Manuel Mattheisen

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Hieab H H Adams, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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  • Derrek P Hibar, Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
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  • Vincent Chouraki, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
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  • Jason L Stein, Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
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  • Paul A Nyquist, Department of Neurology, Department of Anesthesia/Critical Care Medicine, Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
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  • Miguel E Rentería, QIMR Berghofer Medical Research Institute, Brisbane, Australia
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  • Stella Trompet, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
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  • Alejandro Arias-Vasquez, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Sudha Seshadri, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
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  • Sylvane Desrivières, MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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  • Ashley H Beecham, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.
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  • Neda Jahanshad, Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
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  • Katharina Wittfeld, German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald, Germany.
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  • Sven J Van der Lee, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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  • Lucija Abramovic, Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
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  • Saud Alhusaini, Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, Québec, Canada H3G 1A4.
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  • Najaf Amin, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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  • Micael Andersson, Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
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  • Konstantinos Arfanakis, Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
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  • Benjamin S Aribisala, Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
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  • Nicola J Armstrong, Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
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  • Lavinia Athanasiu, K. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway.
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  • Tomas Axelsson, Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
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  • Alexa Beiser, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
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  • Manon Bernard, University of Toronto & Hospital for Sick Children, Canada
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  • Joshua C Bis, Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
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  • Laura M E Blanken, Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.
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  • Susan H Blanton, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.
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  • Marc M Bohlken, Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
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  • Marco P Boks, Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
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  • Janita Bralten, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Adam M Brickman, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA.
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  • Owen Carmichael, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
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  • M Mallar Chakravarty, Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.
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  • Ganesh Chauhan, INSERM Unit U1219, University of Bordeaux, France.
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  • Qiang Chen, Lieber Institute for Brain Development, Baltimore, Maryland, USA.
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  • Christopher R K Ching, Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
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  • Gabriel Cuellar-Partida, QIMR Berghofer Medical Research Institute, Brisbane, Australia
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  • Anouk Den Braber, Vrije Universiteit Amsterdam
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  • Nhat Trung Doan, K. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway.
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  • Stefan Ehrlich, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany.
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  • Irina Filippi, NSERM Unit 1000 ″Neuroimaging and Psychiatry″, University Paris Sud, University Paris Descartes, Paris, France.
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  • Tian Ge, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, North Carolina, USA.
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  • Sudheer Giddaluru, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, 5009, Bergen, Norway; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021, Bergen, Norway.
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  • Aaron L Goldman, Lieber Institute for Brain Development, Baltimore, Maryland, USA.
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  • Rebecca F Gottesman, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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  • Corina U Greven, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
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  • Oliver Grimm, Central Institute of Mental Health Mannheim, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
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  • Michael E Griswold, Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
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  • Tulio Guadalupe, Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
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  • Johanna Hass, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany.
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  • Unn K Haukvik, K. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway.
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  • Saima Hilal, Department of Pharmacology, National University of Singapore, Singapore.
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  • Edith Hofer, Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria, Graz, Austria.
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  • David Hoehn, Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany.
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  • Avram J Holmes, Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.
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  • Martine Hoogman, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Deborah Janowitz, Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
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  • Tianye Jia, MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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  • Dalia Kasperaviciute, UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, UK.
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  • Sungeun Kim, Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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  • Marieke Klein, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Bernd Kraemer, Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
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  • Phil H Lee, Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.
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  • Jiemin Liao, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
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  • David C M Liewald, Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
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  • Lorna M Lopez, Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
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  • Michelle Luciano, Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
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  • Christine Macare, MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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  • Andre Marquand, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
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  • Mar Matarin, UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, UK.
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  • Karen A Mather, Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
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  • Manuel Mattheisen
  • Bernard Mazoyer, UMR5296 University of Bordeaux, CNRS, CEA, Bordeaux, France.
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  • David R McKay, Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
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  • Rebekah McWhirter, Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
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  • Yuri Milaneschi, Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands.
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  • Nazanin Mirza-Schreiber, Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany.
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  • Ryan L Muetzel, Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.
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  • Susana Muñoz Maniega, Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
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  • Kwangsik Nho, Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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  • Allison C Nugent, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
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  • Loes M Olde Loohuis, The Center for Neurobehavioral Genetics, University of California Los Angeles, USA and the Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, the Netherlands.
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  • Jaap Oosterlaan, Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, the Netherlands.
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  • Martina Papmeyer, 6. Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, Scotland
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  • Irene Pappa, Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.
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  • Lukas Pirpamer, Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria, Graz, Austria.
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  • Sara Pudas, Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
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  • Benno Pütz, Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany.
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  • Kumar B Rajan, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
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  • Adaikalavan Ramasamy, Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
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  • Jennifer S Richards, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
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  • Shannon L Risacher, Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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  • Roberto Roiz-Santiañez, Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
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  • Nanda Rommelse, Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands.
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  • Emma J Rose, Psychosis Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin.
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  • Natalie A Royle, Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
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  • Tatjana Rundek, Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA.
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  • Philipp G Sämann, Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany.
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  • Claudia L Satizabal, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
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  • Lianne Schmaal, Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia.
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  • Andrew J Schork, 1] Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA [2] Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, CA, USA [3] Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA [4] Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
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  • Li Shen, Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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  • Jean Shin, University of Toronto & Hospital for Sick Children, Canada
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  • Elena Shumskaya, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Albert V Smith, Icelandic Heart Association, IS-201 Kopavogur, Iceland.
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  • Emma Sprooten, Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
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  • Lachlan T Strike, QIMR Berghofer Medical Research Institute, Brisbane, Australia
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  • Alexander Teumer, 1] Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany. [2] DZHK (German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.
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  • Russell Thomson, School of Computing Engineering and Mathematics, Western Sydney University, Parramatta, Australia.
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  • Diana Tordesillas-Gutierrez, CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, Spain.
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  • Roberto Toro, Innate Immunity Unit, Institut Pasteur, Paris, France
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  • Daniah Trabzuni, Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
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  • Dhananjay Vaidya, GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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  • Jeroen Van der Grond, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
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  • Dennis Van der Meer, Department of Psychiatry, University of Groningen, University Medical Center Groningen, P.O. Box 72, 9700 AB Groningen, The Netherlands.
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  • Marjolein M J Van Donkelaar, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Kristel R Van Eijk, Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht, Utrecht, the Netherlands.
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  • Theo G M Van Erp, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA
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  • Daan Van Rooij, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
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  • Esther Walton, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany.
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  • Lars T Westlye, K. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway.
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  • Christopher D Whelan, Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
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  • Beverly G Windham, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
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  • Anderson M Winkler, Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
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  • Girma Woldehawariat, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
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  • Christiane Wolf, University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany.
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  • Thomas Wolfers, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Bing Xu, MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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  • Lisa R Yanek, GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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  • Jingyun Yang, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
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  • Alex Zijdenbos, Biospective Inc, Montreal, Quebec, Canada, Montréal, Québec, Canada.
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  • Marcel P Zwiers, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
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  • Ingrid Agartz, K. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway.
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  • Neelum T Aggarwal, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
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  • Laura Almasy, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
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  • David Ames, National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia.
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  • Philippe Amouyel, Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, France.
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  • Ole A Andreassen, K. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway.
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  • Sampath Arepalli, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
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  • Amelia A Assareh, Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
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  • Sandra Barral, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA.
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  • Mark E Bastin, Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
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  • Diane M Becker, GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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  • James T Becker, Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
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  • David A Bennett, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
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  • John Blangero, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
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  • Hans van Bokhoven, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Dorret I Boomsma, Vrije Universiteit Amsterdam
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  • Henry Brodaty, Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
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  • Rachel M Brouwer, Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
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  • Han G Brunner, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • Randy L Buckner, Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.
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  • Jan K Buitelaar, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
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  • Kazima B Bulayeva, Department of Evolution and Genetics, Dagestan State University, Makhachkala, Dagestan, Russia.
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  • Wiepke Cahn, Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
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  • Vince D Calhoun, The Mind Research Network and LBERI, Albuquerque, New Mexico, USA.
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  • Dara M Cannon, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
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  • Gianpiero L Cavalleri, The Royal College of Surgeons in Ireland, Dublin 2, Ireland.
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  • Christopher Chen, Department of Pharmacology, National University of Singapore, Singapore.
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  • Ching-Yu Cheng, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
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  • Sven Cichon, The Institute of Human Genetics, University of Bonn, the Department of Genomics, Life and Brain Center, Bonn, Germany, and the Division of Medical Genetics, University Hospital Basel and Department of Biomedicine, University of Basel, Switzerland.
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  • Mark R Cookson, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
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  • Aiden Corvin, Psychosis Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin.
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  • Benedicto Crespo-Facorro, Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
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  • Joanne E Curran, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
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  • Michael Czisch, Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany.
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  • Anders M Dale, Center for Multimodal Imaging and Genetics, University of California, San Diego, California, USA.
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  • Gareth E Davies, Avera Institute for Human Genetics, Sioux Falls, South Dakota, USA.
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  • Eco J C De Geus, Vrije Universiteit Amsterdam
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  • Philip L De Jager, 1] Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts 02131, USA.
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  • Greig I de Zubicaray, Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia.
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  • Norman Delanty, The Royal College of Surgeons in Ireland, Dublin 2, Ireland.
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  • Chantal Depondt, Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium.
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  • Anita L DeStefano, NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
  • ,
  • Allissa Dillman, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
  • ,
  • Srdjan Djurovic, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, 5009, Bergen, Norway; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021, Bergen, Norway.
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  • Gary Donohoe, Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition and Genomics Centre (NICOG) and NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.
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  • Wayne C Drevets, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
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  • Ravi Duggirala, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
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  • Thomas D Dyer, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
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  • Susanne Erk, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany.
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  • Thomas Espeseth, K. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway.
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  • Denis A Evans, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
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  • Iryna O Fedko, Vrije Universiteit Amsterdam
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  • Guillén Fernández, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
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  • Luigi Ferrucci, Intramural Research Program of the National Institute on Aging, Baltimore, Maryland, USA.
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  • Simon E Fisher, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
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  • Debra A Fleischman, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
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  • Ian Ford, Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
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  • Tatiana M Foroud, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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  • Peter T Fox, University of Texas Health Science Center, San Antonio, Texas, USA.
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  • Clyde Francks, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
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  • Masaki Fukunaga, Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.
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  • J Raphael Gibbs, Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
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  • David C Glahn, Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
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  • Randy L Gollub, Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.
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  • Harald H H Göring, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
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  • Hans J Grabe, Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
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  • Robert C Green, 1] Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts 02131, USA.
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  • Oliver Gruber, Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
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Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.

Original languageEnglish
JournalNature Neuroscience
Volume19
Pages (from-to)1569-1582
Number of pages14
ISSN1097-6256
DOIs
Publication statusPublished - 3 Oct 2016

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