Department of Economics and Business Economics

Manuel Mattheisen

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Shared genetic risk between eating disorder- and substance-use-related phenotypes : Evidence from genome-wide association studies. / Munn-Chernoff, Melissa A.; Johnson, Emma C.; Chou, Yi Ling; Coleman, Jonathan R.I.; Thornton, Laura M.; Walters, Raymond K.; Yilmaz, Zeynep; Baker, Jessica H.; Hübel, Christopher; Gordon, Scott; Medland, Sarah E.; Watson, Hunna J.; Gaspar, Héléna A.; Bryois, Julien; Hinney, Anke; Leppä, Virpi M.; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola; Hanscombe, Ken B.; Adan, Roger A.H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A.; Berrettini, Wade H.; Boehm, Ilka; Boni, Claudette; Boraska Perica, Vesna; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D.; Courtet, Philippe; Crow, Scott; Crowley, James J.; Danner, Unna N.; Davis, Oliver S.P.; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E.; Dick, Danielle M.; Dikeos, Dimitris; Dina, Christian; Dmitrzak-Weglarz, Monika; Docampo, Elisa; Duncan, Laramie E.; Egberts, Karin; Ehrlich, Stefan; Escaramís, Geòrgia; Esko, Tõnu; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández-Aranda, Fernando; Fichter, Manfred M.; Fischer, Krista; Föcker, Manuel; Foretova, Lenka; Forstner, Andreas J.; Forzan, Monica; Franklin, Christopher S.; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Gratacos Mayora, Monica; Guillaume, Sébastien; Guo, Yiran; Hakonarson, Hakon; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; Helder, Sietske G.; Herms, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Huckins, Laura M.; Hudson, James I.; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jiménez-Murcia, Susana; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J.H.; Kennedy, James L.; Keski-Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl Ri; Klump, Kelly L.; Knudsen, Gun Peggy S.; La Via, Maria C.; Le Hellard, Stephanie; Levitan, Robert D.; Li, Dong; Lilenfeld, Lisa; Lin, Bochao Danae; Lissowska, Jolanta; Luykx, Jurjen; Magistretti, Pierre J.; Maj, Mario; Mannik, Katrin; Marsal, Sara; Marshall, Christian R.; Mattingsdal, Morten; McDevitt, Sara; McGuffin, Peter; Metspalu, Andres; Meulenbelt, Ingrid; Micali, Nadia; Mitchell, Karen; Monteleone, Alessio Maria; Monteleone, Palmiero; Nacmias, Benedetta; Navratilova, Marie; Ntalla, Ioanna; O'Toole, Julie K.; Ophoff, Roel A.; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papezova, Hana; Pinto, Dalila; Rabionet, Raquel; Raevuori, Anu; Ramoz, Nicolas; Reichborn-Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rotondo, Alessandro; Rujescu, Dan; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André; Scherer, Stephen W.; Schmidt, Ulrike; Schork, Nicholas J.; Schosser, Alexandra; Seitz, Jochen; Slachtova, Lenka; Slagboom, P. Eline; Slof-Op't Landt, Margarita C.T.; Slopien, Agnieszka; Sorbi, Sandro; Świątkowska, Beata; Szatkiewicz, Jin P.; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Treasure, Janet; Tsitsika, Artemis; Tyszkiewicz-Nwafor, Marta; Tziouvas, Konstantinos; van Elburg, Annemarie A.; van Furth, Eric F.; Wagner, Gudrun; Walton, Esther; Widen, Elisabeth; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; Bergen, Andrew W.; Boden, Joseph M.; Brandt, Harry; Crawford, Steven; Halmi, Katherine A.; Horwood, L. John; Johnson, Craig; Kaplan, Allan S.; Kaye, Walter H.; Mitchell, James; Olsen, Catherine M.; Pearson, John F.; Pedersen, Nancy L.; Strober, Michael; Werge, Thomas; Whiteman, David C.; Woodside, D. Blake; Grove, Jakob; Henders, Anjali K.; Larsen, Janne T.; Parker, Richard; Petersen, Liselotte V.; Jordan, Jennifer; Kennedy, Martin A.; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Landén, Mikael; Mortensen, Preben Bo; Polimanti, Renato; McClintick, Jeanette N.; Adkins, Amy E.; Aliev, Fazil; Bacanu, Silviu Alin; Batzler, Anthony; Bertelsen, Sarah; Biernacka, Joanna M.; Bigdeli, Tim B.; Chen, Li Shiun; Clarke, Toni Kim; Degenhardt, Franziska; Docherty, Anna R.; Edwards, Alexis C.; Foo, Jerome C.; Fox, Louis; Frank, Josef; Hack, Laura M.; Hartmann, Annette M.; Hartz, Sarah M.; Heilmann-Heimbach, Stefanie; Hodgkinson, Colin; Hoffmann, Per; Hottenga, Jouke Jan; Konte, Bettina; Lahti, Jari; Lahti-Pulkkinen, Marius; Lai, Dongbing; Ligthart, Lannie; Loukola, Anu; Maher, Brion S.; Mbarek, Hamdi; McIntosh, Andrew M.; McQueen, Matthew B.; Meyers, Jacquelyn L.; Milaneschi, Yuri; Palviainen, Teemu; Peterson, Roseann E.; Ryu, Euijung; Saccone, Nancy L.; Salvatore, Jessica E.; Sanchez-Roige, Sandra; Schwandt, Melanie; Sherva, Richard; Streit, Fabian; Strohmaier, Jana; Thomas, Nathaniel; Wang, Jen Chyong; Webb, Bradley T.; Wedow, Robbee; Wetherill, Leah; Wills, Amanda G.; Zhou, Hang; Boardman, Jason D.; Chen, Danfeng; Choi, Doo Sup; Copeland, William E.; Culverhouse, Robert C.; Dahmen, Norbert; Degenhardt, Louisa; Domingue, Benjamin W.; Frye, Mark A.; Gäbel, Wolfgang; Hayward, Caroline; Ising, Marcus; Keyes, Margaret; Kiefer, Falk; Koller, Gabriele; Kramer, John; Kuperman, Samuel; Lucae, Susanne; Lynskey, Michael T.; Maier, Wolfgang; Mann, Karl; Männistö, Satu; Müller-Myhsok, Bertram; Murray, Alison D.; Nurnberger, John I.; Preuss, Ulrich; Räikkönen, Katri; Reynolds, Maureen D.; Ridinger, Monika; Scherbaum, Norbert; Schuckit, Marc A.; Soyka, Michael; Treutlein, Jens; Witt, Stephanie H.; Wodarz, Norbert; Zill, Peter; Adkins, Daniel E.; Boomsma, Dorret I.; Bierut, Laura J.; Brown, Sandra A.; Bucholz, Kathleen K.; Costello, E. Jane; de Wit, Harriet; Diazgranados, Nancy; Eriksson, Johan G.; Farrer, Lindsay A.; Foroud, Tatiana M.; Gillespie, Nathan A.; Goate, Alison M.; Goldman, David; Grucza, Richard A.; Hancock, Dana B.; Harris, Kathleen Mullan; Hesselbrock, Victor; Hewitt, John K.; Hopfer, Christian J.; Iacono, William G.; Johnson, Eric O.; Karpyak, Victor M.; Kendler, Kenneth S.; Kranzler, Henry R.; Krauter, Kenneth; Lind, Penelope A.; McGue, Matt; MacKillop, James; Madden, Pamela A.F.; Maes, Hermine H.; Magnusson, Patrik K.E.; Nelson, Elliot C.; Nöthen, Markus M.; Palmer, Abraham A.; Penninx, Brenda W.J.H.; Porjesz, Bernice; Rice, John P.; Rietschel, Marcella; Riley, Brien P.; Rose, Richard J.; Shen, Pei Hong; Silberg, Judy; Stallings, Michael C.; Tarter, Ralph E.; Vanyukov, Michael M.; Vrieze, Scott; Wall, Tamara L.; Whitfield, John B.; Zhao, Hongyu; Neale, Benjamin M.; Wade, Tracey D.; Heath, Andrew C.; Montgomery, Grant W.; Martin, Nicholas G.; Sullivan, Patrick F.; Kaprio, Jaakko; Breen, Gerome; Gelernter, Joel; Edenberg, Howard J.; Bulik, Cynthia M.; Agrawal, Arpana.

In: Addiction Biology, Vol. 26, No. 1, e12880, 01.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Munn-Chernoff, MA, Johnson, EC, Chou, YL, Coleman, JRI, Thornton, LM, Walters, RK, Yilmaz, Z, Baker, JH, Hübel, C, Gordon, S, Medland, SE, Watson, HJ, Gaspar, HA, Bryois, J, Hinney, A, Leppä, VM, Mattheisen, M, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, KB, Adan, RAH, Alfredsson, L, Ando, T, Andreassen, OA, Berrettini, WH, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, RD, Courtet, P, Crow, S, Crowley, JJ, Danner, UN, Davis, OSP, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, JE, Dick, DM, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, LE, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Estivill, X, Farmer, A, Favaro, A, Fernández-Aranda, F, Fichter, MM, Fischer, K, Föcker, M, Foretova, L, Forstner, AJ, Forzan, M, Franklin, CS, Gallinger, S, Giegling, I, Giuranna, J, Gonidakis, F, Gorwood, P, Gratacos Mayora, M, Guillaume, S, Guo, Y, Hakonarson, H, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, SG, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Huckins, LM, Hudson, JI, Imgart, H, Inoko, H, Janout, V, Jiménez-Murcia, S, Julià, A, Kalsi, G, Kaminská, D, Karhunen, L, Karwautz, A, Kas, MJH, Kennedy, JL, Keski-Rahkonen, A, Kiezebrink, K, Kim, YR, Klump, KL, Knudsen, GPS, La Via, MC, Le Hellard, S, Levitan, RD, Li, D, Lilenfeld, L, Lin, BD, Lissowska, J, Luykx, J, Magistretti, PJ, Maj, M, Mannik, K, Marsal, S, Marshall, CR, Mattingsdal, M, McDevitt, S, McGuffin, P, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, K, Monteleone, AM, Monteleone, P, Nacmias, B, Navratilova, M, Ntalla, I, O'Toole, JK, Ophoff, RA, Padyukov, L, Palotie, A, Pantel, J, Papezova, H, Pinto, D, Rabionet, R, Raevuori, A, Ramoz, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, SW, Schmidt, U, Schork, NJ, Schosser, A, Seitz, J, Slachtova, L, Slagboom, PE, Slof-Op't Landt, MCT, Slopien, A, Sorbi, S, Świątkowska, B, Szatkiewicz, JP, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tsitsika, A, Tyszkiewicz-Nwafor, M, Tziouvas, K, van Elburg, AA, van Furth, EF, Wagner, G, Walton, E, Widen, E, Zeggini, E, Zerwas, S, Zipfel, S, Bergen, AW, Boden, JM, Brandt, H, Crawford, S, Halmi, KA, Horwood, LJ, Johnson, C, Kaplan, AS, Kaye, WH, Mitchell, J, Olsen, CM, Pearson, JF, Pedersen, NL, Strober, M, Werge, T, Whiteman, DC, Woodside, DB, Grove, J, Henders, AK, Larsen, JT, Parker, R, Petersen, LV, Jordan, J, Kennedy, MA, Birgegård, A, Lichtenstein, P, Norring, C, Landén, M, Mortensen, PB, Polimanti, R, McClintick, JN, Adkins, AE, Aliev, F, Bacanu, SA, Batzler, A, Bertelsen, S, Biernacka, JM, Bigdeli, TB, Chen, LS, Clarke, TK, Degenhardt, F, Docherty, AR, Edwards, AC, Foo, JC, Fox, L, Frank, J, Hack, LM, Hartmann, AM, Hartz, SM, Heilmann-Heimbach, S, Hodgkinson, C, Hoffmann, P, Hottenga, JJ, Konte, B, Lahti, J, Lahti-Pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, BS, Mbarek, H, McIntosh, AM, McQueen, MB, Meyers, JL, Milaneschi, Y, Palviainen, T, Peterson, RE, Ryu, E, Saccone, NL, Salvatore, JE, Sanchez-Roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, JC, Webb, BT, Wedow, R, Wetherill, L, Wills, AG, Zhou, H, Boardman, JD, Chen, D, Choi, DS, Copeland, WE, Culverhouse, RC, Dahmen, N, Degenhardt, L, Domingue, BW, Frye, MA, Gäbel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Koller, G, Kramer, J, Kuperman, S, Lucae, S, Lynskey, MT, Maier, W, Mann, K, Männistö, S, Müller-Myhsok, B, Murray, AD, Nurnberger, JI, Preuss, U, Räikkönen, K, Reynolds, MD, Ridinger, M, Scherbaum, N, Schuckit, MA, Soyka, M, Treutlein, J, Witt, SH, Wodarz, N, Zill, P, Adkins, DE, Boomsma, DI, Bierut, LJ, Brown, SA, Bucholz, KK, Costello, EJ, de Wit, H, Diazgranados, N, Eriksson, JG, Farrer, LA, Foroud, TM, Gillespie, NA, Goate, AM, Goldman, D, Grucza, RA, Hancock, DB, Harris, KM, Hesselbrock, V, Hewitt, JK, Hopfer, CJ, Iacono, WG, Johnson, EO, Karpyak, VM, Kendler, KS, Kranzler, HR, Krauter, K, Lind, PA, McGue, M, MacKillop, J, Madden, PAF, Maes, HH, Magnusson, PKE, Nelson, EC, Nöthen, MM, Palmer, AA, Penninx, BWJH, Porjesz, B, Rice, JP, Rietschel, M, Riley, BP, Rose, RJ, Shen, PH, Silberg, J, Stallings, MC, Tarter, RE, Vanyukov, MM, Vrieze, S, Wall, TL, Whitfield, JB, Zhao, H, Neale, BM, Wade, TD, Heath, AC, Montgomery, GW, Martin, NG, Sullivan, PF, Kaprio, J, Breen, G, Gelernter, J, Edenberg, HJ, Bulik, CM & Agrawal, A 2021, 'Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies', Addiction Biology, vol. 26, no. 1, e12880. https://doi.org/10.1111/adb.12880

APA

Munn-Chernoff, M. A., Johnson, E. C., Chou, Y. L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., Yilmaz, Z., Baker, J. H., Hübel, C., Gordon, S., Medland, S. E., Watson, H. J., Gaspar, H. A., Bryois, J., Hinney, A., Leppä, V. M., Mattheisen, M., Ripke, S., Yao, S., ... Agrawal, A. (2021). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology, 26(1), [e12880]. https://doi.org/10.1111/adb.12880

CBE

Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, Yilmaz Z, Baker JH, Hübel C, Gordon S, Medland SE, Watson HJ, Gaspar HA, Bryois J, Hinney A, Leppä VM, Mattheisen M, Ripke S, Yao S, Giusti-Rodríguez P, Hanscombe KB, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Berrettini WH, Boehm I, Boni C, Boraska Perica V, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter MM, Fischer K, Föcker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Gratacos Mayora M, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op't Landt MCT, Slopien A, Sorbi S, Świątkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell J, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Grove J, Henders AK, Larsen JT, Parker R, Petersen LV, Jordan J, Kennedy MA, Birgegård A, Lichtenstein P, Norring C, Landén M, Mortensen PB, Polimanti R, McClintick JN, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Degenhardt F, Docherty AR, Edwards AC, Foo JC, Fox L, Frank J, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Hodgkinson C, Hoffmann P, Hottenga JJ, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Peterson RE, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Zhou H, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Koller G, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt SH, Wodarz N, Zill P, Adkins DE, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Costello EJ, de Wit H, Diazgranados N, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Hesselbrock V, Hewitt JK, Hopfer CJ, Iacono WG, Johnson EO, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson PKE, Nelson EC, Nöthen MM, Palmer AA, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose RJ, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Wade TD, Heath AC, Montgomery GW, Martin NG, Sullivan PF, Kaprio J, Breen G, Gelernter J, Edenberg HJ, Bulik CM, Agrawal A. 2021. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology. 26(1):Article e12880. https://doi.org/10.1111/adb.12880

MLA

Vancouver

Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK et al. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology. 2021 Jan;26(1). e12880. https://doi.org/10.1111/adb.12880

Author

Munn-Chernoff, Melissa A. ; Johnson, Emma C. ; Chou, Yi Ling ; Coleman, Jonathan R.I. ; Thornton, Laura M. ; Walters, Raymond K. ; Yilmaz, Zeynep ; Baker, Jessica H. ; Hübel, Christopher ; Gordon, Scott ; Medland, Sarah E. ; Watson, Hunna J. ; Gaspar, Héléna A. ; Bryois, Julien ; Hinney, Anke ; Leppä, Virpi M. ; Mattheisen, Manuel ; Ripke, Stephan ; Yao, Shuyang ; Giusti-Rodríguez, Paola ; Hanscombe, Ken B. ; Adan, Roger A.H. ; Alfredsson, Lars ; Ando, Tetsuya ; Andreassen, Ole A. ; Berrettini, Wade H. ; Boehm, Ilka ; Boni, Claudette ; Boraska Perica, Vesna ; Buehren, Katharina ; Burghardt, Roland ; Cassina, Matteo ; Cichon, Sven ; Clementi, Maurizio ; Cone, Roger D. ; Courtet, Philippe ; Crow, Scott ; Crowley, James J. ; Danner, Unna N. ; Davis, Oliver S.P. ; de Zwaan, Martina ; Dedoussis, George ; Degortes, Daniela ; DeSocio, Janiece E. ; Dick, Danielle M. ; Dikeos, Dimitris ; Dina, Christian ; Dmitrzak-Weglarz, Monika ; Docampo, Elisa ; Duncan, Laramie E. ; Egberts, Karin ; Ehrlich, Stefan ; Escaramís, Geòrgia ; Esko, Tõnu ; Estivill, Xavier ; Farmer, Anne ; Favaro, Angela ; Fernández-Aranda, Fernando ; Fichter, Manfred M. ; Fischer, Krista ; Föcker, Manuel ; Foretova, Lenka ; Forstner, Andreas J. ; Forzan, Monica ; Franklin, Christopher S. ; Gallinger, Steven ; Giegling, Ina ; Giuranna, Johanna ; Gonidakis, Fragiskos ; Gorwood, Philip ; Gratacos Mayora, Monica ; Guillaume, Sébastien ; Guo, Yiran ; Hakonarson, Hakon ; Hatzikotoulas, Konstantinos ; Hauser, Joanna ; Hebebrand, Johannes ; Helder, Sietske G. ; Herms, Stefan ; Herpertz-Dahlmann, Beate ; Herzog, Wolfgang ; Huckins, Laura M. ; Hudson, James I. ; Imgart, Hartmut ; Inoko, Hidetoshi ; Janout, Vladimir ; Jiménez-Murcia, Susana ; Julià, Antonio ; Kalsi, Gursharan ; Kaminská, Deborah ; Karhunen, Leila ; Karwautz, Andreas ; Kas, Martien J.H. ; Kennedy, James L. ; Keski-Rahkonen, Anna ; Kiezebrink, Kirsty ; Kim, Youl Ri ; Klump, Kelly L. ; Knudsen, Gun Peggy S. ; La Via, Maria C. ; Le Hellard, Stephanie ; Levitan, Robert D. ; Li, Dong ; Lilenfeld, Lisa ; Lin, Bochao Danae ; Lissowska, Jolanta ; Luykx, Jurjen ; Magistretti, Pierre J. ; Maj, Mario ; Mannik, Katrin ; Marsal, Sara ; Marshall, Christian R. ; Mattingsdal, Morten ; McDevitt, Sara ; McGuffin, Peter ; Metspalu, Andres ; Meulenbelt, Ingrid ; Micali, Nadia ; Mitchell, Karen ; Monteleone, Alessio Maria ; Monteleone, Palmiero ; Nacmias, Benedetta ; Navratilova, Marie ; Ntalla, Ioanna ; O'Toole, Julie K. ; Ophoff, Roel A. ; Padyukov, Leonid ; Palotie, Aarno ; Pantel, Jacques ; Papezova, Hana ; Pinto, Dalila ; Rabionet, Raquel ; Raevuori, Anu ; Ramoz, Nicolas ; Reichborn-Kjennerud, Ted ; Ricca, Valdo ; Ripatti, Samuli ; Ritschel, Franziska ; Roberts, Marion ; Rotondo, Alessandro ; Rujescu, Dan ; Rybakowski, Filip ; Santonastaso, Paolo ; Scherag, André ; Scherer, Stephen W. ; Schmidt, Ulrike ; Schork, Nicholas J. ; Schosser, Alexandra ; Seitz, Jochen ; Slachtova, Lenka ; Slagboom, P. Eline ; Slof-Op't Landt, Margarita C.T. ; Slopien, Agnieszka ; Sorbi, Sandro ; Świątkowska, Beata ; Szatkiewicz, Jin P. ; Tachmazidou, Ioanna ; Tenconi, Elena ; Tortorella, Alfonso ; Tozzi, Federica ; Treasure, Janet ; Tsitsika, Artemis ; Tyszkiewicz-Nwafor, Marta ; Tziouvas, Konstantinos ; van Elburg, Annemarie A. ; van Furth, Eric F. ; Wagner, Gudrun ; Walton, Esther ; Widen, Elisabeth ; Zeggini, Eleftheria ; Zerwas, Stephanie ; Zipfel, Stephan ; Bergen, Andrew W. ; Boden, Joseph M. ; Brandt, Harry ; Crawford, Steven ; Halmi, Katherine A. ; Horwood, L. John ; Johnson, Craig ; Kaplan, Allan S. ; Kaye, Walter H. ; Mitchell, James ; Olsen, Catherine M. ; Pearson, John F. ; Pedersen, Nancy L. ; Strober, Michael ; Werge, Thomas ; Whiteman, David C. ; Woodside, D. Blake ; Grove, Jakob ; Henders, Anjali K. ; Larsen, Janne T. ; Parker, Richard ; Petersen, Liselotte V. ; Jordan, Jennifer ; Kennedy, Martin A. ; Birgegård, Andreas ; Lichtenstein, Paul ; Norring, Claes ; Landén, Mikael ; Mortensen, Preben Bo ; Polimanti, Renato ; McClintick, Jeanette N. ; Adkins, Amy E. ; Aliev, Fazil ; Bacanu, Silviu Alin ; Batzler, Anthony ; Bertelsen, Sarah ; Biernacka, Joanna M. ; Bigdeli, Tim B. ; Chen, Li Shiun ; Clarke, Toni Kim ; Degenhardt, Franziska ; Docherty, Anna R. ; Edwards, Alexis C. ; Foo, Jerome C. ; Fox, Louis ; Frank, Josef ; Hack, Laura M. ; Hartmann, Annette M. ; Hartz, Sarah M. ; Heilmann-Heimbach, Stefanie ; Hodgkinson, Colin ; Hoffmann, Per ; Hottenga, Jouke Jan ; Konte, Bettina ; Lahti, Jari ; Lahti-Pulkkinen, Marius ; Lai, Dongbing ; Ligthart, Lannie ; Loukola, Anu ; Maher, Brion S. ; Mbarek, Hamdi ; McIntosh, Andrew M. ; McQueen, Matthew B. ; Meyers, Jacquelyn L. ; Milaneschi, Yuri ; Palviainen, Teemu ; Peterson, Roseann E. ; Ryu, Euijung ; Saccone, Nancy L. ; Salvatore, Jessica E. ; Sanchez-Roige, Sandra ; Schwandt, Melanie ; Sherva, Richard ; Streit, Fabian ; Strohmaier, Jana ; Thomas, Nathaniel ; Wang, Jen Chyong ; Webb, Bradley T. ; Wedow, Robbee ; Wetherill, Leah ; Wills, Amanda G. ; Zhou, Hang ; Boardman, Jason D. ; Chen, Danfeng ; Choi, Doo Sup ; Copeland, William E. ; Culverhouse, Robert C. ; Dahmen, Norbert ; Degenhardt, Louisa ; Domingue, Benjamin W. ; Frye, Mark A. ; Gäbel, Wolfgang ; Hayward, Caroline ; Ising, Marcus ; Keyes, Margaret ; Kiefer, Falk ; Koller, Gabriele ; Kramer, John ; Kuperman, Samuel ; Lucae, Susanne ; Lynskey, Michael T. ; Maier, Wolfgang ; Mann, Karl ; Männistö, Satu ; Müller-Myhsok, Bertram ; Murray, Alison D. ; Nurnberger, John I. ; Preuss, Ulrich ; Räikkönen, Katri ; Reynolds, Maureen D. ; Ridinger, Monika ; Scherbaum, Norbert ; Schuckit, Marc A. ; Soyka, Michael ; Treutlein, Jens ; Witt, Stephanie H. ; Wodarz, Norbert ; Zill, Peter ; Adkins, Daniel E. ; Boomsma, Dorret I. ; Bierut, Laura J. ; Brown, Sandra A. ; Bucholz, Kathleen K. ; Costello, E. Jane ; de Wit, Harriet ; Diazgranados, Nancy ; Eriksson, Johan G. ; Farrer, Lindsay A. ; Foroud, Tatiana M. ; Gillespie, Nathan A. ; Goate, Alison M. ; Goldman, David ; Grucza, Richard A. ; Hancock, Dana B. ; Harris, Kathleen Mullan ; Hesselbrock, Victor ; Hewitt, John K. ; Hopfer, Christian J. ; Iacono, William G. ; Johnson, Eric O. ; Karpyak, Victor M. ; Kendler, Kenneth S. ; Kranzler, Henry R. ; Krauter, Kenneth ; Lind, Penelope A. ; McGue, Matt ; MacKillop, James ; Madden, Pamela A.F. ; Maes, Hermine H. ; Magnusson, Patrik K.E. ; Nelson, Elliot C. ; Nöthen, Markus M. ; Palmer, Abraham A. ; Penninx, Brenda W.J.H. ; Porjesz, Bernice ; Rice, John P. ; Rietschel, Marcella ; Riley, Brien P. ; Rose, Richard J. ; Shen, Pei Hong ; Silberg, Judy ; Stallings, Michael C. ; Tarter, Ralph E. ; Vanyukov, Michael M. ; Vrieze, Scott ; Wall, Tamara L. ; Whitfield, John B. ; Zhao, Hongyu ; Neale, Benjamin M. ; Wade, Tracey D. ; Heath, Andrew C. ; Montgomery, Grant W. ; Martin, Nicholas G. ; Sullivan, Patrick F. ; Kaprio, Jaakko ; Breen, Gerome ; Gelernter, Joel ; Edenberg, Howard J. ; Bulik, Cynthia M. ; Agrawal, Arpana. / Shared genetic risk between eating disorder- and substance-use-related phenotypes : Evidence from genome-wide association studies. In: Addiction Biology. 2021 ; Vol. 26, No. 1.

Bibtex

@article{c1c85c6fbe624a0cbc7b7f4da404396a,
title = "Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies",
abstract = "Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.",
keywords = "eating disorders, genetic correlation, substance use, DRUG-USE, GWAS, BULIMIA-NERVOSA, TWIN, COMORBIDITY, WOMEN, ANOREXIA-NERVOSA, ENDOCANNABINOIDS, ENVIRONMENTAL CONTRIBUTIONS, ALCOHOL DEPENDENCE",
author = "Munn-Chernoff, {Melissa A.} and Johnson, {Emma C.} and Chou, {Yi Ling} and Coleman, {Jonathan R.I.} and Thornton, {Laura M.} and Walters, {Raymond K.} and Zeynep Yilmaz and Baker, {Jessica H.} and Christopher H{\"u}bel and Scott Gordon and Medland, {Sarah E.} and Watson, {Hunna J.} and Gaspar, {H{\'e}l{\'e}na A.} and Julien Bryois and Anke Hinney and Lepp{\"a}, {Virpi M.} and Manuel Mattheisen and Stephan Ripke and Shuyang Yao and Paola Giusti-Rodr{\'i}guez and Hanscombe, {Ken B.} and Adan, {Roger A.H.} and Lars Alfredsson and Tetsuya Ando and Andreassen, {Ole A.} and Berrettini, {Wade H.} and Ilka Boehm and Claudette Boni and {Boraska Perica}, Vesna and Katharina Buehren and Roland Burghardt and Matteo Cassina and Sven Cichon and Maurizio Clementi and Cone, {Roger D.} and Philippe Courtet and Scott Crow and Crowley, {James J.} and Danner, {Unna N.} and Davis, {Oliver S.P.} and {de Zwaan}, Martina and George Dedoussis and Daniela Degortes and DeSocio, {Janiece E.} and Dick, {Danielle M.} and Dimitris Dikeos and Christian Dina and Monika Dmitrzak-Weglarz and Elisa Docampo and Duncan, {Laramie E.} and Karin Egberts and Stefan Ehrlich and Ge{\`o}rgia Escaram{\'i}s and T{\~o}nu Esko and Xavier Estivill and Anne Farmer and Angela Favaro and Fernando Fern{\'a}ndez-Aranda and Fichter, {Manfred M.} and Krista Fischer and Manuel F{\"o}cker and Lenka Foretova and Forstner, {Andreas J.} and Monica Forzan and Franklin, {Christopher S.} and Steven Gallinger and Ina Giegling and Johanna Giuranna and Fragiskos Gonidakis and Philip Gorwood and {Gratacos Mayora}, Monica and S{\'e}bastien Guillaume and Yiran Guo and Hakon Hakonarson and Konstantinos Hatzikotoulas and Joanna Hauser and Johannes Hebebrand and Helder, {Sietske G.} and Stefan Herms and Beate Herpertz-Dahlmann and Wolfgang Herzog and Huckins, {Laura M.} and Hudson, {James I.} and Hartmut Imgart and Hidetoshi Inoko and Vladimir Janout and Susana Jim{\'e}nez-Murcia and Antonio Juli{\`a} and Gursharan Kalsi and Deborah Kaminsk{\'a} and Leila Karhunen and Andreas Karwautz and Kas, {Martien J.H.} and Kennedy, {James L.} and Anna Keski-Rahkonen and Kirsty Kiezebrink and Kim, {Youl Ri} and Klump, {Kelly L.} and Knudsen, {Gun Peggy S.} and {La Via}, {Maria C.} and {Le Hellard}, Stephanie and Levitan, {Robert D.} and Dong Li and Lisa Lilenfeld and Lin, {Bochao Danae} and Jolanta Lissowska and Jurjen Luykx and Magistretti, {Pierre J.} and Mario Maj and Katrin Mannik and Sara Marsal and Marshall, {Christian R.} and Morten Mattingsdal and Sara McDevitt and Peter McGuffin and Andres Metspalu and Ingrid Meulenbelt and Nadia Micali and Karen Mitchell and Monteleone, {Alessio Maria} and Palmiero Monteleone and Benedetta Nacmias and Marie Navratilova and Ioanna Ntalla and O'Toole, {Julie K.} and Ophoff, {Roel A.} and Leonid Padyukov and Aarno Palotie and Jacques Pantel and Hana Papezova and Dalila Pinto and Raquel Rabionet and Anu Raevuori and Nicolas Ramoz and Ted Reichborn-Kjennerud and Valdo Ricca and Samuli Ripatti and Franziska Ritschel and Marion Roberts and Alessandro Rotondo and Dan Rujescu and Filip Rybakowski and Paolo Santonastaso and Andr{\'e} Scherag and Scherer, {Stephen W.} and Ulrike Schmidt and Schork, {Nicholas J.} and Alexandra Schosser and Jochen Seitz and Lenka Slachtova and Slagboom, {P. Eline} and {Slof-Op't Landt}, {Margarita C.T.} and Agnieszka Slopien and Sandro Sorbi and Beata {\'S}wi{\c a}tkowska and Szatkiewicz, {Jin P.} and Ioanna Tachmazidou and Elena Tenconi and Alfonso Tortorella and Federica Tozzi and Janet Treasure and Artemis Tsitsika and Marta Tyszkiewicz-Nwafor and Konstantinos Tziouvas and {van Elburg}, {Annemarie A.} and {van Furth}, {Eric F.} and Gudrun Wagner and Esther Walton and Elisabeth Widen and Eleftheria Zeggini and Stephanie Zerwas and Stephan Zipfel and Bergen, {Andrew W.} and Boden, {Joseph M.} and Harry Brandt and Steven Crawford and Halmi, {Katherine A.} and Horwood, {L. John} and Craig Johnson and Kaplan, {Allan S.} and Kaye, {Walter H.} and James Mitchell and Olsen, {Catherine M.} and Pearson, {John F.} and Pedersen, {Nancy L.} and Michael Strober and Thomas Werge and Whiteman, {David C.} and Woodside, {D. Blake} and Jakob Grove and Henders, {Anjali K.} and Larsen, {Janne T.} and Richard Parker and Petersen, {Liselotte V.} and Jennifer Jordan and Kennedy, {Martin A.} and Andreas Birgeg{\aa}rd and Paul Lichtenstein and Claes Norring and Mikael Land{\'e}n and Mortensen, {Preben Bo} and Renato Polimanti and McClintick, {Jeanette N.} and Adkins, {Amy E.} and Fazil Aliev and Bacanu, {Silviu Alin} and Anthony Batzler and Sarah Bertelsen and Biernacka, {Joanna M.} and Bigdeli, {Tim B.} and Chen, {Li Shiun} and Clarke, {Toni Kim} and Franziska Degenhardt and Docherty, {Anna R.} and Edwards, {Alexis C.} and Foo, {Jerome C.} and Louis Fox and Josef Frank and Hack, {Laura M.} and Hartmann, {Annette M.} and Hartz, {Sarah M.} and Stefanie Heilmann-Heimbach and Colin Hodgkinson and Per Hoffmann and Hottenga, {Jouke Jan} and Bettina Konte and Jari Lahti and Marius Lahti-Pulkkinen and Dongbing Lai and Lannie Ligthart and Anu Loukola and Maher, {Brion S.} and Hamdi Mbarek and McIntosh, {Andrew M.} and McQueen, {Matthew B.} and Meyers, {Jacquelyn L.} and Yuri Milaneschi and Teemu Palviainen and Peterson, {Roseann E.} and Euijung Ryu and Saccone, {Nancy L.} and Salvatore, {Jessica E.} and Sandra Sanchez-Roige and Melanie Schwandt and Richard Sherva and Fabian Streit and Jana Strohmaier and Nathaniel Thomas and Wang, {Jen Chyong} and Webb, {Bradley T.} and Robbee Wedow and Leah Wetherill and Wills, {Amanda G.} and Hang Zhou and Boardman, {Jason D.} and Danfeng Chen and Choi, {Doo Sup} and Copeland, {William E.} and Culverhouse, {Robert C.} and Norbert Dahmen and Louisa Degenhardt and Domingue, {Benjamin W.} and Frye, {Mark A.} and Wolfgang G{\"a}bel and Caroline Hayward and Marcus Ising and Margaret Keyes and Falk Kiefer and Gabriele Koller and John Kramer and Samuel Kuperman and Susanne Lucae and Lynskey, {Michael T.} and Wolfgang Maier and Karl Mann and Satu M{\"a}nnist{\"o} and Bertram M{\"u}ller-Myhsok and Murray, {Alison D.} and Nurnberger, {John I.} and Ulrich Preuss and Katri R{\"a}ikk{\"o}nen and Reynolds, {Maureen D.} and Monika Ridinger and Norbert Scherbaum and Schuckit, {Marc A.} and Michael Soyka and Jens Treutlein and Witt, {Stephanie H.} and Norbert Wodarz and Peter Zill and Adkins, {Daniel E.} and Boomsma, {Dorret I.} and Bierut, {Laura J.} and Brown, {Sandra A.} and Bucholz, {Kathleen K.} and Costello, {E. Jane} and {de Wit}, Harriet and Nancy Diazgranados and Eriksson, {Johan G.} and Farrer, {Lindsay A.} and Foroud, {Tatiana M.} and Gillespie, {Nathan A.} and Goate, {Alison M.} and David Goldman and Grucza, {Richard A.} and Hancock, {Dana B.} and Harris, {Kathleen Mullan} and Victor Hesselbrock and Hewitt, {John K.} and Hopfer, {Christian J.} and Iacono, {William G.} and Johnson, {Eric O.} and Karpyak, {Victor M.} and Kendler, {Kenneth S.} and Kranzler, {Henry R.} and Kenneth Krauter and Lind, {Penelope A.} and Matt McGue and James MacKillop and Madden, {Pamela A.F.} and Maes, {Hermine H.} and Magnusson, {Patrik K.E.} and Nelson, {Elliot C.} and N{\"o}then, {Markus M.} and Palmer, {Abraham A.} and Penninx, {Brenda W.J.H.} and Bernice Porjesz and Rice, {John P.} and Marcella Rietschel and Riley, {Brien P.} and Rose, {Richard J.} and Shen, {Pei Hong} and Judy Silberg and Stallings, {Michael C.} and Tarter, {Ralph E.} and Vanyukov, {Michael M.} and Scott Vrieze and Wall, {Tamara L.} and Whitfield, {John B.} and Hongyu Zhao and Neale, {Benjamin M.} and Wade, {Tracey D.} and Heath, {Andrew C.} and Montgomery, {Grant W.} and Martin, {Nicholas G.} and Sullivan, {Patrick F.} and Jaakko Kaprio and Gerome Breen and Joel Gelernter and Edenberg, {Howard J.} and Bulik, {Cynthia M.} and Arpana Agrawal",
year = "2021",
month = jan,
doi = "10.1111/adb.12880",
language = "English",
volume = "26",
journal = "Addiction Biology (Online)",
issn = "1369-1600",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Shared genetic risk between eating disorder- and substance-use-related phenotypes

T2 - Evidence from genome-wide association studies

AU - Munn-Chernoff, Melissa A.

AU - Johnson, Emma C.

AU - Chou, Yi Ling

AU - Coleman, Jonathan R.I.

AU - Thornton, Laura M.

AU - Walters, Raymond K.

AU - Yilmaz, Zeynep

AU - Baker, Jessica H.

AU - Hübel, Christopher

AU - Gordon, Scott

AU - Medland, Sarah E.

AU - Watson, Hunna J.

AU - Gaspar, Héléna A.

AU - Bryois, Julien

AU - Hinney, Anke

AU - Leppä, Virpi M.

AU - Mattheisen, Manuel

AU - Ripke, Stephan

AU - Yao, Shuyang

AU - Giusti-Rodríguez, Paola

AU - Hanscombe, Ken B.

AU - Adan, Roger A.H.

AU - Alfredsson, Lars

AU - Ando, Tetsuya

AU - Andreassen, Ole A.

AU - Berrettini, Wade H.

AU - Boehm, Ilka

AU - Boni, Claudette

AU - Boraska Perica, Vesna

AU - Buehren, Katharina

AU - Burghardt, Roland

AU - Cassina, Matteo

AU - Cichon, Sven

AU - Clementi, Maurizio

AU - Cone, Roger D.

AU - Courtet, Philippe

AU - Crow, Scott

AU - Crowley, James J.

AU - Danner, Unna N.

AU - Davis, Oliver S.P.

AU - de Zwaan, Martina

AU - Dedoussis, George

AU - Degortes, Daniela

AU - DeSocio, Janiece E.

AU - Dick, Danielle M.

AU - Dikeos, Dimitris

AU - Dina, Christian

AU - Dmitrzak-Weglarz, Monika

AU - Docampo, Elisa

AU - Duncan, Laramie E.

AU - Egberts, Karin

AU - Ehrlich, Stefan

AU - Escaramís, Geòrgia

AU - Esko, Tõnu

AU - Estivill, Xavier

AU - Farmer, Anne

AU - Favaro, Angela

AU - Fernández-Aranda, Fernando

AU - Fichter, Manfred M.

AU - Fischer, Krista

AU - Föcker, Manuel

AU - Foretova, Lenka

AU - Forstner, Andreas J.

AU - Forzan, Monica

AU - Franklin, Christopher S.

AU - Gallinger, Steven

AU - Giegling, Ina

AU - Giuranna, Johanna

AU - Gonidakis, Fragiskos

AU - Gorwood, Philip

AU - Gratacos Mayora, Monica

AU - Guillaume, Sébastien

AU - Guo, Yiran

AU - Hakonarson, Hakon

AU - Hatzikotoulas, Konstantinos

AU - Hauser, Joanna

AU - Hebebrand, Johannes

AU - Helder, Sietske G.

AU - Herms, Stefan

AU - Herpertz-Dahlmann, Beate

AU - Herzog, Wolfgang

AU - Huckins, Laura M.

AU - Hudson, James I.

AU - Imgart, Hartmut

AU - Inoko, Hidetoshi

AU - Janout, Vladimir

AU - Jiménez-Murcia, Susana

AU - Julià, Antonio

AU - Kalsi, Gursharan

AU - Kaminská, Deborah

AU - Karhunen, Leila

AU - Karwautz, Andreas

AU - Kas, Martien J.H.

AU - Kennedy, James L.

AU - Keski-Rahkonen, Anna

AU - Kiezebrink, Kirsty

AU - Kim, Youl Ri

AU - Klump, Kelly L.

AU - Knudsen, Gun Peggy S.

AU - La Via, Maria C.

AU - Le Hellard, Stephanie

AU - Levitan, Robert D.

AU - Li, Dong

AU - Lilenfeld, Lisa

AU - Lin, Bochao Danae

AU - Lissowska, Jolanta

AU - Luykx, Jurjen

AU - Magistretti, Pierre J.

AU - Maj, Mario

AU - Mannik, Katrin

AU - Marsal, Sara

AU - Marshall, Christian R.

AU - Mattingsdal, Morten

AU - McDevitt, Sara

AU - McGuffin, Peter

AU - Metspalu, Andres

AU - Meulenbelt, Ingrid

AU - Micali, Nadia

AU - Mitchell, Karen

AU - Monteleone, Alessio Maria

AU - Monteleone, Palmiero

AU - Nacmias, Benedetta

AU - Navratilova, Marie

AU - Ntalla, Ioanna

AU - O'Toole, Julie K.

AU - Ophoff, Roel A.

AU - Padyukov, Leonid

AU - Palotie, Aarno

AU - Pantel, Jacques

AU - Papezova, Hana

AU - Pinto, Dalila

AU - Rabionet, Raquel

AU - Raevuori, Anu

AU - Ramoz, Nicolas

AU - Reichborn-Kjennerud, Ted

AU - Ricca, Valdo

AU - Ripatti, Samuli

AU - Ritschel, Franziska

AU - Roberts, Marion

AU - Rotondo, Alessandro

AU - Rujescu, Dan

AU - Rybakowski, Filip

AU - Santonastaso, Paolo

AU - Scherag, André

AU - Scherer, Stephen W.

AU - Schmidt, Ulrike

AU - Schork, Nicholas J.

AU - Schosser, Alexandra

AU - Seitz, Jochen

AU - Slachtova, Lenka

AU - Slagboom, P. Eline

AU - Slof-Op't Landt, Margarita C.T.

AU - Slopien, Agnieszka

AU - Sorbi, Sandro

AU - Świątkowska, Beata

AU - Szatkiewicz, Jin P.

AU - Tachmazidou, Ioanna

AU - Tenconi, Elena

AU - Tortorella, Alfonso

AU - Tozzi, Federica

AU - Treasure, Janet

AU - Tsitsika, Artemis

AU - Tyszkiewicz-Nwafor, Marta

AU - Tziouvas, Konstantinos

AU - van Elburg, Annemarie A.

AU - van Furth, Eric F.

AU - Wagner, Gudrun

AU - Walton, Esther

AU - Widen, Elisabeth

AU - Zeggini, Eleftheria

AU - Zerwas, Stephanie

AU - Zipfel, Stephan

AU - Bergen, Andrew W.

AU - Boden, Joseph M.

AU - Brandt, Harry

AU - Crawford, Steven

AU - Halmi, Katherine A.

AU - Horwood, L. John

AU - Johnson, Craig

AU - Kaplan, Allan S.

AU - Kaye, Walter H.

AU - Mitchell, James

AU - Olsen, Catherine M.

AU - Pearson, John F.

AU - Pedersen, Nancy L.

AU - Strober, Michael

AU - Werge, Thomas

AU - Whiteman, David C.

AU - Woodside, D. Blake

AU - Grove, Jakob

AU - Henders, Anjali K.

AU - Larsen, Janne T.

AU - Parker, Richard

AU - Petersen, Liselotte V.

AU - Jordan, Jennifer

AU - Kennedy, Martin A.

AU - Birgegård, Andreas

AU - Lichtenstein, Paul

AU - Norring, Claes

AU - Landén, Mikael

AU - Mortensen, Preben Bo

AU - Polimanti, Renato

AU - McClintick, Jeanette N.

AU - Adkins, Amy E.

AU - Aliev, Fazil

AU - Bacanu, Silviu Alin

AU - Batzler, Anthony

AU - Bertelsen, Sarah

AU - Biernacka, Joanna M.

AU - Bigdeli, Tim B.

AU - Chen, Li Shiun

AU - Clarke, Toni Kim

AU - Degenhardt, Franziska

AU - Docherty, Anna R.

AU - Edwards, Alexis C.

AU - Foo, Jerome C.

AU - Fox, Louis

AU - Frank, Josef

AU - Hack, Laura M.

AU - Hartmann, Annette M.

AU - Hartz, Sarah M.

AU - Heilmann-Heimbach, Stefanie

AU - Hodgkinson, Colin

AU - Hoffmann, Per

AU - Hottenga, Jouke Jan

AU - Konte, Bettina

AU - Lahti, Jari

AU - Lahti-Pulkkinen, Marius

AU - Lai, Dongbing

AU - Ligthart, Lannie

AU - Loukola, Anu

AU - Maher, Brion S.

AU - Mbarek, Hamdi

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AU - McQueen, Matthew B.

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AU - Gäbel, Wolfgang

AU - Hayward, Caroline

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AU - Keyes, Margaret

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AU - Kramer, John

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AU - Lynskey, Michael T.

AU - Maier, Wolfgang

AU - Mann, Karl

AU - Männistö, Satu

AU - Müller-Myhsok, Bertram

AU - Murray, Alison D.

AU - Nurnberger, John I.

AU - Preuss, Ulrich

AU - Räikkönen, Katri

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AU - Ridinger, Monika

AU - Scherbaum, Norbert

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AU - Foroud, Tatiana M.

AU - Gillespie, Nathan A.

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AU - Goldman, David

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AU - Harris, Kathleen Mullan

AU - Hesselbrock, Victor

AU - Hewitt, John K.

AU - Hopfer, Christian J.

AU - Iacono, William G.

AU - Johnson, Eric O.

AU - Karpyak, Victor M.

AU - Kendler, Kenneth S.

AU - Kranzler, Henry R.

AU - Krauter, Kenneth

AU - Lind, Penelope A.

AU - McGue, Matt

AU - MacKillop, James

AU - Madden, Pamela A.F.

AU - Maes, Hermine H.

AU - Magnusson, Patrik K.E.

AU - Nelson, Elliot C.

AU - Nöthen, Markus M.

AU - Palmer, Abraham A.

AU - Penninx, Brenda W.J.H.

AU - Porjesz, Bernice

AU - Rice, John P.

AU - Rietschel, Marcella

AU - Riley, Brien P.

AU - Rose, Richard J.

AU - Shen, Pei Hong

AU - Silberg, Judy

AU - Stallings, Michael C.

AU - Tarter, Ralph E.

AU - Vanyukov, Michael M.

AU - Vrieze, Scott

AU - Wall, Tamara L.

AU - Whitfield, John B.

AU - Zhao, Hongyu

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AU - Wade, Tracey D.

AU - Heath, Andrew C.

AU - Montgomery, Grant W.

AU - Martin, Nicholas G.

AU - Sullivan, Patrick F.

AU - Kaprio, Jaakko

AU - Breen, Gerome

AU - Gelernter, Joel

AU - Edenberg, Howard J.

AU - Bulik, Cynthia M.

AU - Agrawal, Arpana

PY - 2021/1

Y1 - 2021/1

N2 - Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

AB - Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

KW - eating disorders

KW - genetic correlation

KW - substance use

KW - DRUG-USE

KW - GWAS

KW - BULIMIA-NERVOSA

KW - TWIN

KW - COMORBIDITY

KW - WOMEN

KW - ANOREXIA-NERVOSA

KW - ENDOCANNABINOIDS

KW - ENVIRONMENTAL CONTRIBUTIONS

KW - ALCOHOL DEPENDENCE

UR - http://www.scopus.com/inward/record.url?scp=85079714981&partnerID=8YFLogxK

U2 - 10.1111/adb.12880

DO - 10.1111/adb.12880

M3 - Journal article

C2 - 32064741

AN - SCOPUS:85079714981

VL - 26

JO - Addiction Biology (Online)

JF - Addiction Biology (Online)

SN - 1369-1600

IS - 1

M1 - e12880

ER -