Manuel Mattheisen

The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Bjarte Håvik
  • ,
  • Stephanie Le Hellard
  • ,
  • Marcella Rietschel
  • ,
  • Helle Lybæk
  • ,
  • Srdjan Djurovic
  • ,
  • Manuel Mattheisen
  • Thomas W Mühleisen
  • ,
  • Franziska Degenhardt
  • ,
  • Lutz Priebe
  • ,
  • Wolfgang Maier
  • ,
  • Rene Breuer
  • ,
  • Thomas G Schulze
  • ,
  • Ingrid Agartz
  • ,
  • Ingrid Melle
  • ,
  • Thomas Hansen
  • ,
  • Clive R Bramham
  • ,
  • Markus M Nöthen
  • ,
  • Beth Stevens
  • ,
  • Thomas Werge
  • ,
  • Ole A Andreassen
  • ,
  • Sven Cichon
  • ,
  • Vidar M Steen
Patients with schizophrenia often suffer from cognitive dysfunction, including impaired learning and memory. We recently demonstrated that long-term potentiation in rat hippocampus, a mechanistic model of learning and memory, is linked to gene expression changes in immunity-related processes involved in complement activity and antigen presentation. We therefore aimed to examine whether key regulators of these processes are genetic susceptibility factors in schizophrenia.
Original languageEnglish
Book seriesAdvances in Biological Psychiatry
Volume70
Issue1
Pages (from-to)35-42
Number of pages8
ISSN0378-7354
DOIs
Publication statusPublished - 1 Jul 2011
Externally publishedYes

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