Marco Capogna

The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles

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DOI

  • Marco Capogna
  • Pablo E. Castillo, Albert Einstein College of Medicine
  • ,
  • Arianna Maffei, Stony Brook University

GABAergic interneurons are highly diverse, and their synaptic outputs express various forms of plasticity. Compelling evidence indicates that activity-dependent changes of inhibitory synaptic transmission play a significant role in regulating neural circuits critically involved in learning and memory and circuit refinement. Here, we provide an updated overview of inhibitory synaptic plasticity with a focus on the hippocampus and neocortex. To illustrate the diversity of inhibitory interneurons, we discuss the case of two highly divergent interneuron types, parvalbumin-expressing basket cells and neurogliaform cells, which support unique roles on circuit dynamics. We also present recent progress on the molecular mechanisms underlying long-term, activity-dependent plasticity of fast inhibitory transmission. Lastly, we discuss the role of inhibitory synaptic plasticity in neuronal circuits' function. The emerging picture is that inhibitory synaptic transmission in the CNS is extremely diverse, undergoes various mechanistically distinct forms of plasticity and contributes to a much more refined computational role than initially thought. Both the remarkable diversity of inhibitory interneurons and the various forms of plasticity expressed by GABAergic synapses provide an amazingly rich inhibitory repertoire that is central to a variety of complex neural circuit functions, including memory.

Original languageEnglish
JournalEuropean Journal of Neuroscience
Number of pages20
ISSN0953-816X
DOIs
Publication statusE-pub ahead of print - 2020

    Research areas

  • hippocampus, memory, neocortex, neural circuits, synaptic inhibition, synaptic plasticity, LONG-TERM POTENTIATION, CRITICAL-PERIOD PLASTICITY, PARVALBUMIN-EXPRESSING INTERNEURONS, GABA(A) RECEPTOR TRAFFICKING, HIPPOCAMPAL PYRAMIDAL CELLS, TIMING-DEPENDENT PLASTICITY, SPIKING GABAERGIC NEURONS, VISUAL-CORTEX, TRANSMITTER RELEASE, NEUROTROPHIC FACTOR

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