Marco Capogna

Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare. / Price, Christopher J; Karayannis, Theofanis; Pál, Balázs Zoltán et al.

In: Neuropharmacology, Vol. 49 Suppl 1, 2005, p. 45-56.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Price CJ, Karayannis T, Pál BZ, Capogna M. Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare. Neuropharmacology. 2005;49 Suppl 1:45-56. doi: 10.1016/j.neuropharm.2005.05.009

Author

Price, Christopher J ; Karayannis, Theofanis ; Pál, Balázs Zoltán et al. / Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare. In: Neuropharmacology. 2005 ; Vol. 49 Suppl 1. pp. 45-56.

Bibtex

@article{3d8ab37c0c554f63a06f23d4fcf73c10,
title = "Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare",
abstract = "We have studied the effects of groups II and III metabotropic glutamate receptor (mGluR) activation on excitatory responses recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare (SLM). Excitatory postsynaptic currents (EPSCs) evoked by stimulation of the perforant pathway were reduced either by the group II mGluR agonist LY354740 (50-100 nM, 49.1+/-5.7% of control) or by the group III mGluR agonist l-2-amino-4-phosphonobutyric acid (l-AP4) (50 microM, 36.8+/-4.4% of control). Both drugs significantly enhanced paired-pulse facilitation of the EPSCs. Furthermore, both 100 nM LY354740 and 50 microM l-AP4 reduced the frequency, but not the amplitude, of miniature excitatory synaptic currents (mEPSCs), recorded in the presence of 1 microM TTX and 50 microM picrotoxin, or EPSCs evoked by perforant pathway stimulation in the presence of 2.5 mM Sr2+. The broad-spectrum mGluR antagonist LY341495 (10-50 microM) did not affect test EPSCs elicited 210 ms after stimulation at 100 Hz. At network level, 1-5 microM LY354740 significantly reduced the power of gamma frequency oscillations induced by 20 microM carbachol, 600 nM kainate and 5 mM K+ in hippocampal CA1 area. Our results show powerful modulation of excitatory transmission impinging on interneurons of CA1 SLM by presynaptic group II or III mGluRs.",
keywords = "Amino Acids/pharmacology, Aminobutyrates/pharmacology, Analysis of Variance, Animals, Animals, Newborn, Bridged Bicyclo Compounds/pharmacology, Electric Stimulation/methods, Excitatory Amino Acid Agonists/pharmacology, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/drug effects, Hippocampus/cytology, In Vitro Techniques, Interneurons/drug effects, Neural Inhibition/drug effects, Perforant Pathway, Presynaptic Terminals/drug effects, Rats, Rats, Sprague-Dawley, Receptors, Metabotropic Glutamate/physiology, Strontium/pharmacology, Tetrodotoxin/pharmacology, Time Factors, Xanthenes/pharmacology",
author = "Price, {Christopher J} and Theofanis Karayannis and P{\'a}l, {Bal{\'a}zs Zolt{\'a}n} and Marco Capogna",
year = "2005",
doi = "10.1016/j.neuropharm.2005.05.009",
language = "English",
volume = "49 Suppl 1",
pages = "45--56",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare

AU - Price, Christopher J

AU - Karayannis, Theofanis

AU - Pál, Balázs Zoltán

AU - Capogna, Marco

PY - 2005

Y1 - 2005

N2 - We have studied the effects of groups II and III metabotropic glutamate receptor (mGluR) activation on excitatory responses recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare (SLM). Excitatory postsynaptic currents (EPSCs) evoked by stimulation of the perforant pathway were reduced either by the group II mGluR agonist LY354740 (50-100 nM, 49.1+/-5.7% of control) or by the group III mGluR agonist l-2-amino-4-phosphonobutyric acid (l-AP4) (50 microM, 36.8+/-4.4% of control). Both drugs significantly enhanced paired-pulse facilitation of the EPSCs. Furthermore, both 100 nM LY354740 and 50 microM l-AP4 reduced the frequency, but not the amplitude, of miniature excitatory synaptic currents (mEPSCs), recorded in the presence of 1 microM TTX and 50 microM picrotoxin, or EPSCs evoked by perforant pathway stimulation in the presence of 2.5 mM Sr2+. The broad-spectrum mGluR antagonist LY341495 (10-50 microM) did not affect test EPSCs elicited 210 ms after stimulation at 100 Hz. At network level, 1-5 microM LY354740 significantly reduced the power of gamma frequency oscillations induced by 20 microM carbachol, 600 nM kainate and 5 mM K+ in hippocampal CA1 area. Our results show powerful modulation of excitatory transmission impinging on interneurons of CA1 SLM by presynaptic group II or III mGluRs.

AB - We have studied the effects of groups II and III metabotropic glutamate receptor (mGluR) activation on excitatory responses recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare (SLM). Excitatory postsynaptic currents (EPSCs) evoked by stimulation of the perforant pathway were reduced either by the group II mGluR agonist LY354740 (50-100 nM, 49.1+/-5.7% of control) or by the group III mGluR agonist l-2-amino-4-phosphonobutyric acid (l-AP4) (50 microM, 36.8+/-4.4% of control). Both drugs significantly enhanced paired-pulse facilitation of the EPSCs. Furthermore, both 100 nM LY354740 and 50 microM l-AP4 reduced the frequency, but not the amplitude, of miniature excitatory synaptic currents (mEPSCs), recorded in the presence of 1 microM TTX and 50 microM picrotoxin, or EPSCs evoked by perforant pathway stimulation in the presence of 2.5 mM Sr2+. The broad-spectrum mGluR antagonist LY341495 (10-50 microM) did not affect test EPSCs elicited 210 ms after stimulation at 100 Hz. At network level, 1-5 microM LY354740 significantly reduced the power of gamma frequency oscillations induced by 20 microM carbachol, 600 nM kainate and 5 mM K+ in hippocampal CA1 area. Our results show powerful modulation of excitatory transmission impinging on interneurons of CA1 SLM by presynaptic group II or III mGluRs.

KW - Amino Acids/pharmacology

KW - Aminobutyrates/pharmacology

KW - Analysis of Variance

KW - Animals

KW - Animals, Newborn

KW - Bridged Bicyclo Compounds/pharmacology

KW - Electric Stimulation/methods

KW - Excitatory Amino Acid Agonists/pharmacology

KW - Excitatory Amino Acid Antagonists/pharmacology

KW - Excitatory Postsynaptic Potentials/drug effects

KW - Hippocampus/cytology

KW - In Vitro Techniques

KW - Interneurons/drug effects

KW - Neural Inhibition/drug effects

KW - Perforant Pathway

KW - Presynaptic Terminals/drug effects

KW - Rats

KW - Rats, Sprague-Dawley

KW - Receptors, Metabotropic Glutamate/physiology

KW - Strontium/pharmacology

KW - Tetrodotoxin/pharmacology

KW - Time Factors

KW - Xanthenes/pharmacology

U2 - 10.1016/j.neuropharm.2005.05.009

DO - 10.1016/j.neuropharm.2005.05.009

M3 - Journal article

C2 - 15998525

VL - 49 Suppl 1

SP - 45

EP - 56

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

ER -