Marco Capogna

Presynaptic facilitation of synaptic transmission in the hippocampus

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

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Presynaptic facilitation of synaptic transmission in the hippocampus. / Capogna, M.

In: Pharmacology & Therapeutics, Vol. 77, No. 3, 03.1998, p. 203-23.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Capogna, M 1998, 'Presynaptic facilitation of synaptic transmission in the hippocampus', Pharmacology & Therapeutics, vol. 77, no. 3, pp. 203-23.

APA

Capogna, M. (1998). Presynaptic facilitation of synaptic transmission in the hippocampus. Pharmacology & Therapeutics, 77(3), 203-23.

CBE

Capogna M. 1998. Presynaptic facilitation of synaptic transmission in the hippocampus. Pharmacology & Therapeutics. 77(3):203-23.

MLA

Vancouver

Capogna M. Presynaptic facilitation of synaptic transmission in the hippocampus. Pharmacology & Therapeutics. 1998 Mar;77(3):203-23.

Author

Capogna, M. / Presynaptic facilitation of synaptic transmission in the hippocampus. In: Pharmacology & Therapeutics. 1998 ; Vol. 77, No. 3. pp. 203-23.

Bibtex

@article{43ceb858359a4f31b3313deca9294a3d,
title = "Presynaptic facilitation of synaptic transmission in the hippocampus",
abstract = "Biochemical and genetic characterization of proteins in presynaptic axon terminals have led to models of the biochemical pathways underlying synaptic vesicle docking, activation, and fusion. Several studies have attempted recently to assign a precise physiological role to these proteins. This review deals with some of these studies, concentrating on those performed with hippocampal synapses. It is shown that changes in the state of these presynaptic proteins, together with modifications in Ca2+ dynamics in axon terminals, functionally determine the level of basal synaptic transmission, and underlie pharmacologically induced and activity-dependent facilitation of transmitter release in the central nervous system.",
keywords = "Animals, Calcium/metabolism, Glutamic Acid/metabolism, Hippocampus/metabolism, Membrane Proteins/metabolism, Nerve Tissue Proteins/metabolism, Neuronal Plasticity/physiology, Presynaptic Terminals/metabolism, Synaptic Transmission/physiology, gamma-Aminobutyric Acid/metabolism",
author = "M Capogna",
year = "1998",
month = mar,
language = "English",
volume = "77",
pages = "203--23",
journal = "Pharmacology & Therapeutics",
issn = "0163-7258",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Presynaptic facilitation of synaptic transmission in the hippocampus

AU - Capogna, M

PY - 1998/3

Y1 - 1998/3

N2 - Biochemical and genetic characterization of proteins in presynaptic axon terminals have led to models of the biochemical pathways underlying synaptic vesicle docking, activation, and fusion. Several studies have attempted recently to assign a precise physiological role to these proteins. This review deals with some of these studies, concentrating on those performed with hippocampal synapses. It is shown that changes in the state of these presynaptic proteins, together with modifications in Ca2+ dynamics in axon terminals, functionally determine the level of basal synaptic transmission, and underlie pharmacologically induced and activity-dependent facilitation of transmitter release in the central nervous system.

AB - Biochemical and genetic characterization of proteins in presynaptic axon terminals have led to models of the biochemical pathways underlying synaptic vesicle docking, activation, and fusion. Several studies have attempted recently to assign a precise physiological role to these proteins. This review deals with some of these studies, concentrating on those performed with hippocampal synapses. It is shown that changes in the state of these presynaptic proteins, together with modifications in Ca2+ dynamics in axon terminals, functionally determine the level of basal synaptic transmission, and underlie pharmacologically induced and activity-dependent facilitation of transmitter release in the central nervous system.

KW - Animals

KW - Calcium/metabolism

KW - Glutamic Acid/metabolism

KW - Hippocampus/metabolism

KW - Membrane Proteins/metabolism

KW - Nerve Tissue Proteins/metabolism

KW - Neuronal Plasticity/physiology

KW - Presynaptic Terminals/metabolism

KW - Synaptic Transmission/physiology

KW - gamma-Aminobutyric Acid/metabolism

M3 - Review

C2 - 9576628

VL - 77

SP - 203

EP - 223

JO - Pharmacology & Therapeutics

JF - Pharmacology & Therapeutics

SN - 0163-7258

IS - 3

ER -