Marco Capogna

Miniature synaptic events maintain dendritic spines via AMPA receptor activation

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Miniature synaptic events maintain dendritic spines via AMPA receptor activation. / McKinney, R A; Capogna, M; Dürr, R et al.

In: Nature Neuroscience, Vol. 2, No. 1, 01.1999, p. 44-9.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

McKinney, RA, Capogna, M, Dürr, R, Gähwiler, BH & Thompson, SM 1999, 'Miniature synaptic events maintain dendritic spines via AMPA receptor activation', Nature Neuroscience, vol. 2, no. 1, pp. 44-9. https://doi.org/10.1038/4548

APA

McKinney, R. A., Capogna, M., Dürr, R., Gähwiler, B. H., & Thompson, S. M. (1999). Miniature synaptic events maintain dendritic spines via AMPA receptor activation. Nature Neuroscience, 2(1), 44-9. https://doi.org/10.1038/4548

CBE

McKinney RA, Capogna M, Dürr R, Gähwiler BH, Thompson SM. 1999. Miniature synaptic events maintain dendritic spines via AMPA receptor activation. Nature Neuroscience. 2(1):44-9. https://doi.org/10.1038/4548

MLA

Vancouver

McKinney RA, Capogna M, Dürr R, Gähwiler BH, Thompson SM. Miniature synaptic events maintain dendritic spines via AMPA receptor activation. Nature Neuroscience. 1999 Jan;2(1):44-9. doi: 10.1038/4548

Author

McKinney, R A ; Capogna, M ; Dürr, R et al. / Miniature synaptic events maintain dendritic spines via AMPA receptor activation. In: Nature Neuroscience. 1999 ; Vol. 2, No. 1. pp. 44-9.

Bibtex

@article{c40cc06b22b54065aa4de9987cfd76c2,
title = "Miniature synaptic events maintain dendritic spines via AMPA receptor activation",
abstract = "We investigated the influence of synaptically released glutamate on postsynaptic structure by comparing the effects of deafferentation, receptor antagonists and blockers of glutamate release in hippocampal slice cultures. CA1 pyramidal cell spine density and length decreased after transection of Schaffer collaterals and after application of AMPA receptor antagonists or botulinum toxin to unlesioned cultures. Loss of spines induced by lesion or by botulinum toxin was prevented by simultaneous AMPA application. Tetrodotoxin did not affect spine density. Synaptically released glutamate thus exerts a trophic effect on spines by acting at AMPA receptors. We conclude that AMPA receptor activation by spontaneous vesicular glutamate release is sufficient to maintain dendritic spines.",
keywords = "Afferent Pathways/physiology, Botulinum Toxins/pharmacology, Dendrites/drug effects, Denervation, Excitatory Amino Acid Antagonists/pharmacology, Glutamic Acid/metabolism, Hippocampus/drug effects, In Vitro Techniques, Receptors, AMPA/antagonists & inhibitors, Synapses/metabolism, Tetrodotoxin/pharmacology, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology",
author = "McKinney, {R A} and M Capogna and R D{\"u}rr and G{\"a}hwiler, {B H} and Thompson, {S M}",
year = "1999",
month = jan,
doi = "10.1038/4548",
language = "English",
volume = "2",
pages = "44--9",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Miniature synaptic events maintain dendritic spines via AMPA receptor activation

AU - McKinney, R A

AU - Capogna, M

AU - Dürr, R

AU - Gähwiler, B H

AU - Thompson, S M

PY - 1999/1

Y1 - 1999/1

N2 - We investigated the influence of synaptically released glutamate on postsynaptic structure by comparing the effects of deafferentation, receptor antagonists and blockers of glutamate release in hippocampal slice cultures. CA1 pyramidal cell spine density and length decreased after transection of Schaffer collaterals and after application of AMPA receptor antagonists or botulinum toxin to unlesioned cultures. Loss of spines induced by lesion or by botulinum toxin was prevented by simultaneous AMPA application. Tetrodotoxin did not affect spine density. Synaptically released glutamate thus exerts a trophic effect on spines by acting at AMPA receptors. We conclude that AMPA receptor activation by spontaneous vesicular glutamate release is sufficient to maintain dendritic spines.

AB - We investigated the influence of synaptically released glutamate on postsynaptic structure by comparing the effects of deafferentation, receptor antagonists and blockers of glutamate release in hippocampal slice cultures. CA1 pyramidal cell spine density and length decreased after transection of Schaffer collaterals and after application of AMPA receptor antagonists or botulinum toxin to unlesioned cultures. Loss of spines induced by lesion or by botulinum toxin was prevented by simultaneous AMPA application. Tetrodotoxin did not affect spine density. Synaptically released glutamate thus exerts a trophic effect on spines by acting at AMPA receptors. We conclude that AMPA receptor activation by spontaneous vesicular glutamate release is sufficient to maintain dendritic spines.

KW - Afferent Pathways/physiology

KW - Botulinum Toxins/pharmacology

KW - Dendrites/drug effects

KW - Denervation

KW - Excitatory Amino Acid Antagonists/pharmacology

KW - Glutamic Acid/metabolism

KW - Hippocampus/drug effects

KW - In Vitro Techniques

KW - Receptors, AMPA/antagonists & inhibitors

KW - Synapses/metabolism

KW - Tetrodotoxin/pharmacology

KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology

U2 - 10.1038/4548

DO - 10.1038/4548

M3 - Journal article

C2 - 10195179

VL - 2

SP - 44

EP - 49

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 1

ER -