Manuel Mattheisen

Role of common and rare APP DNA sequence variants in Alzheimer disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • B V Hooli
  • ,
  • G Mohapatra
  • ,
  • Manuel Mattheisen
  • A R Parrado
  • ,
  • J T Roehr
  • ,
  • Y Shen
  • ,
  • J F Gusella
  • ,
  • R Moir
  • ,
  • A J Saunders
  • ,
  • C Lange
  • ,
  • R E Tanzi
  • ,
  • L Bertram
More than 30 different rare mutations, including copy number variants (CNVs), in the amyloid precursor protein gene (APP) cause early-onset familial Alzheimer disease (EOFAD), whereas the contribution of common APP variants to disease risk remains controversial. In this study we systematically assessed the role of both rare and common APP DNA variants in Alzheimer disease (AD) families.
Original languageEnglish
JournalNeurology Alert
Volume78
Issue16
Pages (from-to)1250-7
Number of pages8
ISSN0741-4234
DOIs
Publication statusPublished - 17 Apr 2012
Externally publishedYes

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