 Predicts Response to Nivolumab plus Ipilimumab in Melanoma

Pedersen, J. G., Sokac, M., Sørensen, B. S., Luczak, A. A., Aggerholm-Pedersen, N., Birkbak, N. J., Øllegaard, T. H. & Jakobsen, M. R., Jul 2022, In: Cancers. 14, 14, 3342.

Plasmacytoid dendritic cells during COVID-19: Ally or adversary?

van der Sluis, R. M., Holm, C. K. & Jakobsen, M. R., Jul 2022, In: Cell Reports. 40, 4, 111148.

IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection

Griffante, G., Hewelt-Belka, W., Albano, C., Gugliesi, F., Pasquero, S., Castillo Pacheco, S. F., Bajetto, G., Porporato, P. E., Mina, E., Vallino, M., Krapp, C., Jakobsen, M. R., Purdy, J., von Einem, J., Landolfo, S., Dell'Oste, V. & Biolatti, M., Jun 2022, In: mBio. 13, 3, p. e0043522 19 p.

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection

van der Sluis, R. M., Cham, L. B., Gris-Oliver, A., Gammelgaard, K. R., Pedersen, J. G., Idorn, M., Ahmadov, U., Hernandez, S. S., Cémalovic, E., Godsk, S. H., Thyrsted, J., Gunst, J. D., Nielsen, S. D., Jørgensen, J. J., Bjerg, T. W., Laustsen, A., Reinert, L. S., Olagnier, D., Bak, R. O., Kjolby, M., Holm, C. K., Tolstrup, M., Paludan, S. R., Kristensen, L. S., Søgaard, O. S. & Jakobsen, M. R., May 2022, In: EMBO Journal. 41, 10, 19 p., e109622.

Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis

Køster, D., Egedal, J. H., Lomholt, S., Hvid, M., Jakobsen, M. R., Müller-Ladner, U., Eibel, H., Deleuran, B., Kragstrup, T. W., Neumann, E. & Nielsen, M. A., Dec 2021, In: Scientific Reports. 11, 1, 22168.

Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern

Carter-Timofte, M. E., Arulanandam, R., Kurmasheva, N., Fu, K., Laroche, G., Taha, Z., Van Der Horst, D., Cassin, L., Van Der Sluis, R. M., Palermo, E., Di Carlo, D., Jacobs, D., Maznyi, G., Azad, T., Singaravelu, R., Ren, F., Hansen, A. L., Idorn, M., Holm, C. K., Jakobsen, M. R., Van Grevenynghe, J., Hiscott, J., Paludan, S. R., Bell, J. C., Seguin, J., Sabourin, L. A., Côté, M., Diallo, J. S., Alain, T. & Olagnier, D., Oct 2021, In: ACS Infectious Diseases. 7, 11, p. 3034-3051 18 p.

Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

Laustsen, A., van der Sluis, R. M., Gris Oliver, A., Sanchez Hernandez, S., Cemalovic, E., Tang, H. Q., Pedersen, L. H., Uldbjerg, N., Jakobsen, M. R. & Bak, R., Sep 2021, In: eLife. 10, 21 p., e65528.

Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection

Egedal, J. H., Xie, G., Packard, T. A., Laustsen, A., Neidleman, J., Georgiou, K., Pillai, S. K., Greene, W. C., Jakobsen, M. R. & Roan, N. R., Sep 2021, In: Mucosal Immunology. 14, 5, p. 1203-1213 11 p.

Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the cGAS-STING Pathway

Liu, H., Ottosen, R. N., Jennet, K. M., Svenningsen, E. B., Kristensen, T. F., Biltoft, M., Jakobsen, M. R. & Poulsen, T. B., Aug 2021, In: Angewandte Chemie International Edition. 60, 34, p. 18734-18741 8 p.

cGAS-STING pathway expression as a prognostic tool in NSCLC

Raaby Gammelgaard, K., Sandfeld-Paulsen, B., Godsk, S. H., Demuth, C., Meldgaard, P., Sorensen, B. S. & Jakobsen, M. R., Jan 2021, In: Translational lung cancer research. 10, 1, p. 340-354 15 p.

Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C-C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status

Pedersen, J. G., Egedal, J. H., Packard, T. A., Thavachelvam, K., Xie, G., van der Sluis, R. M., Greene, W. C., Roan, N. R. & Jakobsen, M. R., 2021, In: Frontiers in Microbiology. 12, 11 p., 763030.

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Olagnier, D., Farahani, E., Thyrsted, J., Blay-Cadanet, J., Herengt, A., Idorn, M., Hait, A., Hernaez, B., Knudsen, A., Iversen, M. B., Schilling, M., Jørgensen, S. E., Thomsen, M., Reinert, L. S., Lappe, M., Hoang, H-D., Gilchrist, V. H., Hansen, A. L., Ottosen, R., Nielsen, C. G., Møller, C., van der Horst, D., Peri, S., Balachandran, S., Huang, J., Jakobsen, M., Svenningsen, E. B., Poulsen, T. B., Bartsch, L., Thielke, A. L., Luo, Y., Alain, T., Rehwinkel, J., Alcamí, A., Hiscott, J., Mogensen, T. H., Paludan, S. R. & Holm, C. K., 21 Oct 2020, In: Nature Communications. 11, 1, 1 p., 5419.

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Olagnier, D., Farahani, E., Thyrsted, J., Blay-Cadanet, J., Herengt, A., Idorn, M., Hait, A., Hernaez, B., Knudsen, A., Iversen, M. B., Schilling, M., Jørgensen, S. E., Thomsen, M., Reinert, L. S., Lappe, M., Hoang, H-D., Gilchrist, V. H., Hansen, A. L., Ottosen, R., Nielsen, C. G., Møller, C., van der Horst, D., Peri, S., Balachandran, S., Huang, J., Jakobsen, M., Svenningsen, E. B., Poulsen, T. B., Bartsch, L., Thielke, A. L., Luo, Y., Alain, T., Rehwinkel, J., Alcamí, A., Hiscott, J., Mogensen, T. H., Paludan, S. R. & Holm, C. K., Oct 2020, In: Nature Communications. 11, 1, 12 p., 4938.

Inflammatory Cytokines and ctDNA Are Biomarkers for Progression in Advanced-Stage Melanoma Patients Receiving Checkpoint Inhibitors

Pedersen, J. G., Madsen, A. T., Gammelgaard, K. R., Aggerholm-Pedersen, N., Sørensen, B. S., Øllegaard, T. H. & Jakobsen, M. R., Jun 2020, In: Cancers. 12, 6, 1414.

Plasmacytoid Dendritic Cells as Cell-Based Therapeutics: A Novel Immunotherapy to Treat Human Immunodeficiency Virus Infection?

van der Sluis, R. M., Egedal, J. H. & Jakobsen, M. R., May 2020, In: Frontiers in cellular and infection microbiology. 10, 12 p., 249.

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

Van der Sluis, R. M., Zerbato, J. M., Rhodes, J. W., Pascoe, R. D., Solomon, A., Kumar, N. A., Dantanarayana, A. I., Tennakoon, S., Dufloo, J., McMahon, J., Chang, J. J., Evans, V. A., Hertzog, P. J., Jakobsen, M. R., Harman, A. N., Lewin, S. R. & Cameron, P. U., 2020, In: PLOS Pathogens. 16, 2, 27 p., e1008151.

Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis

Køster, D., Egedal, J. H., Hvid, M., Jakobsen, M. R., Mueller-Ladner, U., Deleuran, B., Kragstrup, T. W., Neumann, E. & Nielsen, M. A., 2020, In: Annals of the Rheumatic Diseases. 79, Suppl.1, p. 1345 1 p., AB0100.

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling

George, A. F., Jang, K. S., Nyegaard, M., Neidleman, J., Spitzer, T. L., Xie, G., Chen, J. C., Herzig, E., Laustsen, A., Marques de Menezes, E. G., Houshdaran, S., Pilcher, C. D., Norris, P. J., Jakobsen, M. R., Greene, W. C., Giudice, L. C. & Roan, N. R., 2020, In: Human Reproduction. 35, 3, p. 617-640 24 p.

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

Hotter, D., Bosso, M., Jønsson, K. L., Krapp, C., Stürzel, C. M., Das, A., Littwitz-Salomon, E., Berkhout, B., Russ, A., Wittmann, S., Gramberg, T., Zheng, Y., Martins, L. J., Planelles, V., Jakobsen, M. R., Hahn, B. H., Dittmer, U., Sauter, D. & Kirchhoff, F., Jun 2019, In: Cell Host & Microbe. 25, 6, p. 858-872.e13 29 p.

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Braun, E., Hotter, D., Koepke, L., Zech, F., Groß, R., Sparrer, K. M. J., Müller, J. A., Pfaller, C. K., Heusinger, E., Wombacher, R., Sutter, K., Dittmer, U., Winkler, M., Simmons, G., Jakobsen, M. R., Conzelmann, K-K., Pöhlmann, S., Münch, J., Fackler, O. T., Kirchhoff, F. & Sauter, D., 14 May 2019, In: Cell Reports. 27, 7, p. 2092-2104.e10 23 p.

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination

Martin, R. M., Ikeda, K., Cromer, M. K., Uchida, N., Nishimura, T., Romano, R., Tong, A. J., Lemgart, V. T., Camarena, J., Pavel-Dinu, M., Sindhu, C., Wiebking, V., Vaidyanathan, S., Dever, D. P., Bak, R. O., Laustsen, A., Lesch, B. J., Jakobsen, M. R., Sebastiano, V., Nakauchi, H. & Porteus, M. H., 2 May 2019, In: Cell Stem Cell. 24, 5, p. 821-828.e5 13 p.

Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids

Sun, C., Luecke, S., Bodda, C., Jønsson, K. L., Cai, Y., Zhang, B. C., Jensen, S. B., Nordentoft, I., Jensen, J. M., Jakobsen, M. R. & Paludan, S. R., 2019, In: Journal of Interferon and Cytokine Research. 39, 4, p. 191-204 14 p.

cAIMP administration in humanized mice induces a chimerization-level-dependent STING response

Andersen, A. H. F., Olesen, R., Jønsson, K. L., Højen, J. F., Krapp, C., Mack, K., Thomsen, M. K., Østergaard, L., Tolstrup, M., Dagnæs-Hansen, F., Jakobsen, M. R. & Denton, P. W., 2019, In: Immunology. 157, 2, p. 163-172 10 p.

Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules

Nissen, S. K., Christiansen, M., Helleberg, M., Kjær, K., Jørgensen, S. E., Gerstoft, J., Katzenstein, T. L., Benfield, T., Kronborg, G., Larsen, C. S., Laursen, A., Pedersen, G., Jakobsen, M. R., Tolstrup, M. & Mogensen, T. H., 15 Oct 2018, In: Scientific Reports. 8, 1, p. 15253

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

Dunphy, G., Flannery, S. M., Almine, J. F., Connolly, D. J., Paulus, C., Jønsson, K. L., Jakobsen, M. R., Nevels, M. M., Bowie, A. G. & Unterholzner, L., 6 Sep 2018, In: Molecular Cell. 71, 5, p. 745-760.e5

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Laustsen, A., Bak, R., Krapp, C., Kjær, L., Egedahl, J. H., Petersen, C. C., Pillai, S., Tang, H. Q., Uldbjerg, N., Porteus, M., Roan, N. R., Nyegaard, M., Denton, P. W. & Jakobsen, M. R., 30 Aug 2018, In: Nature Communications. 9, 1, 14 p., 3525.

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Olagnier, D., Brandtoft, A. M., Gunderstofte, C., Villadsen, N. L., Krapp, C., Thielke, A. L., Laustsen, A., Peri, S., Hansen, A. L., Bonefeld, L., Thyrsted, J., Bruun, V., Iversen, M. B., Lin, L., Artegoitia, V. M., Su, C., Yang, L., Lin, R., Balachandran, S., Luo, Y., Nyegaard, M., Marrero, B., Goldbach-Mansky, R., Motwani, M., Ryan, D. G., Fitzgerald, K. A., O'Neill, L. A., Hollensen, A. K., Damgaard, C. K., de Paoli, F. V., Bertram, H. C., Jakobsen, M. R., Poulsen, T. B. & Holm, C. K., 29 Aug 2018, In: Nature Communications. 9, 1, 13 p., 3506.

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

Hansen, A. L., Buchan, G. J., Rühl, M., Mukai, K., Salvatore, S. R., Ogawa, E., Andersen, S. D., Iversen, M. B., Thielke, A. L., Gunderstofte, C., Motwani, M., Møller, C. T., Jakobsen, A. S., Fitzgerald, K. A., Roos, J., Lin, R., Maier, T. J., Goldbach-Mansky, R., Miner, C. A., Qian, W., Miner, J. J., Rigby, R. E., Rehwinkel, J., Jakobsen, M. R., Arai, H., Taguchi, T., Schopfer, F. J., Olagnier, D. & Holm, C. K., 14 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. E7768-E7775 8 p.

Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors

Nissen, S. K., Pedersen, J. G., Helleberg, M., Kjaer, K., Thavachelvam, K., Obel, N., Tolstrup, M., Jakobsen, M. R. & Mogensen, T. H., 15 May 2018, In: Journal of Immunology. 200, 10, p. 3372-3382 11 p.

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

Prabakaran, T., Bodda, C., Krapp, C., Zhang, B-C., Christensen, M. H., Sun, C., Reinert, L., Cai, Y., Jensen, S. B., Skouboe, M. K., Nyengaard, J. R., Thompson, C. B., Lebbink, R. J., Sen, G. C., van Loo, G., Nielsen, R., Komatsu, M., Nejsum, L. N., Jakobsen, M. R., Gyrd-Hansen, M. & Paludan, S. R., 13 Apr 2018, In: E M B O Journal. 37, 8, E97858.

STING dependent sensing - Does HIV actually care?

Krapp, C., Jønsson, K. & Jakobsen, M. R., Apr 2018, In: Cytokine & Growth Factor Reviews. p. 68-76 9 p.

Human cytomegalovirus tegument protein pp65 (pUL83) dampens type I interferon production by inactivating the DNA sensor cGAS without affecting STING

Biolatti, M., Dell'Oste, V., Pautasso, S., Gugliesi, F., von Einem, J., Krapp, C., Jakobsen, M. R., Borgogna, C., Gariglio, M., De Andrea, M. & Landolfo, S., Mar 2018, In: Journal of Virology. 92, 6, 18 p., e01774-17.

ERAdP standing in the shadow of STING innate immune signaling

Jakobsen, M. R., 18 Jan 2018, In: Nature Immunology. 19, p. 105-107 3 p.

CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS- and STING-dependent Maturation

Laursen, M. F., Christensen, E., Degn, L. L. T., Jønsson, K., Jakobsen, M. R., Agger, R. & Kofod-Olsen, E., Jan 2018, In: Journal of Immunotherapy. 41, 1, p. 9-18 10 p.

The Impact of genetic Variants of STING and IFI16 on Non-Small Cell Lung Cancer

Gammelgaard, K. R., Paulsen, B. S., Demuth, C., Pedersen, J. G., Nyegaard, M., Meldgaard, P., Sørensen, B. S. & Jakobsen, M. R., 2018.

cGAS is activated by DNA in a length-dependent manner

Luecke, S., Holleufer, A., Christensen, M. H., Jønsson, K. L., Boni, G. A., Sørensen, L. K., Johannsen, M., Jakobsen, M. R., Hartmann, R. & Paludan, S. R., Oct 2017, In: E M B O Reports. 18, 10, p. 1707–1715

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

Jønsson, K. L., Laustsen, A., Krapp, C., Skipper, K. A., Thavachelvam, K., Hotter, D., Egedal, J. H., Kjolby, M., Mohammadi, P., Prabakaran, T., Sørensen, L. K., Sun, C., Jensen, S. B., Holm, C. K., Lebbink, R. J., Johannsen, M., Nyegaard, M., Mikkelsen, J. G., Kirchhoff, F., Paludan, S. R. & Jakobsen, M. R., 10 Feb 2017, In: Nature Communications. 8, 14391.

Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells

Neidleman, J. A., Chen, J. C., Kohgadai, N., Müller, J. A., Laustsen, A., Thavachelvam, K., Jang, K. S., Stürzel, C. M., Jones, J., Ochsenbauer, C., Chitre, A., Somsouk, M., Garcia, M. M., Smith, J. F., Greenblatt, R. M., Münch, J., Jakobsen, M. R., Giudice, L. C., Greene, W. C. & Roan, N. R., Feb 2017, In: P L o S Pathogens. 13, 2, p. e1006163

Inhibition of P2X receptors protects human monocytes against damage by leukotoxin from Aggregatibacter actinomycetemcomitans and α-hemolysin from Escherichia coli

Fagerberg, S. K., Jakobsen, M. R., Skals, M. & Praetorius, H. A., 15 Nov 2016, In: Infection and Immunity. 84, 11, p. 3114-3130 17 p.

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

Borm, K., Jakobsen, M. R., Cashin, K., Flynn, J. K., Ellenberg, P., Østergaard, L., Lee, B., Churchill, M. J., Roche, M. & Gorry, P. R., 3 Nov 2016, In: Retrovirology. 13, 1, 13 p., 74.

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Holm, C. K., Rahbek, S. H., Gad, H. H., Bak, R. O., Jakobsen, M. R., Jiang, Z., Hansen, A. L., Jensen, S. K., Sun, C., Thomsen, M. K., Laustsen, A., Nielsen, C. G., Severinsen, K., Xiong, Y., Burdette, D. L., Hornung, V., Lebbink, R. J., Duch, M., Fitzgerald, K. A., Bahrami, S., Mikkelsen, J. G., Hartmann, R. & Paludan, S. R., 19 Feb 2016, In: Nature Communications. 7, 10680.

Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract

Roan, N. R. & Jakobsen, M. R., 15 Feb 2016, In: Current HIV - AIDS Reports. 13, 1, p. 53-63 11 p.

Macrophage activation in HIV-2 infected patients is less affected by antiretroviral treatment - sCD163 in HIV-1, HIV-2 and HIV-1/2 dually infected patients

HØnge, B. L., Andersen, M. N., Jespersen, S., Medina, C., Correira, F. G., Jakobsen, M. R., Laursen, A., Erikstrup, C., MØller, H. J., Wejse, C. & Bissau HIV Cohort Study Group, 27 Jan 2016, In: J A I D S.

Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors

Cai, Y., Laustsen, A., Zhou, Y., Sun, C., Anderson, M. V., Li, S., Uldbjerg, N., Luo, Y., Jakobsen, M. R. & Mikkelsen, J. G., 2016, In: eLife. 5

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection

Sun, C., Schattgen, S. A., Pisitkun, P., Jorgensen, J. P., Hilterbrand, A. T., Wang, L. J., West, J. A., Hansen, K., Horan, K. A., Jakobsen, M. R., O'Hare, P., Adler, H., Sun, R., Ploegh, H. L., Damania, B., Upton, J. W., Fitzgerald, K. A. & Paludan, S. R., 15 Feb 2015, In: Journal of Immunology. 194, 4, p. 1819-31 13 p.

Histone Deacetylase Inhibitor Romidepsin Inhibits de novo HIV-1 Infections

Jønsson, K. L., Tolstrup, M., Vad-Nielsen, J., Kjær, K., Laustsen, A., Andersen, M. N., Rasmussen, T. A., Søgaard, O. S., Østergaard, L. J., Denton, P. W. & Jakobsen, M. R., 2015, In: Antimicrobial Agents and Chemotherapy. 59, 7, p. 3984-3994 11 p.

Innate immune sensing of HIV-1 infection

Jakobsen, M. R., Olagnier, D. & Hiscott, J., 5 Dec 2014, In: Current Opinion in HIV and AIDS.

Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4 + T-cell subsets, including stem cell memory T-cells

Cashin, K., Paukovics, G., Jakobsen, M. R., Ostergaard, L., Churchill, M. J., Gorry, P. R. & Flynn, J. K., 12 Nov 2014, In: Retrovirology. 11, 1, p. 97

Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

Hansen, K., Prabakaran, T., Laustsen, A., Jørgensen, S. E., Rahbek, S. H., Jensen, S. B., Nielsen, R., Leber, J. H., Decker, T., Horan, K. A., Jakobsen, M. R. & Paludan, S. R., 1 Aug 2014, In: E M B O Journal. 33, 15, p. 1654-66 13 p.

IFI16: At the interphase between innate DNA sensing and genome regulation

Jakobsen, M. R. & Paludan, S. R., 21 Jun 2014, In: Cytokine & Growth Factor Reviews.

Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates to chronic immune activation

Nissen, S. K., Højen, J. F., Andersen, K. L. D., Kofod-Olsen, E., Berg, R. K., Paludan, S. R., Ostergaard, L., Jakobsen, M. R., Tolstrup, M. & Mogensen, T. H., 5 Mar 2014, In: Clinical and Experimental Immunology. 177, 1, p. 295-309 15 p.

Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA

Chiliveru, S., Rahbek, S. H., Jensen, S. K., Jørgensen, S. E., Nissen, S. K., Christiansen, S. H., Mogensen, T. H., Jakobsen, M. R., Iversen, L., Johansen, C. & Paludan, S. R., 2014, In: Journal of Immunology.

Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains

Flynn, J. K., Paukovics, G., Cashin, K., Borm, K., Ellett, A., Roche, M., Jakobsen, M. R., Churchill, M. J. & Gorry, P. R., 2014, In: Viruses. 6, 2, p. 709-26 18 p.

T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication

Berg, R. K., Rahbek, S. H., Kofod-Olsen, E., Holm, C. K., Melchjorsen, J., Jensen, D. G., Hansen, A. L., Jørgensen, L. B., Østergaard, L. J., Tolstrup, M., Larsen, C. S., Paludan, S. R., Jakobsen, M. R. & Mogensen, T. H., 2014, In: PLOS ONE. 9, 1, p. e84513

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

Jakobsen, M. R., Bak, R. O., Andersen, A., Berg, R. K., Jensen, S. B., Tengchuan, J., Laustsen, A., Hansen, K., Ostergaard, L., Fitzgerald, K. A., Xiao, T. S., Mikkelsen, J. G., Mogensen, T. H. & Paludan, S. R., 23 Oct 2013, In: Proceedings of the National Academy of Sciences of the United States of America.

Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection

Cashin, K., Jakobsen, M. R., Sterjovski, J., Roche, M., Ellett, A., Flynn, J. K., Borm, K., Gouillou, M., Churchill, M. J. & Gorry, P. R., 16 Sep 2013, In: Retrovirology. 10, 1, p. 98

Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R., 1 Mar 2013, In: Journal of Immunology. 190, 5, p. 2311-2329 18 p.

CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm

Cashin, K., Gray, L. R., Jakobsen, M. R., Sterjovski, J., Churchill, M. J. & Gorry, P. R., 2013, In: Retrovirology. 10, 1, p. 24

Efficient sleeping beauty DNA transposition from DNA minicircles

Sharma, N., Cai, Y., Bak, R. O., Jakobsen, M. R., Schrøder, L. D. & Mikkelsen, J. G., 2013, In: Molecular Therapy - Nucleic Acids. 2, p. e74

Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection

Jakobsen, M. R., Cashin, K., Roche, M., Sterjovski, J., Ellett, A., Borm, K., Flynn, J., Erikstrup, C., Gouillou, M., Gray, L. R., Saksena, N. K., Wang, B., Purcell, D. F. J., Kallestrup, P., Zinyama-Gutsire, R., Gomo, E., Ullum, H., Ostergaard, L., Lee, B., Ramsland, P. A., Churchill, M. J. & Gorry, P. R., 2013, In: P L o S One. 8, 6, p. e65950

Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein

Jakobsen, M. R., Mogensen, T. H. & Paludan, S. R., 2012, In: Cell Research.

Impact of Minority Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Resistance Genotype after Virologic Failure

Li, J. Z., Paredes, R., Ribaudo, H., Kozal, M. J., Svarovskaia, E. S., Johnson, J. A., Geretti, A. M., Metzner, K. J., Jakobsen, M. R., Hullsiek, K. H., Østergaard, L. J., Miller, M. D. & Kuritzkes, D. R., 2012, In: The Internet Journal of Infectious Diseases.

V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc

Berro, R., Klasse, P. J., Jakobsen, M. R., Gorry, P. R., Moore, J. P. & Sanders, R. W., 2012, In: Virology. 427, 2, p. 158-65 8 p.

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

Holm, C. K., Jensen, S. B., Jakobsen, M. R., Cheshenko, N., Horan, K. A., Moeller, H. B., Gonzalez-Dosal, R., Rasmussen, S. B., Christensen, M. H., Yarovinsky, T. O., Rixon, F. J., Herold, B. C., Fitzgerald, K. A. & Paludan, S. R., 2012, In: Nature Immunology. 13, 8, p. 737-43 7 p.

HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism

Roche, M., Jakobsen, M. R., Sterjovski, J., Ellett, A., Posta, F., Lee, B., Jubb, B., Westby, M., Lewin, S. R., Ramsland, P. A., Churchill, M. J. & Gorry, P. R., 1 May 2011, In: Indian Journal of Virology. 85, 9, p. 4330-42 13 p.

Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis

Li, J. Z., Paredes, R., Ribaudo, H. J., Svarovskaia, E. S., Metzner, K. J., Kozal, M. J., Hullsiek, K. H., Balduin, M., Jakobsen, M. R., Geretti, A. M., Thiebaut, R., Ostergaard, L., Masquelier, B., Johnson, J. A., Miller, M. D. & Kuritzkes, D. R., 6 Apr 2011, In: JAMA: The Journal of the American Medical Association. 305, 13, p. 1327-35 9 p.

Characterization of the virus-cell interactions by HIV-1 subtype C variants from an antiretroviral therapy-naïve subject with baseline resistance to the CCR5 inhibitor maraviroc

Jakobsen, M. R., 20 Mar 2011.

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

Roche, M., Jakobsen, M. R., Ellett, A., Salimiseyedabad, H., Jubb, B., Westby, M., Lee, B., Lewin, S. R., Churchill, M. J. & Gorry, P. R., 2011, In: Retrovirology. 8, p. 89

Enhanced CD4+ cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection

Wade, J., Sterjovski, J., Gray, L., Roche, M., Chiavaroli, L., Ellett, A., Jakobsen, M. R., Cowley, D., Pereira, C. D. F., Saksena, N., Wang, B., Purcell, D. F. J., Karlsson, I., Fenyö, E-M., Churchill, M. & Gorry, P. R., 2010, In: Virology. 396, 2, p. 246-55 9 p.

Transmission of HIV-1 Drug-Resistant Variants: Prevalence and Effect on Treatment Outcome

Jakobsen, M. R., Tolstrup, M., Søgaard, O. S., Jørgensen, L. B., Gorry, P. R., Laursen, A. & Østergaard, L. J., 2010, In: Clinical Infectious Diseases.

Pre-screening HIV-1 reverse transcriptase resistance mutations in subtype B patients using a novel multiplex primer extension assay

Jakobsen, M. R., Aggerholm, A., Jørgensen, L. B., Laursen, A. & Østergaard, L. J., 2009, In: Current H I V Research. 7, 4, p. 398-409 11 p.

Transmission of HIV-1 drug resistant variants: Prevalence and impact on treatment outcome

Jakobsen, M. R., Tolstrup, M., Søgaard, O. S., Bruun-Jørgensen, L., Gorry, P., Laursen, A. L. & Østergaard, L. J., 2009, In: Clinical Infectious Diseases.

C-reactive protein predicts future arterial and cardiovascular events in patients with symptomatic peripheral arterial disease.

Høgh, A. L., Joensen, J., Lindholt, J. S., Jakobsen, M. R. & Østergaard, L., 2008, In: Vascular and Endovascular Surgery. 42, 4, p. 341-7 6 p.

Entecavir therapy induces de novo HIV reverse-transcriptase M184V mutation in an antiretroviral therapy-naive patient.

Jakobsen, M. R., Arildsen, H., Krarup, H. B., Tolstrup, M., Østergaard, L. & Laursen, A. L., 2008, In: Clinical Infectious Diseases. 46, 9, p. e88-91

Dynamics of 103K/N and 184M/V HIV-1 drug resistant populations: relative comparison in plasma virus RNA versus CD45RO+T cell proviral DNA.

Jakobsen, M. R., Tolstrup, M., Bertelsen, L., Laursen, A. L., Obel, N., Østergaard, L. & Mohey, R., 2007, In: Journal of Clinical Virology. 39, 3, p. 215-21 6 p.

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

Jakobsen, M. R., Haasnoot, J., Wengel, J., Berkhout, B. & Kjems, J., 2007, In: Retrovirology. 4, 29, p. 1-13 13 p.

A genomic selection strategy to identify accessible and dimerization blocking targets in the 5'-UTR of HIV-1 RNA

Jakobsen, M. R., Damgaard, C. K., Andersen, E. S., Podhajska, A. & Kjems, J., 2004, In: Nucleic Acids Research. 32, 7, p. e67 10 p.