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Marcello Mannino

The genetic history of Ice Age Europe

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DOI

  • Qiaomei Fu, Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, IVPP, CAS, Beijing 100044, China
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  • Cosimo Posth, Institute for Archaeological Sciences, Archaeo and Palaeogenetics, University of Tübingen, 72070 Tübingen, Germany
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  • Mateja Hajdinjak, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • Martin Petr, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • Swapan Mallick, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • Daniel Fernandes, School of Archaeology and Earth Institute, University College Dublin, Belfield, Dublin 4, Ireland
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  • Anja Furtwängler, Institute for Archaeological Sciences, Archaeo and Palaeogenetics, University of Tübingen, 72070 Tübingen, Germany
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  • Wolfgang Haak, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany
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  • Matthias Meyer, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • Alissa Mittnik, Institute for Archaeological Sciences, Archaeo and Palaeogenetics, University of Tübingen, 72070 Tübingen, Germany
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  • Birgit Nickel, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • Alexander Peltzer, Institute for Archaeological Sciences, Archaeo and Palaeogenetics, University of Tübingen, 72070 Tübingen, Germany
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  • Nadin Rohland, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • Vivian Slon, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • Sahra Talamo, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • Iosif Lazaridis, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • Mark Lipson, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • Iain Mathieson, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • Stephan Schiffels, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany
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  • Pontus Skoglund, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • Anatoly P. Derevianko, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 17 Novosibirsk, RU-630090, Russia
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  • Nikolai Drozdov, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 17 Novosibirsk, RU-630090, Russia
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  • Vyacheslav Slavinsky, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 17 Novosibirsk, RU-630090, Russia
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  • Alexander Tsybankov, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 17 Novosibirsk, RU-630090, Russia
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  • Renata Grifoni Cremonesi, University of Pisa
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  • Francesco Mallegni, University of Pisa
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  • Bernard Gély, Direction régionale des affaires culturelles Rhône-Alpes, 69283 Lyon, Cedex 01, France
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  • Eligio Vacca, Dipartimento di Biologia, Università degli Studi di Bari ‘Aldo Moro’, 70125 Bari, Italy
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  • Manuel R. González Morales, Instituto Internacional de Investigaciones Prehistóricas, Universidad de Cantabria, 39005 Santander, Spain
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  • Lawrence G. Straus, Instituto Internacional de Investigaciones Prehistóricas, Universidad de Cantabria, 39005 Santander, Spain
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  • Christine Neugebauer-Maresch, Quaternary Archaeology, Institute for Oriental and European Archaeology, Austrian Academy of Sciences, 1010 Vienna, Austria
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  • Maria Teschler-Nicola, Department of Anthropology, Natural History Museum Vienna, 1010 Vienna, Austria
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  • Silviu Constantin, “Emil Racoviţă” Institute of Speleology, 010986 Bucharest 12, Romania
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  • Oana Teodora Moldovan, “Emil Racoviţă” Institute of Speleology, Cluj Branch, 400006 Cluj, Romania
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  • Stefano Benazzi, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • Marco Peresani, Sezione di Scienze Preistoriche e Antropologiche, Dipartimento di Studi Umanistici, Università di Ferrara, 44100 Ferrara, Italy
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  • Donato Coppola, Università degli Studi di Bari ‘Aldo Moro’, 70125 Bari, Italy
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  • Martina Lari, Dipartimento di Biologia, Università di Firenze, 50122 Florence, Italy
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  • Stefano Ricci, Dipartimento di Scienze Fisiche, della Terra e dell’Ambiente, U.R. Preistoria e Antropologia, Università degli Studi di Siena, 53100 Siena, Italy
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  • Annamaria Ronchitelli, Dipartimento di Scienze Fisiche, della Terra e dell’Ambiente, U.R. Preistoria e Antropologia, Università degli Studi di Siena, 53100 Siena, Italy
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  • Frédérique Valentin, CNRS/UMR 7041 ArScAn MAE, 92023 Nanterre, France
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  • Corinne Thevenet, INRAP/UMR 8215 Trajectoires 21, 92023 Nanterre, France
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  • Kurt Wehrberger, Ulmer Museum, 89073 Ulm, Germany
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  • Dan Grigorescu, University of Bucharest, Faculty of Geology and Geophysics, Department of Geology, 01041 Bucharest, Romania
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  • Hélène Rougier, Department of Anthropology, California State University Northridge, Northridge, California 91330-8244, USA
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  • Isabelle Crevecoeur, Université de Bordeaux, CNRS, UMR 5199-PACEA, 33615 Pessac Cedex, France
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  • Damien Flas, TRACES – UMR 5608, Université Toulouse Jean Jaurès, Maison de la Recherche, 31058 Toulouse Cedex 9, France
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  • Patrick Semal, Royal Belgian Institute of Natural Sciences, 1000 Brussels, Belgium
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  • Marcello Mannino
  • Christophe Cupillard, Service Régional d’Archéologie de Franche-Comté, 25043 Besançon Cedex, France
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  • Hervé Bocherens, Department of Geosciences, Biogeology, University of Tübingen, 72074 Tübingen, Germany
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  • Nicholas J. Conard, Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tübingen, 72072 Tübingen, Germany
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  • Katerina Harvati, Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tübingen, 72072 Tübingen, Germany
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  • Vyacheslav Moiseyev, Museum of Anthropology and Ethnography, Saint Petersburg 34, Russia
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  • Dorothée G. Drucker, Department of Geosciences, Biogeology, University of Tübingen, 72074 Tübingen, Germany
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  • Jiří Svoboda, Department of Anthropology, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic
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  • Michael P. Richards, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • David Caramelli, Dipartimento di Biologia, Università di Firenze, 50122 Florence, Italy
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  • Ron Pinhasi, School of Archaeology and Earth Institute, University College Dublin, Belfield, Dublin 4, Ireland
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  • Janet Kelso, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • Nick Patterson, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
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  • Johannes Krause, Institute for Archaeological Sciences, Archaeo and Palaeogenetics, University of Tübingen, 72070 Tübingen, Germany
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  • Svante Pääbo, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
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  • David Reich, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Modern humans arrived in Europe ~45,000 years ago, but little is known about their genetic composition before the start of farming ~8,500 years ago. Here we analyse genome-wide data from 51 Eurasians from ~45,000–7,000 years ago. Over this time, the proportion of Neanderthal DNA decreased from 3–6% to around 2%, consistent with natural selection against Neanderthal variants in modern humans. Whereas there is no evidence of the earliest modern humans in Europe contributing to the genetic composition of present-day Europeans, all individuals between ~37,000 and ~14,000 years ago descended from a single founder population which forms part of the ancestry of present-day Europeans. An ~35,000-year-old individual from northwest Europe represents an early branch of this founder population which was then displaced across a broad region, before reappearing in southwest Europe at the height of the last Ice Age ~19,000 years ago. During the major warming period after ~14,000 years ago, a genetic component related to present-day Near Easterners became widespread in Europe. These results document how population turnover and migration have been recurring themes of European prehistory.
Original languageEnglish
JournalNature
Volume534
Issue7606
Pages (from-to)200-205
Number of pages6
ISSN0028-0836
DOIs
Publication statusPublished - 9 Jun 2016

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