Marco Capogna

Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Thomas C M Bienvenu, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK. thomas.bienvenu@inserm.fr
  • ,
  • Daniela Busti
  • ,
  • Peter J Magill
  • ,
  • Francesco Ferraguti
  • ,
  • Marco Capogna

Neuronal synchrony in the basolateral amygdala (BLA) is critical for emotional behavior. Coordinated theta-frequency oscillations between the BLA and the hippocampus and precisely timed integration of salient sensory stimuli in the BLA are involved in fear conditioning. We characterized GABAergic interneuron types of the BLA and determined their contribution to shaping these network activities. Using in vivo recordings in rats combined with the anatomical identification of neurons, we found that the firing of BLA interneurons associated with network activities was cell type specific. The firing of calbindin-positive interneurons targeting dendrites was precisely theta-modulated, but other cell types were heterogeneously modulated, including parvalbumin-positive basket cells. Salient sensory stimuli selectively triggered axo-axonic cells firing and inhibited firing of a disctinct projecting interneuron type. Thus, GABA is released onto BLA principal neurons in a time-, domain-, and sensory-specific manner. These specific synaptic actions likely cooperate to promote amygdalo-hippocampal synchrony involved in emotional memory formation.

Original languageEnglish
JournalNeuron
Volume74
Issue6
Pages (from-to)1059-74
Number of pages16
ISSN0896-6273
DOIs
Publication statusPublished - 21 Jun 2012

Bibliographical note

Copyright © 2012 Elsevier Inc. All rights reserved.

    Research areas

  • Action Potentials/physiology, Amygdala/metabolism, Animals, Axons/metabolism, Calbindins, Hippocampus/metabolism, Interneurons/metabolism, Male, Nerve Net/physiology, Parvalbumins/metabolism, Rats, Rats, Sprague-Dawley, S100 Calcium Binding Protein G/metabolism, Theta Rhythm/physiology

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