Marco Capogna

Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition. / Li, Gengyu; Stewart, Robert; Canepari, Marco; Capogna, Marco.

In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, No. 4, 22.01.2014, p. 1280-92.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Li, G, Stewart, R, Canepari, M & Capogna, M 2014, 'Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 34, no. 4, pp. 1280-92. https://doi.org/10.1523/JNEUROSCI.3046-13.2014

APA

Li, G., Stewart, R., Canepari, M., & Capogna, M. (2014). Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1280-92. https://doi.org/10.1523/JNEUROSCI.3046-13.2014

CBE

Li G, Stewart R, Canepari M, Capogna M. 2014. Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(4):1280-92. https://doi.org/10.1523/JNEUROSCI.3046-13.2014

MLA

Li, Gengyu et al. "Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition". The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014, 34(4). 1280-92. https://doi.org/10.1523/JNEUROSCI.3046-13.2014

Vancouver

Li G, Stewart R, Canepari M, Capogna M. Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Jan 22;34(4):1280-92. https://doi.org/10.1523/JNEUROSCI.3046-13.2014

Author

Li, Gengyu ; Stewart, Robert ; Canepari, Marco ; Capogna, Marco. / Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition. In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 ; Vol. 34, No. 4. pp. 1280-92.

Bibtex

@article{8904e6e7a03d44d0a9212a403ff6d6a3,
title = "Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition",
abstract = "Little is known about how neuron firing recorded in vivo retrogradely influences synaptic strength. We injected the firing of a rat hippocampal neurogliaform cell (NGFC), a widely expressed GABAergic neuron type, detected in vivo during theta rhythm, into NGFCs of rat or neuronal nitric oxide synthase (nNOS)-Cre-tdTomato mouse recorded in vitro. We found that the {"}in vivo firing pattern{"} produced a transient firing-induced suppression of synaptic inhibition (FSI) evoked by a presynaptic NGFC. Imaging experiments demonstrate that FSI was associated with action potential backpropagation (bAP) and a supralinear increase in dendritic Ca(2+). The application of the L-type Ca(2+) channel antagonist nimodipine blocked FSI. Further pharmacological experiments, such as the application of a nitric oxide-sensitive guanylyl cyclase (NO-sGC) receptor antagonist, a NOS inhibitor, and NO donors, suggested that NO released from postsynaptic cells mediated FSI and likely activated presynaptic receptors to inhibit GABA release. The in vivo firing pattern modulated the size of unitary EPSPs impinging on NGFCs through FSI and not via a direct effect on excitatory synaptic transmission. Our data demonstrate: (1) retrograde signaling initiated by in vivo firing pattern, (2) interneuron bAPs detected with fast temporal resolution, and (3) a novel role for NO expressed by specific interneuron types.",
keywords = "Animals, Excitatory Postsynaptic Potentials, Female, Hippocampus, Interneurons, Male, Mice, Transgenic, Neural Inhibition, Neuronal Plasticity, Neurotransmitter Agents, Nitric Oxide, Patch-Clamp Techniques, Rats, Synapses, Synaptic Transmission, Journal Article, Research Support, Non-U.S. Gov't",
author = "Gengyu Li and Robert Stewart and Marco Canepari and Marco Capogna",
year = "2014",
month = jan,
day = "22",
doi = "10.1523/JNEUROSCI.3046-13.2014",
language = "English",
volume = "34",
pages = "1280--92",
journal = "The Journal of neuroscience : the official journal of the Society for Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "4",

}

RIS

TY - JOUR

T1 - Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition

AU - Li, Gengyu

AU - Stewart, Robert

AU - Canepari, Marco

AU - Capogna, Marco

PY - 2014/1/22

Y1 - 2014/1/22

N2 - Little is known about how neuron firing recorded in vivo retrogradely influences synaptic strength. We injected the firing of a rat hippocampal neurogliaform cell (NGFC), a widely expressed GABAergic neuron type, detected in vivo during theta rhythm, into NGFCs of rat or neuronal nitric oxide synthase (nNOS)-Cre-tdTomato mouse recorded in vitro. We found that the "in vivo firing pattern" produced a transient firing-induced suppression of synaptic inhibition (FSI) evoked by a presynaptic NGFC. Imaging experiments demonstrate that FSI was associated with action potential backpropagation (bAP) and a supralinear increase in dendritic Ca(2+). The application of the L-type Ca(2+) channel antagonist nimodipine blocked FSI. Further pharmacological experiments, such as the application of a nitric oxide-sensitive guanylyl cyclase (NO-sGC) receptor antagonist, a NOS inhibitor, and NO donors, suggested that NO released from postsynaptic cells mediated FSI and likely activated presynaptic receptors to inhibit GABA release. The in vivo firing pattern modulated the size of unitary EPSPs impinging on NGFCs through FSI and not via a direct effect on excitatory synaptic transmission. Our data demonstrate: (1) retrograde signaling initiated by in vivo firing pattern, (2) interneuron bAPs detected with fast temporal resolution, and (3) a novel role for NO expressed by specific interneuron types.

AB - Little is known about how neuron firing recorded in vivo retrogradely influences synaptic strength. We injected the firing of a rat hippocampal neurogliaform cell (NGFC), a widely expressed GABAergic neuron type, detected in vivo during theta rhythm, into NGFCs of rat or neuronal nitric oxide synthase (nNOS)-Cre-tdTomato mouse recorded in vitro. We found that the "in vivo firing pattern" produced a transient firing-induced suppression of synaptic inhibition (FSI) evoked by a presynaptic NGFC. Imaging experiments demonstrate that FSI was associated with action potential backpropagation (bAP) and a supralinear increase in dendritic Ca(2+). The application of the L-type Ca(2+) channel antagonist nimodipine blocked FSI. Further pharmacological experiments, such as the application of a nitric oxide-sensitive guanylyl cyclase (NO-sGC) receptor antagonist, a NOS inhibitor, and NO donors, suggested that NO released from postsynaptic cells mediated FSI and likely activated presynaptic receptors to inhibit GABA release. The in vivo firing pattern modulated the size of unitary EPSPs impinging on NGFCs through FSI and not via a direct effect on excitatory synaptic transmission. Our data demonstrate: (1) retrograde signaling initiated by in vivo firing pattern, (2) interneuron bAPs detected with fast temporal resolution, and (3) a novel role for NO expressed by specific interneuron types.

KW - Animals

KW - Excitatory Postsynaptic Potentials

KW - Female

KW - Hippocampus

KW - Interneurons

KW - Male

KW - Mice, Transgenic

KW - Neural Inhibition

KW - Neuronal Plasticity

KW - Neurotransmitter Agents

KW - Nitric Oxide

KW - Patch-Clamp Techniques

KW - Rats

KW - Synapses

KW - Synaptic Transmission

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1523/JNEUROSCI.3046-13.2014

DO - 10.1523/JNEUROSCI.3046-13.2014

M3 - Journal article

C2 - 24453319

VL - 34

SP - 1280

EP - 1292

JO - The Journal of neuroscience : the official journal of the Society for Neuroscience

JF - The Journal of neuroscience : the official journal of the Society for Neuroscience

SN - 0270-6474

IS - 4

ER -