Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space. / Wise, Petra M.; Neviani, Paolo; Riwaldt, Stefan et al.
In: International Journal of Molecular Sciences , Vol. 22, No. 23, 12841, 11.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space
AU - Wise, Petra M.
AU - Neviani, Paolo
AU - Riwaldt, Stefan
AU - Corydon, Thomas J.
AU - Wehland, Markus
AU - Braun, Markus
AU - Krüger, Marcus
AU - Infanger, Manfred
AU - Grimm, Daniela
PY - 2021/11
Y1 - 2021/11
N2 - As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, research-ing the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Station, we are now taking advantage of the newest technological opportunities to gain more insight into the changes in cell–cell communication of these cells. Analyzing the exosomal microRNA composition after several days of microgravity might elucidate some of the proteomic changes we have reported earlier. An array scan of a total of 754 miRNA targets revealed more than 100 differentially expressed miRNAs in our samples, many of which have been implicated in thyroid disease in other studies.
AB - As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, research-ing the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Station, we are now taking advantage of the newest technological opportunities to gain more insight into the changes in cell–cell communication of these cells. Analyzing the exosomal microRNA composition after several days of microgravity might elucidate some of the proteomic changes we have reported earlier. An array scan of a total of 754 miRNA targets revealed more than 100 differentially expressed miRNAs in our samples, many of which have been implicated in thyroid disease in other studies.
KW - Cell culture
KW - Exosomes
KW - Microgravity
KW - MiRNA
KW - Spaceflight
KW - Thyroid cancer
UR - http://www.scopus.com/inward/record.url?scp=85119930490&partnerID=8YFLogxK
U2 - 10.3390/ijms222312841
DO - 10.3390/ijms222312841
M3 - Journal article
C2 - 34884646
AN - SCOPUS:85119930490
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 23
M1 - 12841
ER -