Manuel Mattheisen

Quick, "imputation-free" meta-analysis with proxy-SNPs

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Christian Meesters
  • ,
  • Markus Leber
  • ,
  • Christine Herold
  • ,
  • Marina Angisch
  • ,
  • Manuel Mattheisen
  • Dmitriy Drichel
  • ,
  • André Lacour
  • ,
  • Tim Becker
Meta-analysis (MA) is widely used to pool genome-wide association studies (GWASes) in order to a) increase the power to detect strong or weak genotype effects or b) as a result verification method. As a consequence of differing SNP panels among genotyping chips, imputation is the method of choice within GWAS consortia to avoid losing too many SNPs in a MA. YAMAS (Yet Another Meta Analysis Software), however, enables cross-GWAS conclusions prior to finished and polished imputation runs, which eventually are time-consuming.
Original languageEnglish
JournalB M C Bioinformatics
Volume13
Pages (from-to)231
ISSN1471-2105
DOIs
Publication statusPublished - 2012
Externally publishedYes

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