Manuel Mattheisen

Novel genetic loci associated with hippocampal volume

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Novel genetic loci associated with hippocampal volume. / Hibar, Derrek P.; Adams, Hieab H. H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteria, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivieres, Sylvane; Vernooij, Meike W.; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Armstrong, Nicola J.; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H.; Beiser, Alexa; Bernard, Manon; Blanton, Susan H.; Bohlken, Marc M.; Boks, Marco P.; Bralten, Janita; Brickman, Adam M.; Carmichael, Owen; Chakravarty, M. Mallar; Chen, Qiang; Ching, Christopher R. K.; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Nhat Trung Doan; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L.; Gottesman, Rebecca F.; Grimm, Oliver; Griswold, Michael E.; Guadalupe, Tulio; Gutman, Boris A.; Hass, Johanna; Haukvik, Unn K.; Hoehn, David; Holmes, Avram J.; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jorgensen, Kjetil N.; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H.; Liewald, David C. M.; Lopez, Lorna M.; Luciano, Michelle; Macare, Christine; Marquand, Andre F.; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; McKay, David R.; Milaneschi, Yuri; Maniega, Susana Munoz; Nho, Kwangsik; Nugent, Allison C.; Nyquist, Paul; Loohuis, Loes M. Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pirpamer, Lukas; Puetz, Benno; Ramasamy, Adaikalavan; Richards, Jennifer S.; Risacher, Shannon L.; Roiz-Santianez, Roberto; Rommelse, Nanda; Ropele, Stefan; Rose, Emma J.; Royle, Natalie A.; Rundek, Tatjana; Saemann, Philipp G.; Saremi, Arvin; Satizabal, Claudia L.; Schmaal, Lianne; Schork, Andrew J.; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V.; Sprooten, Emma; Strike, Lachlan T.; Teumer, Alexander; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Trompet, Stella; Vaidya, Dhananjay; Van der Grond, Jeroen; Van der Lee, Sven J.; Van der Meer, Dennis; Van Donkelaar, Marjolein M. J.; Van Eijk, Kristel R.; Van Erp, Theo G. M.; Van Rooij, Daan; Walton, Esther; Westlye, Lars T.; Whelan, Christopher D.; Windham, Beverly G.; Winkler, Anderson M.; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Yanek, Lisa R.; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P.; Agartz, Ingrid; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole A.; Arepalli, Sampath; Assareh, Amelia A.; Barral, Sandra; Bastin, Mark E.; Becker, Diane M.; Becker, James T.; Bennett, David A.; Blangero, John; van Bokhoven, Hans; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Brunner, Han G.; Buckner, Randy L.; Buitelaar, Jan K.; Bulayeva, Kazima B.; Cahn, Wiepke; Calhoun, Vince D.; Cannon, Dara M.; Cavalleri, Gianpiero L.; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R.; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Czisch, Michael; Dale, Anders M.; Davies, Gareth E.; De Craen, Anton J. M.; De Geus, Eco J. C.; De Jager, Philip L.; De Zubicaray, Greig I.; Deary, Ian J.; Debette, Stephanie; DeCarli, Charles; Delanty, Norman; Depondt, Chantal; DeStefano, Anita; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C.; Duggirala, Ravi; Dyer, Thomas D.; Enzinger, Christian; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O.; Fernandez, Guillen; Ferrucci, Luigi; Fisher, Simon E.; Fleischman, Debra A.; Ford, Ian; Fornage, Myriam; Foroud, Tatiana M.; Fox, Peter T.; Francks, Clyde; Fukunaga, Masaki; Gibbs, J. Raphael; Glahn, David C.; Gollub, Randy L.; Goring, Harald H. H.; Green, Robert C.; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Haberg, Asta K.; Hansell, Narelle K.; Hardy, John; Hartman, Catharina A.; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G.; Heslenfeld, Dirk J.; Ho, Beng-Choon; Hoekstra, Pieter J.; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Huentelman, Matthew; Pol, Hilleke E. Hulshoff; Ikeda, Masashi; Jack, Clifford R.; Jenkinson, Mark; Johnson, Robert; Joensson, Erik G.; Jukema, J. Wouter; Kahn, Rene S.; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S.; Kochunov, Peter; Kwok, John B.; Lawrie, Stephen M.; Lemaitre, Herve; Liu, Xinmin; Longo, Dan L.; Lopez, Oscar L.; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S.; McDonald, Colm; McIntosh, Andrew M.; McMahon, Francis J.; McMahon, Katie L.; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W.; Morris, Derek W.; Mosley, Thomas H.; Muhleisen, Thomas W.; Mueller-Myhsok, Bertram; Nalls, Michael A.; Nauck, Matthias; Nichols, Thomas E.; Niessen, Wiro J.; Nothen, Markus M.; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L.; Ophoff, Roel A.; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W. J. H.; Pike, G. Bruce; Potkin, Steven G.; Psaty, Bruce M.; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L.; Romanczuk-Seiferth, Nina; Rotter, Jerome I.; Ryten, Mina; Sacco, Ralph L.; Sachdev, Perminder S.; Saykin, Andrew J.; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter R.; Sigursson, Sigurdur; Simmons, Andrew; Singleton, Andrew; Sisodiya, Sanjay M.; Smith, Colin; Smoller, Jordan W.; Soininen, Hilkka; Steen, Vidar M.; Stott, David J.; Sussmann, Jessika E.; Thalamuthu, Anbupalam; Toga, Arthur W.; Traynor, Bryan J.; Troncoso, Juan; Tsolaki, Magda; Tzourio, Christophe; Uitterlinden, Andre G.; Hernandez, Maria C. Valdes; Van der Brug, Marcel; van der Lugt, Aad; van der Wee, Nic J. A.; Van Haren, Neeltje E. M.; van't Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N.; Vellas, Bruno; Veltman, Dick J.; Voelzke, Henry; Walter, Henrik; Wardlaw, Joanna M.; Wassink, Thomas H.; Weale, Michael E.; Weinberger, Daniel R.; Weiner, Michael W.; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y.; Wright, Clinton B.; Zielke, Ronald H.; Zonderman, Alan B.; Martin, Nicholas G.; Van Duijn, Cornelia M.; Wright, Margaret J.; Longstreth, W. T.; Schumann, Gunter; Grabe, Hans J.; Franke, Barbara; Launer, Lenore J.; Medland, Sarah E.; Seshadri, Sudha; Thompson, Paul M.; Ikram, M. Arfan.

In: Nature Communications, Vol. 8, 13624, 18.01.2017.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hibar, DP, Adams, HHH, Jahanshad, N, Chauhan, G, Stein, JL, Hofer, E, Renteria, ME, Bis, JC, Arias-Vasquez, A, Ikram, MK, Desrivieres, S, Vernooij, MW, Abramovic, L, Alhusaini, S, Amin, N, Andersson, M, Arfanakis, K, Aribisala, BS, Armstrong, NJ, Athanasiu, L, Axelsson, T, Beecham, AH, Beiser, A, Bernard, M, Blanton, SH, Bohlken, MM, Boks, MP, Bralten, J, Brickman, AM, Carmichael, O, Chakravarty, MM, Chen, Q, Ching, CRK, Chouraki, V, Cuellar-Partida, G, Crivello, F, Den Braber, A, Nhat Trung Doan, Ehrlich, S, Giddaluru, S, Goldman, AL, Gottesman, RF, Grimm, O, Griswold, ME, Guadalupe, T, Gutman, BA, Hass, J, Haukvik, UK, Hoehn, D, Holmes, AJ, Hoogman, M, Janowitz, D, Jia, T, Jorgensen, KN, Karbalai, N, Kasperaviciute, D, Kim, S, Klein, M, Kraemer, B, Lee, PH, Liewald, DCM, Lopez, LM, Luciano, M, Macare, C, Marquand, AF, Matarin, M, Mather, KA, Mattheisen, M, McKay, DR, Milaneschi, Y, Maniega, SM, Nho, K, Nugent, AC, Nyquist, P, Loohuis, LMO, Oosterlaan, J, Papmeyer, M, Pirpamer, L, Puetz, B, Ramasamy, A, Richards, JS, Risacher, SL, Roiz-Santianez, R, Rommelse, N, Ropele, S, Rose, EJ, Royle, NA, Rundek, T, Saemann, PG, Saremi, A, Satizabal, CL, Schmaal, L, Schork, AJ, Shen, L, Shin, J, Shumskaya, E, Smith, AV, Sprooten, E, Strike, LT, Teumer, A, Tordesillas-Gutierrez, D, Toro, R, Trabzuni, D, Trompet, S, Vaidya, D, Van der Grond, J, Van der Lee, SJ, Van der Meer, D, Van Donkelaar, MMJ, Van Eijk, KR, Van Erp, TGM, Van Rooij, D, Walton, E, Westlye, LT, Whelan, CD, Windham, BG, Winkler, AM, Wittfeld, K, Woldehawariat, G, Wolf, C, Wolfers, T, Yanek, LR, Yang, J, Zijdenbos, A, Zwiers, MP, Agartz, I, Almasy, L, Ames, D, Amouyel, P, Andreassen, OA, Arepalli, S, Assareh, AA, Barral, S, Bastin, ME, Becker, DM, Becker, JT, Bennett, DA, Blangero, J, van Bokhoven, H, Boomsma, DI, Brodaty, H, Brouwer, RM, Brunner, HG, Buckner, RL, Buitelaar, JK, Bulayeva, KB, Cahn, W, Calhoun, VD, Cannon, DM, Cavalleri, GL, Cheng, C-Y, Cichon, S, Cookson, MR, Corvin, A, Crespo-Facorro, B, Curran, JE, Czisch, M, Dale, AM, Davies, GE, De Craen, AJM, De Geus, EJC, De Jager, PL, De Zubicaray, GI, Deary, IJ, Debette, S, DeCarli, C, Delanty, N, Depondt, C, DeStefano, A, Dillman, A, Djurovic, S, Donohoe, G, Drevets, WC, Duggirala, R, Dyer, TD, Enzinger, C, Erk, S, Espeseth, T, Fedko, IO, Fernandez, G, Ferrucci, L, Fisher, SE, Fleischman, DA, Ford, I, Fornage, M, Foroud, TM, Fox, PT, Francks, C, Fukunaga, M, Gibbs, JR, Glahn, DC, Gollub, RL, Goring, HHH, Green, RC, Gruber, O, Gudnason, V, Guelfi, S, Haberg, AK, Hansell, NK, Hardy, J, Hartman, CA, Hashimoto, R, Hegenscheid, K, Heinz, A, Le Hellard, S, Hernandez, DG, Heslenfeld, DJ, Ho, B-C, Hoekstra, PJ, Hoffmann, W, Hofman, A, Holsboer, F, Homuth, G, Hosten, N, Hottenga, J-J, Huentelman, M, Pol, HEH, Ikeda, M, Jack, CR, Jenkinson, M, Johnson, R, Joensson, EG, Jukema, JW, Kahn, RS, Kanai, R, Kloszewska, I, Knopman, DS, Kochunov, P, Kwok, JB, Lawrie, SM, Lemaitre, H, Liu, X, Longo, DL, Lopez, OL, Lovestone, S, Martinez, O, Martinot, J-L, Mattay, VS, McDonald, C, McIntosh, AM, McMahon, FJ, McMahon, KL, Mecocci, P, Melle, I, Meyer-Lindenberg, A, Mohnke, S, Montgomery, GW, Morris, DW, Mosley, TH, Muhleisen, TW, Mueller-Myhsok, B, Nalls, MA, Nauck, M, Nichols, TE, Niessen, WJ, Nothen, MM, Nyberg, L, Ohi, K, Olvera, RL, Ophoff, RA, Pandolfo, M, Paus, T, Pausova, Z, Penninx, BWJH, Pike, GB, Potkin, SG, Psaty, BM, Reppermund, S, Rietschel, M, Roffman, JL, Romanczuk-Seiferth, N, Rotter, JI, Ryten, M, Sacco, RL, Sachdev, PS, Saykin, AJ, Schmidt, R, Schmidt, H, Schofield, PR, Sigursson, S, Simmons, A, Singleton, A, Sisodiya, SM, Smith, C, Smoller, JW, Soininen, H, Steen, VM, Stott, DJ, Sussmann, JE, Thalamuthu, A, Toga, AW, Traynor, BJ, Troncoso, J, Tsolaki, M, Tzourio, C, Uitterlinden, AG, Hernandez, MCV, Van der Brug, M, van der Lugt, A, van der Wee, NJA, Van Haren, NEM, van't Ent, D, Van Tol, M-J, Vardarajan, BN, Vellas, B, Veltman, DJ, Voelzke, H, Walter, H, Wardlaw, JM, Wassink, TH, Weale, ME, Weinberger, DR, Weiner, MW, Wen, W, Westman, E, White, T, Wong, TY, Wright, CB, Zielke, RH, Zonderman, AB, Martin, NG, Van Duijn, CM, Wright, MJ, Longstreth, WT, Schumann, G, Grabe, HJ, Franke, B, Launer, LJ, Medland, SE, Seshadri, S, Thompson, PM & Ikram, MA 2017, 'Novel genetic loci associated with hippocampal volume', Nature Communications, vol. 8, 13624. https://doi.org/10.1038/ncomms13624

APA

Hibar, D. P., Adams, H. H. H., Jahanshad, N., Chauhan, G., Stein, J. L., Hofer, E., Renteria, M. E., Bis, J. C., Arias-Vasquez, A., Ikram, M. K., Desrivieres, S., Vernooij, M. W., Abramovic, L., Alhusaini, S., Amin, N., Andersson, M., Arfanakis, K., Aribisala, B. S., Armstrong, N. J., ... Ikram, M. A. (2017). Novel genetic loci associated with hippocampal volume. Nature Communications, 8, [13624]. https://doi.org/10.1038/ncomms13624

CBE

Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivieres S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Nhat Trung Doan, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jorgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Maniega SM, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Puetz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santianez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Saemann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MMJ, Van Eijk KR, Van Erp TGM, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng C-Y, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJM, De Geus EJC, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernandez G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Goring HHH, Green RC, Gruber O, Gudnason V, Guelfi S, Haberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho B-C, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga J-J, Huentelman M, Pol HEH, Ikeda M, Jack CR, Jenkinson M, Johnson R, Joensson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaitre H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot J-L, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Muhleisen TW, Mueller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nothen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernandez MCV, Van der Brug M, van der Lugt A, van der Wee NJA, Van Haren NEM, van't Ent D, Van Tol M-J, Vardarajan BN, Vellas B, Veltman DJ, Voelzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA. 2017. Novel genetic loci associated with hippocampal volume. Nature Communications. 8:Article 13624. https://doi.org/10.1038/ncomms13624

MLA

Vancouver

Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E et al. Novel genetic loci associated with hippocampal volume. Nature Communications. 2017 Jan 18;8. 13624. https://doi.org/10.1038/ncomms13624

Author

Hibar, Derrek P. ; Adams, Hieab H. H. ; Jahanshad, Neda ; Chauhan, Ganesh ; Stein, Jason L. ; Hofer, Edith ; Renteria, Miguel E. ; Bis, Joshua C. ; Arias-Vasquez, Alejandro ; Ikram, M. Kamran ; Desrivieres, Sylvane ; Vernooij, Meike W. ; Abramovic, Lucija ; Alhusaini, Saud ; Amin, Najaf ; Andersson, Micael ; Arfanakis, Konstantinos ; Aribisala, Benjamin S. ; Armstrong, Nicola J. ; Athanasiu, Lavinia ; Axelsson, Tomas ; Beecham, Ashley H. ; Beiser, Alexa ; Bernard, Manon ; Blanton, Susan H. ; Bohlken, Marc M. ; Boks, Marco P. ; Bralten, Janita ; Brickman, Adam M. ; Carmichael, Owen ; Chakravarty, M. Mallar ; Chen, Qiang ; Ching, Christopher R. K. ; Chouraki, Vincent ; Cuellar-Partida, Gabriel ; Crivello, Fabrice ; Den Braber, Anouk ; Nhat Trung Doan ; Ehrlich, Stefan ; Giddaluru, Sudheer ; Goldman, Aaron L. ; Gottesman, Rebecca F. ; Grimm, Oliver ; Griswold, Michael E. ; Guadalupe, Tulio ; Gutman, Boris A. ; Hass, Johanna ; Haukvik, Unn K. ; Hoehn, David ; Holmes, Avram J. ; Hoogman, Martine ; Janowitz, Deborah ; Jia, Tianye ; Jorgensen, Kjetil N. ; Karbalai, Nazanin ; Kasperaviciute, Dalia ; Kim, Sungeun ; Klein, Marieke ; Kraemer, Bernd ; Lee, Phil H. ; Liewald, David C. M. ; Lopez, Lorna M. ; Luciano, Michelle ; Macare, Christine ; Marquand, Andre F. ; Matarin, Mar ; Mather, Karen A. ; Mattheisen, Manuel ; McKay, David R. ; Milaneschi, Yuri ; Maniega, Susana Munoz ; Nho, Kwangsik ; Nugent, Allison C. ; Nyquist, Paul ; Loohuis, Loes M. Olde ; Oosterlaan, Jaap ; Papmeyer, Martina ; Pirpamer, Lukas ; Puetz, Benno ; Ramasamy, Adaikalavan ; Richards, Jennifer S. ; Risacher, Shannon L. ; Roiz-Santianez, Roberto ; Rommelse, Nanda ; Ropele, Stefan ; Rose, Emma J. ; Royle, Natalie A. ; Rundek, Tatjana ; Saemann, Philipp G. ; Saremi, Arvin ; Satizabal, Claudia L. ; Schmaal, Lianne ; Schork, Andrew J. ; Shen, Li ; Shin, Jean ; Shumskaya, Elena ; Smith, Albert V. ; Sprooten, Emma ; Strike, Lachlan T. ; Teumer, Alexander ; Tordesillas-Gutierrez, Diana ; Toro, Roberto ; Trabzuni, Daniah ; Trompet, Stella ; Vaidya, Dhananjay ; Van der Grond, Jeroen ; Van der Lee, Sven J. ; Van der Meer, Dennis ; Van Donkelaar, Marjolein M. J. ; Van Eijk, Kristel R. ; Van Erp, Theo G. M. ; Van Rooij, Daan ; Walton, Esther ; Westlye, Lars T. ; Whelan, Christopher D. ; Windham, Beverly G. ; Winkler, Anderson M. ; Wittfeld, Katharina ; Woldehawariat, Girma ; Wolf, Christiane ; Wolfers, Thomas ; Yanek, Lisa R. ; Yang, Jingyun ; Zijdenbos, Alex ; Zwiers, Marcel P. ; Agartz, Ingrid ; Almasy, Laura ; Ames, David ; Amouyel, Philippe ; Andreassen, Ole A. ; Arepalli, Sampath ; Assareh, Amelia A. ; Barral, Sandra ; Bastin, Mark E. ; Becker, Diane M. ; Becker, James T. ; Bennett, David A. ; Blangero, John ; van Bokhoven, Hans ; Boomsma, Dorret I. ; Brodaty, Henry ; Brouwer, Rachel M. ; Brunner, Han G. ; Buckner, Randy L. ; Buitelaar, Jan K. ; Bulayeva, Kazima B. ; Cahn, Wiepke ; Calhoun, Vince D. ; Cannon, Dara M. ; Cavalleri, Gianpiero L. ; Cheng, Ching-Yu ; Cichon, Sven ; Cookson, Mark R. ; Corvin, Aiden ; Crespo-Facorro, Benedicto ; Curran, Joanne E. ; Czisch, Michael ; Dale, Anders M. ; Davies, Gareth E. ; De Craen, Anton J. M. ; De Geus, Eco J. C. ; De Jager, Philip L. ; De Zubicaray, Greig I. ; Deary, Ian J. ; Debette, Stephanie ; DeCarli, Charles ; Delanty, Norman ; Depondt, Chantal ; DeStefano, Anita ; Dillman, Allissa ; Djurovic, Srdjan ; Donohoe, Gary ; Drevets, Wayne C. ; Duggirala, Ravi ; Dyer, Thomas D. ; Enzinger, Christian ; Erk, Susanne ; Espeseth, Thomas ; Fedko, Iryna O. ; Fernandez, Guillen ; Ferrucci, Luigi ; Fisher, Simon E. ; Fleischman, Debra A. ; Ford, Ian ; Fornage, Myriam ; Foroud, Tatiana M. ; Fox, Peter T. ; Francks, Clyde ; Fukunaga, Masaki ; Gibbs, J. Raphael ; Glahn, David C. ; Gollub, Randy L. ; Goring, Harald H. H. ; Green, Robert C. ; Gruber, Oliver ; Gudnason, Vilmundur ; Guelfi, Sebastian ; Haberg, Asta K. ; Hansell, Narelle K. ; Hardy, John ; Hartman, Catharina A. ; Hashimoto, Ryota ; Hegenscheid, Katrin ; Heinz, Andreas ; Le Hellard, Stephanie ; Hernandez, Dena G. ; Heslenfeld, Dirk J. ; Ho, Beng-Choon ; Hoekstra, Pieter J. ; Hoffmann, Wolfgang ; Hofman, Albert ; Holsboer, Florian ; Homuth, Georg ; Hosten, Norbert ; Hottenga, Jouke-Jan ; Huentelman, Matthew ; Pol, Hilleke E. Hulshoff ; Ikeda, Masashi ; Jack, Clifford R. ; Jenkinson, Mark ; Johnson, Robert ; Joensson, Erik G. ; Jukema, J. Wouter ; Kahn, Rene S. ; Kanai, Ryota ; Kloszewska, Iwona ; Knopman, David S. ; Kochunov, Peter ; Kwok, John B. ; Lawrie, Stephen M. ; Lemaitre, Herve ; Liu, Xinmin ; Longo, Dan L. ; Lopez, Oscar L. ; Lovestone, Simon ; Martinez, Oliver ; Martinot, Jean-Luc ; Mattay, Venkata S. ; McDonald, Colm ; McIntosh, Andrew M. ; McMahon, Francis J. ; McMahon, Katie L. ; Mecocci, Patrizia ; Melle, Ingrid ; Meyer-Lindenberg, Andreas ; Mohnke, Sebastian ; Montgomery, Grant W. ; Morris, Derek W. ; Mosley, Thomas H. ; Muhleisen, Thomas W. ; Mueller-Myhsok, Bertram ; Nalls, Michael A. ; Nauck, Matthias ; Nichols, Thomas E. ; Niessen, Wiro J. ; Nothen, Markus M. ; Nyberg, Lars ; Ohi, Kazutaka ; Olvera, Rene L. ; Ophoff, Roel A. ; Pandolfo, Massimo ; Paus, Tomas ; Pausova, Zdenka ; Penninx, Brenda W. J. H. ; Pike, G. Bruce ; Potkin, Steven G. ; Psaty, Bruce M. ; Reppermund, Simone ; Rietschel, Marcella ; Roffman, Joshua L. ; Romanczuk-Seiferth, Nina ; Rotter, Jerome I. ; Ryten, Mina ; Sacco, Ralph L. ; Sachdev, Perminder S. ; Saykin, Andrew J. ; Schmidt, Reinhold ; Schmidt, Helena ; Schofield, Peter R. ; Sigursson, Sigurdur ; Simmons, Andrew ; Singleton, Andrew ; Sisodiya, Sanjay M. ; Smith, Colin ; Smoller, Jordan W. ; Soininen, Hilkka ; Steen, Vidar M. ; Stott, David J. ; Sussmann, Jessika E. ; Thalamuthu, Anbupalam ; Toga, Arthur W. ; Traynor, Bryan J. ; Troncoso, Juan ; Tsolaki, Magda ; Tzourio, Christophe ; Uitterlinden, Andre G. ; Hernandez, Maria C. Valdes ; Van der Brug, Marcel ; van der Lugt, Aad ; van der Wee, Nic J. A. ; Van Haren, Neeltje E. M. ; van't Ent, Dennis ; Van Tol, Marie-Jose ; Vardarajan, Badri N. ; Vellas, Bruno ; Veltman, Dick J. ; Voelzke, Henry ; Walter, Henrik ; Wardlaw, Joanna M. ; Wassink, Thomas H. ; Weale, Michael E. ; Weinberger, Daniel R. ; Weiner, Michael W. ; Wen, Wei ; Westman, Eric ; White, Tonya ; Wong, Tien Y. ; Wright, Clinton B. ; Zielke, Ronald H. ; Zonderman, Alan B. ; Martin, Nicholas G. ; Van Duijn, Cornelia M. ; Wright, Margaret J. ; Longstreth, W. T. ; Schumann, Gunter ; Grabe, Hans J. ; Franke, Barbara ; Launer, Lenore J. ; Medland, Sarah E. ; Seshadri, Sudha ; Thompson, Paul M. ; Ikram, M. Arfan. / Novel genetic loci associated with hippocampal volume. In: Nature Communications. 2017 ; Vol. 8.

Bibtex

@article{c8df34682aa94227b3956a6c8c97f2d5,
title = "Novel genetic loci associated with hippocampal volume",
abstract = "The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.",
keywords = "GENOME-WIDE ASSOCIATION, TEMPORAL-LOBE EPILEPSY, SUSCEPTIBILITY LOCI, ALZHEIMERS-DISEASE, BIPOLAR DISORDER, COMMON VARIANTS, BRAIN-REGIONS, MEMORY, SUBFIELDS, METAANALYSIS",
author = "Hibar, {Derrek P.} and Adams, {Hieab H. H.} and Neda Jahanshad and Ganesh Chauhan and Stein, {Jason L.} and Edith Hofer and Renteria, {Miguel E.} and Bis, {Joshua C.} and Alejandro Arias-Vasquez and Ikram, {M. Kamran} and Sylvane Desrivieres and Vernooij, {Meike W.} and Lucija Abramovic and Saud Alhusaini and Najaf Amin and Micael Andersson and Konstantinos Arfanakis and Aribisala, {Benjamin S.} and Armstrong, {Nicola J.} and Lavinia Athanasiu and Tomas Axelsson and Beecham, {Ashley H.} and Alexa Beiser and Manon Bernard and Blanton, {Susan H.} and Bohlken, {Marc M.} and Boks, {Marco P.} and Janita Bralten and Brickman, {Adam M.} and Owen Carmichael and Chakravarty, {M. Mallar} and Qiang Chen and Ching, {Christopher R. K.} and Vincent Chouraki and Gabriel Cuellar-Partida and Fabrice Crivello and {Den Braber}, Anouk and {Nhat Trung Doan} and Stefan Ehrlich and Sudheer Giddaluru and Goldman, {Aaron L.} and Gottesman, {Rebecca F.} and Oliver Grimm and Griswold, {Michael E.} and Tulio Guadalupe and Gutman, {Boris A.} and Johanna Hass and Haukvik, {Unn K.} and David Hoehn and Holmes, {Avram J.} and Martine Hoogman and Deborah Janowitz and Tianye Jia and Jorgensen, {Kjetil N.} and Nazanin Karbalai and Dalia Kasperaviciute and Sungeun Kim and Marieke Klein and Bernd Kraemer and Lee, {Phil H.} and Liewald, {David C. M.} and Lopez, {Lorna M.} and Michelle Luciano and Christine Macare and Marquand, {Andre F.} and Mar Matarin and Mather, {Karen A.} and Manuel Mattheisen and McKay, {David R.} and Yuri Milaneschi and Maniega, {Susana Munoz} and Kwangsik Nho and Nugent, {Allison C.} and Paul Nyquist and Loohuis, {Loes M. Olde} and Jaap Oosterlaan and Martina Papmeyer and Lukas Pirpamer and Benno Puetz and Adaikalavan Ramasamy and Richards, {Jennifer S.} and Risacher, {Shannon L.} and Roberto Roiz-Santianez and Nanda Rommelse and Stefan Ropele and Rose, {Emma J.} and Royle, {Natalie A.} and Tatjana Rundek and Saemann, {Philipp G.} and Arvin Saremi and Satizabal, {Claudia L.} and Lianne Schmaal and Schork, {Andrew J.} and Li Shen and Jean Shin and Elena Shumskaya and Smith, {Albert V.} and Emma Sprooten and Strike, {Lachlan T.} and Alexander Teumer and Diana Tordesillas-Gutierrez and Roberto Toro and Daniah Trabzuni and Stella Trompet and Dhananjay Vaidya and {Van der Grond}, Jeroen and {Van der Lee}, {Sven J.} and {Van der Meer}, Dennis and {Van Donkelaar}, {Marjolein M. J.} and {Van Eijk}, {Kristel R.} and {Van Erp}, {Theo G. M.} and {Van Rooij}, Daan and Esther Walton and Westlye, {Lars T.} and Whelan, {Christopher D.} and Windham, {Beverly G.} and Winkler, {Anderson M.} and Katharina Wittfeld and Girma Woldehawariat and Christiane Wolf and Thomas Wolfers and Yanek, {Lisa R.} and Jingyun Yang and Alex Zijdenbos and Zwiers, {Marcel P.} and Ingrid Agartz and Laura Almasy and David Ames and Philippe Amouyel and Andreassen, {Ole A.} and Sampath Arepalli and Assareh, {Amelia A.} and Sandra Barral and Bastin, {Mark E.} and Becker, {Diane M.} and Becker, {James T.} and Bennett, {David A.} and John Blangero and {van Bokhoven}, Hans and Boomsma, {Dorret I.} and Henry Brodaty and Brouwer, {Rachel M.} and Brunner, {Han G.} and Buckner, {Randy L.} and Buitelaar, {Jan K.} and Bulayeva, {Kazima B.} and Wiepke Cahn and Calhoun, {Vince D.} and Cannon, {Dara M.} and Cavalleri, {Gianpiero L.} and Ching-Yu Cheng and Sven Cichon and Cookson, {Mark R.} and Aiden Corvin and Benedicto Crespo-Facorro and Curran, {Joanne E.} and Michael Czisch and Dale, {Anders M.} and Davies, {Gareth E.} and {De Craen}, {Anton J. M.} and {De Geus}, {Eco J. C.} and {De Jager}, {Philip L.} and {De Zubicaray}, {Greig I.} and Deary, {Ian J.} and Stephanie Debette and Charles DeCarli and Norman Delanty and Chantal Depondt and Anita DeStefano and Allissa Dillman and Srdjan Djurovic and Gary Donohoe and Drevets, {Wayne C.} and Ravi Duggirala and Dyer, {Thomas D.} and Christian Enzinger and Susanne Erk and Thomas Espeseth and Fedko, {Iryna O.} and Guillen Fernandez and Luigi Ferrucci and Fisher, {Simon E.} and Fleischman, {Debra A.} and Ian Ford and Myriam Fornage and Foroud, {Tatiana M.} and Fox, {Peter T.} and Clyde Francks and Masaki Fukunaga and Gibbs, {J. Raphael} and Glahn, {David C.} and Gollub, {Randy L.} and Goring, {Harald H. H.} and Green, {Robert C.} and Oliver Gruber and Vilmundur Gudnason and Sebastian Guelfi and Haberg, {Asta K.} and Hansell, {Narelle K.} and John Hardy and Hartman, {Catharina A.} and Ryota Hashimoto and Katrin Hegenscheid and Andreas Heinz and {Le Hellard}, Stephanie and Hernandez, {Dena G.} and Heslenfeld, {Dirk J.} and Beng-Choon Ho and Hoekstra, {Pieter J.} and Wolfgang Hoffmann and Albert Hofman and Florian Holsboer and Georg Homuth and Norbert Hosten and Jouke-Jan Hottenga and Matthew Huentelman and Pol, {Hilleke E. Hulshoff} and Masashi Ikeda and Jack, {Clifford R.} and Mark Jenkinson and Robert Johnson and Joensson, {Erik G.} and Jukema, {J. Wouter} and Kahn, {Rene S.} and Ryota Kanai and Iwona Kloszewska and Knopman, {David S.} and Peter Kochunov and Kwok, {John B.} and Lawrie, {Stephen M.} and Herve Lemaitre and Xinmin Liu and Longo, {Dan L.} and Lopez, {Oscar L.} and Simon Lovestone and Oliver Martinez and Jean-Luc Martinot and Mattay, {Venkata S.} and Colm McDonald and McIntosh, {Andrew M.} and McMahon, {Francis J.} and McMahon, {Katie L.} and Patrizia Mecocci and Ingrid Melle and Andreas Meyer-Lindenberg and Sebastian Mohnke and Montgomery, {Grant W.} and Morris, {Derek W.} and Mosley, {Thomas H.} and Muhleisen, {Thomas W.} and Bertram Mueller-Myhsok and Nalls, {Michael A.} and Matthias Nauck and Nichols, {Thomas E.} and Niessen, {Wiro J.} and Nothen, {Markus M.} and Lars Nyberg and Kazutaka Ohi and Olvera, {Rene L.} and Ophoff, {Roel A.} and Massimo Pandolfo and Tomas Paus and Zdenka Pausova and Penninx, {Brenda W. J. H.} and Pike, {G. Bruce} and Potkin, {Steven G.} and Psaty, {Bruce M.} and Simone Reppermund and Marcella Rietschel and Roffman, {Joshua L.} and Nina Romanczuk-Seiferth and Rotter, {Jerome I.} and Mina Ryten and Sacco, {Ralph L.} and Sachdev, {Perminder S.} and Saykin, {Andrew J.} and Reinhold Schmidt and Helena Schmidt and Schofield, {Peter R.} and Sigurdur Sigursson and Andrew Simmons and Andrew Singleton and Sisodiya, {Sanjay M.} and Colin Smith and Smoller, {Jordan W.} and Hilkka Soininen and Steen, {Vidar M.} and Stott, {David J.} and Sussmann, {Jessika E.} and Anbupalam Thalamuthu and Toga, {Arthur W.} and Traynor, {Bryan J.} and Juan Troncoso and Magda Tsolaki and Christophe Tzourio and Uitterlinden, {Andre G.} and Hernandez, {Maria C. Valdes} and {Van der Brug}, Marcel and {van der Lugt}, Aad and {van der Wee}, {Nic J. A.} and {Van Haren}, {Neeltje E. M.} and {van't Ent}, Dennis and {Van Tol}, Marie-Jose and Vardarajan, {Badri N.} and Bruno Vellas and Veltman, {Dick J.} and Henry Voelzke and Henrik Walter and Wardlaw, {Joanna M.} and Wassink, {Thomas H.} and Weale, {Michael E.} and Weinberger, {Daniel R.} and Weiner, {Michael W.} and Wei Wen and Eric Westman and Tonya White and Wong, {Tien Y.} and Wright, {Clinton B.} and Zielke, {Ronald H.} and Zonderman, {Alan B.} and Martin, {Nicholas G.} and {Van Duijn}, {Cornelia M.} and Wright, {Margaret J.} and Longstreth, {W. T.} and Gunter Schumann and Grabe, {Hans J.} and Barbara Franke and Launer, {Lenore J.} and Medland, {Sarah E.} and Sudha Seshadri and Thompson, {Paul M.} and Ikram, {M. Arfan}",
year = "2017",
month = jan,
day = "18",
doi = "10.1038/ncomms13624",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Novel genetic loci associated with hippocampal volume

AU - Hibar, Derrek P.

AU - Adams, Hieab H. H.

AU - Jahanshad, Neda

AU - Chauhan, Ganesh

AU - Stein, Jason L.

AU - Hofer, Edith

AU - Renteria, Miguel E.

AU - Bis, Joshua C.

AU - Arias-Vasquez, Alejandro

AU - Ikram, M. Kamran

AU - Desrivieres, Sylvane

AU - Vernooij, Meike W.

AU - Abramovic, Lucija

AU - Alhusaini, Saud

AU - Amin, Najaf

AU - Andersson, Micael

AU - Arfanakis, Konstantinos

AU - Aribisala, Benjamin S.

AU - Armstrong, Nicola J.

AU - Athanasiu, Lavinia

AU - Axelsson, Tomas

AU - Beecham, Ashley H.

AU - Beiser, Alexa

AU - Bernard, Manon

AU - Blanton, Susan H.

AU - Bohlken, Marc M.

AU - Boks, Marco P.

AU - Bralten, Janita

AU - Brickman, Adam M.

AU - Carmichael, Owen

AU - Chakravarty, M. Mallar

AU - Chen, Qiang

AU - Ching, Christopher R. K.

AU - Chouraki, Vincent

AU - Cuellar-Partida, Gabriel

AU - Crivello, Fabrice

AU - Den Braber, Anouk

AU - Nhat Trung Doan, null

AU - Ehrlich, Stefan

AU - Giddaluru, Sudheer

AU - Goldman, Aaron L.

AU - Gottesman, Rebecca F.

AU - Grimm, Oliver

AU - Griswold, Michael E.

AU - Guadalupe, Tulio

AU - Gutman, Boris A.

AU - Hass, Johanna

AU - Haukvik, Unn K.

AU - Hoehn, David

AU - Holmes, Avram J.

AU - Hoogman, Martine

AU - Janowitz, Deborah

AU - Jia, Tianye

AU - Jorgensen, Kjetil N.

AU - Karbalai, Nazanin

AU - Kasperaviciute, Dalia

AU - Kim, Sungeun

AU - Klein, Marieke

AU - Kraemer, Bernd

AU - Lee, Phil H.

AU - Liewald, David C. M.

AU - Lopez, Lorna M.

AU - Luciano, Michelle

AU - Macare, Christine

AU - Marquand, Andre F.

AU - Matarin, Mar

AU - Mather, Karen A.

AU - Mattheisen, Manuel

AU - McKay, David R.

AU - Milaneschi, Yuri

AU - Maniega, Susana Munoz

AU - Nho, Kwangsik

AU - Nugent, Allison C.

AU - Nyquist, Paul

AU - Loohuis, Loes M. Olde

AU - Oosterlaan, Jaap

AU - Papmeyer, Martina

AU - Pirpamer, Lukas

AU - Puetz, Benno

AU - Ramasamy, Adaikalavan

AU - Richards, Jennifer S.

AU - Risacher, Shannon L.

AU - Roiz-Santianez, Roberto

AU - Rommelse, Nanda

AU - Ropele, Stefan

AU - Rose, Emma J.

AU - Royle, Natalie A.

AU - Rundek, Tatjana

AU - Saemann, Philipp G.

AU - Saremi, Arvin

AU - Satizabal, Claudia L.

AU - Schmaal, Lianne

AU - Schork, Andrew J.

AU - Shen, Li

AU - Shin, Jean

AU - Shumskaya, Elena

AU - Smith, Albert V.

AU - Sprooten, Emma

AU - Strike, Lachlan T.

AU - Teumer, Alexander

AU - Tordesillas-Gutierrez, Diana

AU - Toro, Roberto

AU - Trabzuni, Daniah

AU - Trompet, Stella

AU - Vaidya, Dhananjay

AU - Van der Grond, Jeroen

AU - Van der Lee, Sven J.

AU - Van der Meer, Dennis

AU - Van Donkelaar, Marjolein M. J.

AU - Van Eijk, Kristel R.

AU - Van Erp, Theo G. M.

AU - Van Rooij, Daan

AU - Walton, Esther

AU - Westlye, Lars T.

AU - Whelan, Christopher D.

AU - Windham, Beverly G.

AU - Winkler, Anderson M.

AU - Wittfeld, Katharina

AU - Woldehawariat, Girma

AU - Wolf, Christiane

AU - Wolfers, Thomas

AU - Yanek, Lisa R.

AU - Yang, Jingyun

AU - Zijdenbos, Alex

AU - Zwiers, Marcel P.

AU - Agartz, Ingrid

AU - Almasy, Laura

AU - Ames, David

AU - Amouyel, Philippe

AU - Andreassen, Ole A.

AU - Arepalli, Sampath

AU - Assareh, Amelia A.

AU - Barral, Sandra

AU - Bastin, Mark E.

AU - Becker, Diane M.

AU - Becker, James T.

AU - Bennett, David A.

AU - Blangero, John

AU - van Bokhoven, Hans

AU - Boomsma, Dorret I.

AU - Brodaty, Henry

AU - Brouwer, Rachel M.

AU - Brunner, Han G.

AU - Buckner, Randy L.

AU - Buitelaar, Jan K.

AU - Bulayeva, Kazima B.

AU - Cahn, Wiepke

AU - Calhoun, Vince D.

AU - Cannon, Dara M.

AU - Cavalleri, Gianpiero L.

AU - Cheng, Ching-Yu

AU - Cichon, Sven

AU - Cookson, Mark R.

AU - Corvin, Aiden

AU - Crespo-Facorro, Benedicto

AU - Curran, Joanne E.

AU - Czisch, Michael

AU - Dale, Anders M.

AU - Davies, Gareth E.

AU - De Craen, Anton J. M.

AU - De Geus, Eco J. C.

AU - De Jager, Philip L.

AU - De Zubicaray, Greig I.

AU - Deary, Ian J.

AU - Debette, Stephanie

AU - DeCarli, Charles

AU - Delanty, Norman

AU - Depondt, Chantal

AU - DeStefano, Anita

AU - Dillman, Allissa

AU - Djurovic, Srdjan

AU - Donohoe, Gary

AU - Drevets, Wayne C.

AU - Duggirala, Ravi

AU - Dyer, Thomas D.

AU - Enzinger, Christian

AU - Erk, Susanne

AU - Espeseth, Thomas

AU - Fedko, Iryna O.

AU - Fernandez, Guillen

AU - Ferrucci, Luigi

AU - Fisher, Simon E.

AU - Fleischman, Debra A.

AU - Ford, Ian

AU - Fornage, Myriam

AU - Foroud, Tatiana M.

AU - Fox, Peter T.

AU - Francks, Clyde

AU - Fukunaga, Masaki

AU - Gibbs, J. Raphael

AU - Glahn, David C.

AU - Gollub, Randy L.

AU - Goring, Harald H. H.

AU - Green, Robert C.

AU - Gruber, Oliver

AU - Gudnason, Vilmundur

AU - Guelfi, Sebastian

AU - Haberg, Asta K.

AU - Hansell, Narelle K.

AU - Hardy, John

AU - Hartman, Catharina A.

AU - Hashimoto, Ryota

AU - Hegenscheid, Katrin

AU - Heinz, Andreas

AU - Le Hellard, Stephanie

AU - Hernandez, Dena G.

AU - Heslenfeld, Dirk J.

AU - Ho, Beng-Choon

AU - Hoekstra, Pieter J.

AU - Hoffmann, Wolfgang

AU - Hofman, Albert

AU - Holsboer, Florian

AU - Homuth, Georg

AU - Hosten, Norbert

AU - Hottenga, Jouke-Jan

AU - Huentelman, Matthew

AU - Pol, Hilleke E. Hulshoff

AU - Ikeda, Masashi

AU - Jack, Clifford R.

AU - Jenkinson, Mark

AU - Johnson, Robert

AU - Joensson, Erik G.

AU - Jukema, J. Wouter

AU - Kahn, Rene S.

AU - Kanai, Ryota

AU - Kloszewska, Iwona

AU - Knopman, David S.

AU - Kochunov, Peter

AU - Kwok, John B.

AU - Lawrie, Stephen M.

AU - Lemaitre, Herve

AU - Liu, Xinmin

AU - Longo, Dan L.

AU - Lopez, Oscar L.

AU - Lovestone, Simon

AU - Martinez, Oliver

AU - Martinot, Jean-Luc

AU - Mattay, Venkata S.

AU - McDonald, Colm

AU - McIntosh, Andrew M.

AU - McMahon, Francis J.

AU - McMahon, Katie L.

AU - Mecocci, Patrizia

AU - Melle, Ingrid

AU - Meyer-Lindenberg, Andreas

AU - Mohnke, Sebastian

AU - Montgomery, Grant W.

AU - Morris, Derek W.

AU - Mosley, Thomas H.

AU - Muhleisen, Thomas W.

AU - Mueller-Myhsok, Bertram

AU - Nalls, Michael A.

AU - Nauck, Matthias

AU - Nichols, Thomas E.

AU - Niessen, Wiro J.

AU - Nothen, Markus M.

AU - Nyberg, Lars

AU - Ohi, Kazutaka

AU - Olvera, Rene L.

AU - Ophoff, Roel A.

AU - Pandolfo, Massimo

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Penninx, Brenda W. J. H.

AU - Pike, G. Bruce

AU - Potkin, Steven G.

AU - Psaty, Bruce M.

AU - Reppermund, Simone

AU - Rietschel, Marcella

AU - Roffman, Joshua L.

AU - Romanczuk-Seiferth, Nina

AU - Rotter, Jerome I.

AU - Ryten, Mina

AU - Sacco, Ralph L.

AU - Sachdev, Perminder S.

AU - Saykin, Andrew J.

AU - Schmidt, Reinhold

AU - Schmidt, Helena

AU - Schofield, Peter R.

AU - Sigursson, Sigurdur

AU - Simmons, Andrew

AU - Singleton, Andrew

AU - Sisodiya, Sanjay M.

AU - Smith, Colin

AU - Smoller, Jordan W.

AU - Soininen, Hilkka

AU - Steen, Vidar M.

AU - Stott, David J.

AU - Sussmann, Jessika E.

AU - Thalamuthu, Anbupalam

AU - Toga, Arthur W.

AU - Traynor, Bryan J.

AU - Troncoso, Juan

AU - Tsolaki, Magda

AU - Tzourio, Christophe

AU - Uitterlinden, Andre G.

AU - Hernandez, Maria C. Valdes

AU - Van der Brug, Marcel

AU - van der Lugt, Aad

AU - van der Wee, Nic J. A.

AU - Van Haren, Neeltje E. M.

AU - van't Ent, Dennis

AU - Van Tol, Marie-Jose

AU - Vardarajan, Badri N.

AU - Vellas, Bruno

AU - Veltman, Dick J.

AU - Voelzke, Henry

AU - Walter, Henrik

AU - Wardlaw, Joanna M.

AU - Wassink, Thomas H.

AU - Weale, Michael E.

AU - Weinberger, Daniel R.

AU - Weiner, Michael W.

AU - Wen, Wei

AU - Westman, Eric

AU - White, Tonya

AU - Wong, Tien Y.

AU - Wright, Clinton B.

AU - Zielke, Ronald H.

AU - Zonderman, Alan B.

AU - Martin, Nicholas G.

AU - Van Duijn, Cornelia M.

AU - Wright, Margaret J.

AU - Longstreth, W. T.

AU - Schumann, Gunter

AU - Grabe, Hans J.

AU - Franke, Barbara

AU - Launer, Lenore J.

AU - Medland, Sarah E.

AU - Seshadri, Sudha

AU - Thompson, Paul M.

AU - Ikram, M. Arfan

PY - 2017/1/18

Y1 - 2017/1/18

N2 - The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

AB - The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

KW - GENOME-WIDE ASSOCIATION

KW - TEMPORAL-LOBE EPILEPSY

KW - SUSCEPTIBILITY LOCI

KW - ALZHEIMERS-DISEASE

KW - BIPOLAR DISORDER

KW - COMMON VARIANTS

KW - BRAIN-REGIONS

KW - MEMORY

KW - SUBFIELDS

KW - METAANALYSIS

U2 - 10.1038/ncomms13624

DO - 10.1038/ncomms13624

M3 - Journal article

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 13624

ER -