Markus Wehland

Latest knowledge about changes in the proteome in microgravity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • Herbert Schulz, Otto von Guericke University Magdeburg
  • ,
  • Sebastian M Strauch, Universidade da Regiao de Joinville
  • ,
  • Peter Richter, Friedrich-Alexander University
  • ,
  • Markus Wehland
  • Marcus Krüger, Otto von Guericke University Magdeburg
  • ,
  • Jayashree Sahana
  • Thomas J Corydon
  • Petra Wise, Otto von Guericke University Magdeburg, University of Southern California
  • ,
  • Ronni Baran
  • ,
  • Michael Lebert, Friedrich-Alexander University, Space Biology Unlimited SAS, Bordeaux, France.
  • ,
  • Daniela Grimm

INTRODUCTION: : A long-term stay of humans in space causes a large number of well-known health problems and changes in protists and plants. Deep space exploration will increase the time humans or rodents will spend in microgravity (µg). Moreover, they are exposed to cosmic radiation, hypodynamia, and isolation. OMICS investigations will increase our knowledge of the underlying mechanisms of µg-induced alterations in vivo and in vitro.

AREAS COVERED: : We summarize the findings over the recent 3 years on µg-induced changes in the proteome of protists, plants, rodent and human cells. Considering the thematic orientation of microgravity-related publications in that time frame, we focus on medicine-associated findings such as the µg-induced antibiotic resistance of bacteria, the myocardial consequences of µg-induced calpain activation and the role of MMP13 in osteoarthritis. All these point to the fact that µg is an extreme stressor that could not be evolutionarily addressed on Earth.

EXPERT COMMENTARY: : In conclusion, when interpreting µg-experiments, the direct, mostly unspecific stress response, must be distinguished from specific µg-effects. For this reason, recent studies often do not consider single protein findings but place them in the context of protein-protein interactions. This enables an estimation of functional relationships, especially if these are supported by epigenetic and transcriptional data (multi-omics).

Original languageEnglish
JournalExpert Review of Proteomics
Pages (from-to)43-59
Publication statusPublished - Jan 2022

Bibliographical note

Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.

    Research areas

  • Real microgravity, cancer, human cells, plants, proteome, rodents, simulated microgravity

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