Department of Economics and Business Economics

Manuel Mattheisen

The association between neonatal vitamin D status and risk of schizophrenia

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Darryl W. Eyles, The University of Queensland, Park Centre for Mental Health
  • ,
  • Maciej Trzaskowski, The University of Queensland
  • ,
  • Anna A.E. Vinkhuyzen, The University of Queensland
  • ,
  • Manuel Mattheisen
  • Sandra Meier, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Mental Health Centre for Child and Adolescent Psychiatry
  • ,
  • Helen Gooch, The University of Queensland
  • ,
  • Victor Anggono, The University of Queensland
  • ,
  • Xiaoying Cui, The University of Queensland
  • ,
  • Men Chee Tan, The University of Queensland
  • ,
  • Thomas H.J. Burne, The University of Queensland, Park Centre for Mental Health
  • ,
  • Se Eun Jang, The University of Queensland
  • ,
  • David Kvaskoff, The University of Queensland
  • ,
  • David M. Hougaard, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Statens Serum Institut
  • ,
  • Bent Nørgaard-Pedersen, Statens Serum Institut
  • ,
  • Arieh Cohen, Statens Serum Institut
  • ,
  • Esben Agerbo
  • Carsten B. Pedersen
  • Anders D. Børglum
  • Ole Mors
  • Pankaj Sah, The University of Queensland
  • ,
  • Naomi R. Wray, The University of Queensland
  • ,
  • Preben B. Mortensen
  • John J. McGrath

Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The concentration of 25 hydroxyvitamin D (25OHD) was assessed from neonatal dried blood samples. Incidence rate ratios (IRR) were calculated when examined for quintiles of 25OHD concentration. In addition, we examined statistical models that combined 25OHD concentration and the schizophrenia polygenic risk score (PRS) in a sample that combined the new sample with a previous study (total n = 3464; samples assayed and genotyped between 2008-2013). Compared to the reference (fourth) quintile, those in the lowest quintile (<20.4 nmol/L) had a significantly increased risk of schizophrenia (IRR = 1.44, 95%CI: 1.12–1.85). None of the other quintile comparisons were significantly different. There was no significant interaction between 25OHD and the PRS. Neonatal vitamin D deficiency was associated with an increased risk for schizophrenia in later life. These findings could have important public health implications related to the primary prevention of schizophrenia.

Original languageEnglish
Article number17692
JournalScientific Reports
Publication statusPublished - 1 Dec 2018

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