Plasmacytoid Dendritic Cells as a Novel Cell-Based Cancer Immunotherapy
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van der Sluis, R. M., Holm, C. K. & Jakobsen, M. R., Jul 2022, In: Cell Reports. 40, 4, 111148.IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection
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Køster, D., Egedal, J. H., Lomholt, S., Hvid, M., Jakobsen, M. R., Müller-Ladner, U., Eibel, H., Deleuran, B., Kragstrup, T. W., Neumann, E. & Nielsen, M. A., Dec 2021, In: Scientific Reports. 11, 1, 22168.Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern
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Egedal, J. H., Xie, G., Packard, T. A., Laustsen, A., Neidleman, J., Georgiou, K., Pillai, S. K., Greene, W. C., Jakobsen, M. R. & Roan, N. R., Sep 2021, In: Mucosal Immunology. 14, 5, p. 1203-1213 11 p.Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the cGAS-STING Pathway
Liu, H., Ottosen, R. N., Jennet, K. M., Svenningsen, E. B., Kristensen, T. F., Biltoft, M., Jakobsen, M. R. & Poulsen, T. B., Aug 2021, In: Angewandte Chemie International Edition. 60, 34, p. 18734-18741 8 p.cGAS-STING pathway expression as a prognostic tool in NSCLC
Raaby Gammelgaard, K., Sandfeld-Paulsen, B., Godsk, S. H., Demuth, C., Meldgaard, P., Sorensen, B. S. & Jakobsen, M. R., Jan 2021, In: Translational lung cancer research. 10, 1, p. 340-354 15 p.Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C-C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status
Pedersen, J. G., Egedal, J. H., Packard, T. A., Thavachelvam, K., Xie, G., van der Sluis, R. M., Greene, W. C., Roan, N. R. & Jakobsen, M. R., 2021, In: Frontiers in Microbiology. 12, 11 p., 763030.Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
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Pedersen, J. G., Madsen, A. T., Gammelgaard, K. R., Aggerholm-Pedersen, N., Sørensen, B. S., Øllegaard, T. H. & Jakobsen, M. R., Jun 2020, In: Cancers. 12, 6, 1414.Plasmacytoid Dendritic Cells as Cell-Based Therapeutics: A Novel Immunotherapy to Treat Human Immunodeficiency Virus Infection?
van der Sluis, R. M., Egedal, J. H. & Jakobsen, M. R., May 2020, In: Frontiers in cellular and infection microbiology. 10, 12 p., 249.Diverse effects of interferon alpha on the establishment and reversal of HIV latency
Van der Sluis, R. M., Zerbato, J. M., Rhodes, J. W., Pascoe, R. D., Solomon, A., Kumar, N. A., Dantanarayana, A. I., Tennakoon, S., Dufloo, J., McMahon, J., Chang, J. J., Evans, V. A., Hertzog, P. J., Jakobsen, M. R., Harman, A. N., Lewin, S. R. & Cameron, P. U., 2020, In: PLOS Pathogens. 16, 2, 27 p., e1008151.Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis
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Martin, R. M., Ikeda, K., Cromer, M. K., Uchida, N., Nishimura, T., Romano, R., Tong, A. J., Lemgart, V. T., Camarena, J., Pavel-Dinu, M., Sindhu, C., Wiebking, V., Vaidyanathan, S., Dever, D. P., Bak, R. O., Laustsen, A., Lesch, B. J., Jakobsen, M. R., Sebastiano, V., Nakauchi, H. & Porteus, M. H., 2 May 2019, In: Cell Stem Cell. 24, 5, p. 821-828.e5 13 p.Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids
Sun, C., Luecke, S., Bodda, C., Jønsson, K. L., Cai, Y., Zhang, B. C., Jensen, S. B., Nordentoft, I., Jensen, J. M., Jakobsen, M. R. & Paludan, S. R., 2019, In: Journal of Interferon and Cytokine Research. 39, 4, p. 191-204 14 p.cAIMP administration in humanized mice induces a chimerization-level-dependent STING response
Andersen, A. H. F., Olesen, R., Jønsson, K. L., Højen, J. F., Krapp, C., Mack, K., Thomsen, M. K., Østergaard, L., Tolstrup, M., Dagnæs-Hansen, F., Jakobsen, M. R. & Denton, P. W., 2019, In: Immunology. 157, 2, p. 163-172 10 p.Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules
Nissen, S. K., Christiansen, M., Helleberg, M., Kjær, K., Jørgensen, S. E., Gerstoft, J., Katzenstein, T. L., Benfield, T., Kronborg, G., Larsen, C. S., Laursen, A., Pedersen, G., Jakobsen, M. R., Tolstrup, M. & Mogensen, T. H., 15 Oct 2018, In: Scientific Reports. 8, 1, p. 15253Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
Dunphy, G., Flannery, S. M., Almine, J. F., Connolly, D. J., Paulus, C., Jønsson, K. L., Jakobsen, M. R., Nevels, M. M., Bowie, A. G. & Unterholzner, L., 6 Sep 2018, In: Molecular Cell. 71, 5, p. 745-760.e5Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
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Hansen, A. L., Buchan, G. J., Rühl, M., Mukai, K., Salvatore, S. R., Ogawa, E., Andersen, S. D., Iversen, M. B., Thielke, A. L., Gunderstofte, C., Motwani, M., Møller, C. T., Jakobsen, A. S., Fitzgerald, K. A., Roos, J., Lin, R., Maier, T. J., Goldbach-Mansky, R., Miner, C. A., Qian, W., Miner, J. J., Rigby, R. E., Rehwinkel, J., Jakobsen, M. R., Arai, H., Taguchi, T., Schopfer, F. J., Olagnier, D. & Holm, C. K., 14 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. E7768-E7775 8 p.Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors
Nissen, S. K., Pedersen, J. G., Helleberg, M., Kjaer, K., Thavachelvam, K., Obel, N., Tolstrup, M., Jakobsen, M. R. & Mogensen, T. H., 15 May 2018, In: Journal of Immunology. 200, 10, p. 3372-3382 11 p.Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1
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Krapp, C., Jønsson, K. & Jakobsen, M. R., Apr 2018, In: Cytokine & Growth Factor Reviews. p. 68-76 9 p.Human cytomegalovirus tegument protein pp65 (pUL83) dampens type I interferon production by inactivating the DNA sensor cGAS without affecting STING
Biolatti, M., Dell'Oste, V., Pautasso, S., Gugliesi, F., von Einem, J., Krapp, C., Jakobsen, M. R., Borgogna, C., Gariglio, M., De Andrea, M. & Landolfo, S., Mar 2018, In: Journal of Virology. 92, 6, 18 p., e01774-17.ERAdP standing in the shadow of STING innate immune signaling
Jakobsen, M. R., 18 Jan 2018, In: Nature Immunology. 19, p. 105-107 3 p.CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS- and STING-dependent Maturation
Laursen, M. F., Christensen, E., Degn, L. L. T., Jønsson, K., Jakobsen, M. R., Agger, R. & Kofod-Olsen, E., Jan 2018, In: Journal of Immunotherapy. 41, 1, p. 9-18 10 p.The Impact of genetic Variants of STING and IFI16 on Non-Small Cell Lung Cancer
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Luecke, S., Holleufer, A., Christensen, M. H., Jønsson, K. L., Boni, G. A., Sørensen, L. K., Johannsen, M., Jakobsen, M. R., Hartmann, R. & Paludan, S. R., Oct 2017, In: E M B O Reports. 18, 10, p. 1707–1715IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
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Neidleman, J. A., Chen, J. C., Kohgadai, N., Müller, J. A., Laustsen, A., Thavachelvam, K., Jang, K. S., Stürzel, C. M., Jones, J., Ochsenbauer, C., Chitre, A., Somsouk, M., Garcia, M. M., Smith, J. F., Greenblatt, R. M., Münch, J., Jakobsen, M. R., Giudice, L. C., Greene, W. C. & Roan, N. R., Feb 2017, In: P L o S Pathogens. 13, 2, p. e1006163Inhibition of P2X receptors protects human monocytes against damage by leukotoxin from Aggregatibacter actinomycetemcomitans and α-hemolysin from Escherichia coli
Fagerberg, S. K., Jakobsen, M. R., Skals, M. & Praetorius, H. A., 15 Nov 2016, In: Infection and Immunity. 84, 11, p. 3114-3130 17 p.Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc
Borm, K., Jakobsen, M. R., Cashin, K., Flynn, J. K., Ellenberg, P., Østergaard, L., Lee, B., Churchill, M. J., Roche, M. & Gorry, P. R., 3 Nov 2016, In: Retrovirology. 13, 1, 13 p., 74.Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
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Roan, N. R. & Jakobsen, M. R., 15 Feb 2016, In: Current HIV - AIDS Reports. 13, 1, p. 53-63 11 p.Macrophage activation in HIV-2 infected patients is less affected by antiretroviral treatment - sCD163 in HIV-1, HIV-2 and HIV-1/2 dually infected patients
HØnge, B. L., Andersen, M. N., Jespersen, S., Medina, C., Correira, F. G., Jakobsen, M. R., Laursen, A., Erikstrup, C., MØller, H. J., Wejse, C. & Bissau HIV Cohort Study Group, 27 Jan 2016, In: J A I D S.Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors
Cai, Y., Laustsen, A., Zhou, Y., Sun, C., Anderson, M. V., Li, S., Uldbjerg, N., Luo, Y., Jakobsen, M. R. & Mikkelsen, J. G., 2016, In: eLife. 5Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection
Sun, C., Schattgen, S. A., Pisitkun, P., Jorgensen, J. P., Hilterbrand, A. T., Wang, L. J., West, J. A., Hansen, K., Horan, K. A., Jakobsen, M. R., O'Hare, P., Adler, H., Sun, R., Ploegh, H. L., Damania, B., Upton, J. W., Fitzgerald, K. A. & Paludan, S. R., 15 Feb 2015, In: Journal of Immunology. 194, 4, p. 1819-31 13 p.Histone Deacetylase Inhibitor Romidepsin Inhibits de novo HIV-1 Infections
Jønsson, K. L., Tolstrup, M., Vad-Nielsen, J., Kjær, K., Laustsen, A., Andersen, M. N., Rasmussen, T. A., Søgaard, O. S., Østergaard, L. J., Denton, P. W. & Jakobsen, M. R., 2015, In: Antimicrobial Agents and Chemotherapy. 59, 7, p. 3984-3994 11 p.Innate immune sensing of HIV-1 infection
Jakobsen, M. R., Olagnier, D. & Hiscott, J., 5 Dec 2014, In: Current Opinion in HIV and AIDS.Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4 + T-cell subsets, including stem cell memory T-cells
Cashin, K., Paukovics, G., Jakobsen, M. R., Ostergaard, L., Churchill, M. J., Gorry, P. R. & Flynn, J. K., 12 Nov 2014, In: Retrovirology. 11, 1, p. 97Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway
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Jakobsen, M. R. & Paludan, S. R., 21 Jun 2014, In: Cytokine & Growth Factor Reviews.Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates to chronic immune activation
Nissen, S. K., Højen, J. F., Andersen, K. L. D., Kofod-Olsen, E., Berg, R. K., Paludan, S. R., Ostergaard, L., Jakobsen, M. R., Tolstrup, M. & Mogensen, T. H., 5 Mar 2014, In: Clinical and Experimental Immunology. 177, 1, p. 295-309 15 p.Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA
Chiliveru, S., Rahbek, S. H., Jensen, S. K., Jørgensen, S. E., Nissen, S. K., Christiansen, S. H., Mogensen, T. H., Jakobsen, M. R., Iversen, L., Johansen, C. & Paludan, S. R., 2014, In: Journal of Immunology.Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains
Flynn, J. K., Paukovics, G., Cashin, K., Borm, K., Ellett, A., Roche, M., Jakobsen, M. R., Churchill, M. J. & Gorry, P. R., 2014, In: Viruses. 6, 2, p. 709-26 18 p.T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication
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Jakobsen, M. R., Bak, R. O., Andersen, A., Berg, R. K., Jensen, S. B., Tengchuan, J., Laustsen, A., Hansen, K., Ostergaard, L., Fitzgerald, K. A., Xiao, T. S., Mikkelsen, J. G., Mogensen, T. H. & Paludan, S. R., 23 Oct 2013, In: Proceedings of the National Academy of Sciences of the United States of America.Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection
Cashin, K., Jakobsen, M. R., Sterjovski, J., Roche, M., Ellett, A., Flynn, J. K., Borm, K., Gouillou, M., Churchill, M. J. & Gorry, P. R., 16 Sep 2013, In: Retrovirology. 10, 1, p. 98Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors
Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R., 1 Mar 2013, In: Journal of Immunology. 190, 5, p. 2311-2329 18 p.CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm
Cashin, K., Gray, L. R., Jakobsen, M. R., Sterjovski, J., Churchill, M. J. & Gorry, P. R., 2013, In: Retrovirology. 10, 1, p. 24Efficient sleeping beauty DNA transposition from DNA minicircles
Sharma, N., Cai, Y., Bak, R. O., Jakobsen, M. R., Schrøder, L. D. & Mikkelsen, J. G., 2013, In: Molecular Therapy - Nucleic Acids. 2, p. e74Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection
Jakobsen, M. R., Cashin, K., Roche, M., Sterjovski, J., Ellett, A., Borm, K., Flynn, J., Erikstrup, C., Gouillou, M., Gray, L. R., Saksena, N. K., Wang, B., Purcell, D. F. J., Kallestrup, P., Zinyama-Gutsire, R., Gomo, E., Ullum, H., Ostergaard, L., Lee, B., Ramsland, P. A., Churchill, M. J. & Gorry, P. R., 2013, In: P L o S One. 8, 6, p. e65950Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein
Jakobsen, M. R., Mogensen, T. H. & Paludan, S. R., 2012, In: Cell Research.Impact of Minority Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Resistance Genotype after Virologic Failure
Li, J. Z., Paredes, R., Ribaudo, H., Kozal, M. J., Svarovskaia, E. S., Johnson, J. A., Geretti, A. M., Metzner, K. J., Jakobsen, M. R., Hullsiek, K. H., Østergaard, L. J., Miller, M. D. & Kuritzkes, D. R., 2012, In: The Internet Journal of Infectious Diseases.V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc
Berro, R., Klasse, P. J., Jakobsen, M. R., Gorry, P. R., Moore, J. P. & Sanders, R. W., 2012, In: Virology. 427, 2, p. 158-65 8 p.Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
Holm, C. K., Jensen, S. B., Jakobsen, M. R., Cheshenko, N., Horan, K. A., Moeller, H. B., Gonzalez-Dosal, R., Rasmussen, S. B., Christensen, M. H., Yarovinsky, T. O., Rixon, F. J., Herold, B. C., Fitzgerald, K. A. & Paludan, S. R., 2012, In: Nature Immunology. 13, 8, p. 737-43 7 p.HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism
Roche, M., Jakobsen, M. R., Sterjovski, J., Ellett, A., Posta, F., Lee, B., Jubb, B., Westby, M., Lewin, S. R., Ramsland, P. A., Churchill, M. J. & Gorry, P. R., 1 May 2011, In: Indian Journal of Virology. 85, 9, p. 4330-42 13 p.Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
Li, J. Z., Paredes, R., Ribaudo, H. J., Svarovskaia, E. S., Metzner, K. J., Kozal, M. J., Hullsiek, K. H., Balduin, M., Jakobsen, M. R., Geretti, A. M., Thiebaut, R., Ostergaard, L., Masquelier, B., Johnson, J. A., Miller, M. D. & Kuritzkes, D. R., 6 Apr 2011, In: JAMA: The Journal of the American Medical Association. 305, 13, p. 1327-35 9 p.Characterization of the virus-cell interactions by HIV-1 subtype C variants from an antiretroviral therapy-naïve subject with baseline resistance to the CCR5 inhibitor maraviroc
Jakobsen, M. R., 20 Mar 2011.HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry
Roche, M., Jakobsen, M. R., Ellett, A., Salimiseyedabad, H., Jubb, B., Westby, M., Lee, B., Lewin, S. R., Churchill, M. J. & Gorry, P. R., 2011, In: Retrovirology. 8, p. 89Enhanced CD4+ cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection
Wade, J., Sterjovski, J., Gray, L., Roche, M., Chiavaroli, L., Ellett, A., Jakobsen, M. R., Cowley, D., Pereira, C. D. F., Saksena, N., Wang, B., Purcell, D. F. J., Karlsson, I., Fenyö, E-M., Churchill, M. & Gorry, P. R., 2010, In: Virology. 396, 2, p. 246-55 9 p.Transmission of HIV-1 Drug-Resistant Variants: Prevalence and Effect on Treatment Outcome
Jakobsen, M. R., Tolstrup, M., Søgaard, O. S., Jørgensen, L. B., Gorry, P. R., Laursen, A. & Østergaard, L. J., 2010, In: Clinical Infectious Diseases.Pre-screening HIV-1 reverse transcriptase resistance mutations in subtype B patients using a novel multiplex primer extension assay
Jakobsen, M. R., Aggerholm, A., Jørgensen, L. B., Laursen, A. & Østergaard, L. J., 2009, In: Current H I V Research. 7, 4, p. 398-409 11 p.Transmission of HIV-1 drug resistant variants: Prevalence and impact on treatment outcome
Jakobsen, M. R., Tolstrup, M., Søgaard, O. S., Bruun-Jørgensen, L., Gorry, P., Laursen, A. L. & Østergaard, L. J., 2009, In: Clinical Infectious Diseases.C-reactive protein predicts future arterial and cardiovascular events in patients with symptomatic peripheral arterial disease.
Høgh, A. L., Joensen, J., Lindholt, J. S., Jakobsen, M. R. & Østergaard, L., 2008, In: Vascular and Endovascular Surgery. 42, 4, p. 341-7 6 p.Entecavir therapy induces de novo HIV reverse-transcriptase M184V mutation in an antiretroviral therapy-naive patient.
Jakobsen, M. R., Arildsen, H., Krarup, H. B., Tolstrup, M., Østergaard, L. & Laursen, A. L., 2008, In: Clinical Infectious Diseases. 46, 9, p. e88-91Dynamics of 103K/N and 184M/V HIV-1 drug resistant populations: relative comparison in plasma virus RNA versus CD45RO+T cell proviral DNA.
Jakobsen, M. R., Tolstrup, M., Bertelsen, L., Laursen, A. L., Obel, N., Østergaard, L. & Mohey, R., 2007, In: Journal of Clinical Virology. 39, 3, p. 215-21 6 p.Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites
Jakobsen, M. R., Haasnoot, J., Wengel, J., Berkhout, B. & Kjems, J., 2007, In: Retrovirology. 4, 29, p. 1-13 13 p.A genomic selection strategy to identify accessible and dimerization blocking targets in the 5'-UTR of HIV-1 RNA
Jakobsen, M. R., Damgaard, C. K., Andersen, E. S., Podhajska, A. & Kjems, J., 2004, In: Nucleic Acids Research. 32, 7, p. e67 10 p.