Markus Wehland

Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Marcus Krüger, Otto von Guericke University Magdeburg
  • ,
  • Sascha Kopp, Clinic for Plastic, Otto von Guericke University Magdeburg
  • ,
  • Markus Wehland
  • Johann Bauer, Max Planck Institute of Biochemistry
  • ,
  • Sarah Baatout, Belgian Nuclear Research Centre, Ghent University
  • ,
  • Marjan Moreels, Belgian Nuclear Research Centre
  • ,
  • Marcel Egli, Lucerne University of Applied Sciences and Arts
  • ,
  • Thomas J. Corydon
  • Manfred Infanger, Otto von Guericke University Magdeburg
  • ,
  • Daniela Grimm

Endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks under normal (1g) culture conditions. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we were able to observe scaffold-free growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.

Original languageEnglish
JournalActa Astronautica
Pages (from-to)267-272
Number of pages6
Publication statusPublished - 2019

    Research areas

  • 3D growth, Microgravity, Random positioning machine, Spaceflight, Spheroids, Tubular structures

See relations at Aarhus University Citationformats

ID: 149389856