Find

Department of Biomedicine

Markus Wehland

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Standard

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells. / Grimm, Daniela ; Wehland, Markus ; Corydon, Thomas J et al.

In: Stem Cells Translational Medicine, Vol. 9, No. 8, 2020, p. 882-894.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Vancouver

Grimm D , Wehland M , Corydon TJ, Richter P, Prasad B, Bauer J et al. The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells. Stem Cells Translational Medicine. 2020;9(8):882-894. Epub 2020 Apr 30. doi: 10.1002/sctm.20-0084

Author

Grimm, Daniela ; Wehland, Markus ; Corydon, Thomas J et al. / The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells. In: Stem Cells Translational Medicine. 2020 ; Vol. 9, No. 8. pp. 882-894.

Bibtex

@article{9fc9ae5b68ba49ba9c94aa5f1e466d92,

title = "The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells",

abstract = "A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (μg) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long-term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r-) and simulated (s-) μg is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r- and s-μg as well as the impact of μg on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to μg conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.",

keywords = "cancer stem cells, microgravity, multicellular spheroids, organoids, random positioning machine, rotating wall vessel, spaceflight, stem cells, tissue engineering",

author = "Daniela Grimm and Markus Wehland and Corydon, {Thomas J} and Peter Richter and Binod Prasad and Johann Bauer and Marcel Egli and Sascha Kopp and Michael Lebert and Marcus Kr{\"u}ger",

note = "{\textcopyright} 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.",

year = "2020",

doi = "10.1002/sctm.20-0084",

language = "English",

volume = "9",

pages = "882--894",

journal = "Stem Cells Translational Medicine",

issn = "2157-6564",

publisher = "AlphaMed Press, Inc.",

number = "8",

}

RIS

TY - JOUR

T1 - The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

AU - Grimm, Daniela

AU - Wehland, Markus

AU - Corydon, Thomas J

AU - Richter, Peter

AU - Prasad, Binod

AU - Bauer, Johann

AU - Egli, Marcel

AU - Kopp, Sascha

AU - Lebert, Michael

AU - Krüger, Marcus

PY - 2020

Y1 - 2020

N2 - A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (μg) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long-term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r-) and simulated (s-) μg is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r- and s-μg as well as the impact of μg on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to μg conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.

AB - A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (μg) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long-term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r-) and simulated (s-) μg is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r- and s-μg as well as the impact of μg on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to μg conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.

KW - cancer stem cells

KW - microgravity

KW - multicellular spheroids

KW - organoids

KW - random positioning machine

KW - rotating wall vessel

KW - spaceflight

KW - stem cells

KW - tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85084218415&partnerID=8YFLogxK

U2 - 10.1002/sctm.20-0084

DO - 10.1002/sctm.20-0084

M3 - Review

C2 - 32352658

VL - 9

SP - 882

EP - 894

JO - Stem Cells Translational Medicine

JF - Stem Cells Translational Medicine

SN - 2157-6564

IS - 8

ER -