Marco Capogna

Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures. / Thompson, S M; Poncer, J C; Capogna, M et al.

In: Canadian Journal of Physiology and Pharmacology, Vol. 75, No. 5, 05.1997, p. 495-9.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Thompson, SM, Poncer, JC, Capogna, M & Gähwiler, BH 1997, 'Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures', Canadian Journal of Physiology and Pharmacology, vol. 75, no. 5, pp. 495-9.

APA

Thompson, S. M., Poncer, J. C., Capogna, M., & Gähwiler, B. H. (1997). Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures. Canadian Journal of Physiology and Pharmacology, 75(5), 495-9.

CBE

Thompson SM, Poncer JC, Capogna M, Gähwiler BH. 1997. Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures. Canadian Journal of Physiology and Pharmacology. 75(5):495-9.

MLA

Thompson, S M et al. "Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures". Canadian Journal of Physiology and Pharmacology. 1997, 75(5). 495-9.

Vancouver

Thompson SM, Poncer JC, Capogna M, Gähwiler BH. Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures. Canadian Journal of Physiology and Pharmacology. 1997 May;75(5):495-9.

Author

Thompson, S M ; Poncer, J C ; Capogna, M et al. / Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures. In: Canadian Journal of Physiology and Pharmacology. 1997 ; Vol. 75, No. 5. pp. 495-9.

Bibtex

@article{9e18406188324de39e5b56dac46957ce,
title = "Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures",
abstract = "Miniature, gamma-aminobutyric acid A receptor mediated inhibitory postsynaptic currents (mIPSCs) were recorded from CA3 pyramidal cells in hippocampal slice cultures using whole-cell techniques in the presence of tetrodotoxin. The kinetics and amplitudes of the mIPSCs were analyzed with the aim of determining whether subclasses of events arising from distinct populations of presynaptic interneurons could be distinguished. Histograms of mIPSC amplitude, rise time constant, and decay time constant were all positively skewed, but discrete subsets of events could not be distinguished. The positive skew did not appear to result from electrotonic filtering of distal synaptic currents because there was no correlation among mIPSC amplitudes and the kinetic parameters. Analysis of the intervals between mIPSCs indicated that each event occurred independently. The analysis of spontaneous mIPSCs does not provide evidence of the innervation of pyramidal cells by heterogeneous interneurons.",
keywords = "Action Potentials/physiology, Animals, Hippocampus/physiology, Interneurons/physiology, Neural Inhibition, Pyramidal Cells/physiology, Rats, Receptors, GABA-A/physiology, Synaptic Transmission, Time Factors",
author = "Thompson, {S M} and Poncer, {J C} and M Capogna and G{\"a}hwiler, {B H}",
year = "1997",
month = may,
language = "English",
volume = "75",
pages = "495--9",
journal = "Canadian Journal of Physiology and Pharmacology",
issn = "0008-4212",
publisher = "N R C Research Press",
number = "5",

}

RIS

TY - JOUR

T1 - Properties of spontaneous miniature GABAA receptor mediated synaptic currents in area CA3 of rat hippocampal slice cultures

AU - Thompson, S M

AU - Poncer, J C

AU - Capogna, M

AU - Gähwiler, B H

PY - 1997/5

Y1 - 1997/5

N2 - Miniature, gamma-aminobutyric acid A receptor mediated inhibitory postsynaptic currents (mIPSCs) were recorded from CA3 pyramidal cells in hippocampal slice cultures using whole-cell techniques in the presence of tetrodotoxin. The kinetics and amplitudes of the mIPSCs were analyzed with the aim of determining whether subclasses of events arising from distinct populations of presynaptic interneurons could be distinguished. Histograms of mIPSC amplitude, rise time constant, and decay time constant were all positively skewed, but discrete subsets of events could not be distinguished. The positive skew did not appear to result from electrotonic filtering of distal synaptic currents because there was no correlation among mIPSC amplitudes and the kinetic parameters. Analysis of the intervals between mIPSCs indicated that each event occurred independently. The analysis of spontaneous mIPSCs does not provide evidence of the innervation of pyramidal cells by heterogeneous interneurons.

AB - Miniature, gamma-aminobutyric acid A receptor mediated inhibitory postsynaptic currents (mIPSCs) were recorded from CA3 pyramidal cells in hippocampal slice cultures using whole-cell techniques in the presence of tetrodotoxin. The kinetics and amplitudes of the mIPSCs were analyzed with the aim of determining whether subclasses of events arising from distinct populations of presynaptic interneurons could be distinguished. Histograms of mIPSC amplitude, rise time constant, and decay time constant were all positively skewed, but discrete subsets of events could not be distinguished. The positive skew did not appear to result from electrotonic filtering of distal synaptic currents because there was no correlation among mIPSC amplitudes and the kinetic parameters. Analysis of the intervals between mIPSCs indicated that each event occurred independently. The analysis of spontaneous mIPSCs does not provide evidence of the innervation of pyramidal cells by heterogeneous interneurons.

KW - Action Potentials/physiology

KW - Animals

KW - Hippocampus/physiology

KW - Interneurons/physiology

KW - Neural Inhibition

KW - Pyramidal Cells/physiology

KW - Rats

KW - Receptors, GABA-A/physiology

KW - Synaptic Transmission

KW - Time Factors

M3 - Journal article

C2 - 9250383

VL - 75

SP - 495

EP - 499

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

SN - 0008-4212

IS - 5

ER -