Marco Capogna

Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors

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Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex : possible involvement of excitatory amino acid receptors. / Zeise, M L; Kasparov, S; Capogna, M et al.

In: European Journal of Pharmacology, Vol. 231, No. 1, 26.01.1993, p. 47-52.

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Zeise, ML, Kasparov, S, Capogna, M & Zieglgänsberger, W 1993, 'Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors', European Journal of Pharmacology, vol. 231, no. 1, pp. 47-52.

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@article{198297bfb6374384857871a95a4de0b6,
title = "Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors",
abstract = "Acamprosate (calciumacetylhomotaurinate) is used therapeutically against relapse in weaned alcoholics. In the present study, the mechanism of action was investigated by making intracellular in vitro and extracellular in vivo recordings from rat neocortical neurons. Acamprosate (0.1-1 mM) added to the perfusion fluid in vitro reduced excitatory and inhibitory postsynaptic potentials and the depolarizing responses evoked by iontophoretic application of the excitatory amino acids, L-glutamate, L-aspartate, L-homocysteate and N-methyl-D-aspartate, but did not alter the responses to gamma-aminobutyric acid. Acamprosate decreased electrical excitability without apparently changing membrane potential, input resistance, afterhyperpolarization, or threshold and amplitude of the action potential. In vivo iontophoretic application of acamprosate reduced the extracellularly recorded unit activity elicited by iontophoretically applied L-glutamate, whereas spontaneous discharges remained unaffected. These data suggest that acamprosate reduces the postsynaptic efficacy of excitatory amino acid neurotransmitters and lowers neuronal excitability in the neocortex of the rat.",
keywords = "Acamprosate, Action Potentials/drug effects, Animals, Cerebral Cortex/cytology, Evoked Potentials/drug effects, In Vitro Techniques, Male, Neurons/drug effects, Rats, Rats, Sprague-Dawley, Rats, Wistar, Receptors, Amino Acid/drug effects, Synapses/physiology, Taurine/analogs & derivatives",
author = "Zeise, {M L} and S Kasparov and M Capogna and W Zieglg{\"a}nsberger",
year = "1993",
month = jan,
day = "26",
language = "English",
volume = "231",
pages = "47--52",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier BV",
number = "1",

}

RIS

TY - JOUR

T1 - Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex

T2 - possible involvement of excitatory amino acid receptors

AU - Zeise, M L

AU - Kasparov, S

AU - Capogna, M

AU - Zieglgänsberger, W

PY - 1993/1/26

Y1 - 1993/1/26

N2 - Acamprosate (calciumacetylhomotaurinate) is used therapeutically against relapse in weaned alcoholics. In the present study, the mechanism of action was investigated by making intracellular in vitro and extracellular in vivo recordings from rat neocortical neurons. Acamprosate (0.1-1 mM) added to the perfusion fluid in vitro reduced excitatory and inhibitory postsynaptic potentials and the depolarizing responses evoked by iontophoretic application of the excitatory amino acids, L-glutamate, L-aspartate, L-homocysteate and N-methyl-D-aspartate, but did not alter the responses to gamma-aminobutyric acid. Acamprosate decreased electrical excitability without apparently changing membrane potential, input resistance, afterhyperpolarization, or threshold and amplitude of the action potential. In vivo iontophoretic application of acamprosate reduced the extracellularly recorded unit activity elicited by iontophoretically applied L-glutamate, whereas spontaneous discharges remained unaffected. These data suggest that acamprosate reduces the postsynaptic efficacy of excitatory amino acid neurotransmitters and lowers neuronal excitability in the neocortex of the rat.

AB - Acamprosate (calciumacetylhomotaurinate) is used therapeutically against relapse in weaned alcoholics. In the present study, the mechanism of action was investigated by making intracellular in vitro and extracellular in vivo recordings from rat neocortical neurons. Acamprosate (0.1-1 mM) added to the perfusion fluid in vitro reduced excitatory and inhibitory postsynaptic potentials and the depolarizing responses evoked by iontophoretic application of the excitatory amino acids, L-glutamate, L-aspartate, L-homocysteate and N-methyl-D-aspartate, but did not alter the responses to gamma-aminobutyric acid. Acamprosate decreased electrical excitability without apparently changing membrane potential, input resistance, afterhyperpolarization, or threshold and amplitude of the action potential. In vivo iontophoretic application of acamprosate reduced the extracellularly recorded unit activity elicited by iontophoretically applied L-glutamate, whereas spontaneous discharges remained unaffected. These data suggest that acamprosate reduces the postsynaptic efficacy of excitatory amino acid neurotransmitters and lowers neuronal excitability in the neocortex of the rat.

KW - Acamprosate

KW - Action Potentials/drug effects

KW - Animals

KW - Cerebral Cortex/cytology

KW - Evoked Potentials/drug effects

KW - In Vitro Techniques

KW - Male

KW - Neurons/drug effects

KW - Rats

KW - Rats, Sprague-Dawley

KW - Rats, Wistar

KW - Receptors, Amino Acid/drug effects

KW - Synapses/physiology

KW - Taurine/analogs & derivatives

M3 - Journal article

C2 - 8444281

VL - 231

SP - 47

EP - 52

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -