Marco Capogna

Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. / Scanziani, M; Capogna, M; Gähwiler, B H et al.

In: Neuron, Vol. 9, No. 5, 11.1992, p. 919-27.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Scanziani, M, Capogna, M, Gähwiler, BH & Thompson, SM 1992, 'Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus', Neuron, vol. 9, no. 5, pp. 919-27.

APA

Scanziani, M., Capogna, M., Gähwiler, B. H., & Thompson, S. M. (1992). Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. Neuron, 9(5), 919-27.

CBE

MLA

Vancouver

Author

Scanziani, M ; Capogna, M ; Gähwiler, B H et al. / Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. In: Neuron. 1992 ; Vol. 9, No. 5. pp. 919-27.

Bibtex

@article{710502a1eb6444cd8230db045b6279c9,
title = "Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus",
abstract = "Presynaptic inhibition of neurotransmitter release is thought to be mediated by a reduction of axon terminal Ca2+ current. We have compared the actions of several known inhibitors of evoked glutamate release with the actions of the Ca2+ channel antagonist Cd2+ on action potential-independent synaptic currents recorded from CA3 neurons in hippocampal slice cultures. Baclofen and adenosine decreased the frequency of miniature excitatory postsynaptic currents (mEPSCs) without affecting the distribution of their amplitudes. Cd2+ blocked evoked synaptic transmission, but had no effect on the frequency or amplitude of either mEPSCs or inhibitory postsynaptic currents (IPSCs). Inhibition of presynaptic Ca2+ current therefore appears not to be required for the inhibition of glutamate release by adenosine and baclofen. Baclofen had no effect on the frequency of miniature IPSCs, indicating that gamma-aminobutyric acid B-type receptors exert distinct presynaptic actions at excitatory and inhibitory synapses.",
keywords = "2-Amino-5-phosphonovalerate/pharmacology, 6-Cyano-7-nitroquinoxaline-2,3-dione, Action Potentials, Adenosine/pharmacology, Animals, Baclofen/pharmacology, Bicuculline/pharmacology, Cadmium/pharmacology, Calcium/metabolism, Electric Conductivity, Excitatory Amino Acid Antagonists, GABA-A Receptor Antagonists, Glutamates/metabolism, Glutamic Acid, Hippocampus/drug effects, Quinoxalines/pharmacology, Rats, Receptors, GABA-A/physiology, Synapses/drug effects, Tetrodotoxin/pharmacology",
author = "M Scanziani and M Capogna and G{\"a}hwiler, {B H} and Thompson, {S M}",
year = "1992",
month = nov,
language = "English",
volume = "9",
pages = "919--27",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus

AU - Scanziani, M

AU - Capogna, M

AU - Gähwiler, B H

AU - Thompson, S M

PY - 1992/11

Y1 - 1992/11

N2 - Presynaptic inhibition of neurotransmitter release is thought to be mediated by a reduction of axon terminal Ca2+ current. We have compared the actions of several known inhibitors of evoked glutamate release with the actions of the Ca2+ channel antagonist Cd2+ on action potential-independent synaptic currents recorded from CA3 neurons in hippocampal slice cultures. Baclofen and adenosine decreased the frequency of miniature excitatory postsynaptic currents (mEPSCs) without affecting the distribution of their amplitudes. Cd2+ blocked evoked synaptic transmission, but had no effect on the frequency or amplitude of either mEPSCs or inhibitory postsynaptic currents (IPSCs). Inhibition of presynaptic Ca2+ current therefore appears not to be required for the inhibition of glutamate release by adenosine and baclofen. Baclofen had no effect on the frequency of miniature IPSCs, indicating that gamma-aminobutyric acid B-type receptors exert distinct presynaptic actions at excitatory and inhibitory synapses.

AB - Presynaptic inhibition of neurotransmitter release is thought to be mediated by a reduction of axon terminal Ca2+ current. We have compared the actions of several known inhibitors of evoked glutamate release with the actions of the Ca2+ channel antagonist Cd2+ on action potential-independent synaptic currents recorded from CA3 neurons in hippocampal slice cultures. Baclofen and adenosine decreased the frequency of miniature excitatory postsynaptic currents (mEPSCs) without affecting the distribution of their amplitudes. Cd2+ blocked evoked synaptic transmission, but had no effect on the frequency or amplitude of either mEPSCs or inhibitory postsynaptic currents (IPSCs). Inhibition of presynaptic Ca2+ current therefore appears not to be required for the inhibition of glutamate release by adenosine and baclofen. Baclofen had no effect on the frequency of miniature IPSCs, indicating that gamma-aminobutyric acid B-type receptors exert distinct presynaptic actions at excitatory and inhibitory synapses.

KW - 2-Amino-5-phosphonovalerate/pharmacology

KW - 6-Cyano-7-nitroquinoxaline-2,3-dione

KW - Action Potentials

KW - Adenosine/pharmacology

KW - Animals

KW - Baclofen/pharmacology

KW - Bicuculline/pharmacology

KW - Cadmium/pharmacology

KW - Calcium/metabolism

KW - Electric Conductivity

KW - Excitatory Amino Acid Antagonists

KW - GABA-A Receptor Antagonists

KW - Glutamates/metabolism

KW - Glutamic Acid

KW - Hippocampus/drug effects

KW - Quinoxalines/pharmacology

KW - Rats

KW - Receptors, GABA-A/physiology

KW - Synapses/drug effects

KW - Tetrodotoxin/pharmacology

M3 - Journal article

C2 - 1358131

VL - 9

SP - 919

EP - 927

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 5

ER -