Marco Capogna

Effects of dopamine, D-1 and D-2 dopaminergic agonists on the excitability of hippocampal CA1 pyramidal cells in guinea pig

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • N Berretta, Department of Physiology and Biochemistry G. Moruzzi, University of Pisa, Italy.
  • ,
  • F Berton
  • ,
  • R Bianchi
  • ,
  • M Capogna
  • W Francesconi
  • ,
  • M Brunelli

In hippocampal pyramidal cells (HPCs), Dopamine (DA) application (1 microM) produced, in 50% of recorded cells, an hyperpolarization of the resting membrane potential (r.m.p.) and an increase of the afterhyperpolarization (AHP) amplitude and duration in 79% of recorded cells. DA-induced effects on both the r.m.p. and AHP were mimicked by bath application of a D-1 selective agonist, SKF 38393 (20 microM). In addition, we have observed that a D-1 selective antagonist such as SCH 23390 (1 microM) abolished the action of both DA and SKF 38393. In contrast, the activation of D-2 receptors through LY 171555 (10 microns) produced, in 50% of cells, a depolarization of the r.m.p. and a depression of the AHP in 67% of recorded cells. These results suggest that the effects observed in hippocampal pyramidal neurons after DA application of micromolar concentration are mediated by D-1 subtype of receptors.

Original languageEnglish
JournalExperimental Brain Research
Volume83
Issue1
Pages (from-to)124-30
Number of pages7
ISSN0014-4819
Publication statusPublished - 1990

    Research areas

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology, Animals, Dopamine/pharmacology, Dopamine Agents/pharmacology, Electrophysiology, Ergolines/pharmacology, Guinea Pigs, Hippocampus/cytology, Membrane Potentials/drug effects, Quinpirole

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