Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Breast Cancer Cells in Microgravity : New Aspects for Cancer Research. / Nassef, Mohamed Zakaria; Melnik, Daniela; Kopp, Sascha et al.
In: International Journal of Molecular Sciences , Vol. 21, No. 19, 7345, 10.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
}
TY - JOUR
T1 - Breast Cancer Cells in Microgravity
T2 - New Aspects for Cancer Research
AU - Nassef, Mohamed Zakaria
AU - Melnik, Daniela
AU - Kopp, Sascha
AU - Sahana, Jayashree
AU - Infanger, Manfred
AU - Lützenberg, Ronald
AU - Relja, Borna
AU - Wehland, Markus
AU - Grimm, Daniela
AU - Krüger, Marcus
PY - 2020/10
Y1 - 2020/10
N2 - Breast cancer is the leading cause of cancer death in females. The incidence has risen dramatically during recent decades. Dismissed as an "unsolved problem of the last century", breast cancer still represents a health burden with no effective solution identified so far. Microgravity (µg) research might be an unusual method to combat the disease, but cancer biologists decided to harness the power of µg as an exceptional method to increase efficacy and precision of future breast cancer therapies. Numerous studies have indicated that µg has a great impact on cancer cells; by influencing proliferation, survival, and migration, it shifts breast cancer cells toward a less aggressive phenotype. In addition, through the de novo generation of tumor spheroids, µg research provides a reliable in vitro 3D tumor model for preclinical cancer drug development and to study various processes of cancer progression. In summary, µg has become an important tool in understanding and influencing breast cancer biology.
AB - Breast cancer is the leading cause of cancer death in females. The incidence has risen dramatically during recent decades. Dismissed as an "unsolved problem of the last century", breast cancer still represents a health burden with no effective solution identified so far. Microgravity (µg) research might be an unusual method to combat the disease, but cancer biologists decided to harness the power of µg as an exceptional method to increase efficacy and precision of future breast cancer therapies. Numerous studies have indicated that µg has a great impact on cancer cells; by influencing proliferation, survival, and migration, it shifts breast cancer cells toward a less aggressive phenotype. In addition, through the de novo generation of tumor spheroids, µg research provides a reliable in vitro 3D tumor model for preclinical cancer drug development and to study various processes of cancer progression. In summary, µg has become an important tool in understanding and influencing breast cancer biology.
U2 - 10.3390/ijms21197345
DO - 10.3390/ijms21197345
M3 - Review
C2 - 33027908
VL - 21
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 19
M1 - 7345
ER -