Manuel Mattheisen

Novel genetic loci associated with hippocampal volume

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Derrek P. Hibar, Univ Southern Calif, University of Southern California, Imaging Genet Ctr, USC Mark & Mary Stevens Neuroimaging & Informat I, Keck Sch Med
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  • Hieab H. H. Adams, Erasmus MC, Erasmus University Rotterdam, Dept Radiol & Nucl Med
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  • Neda Jahanshad, Univ Southern Calif, University of Southern California, Imaging Genet Ctr, USC Mark & Mary Stevens Neuroimaging & Informat I, Keck Sch Med
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  • Ganesh Chauhan, Univ Bordeaux, Communaute d'Universites et Etablissements d'Aquitaine (ComUE), INSERM Unit U1219
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  • Jason L. Stein, UNC, University of North Carolina Chapel Hill, University of North Carolina, UNC Neurosci Ctr
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  • Edith Hofer, Med Univ Graz, Medical University of Graz, Inst Med Informat Stat & Documentat
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  • Miguel E. Renteria, QIMR Berghofer Med Res Inst, QIMR Berghofer Medical Research Institute, Dept Genet & Computat Biol
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  • Joshua C. Bis, Univ Washington, University of Washington Seattle, University of Washington, Dept Med, Cardiovasc Hlth Res Unit
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  • Alejandro Arias-Vasquez, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Inst Brain Cognit & Behav
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  • M. Kamran Ikram, Natl Univ Singapore, National University of Singapore, Dept Pharmacol
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  • Sylvane Desrivieres, Kings Coll London, Kings College London, University of London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci
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  • Meike W. Vernooij, Erasmus MC, Erasmus University Rotterdam, Dept Radiol & Nucl Med
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  • Lucija Abramovic, UMC Utrecht, Utrecht University, Utrecht University Medical Center, Brain Ctr Rudolf Magnus, Dept Psychiat
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  • Saud Alhusaini, Royal Coll Surgeons Ireland, Royal College of Surgeons - Ireland
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  • Najaf Amin, Erasmus Univ, Erasmus University Rotterdam, Med Ctr, Dept Epidemiol
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  • Micael Andersson, Umea Univ, Umea University, Umea Ctr Funct Brain Imaging
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  • Konstantinos Arfanakis, Rush Univ, Rush University, Med Ctr, Dept Diagnost Radiol & Nucl Med
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  • Benjamin S. Aribisala, Univ Edinburgh, University of Edinburgh, Dept Neuroimaging Sci, Scottish Imaging Network, Platform Sci Excellence SINAPSE Collaborat
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  • Nicola J. Armstrong, Murdoch Univ, Murdoch University, Math & Stat
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  • Lavinia Athanasiu, Oslo Univ Hosp, University of Oslo, NORMENT KG Jebsen Ctr, Div Mental Hlth & Addict
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  • Tomas Axelsson, Uppsala Univ, Uppsala University, Dept Med Sci Mol Med & Sci Life Lab
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  • Ashley H. Beecham, Univ Miami, University of Miami, Miller Sch Med, John P Hussman Inst Human Gen
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  • Alexa Beiser, Framingham Heart Dis Epidemiol Study, Framingham Heart Study
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  • Manon Bernard, Univ Toronto, Hospital for Sick Children (SickKids), University of Toronto, Hosp Sick Children
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  • Susan H. Blanton, Univ Miami, University of Miami, Miller Sch Med, John P Hussman Inst Human Gen
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  • Marc M. Bohlken, UMC Utrecht, Utrecht University, Utrecht University Medical Center, Brain Ctr Rudolf Magnus, Dept Psychiat
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  • Marco P. Boks, UMC Utrecht, Utrecht University, Utrecht University Medical Center, Brain Ctr Rudolf Magnus, Dept Psychiat
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  • Janita Bralten, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Inst Brain Cognit & Behav
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  • Adam M. Brickman, Columbia Univ, Columbia University, Med Ctr, Dept Neurol
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  • Owen Carmichael, Pennington Biomed Res Ctr, University of Louisiana Lafayette, Pennington Biomedical Research Center
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  • M. Mallar Chakravarty, McGill Univ, McGill University, Dept Psychiat & Biomed Engn
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  • Qiang Chen, Lieber Inst Brain Dev
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  • Christopher R. K. Ching, Univ Calif Los Angeles, University of California Los Angeles, University of California System, Sch Med, Interdept Neurosci Grad Program
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  • Vincent Chouraki, Univ Lille, Universite Lille-Nord-de-France (ComUE), CHU Lille, Institut Pasteur Lille, University of Lille II, Le Reseau International des Instituts Pasteur (RIIP), Institut National de la Sante et de la Recherche Medicale (Inserm), CHU Lille, INSERM, Inst Pasteur Lille,RID AGE Risk Factors & Mol Det
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  • Gabriel Cuellar-Partida, QIMR Berghofer Med Res Inst, QIMR Berghofer Medical Research Institute, Dept Genet & Computat Biol
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  • Fabrice Crivello, Univ Bordeaux, Centre National de la Recherche Scientifique (CNRS), CEA, Communaute d'Universites et Etablissements d'Aquitaine (ComUE), IMN UMR5293, GIN, CNRS,CEA
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  • Anouk Den Braber, Vrije Universiteit Amsterdam
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  • Nhat Trung Doan, Univ Oslo, University of Oslo, NORMENT KG Jebsen Ctr, Inst Clin Med
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  • Stefan Ehrlich, Massachusetts Gen Hosp, Harvard University, VA Boston Healthcare System, Massachusetts General Hospital, Martinos Ctr Biomed Imaging
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  • Sudheer Giddaluru, Haukeland Hosp, University of Bergen, Dr Einar Martens Res Grp Biol Psychiat, Ctr Med Genet & Mol Med
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  • Aaron L. Goldman, Lieber Inst Brain Dev
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  • Rebecca F. Gottesman, Johns Hopkins Univ, Johns Hopkins University, Sch Med, Dept Neurol
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  • Oliver Grimm, Heidelberg Univ, Ruprecht Karl University Heidelberg, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Data Sci
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  • Michael E. Griswold, Univ Mississippi, University of Mississippi Medical Center, University of Mississippi, Med Ctr, Dept Data Sci
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  • Tulio Guadalupe, Int Max Planck Res Sch Language Sci, Max Planck Society
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  • Boris A. Gutman, Univ Southern Calif, University of Southern California, Imaging Genet Ctr, USC Mark & Mary Stevens Neuroimaging & Informat I, Keck Sch Med
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  • Johanna Hass, Tech Univ Dresden, Dresden University of Technology, Fac Med, Dept Child & Adolescent Psychiat
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  • Unn K. Haukvik, Diakonhjemmet Hosp, Dept Res & Dev
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  • David Hoehn, Max Planck Inst Psychiat, Max Planck Society
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  • Avram J. Holmes, Yale Univ, Yale University, Dept Psychol
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  • Martine Hoogman, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Inst Brain Cognit & Behav
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  • Deborah Janowitz, Univ Med Greifswald, Dept Psychiat
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  • Tianye Jia, Kings Coll London, Kings College London, University of London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci
  • ,
  • Kjetil N. Jorgensen, Diakonhjemmet Hosp, Dept Res & Dev
  • ,
  • Nazanin Karbalai, Max Planck Inst Psychiat, Max Planck Society
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  • Dalia Kasperaviciute, Univ London Imperial Coll Sci Technol & Med, Imperial College London, Dept Earth Sci & Engn
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  • Sungeun Kim, Indiana Univ Sch Med, Indiana University-Purdue University Indianapolis, Indiana University System, Indiana Alzheimer Dis Ctr
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  • Marieke Klein, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Inst Brain Cognit & Behav
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  • Bernd Kraemer, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging
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  • Phil H. Lee, Harvard Med Sch, VA Boston Healthcare System, Harvard University, Massachusetts General Hospital, Massachusetts Gen Hosp, Lurie Ctr Autism
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  • David C. M. Liewald, Univ Edinburgh, University of Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol
  • ,
  • Lorna M. Lopez, Univ Edinburgh, University of Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol
  • ,
  • Michelle Luciano, Univ Edinburgh, University of Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol
  • ,
  • Christine Macare, Kings Coll London, Kings College London, University of London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci
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  • Andre F. Marquand, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Ctr Cognit Neuroimaging
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  • Mar Matarin, UCL Inst Neurol, University of London, University College London, Dept Mol Neurosci
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  • Karen A. Mather, Univ New South Wales, University of New South Wales Sydney, Ctr Healthy Brain Ageing, Sch Psychiat
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  • Manuel Mattheisen
  • David R. McKay, Olin Neuropsychiat Res Ctr
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  • Yuri Milaneschi, Vrije Universiteit Amsterdam
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  • Susana Munoz Maniega, Univ Edinburgh, University of Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol
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  • Kwangsik Nho, Indiana Univ Sch Med, Indiana University-Purdue University Indianapolis, Indiana University System, Indiana Alzheimer Dis Ctr
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  • Allison C. Nugent, NIMH, National Institutes of Health (NIH) - USA, NIH National Institute of Mental Health (NIMH), Human Genet Branch, Intramural Res Program
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  • Paul Nyquist, Johns Hopkins, Johns Hopkins University, Dept Neurol, Dept Anesthesia Crit Care Med, Dept Neurosurg
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  • Loes M. Olde Loohuis, Univ Calif Los Angeles, University of California Los Angeles, University of California System, Ctr Neurobehav Genet
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  • Jaap Oosterlaan, Vrije Universiteit Amsterdam
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  • Martina Papmeyer, Univ Bern, University of Bern, Univ Hosp Psychiat, Div Syst Neurosci Psychopathol, Translat Res Ctr
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  • Lukas Pirpamer, Med Univ Graz, Medical University of Graz, Dept Neurol, Clin Div Neurogeriatr
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  • Benno Puetz, Max Planck Inst Psychiat, Max Planck Society
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  • Adaikalavan Ramasamy, Univ Oxford, University of Oxford, Jenner Inst Labs
  • ,
  • Jennifer S. Richards, Karakter Child & Adolescent Psychiat Univ Ctr, Radboud University Nijmegen
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  • Shannon L. Risacher, Indiana Univ Sch Med, Indiana University-Purdue University Indianapolis, Indiana University System, Indiana Alzheimer Dis Ctr
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  • Roberto Roiz-Santianez, CIBERSAM Ctr Invest Biomed Red Salud Mental
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  • Nanda Rommelse, Karakter Child & Adolescent Psychiat Univ Ctr, Radboud University Nijmegen
  • ,
  • Stefan Ropele, Med Univ Graz, Medical University of Graz, Dept Neurol, Clin Div Neurogeriatr
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  • Emma J. Rose, Trinity Coll Dublin, Trinity College Dublin, Trinity Translat Med Inst
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  • Natalie A. Royle, Univ Edinburgh, University of Edinburgh, Ctr Clin Brain Sci
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  • Tatjana Rundek, Univ Miami, University of Miami, Miller Sch Med, Dept Epidemiol & Publ Hlth Sci
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  • Philipp G. Saemann, Max Planck Inst Psychiat, Max Planck Society
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  • Arvin Saremi, Univ Southern Calif, University of Southern California, Imaging Genet Ctr, USC Mark & Mary Stevens Neuroimaging & Informat I, Keck Sch Med
  • ,
  • Claudia L. Satizabal, Framingham Heart Dis Epidemiol Study, Framingham Heart Study
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  • Lianne Schmaal, Vrije Universiteit Amsterdam
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  • Andrew J. Schork, Univ Calif San Diego, University of California San Diego, University of California System, Dept Cognit Sci
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  • Li Shen, Indiana Univ Sch Med, Indiana University-Purdue University Indianapolis, Indiana University System, Indiana Alzheimer Dis Ctr
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  • Jean Shin, Univ Toronto, Hospital for Sick Children (SickKids), University of Toronto, Hosp Sick Children
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  • Elena Shumskaya, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Ctr Cognit Neuroimaging
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  • Albert V. Smith, Univ Iceland, University of Iceland, BMC Biomed Ctr, Fac Med
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  • Emma Sprooten, Icahn Sch Med Mt Sinai, Icahn School of Medicine at Mount Sinai, Dept Psychiat
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  • Lachlan T. Strike, Univ Queensland, University of Queensland, Queensland Brain Inst
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  • Alexander Teumer, Ernst Moritz Arndt Univ Greifswald, Ernst Moritz Arndt Universitat Greifswald, Univ Med Greifswald, Inst Community Med
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  • Diana Tordesillas-Gutierrez, Valdecilla Biomed Res Inst IDIVAL, Neuroimaging Unit, Technol Facilities
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  • Roberto Toro, Inst Pasteur, Institut Pasteur Paris, Le Reseau International des Instituts Pasteur (RIIP), Ctr Bioinformat Biostat & Biol Integrat, Dept Genomes & Genet
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  • Daniah Trabzuni, King Faisal Specialist Hosp & Res Ctr, King Faisal Specialist Hospital & Research Center, Dept Genet
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  • Stella Trompet, Leiden Univ, Leiden University, Med Ctr, Dept Cardiol
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  • Dhananjay Vaidya, Johns Hopkins Univ, Johns Hopkins University, Sch Med, Dept Med, GeneSTAR Res Ctr
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  • Jeroen Van der Grond, Leiden Univ, Leiden University, Med Ctr, Dept Radiol
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  • Sven J. Van der Lee, Erasmus Univ, Erasmus University Rotterdam, Med Ctr, Dept Epidemiol
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  • Dennis Van der Meer, Univ Groningen, University of Groningen, Univ Med Ctr Groningen, Dept Psychiat
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  • Marjolein M. J. Van Donkelaar, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Inst Brain Cognit & Behav
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  • Kristel R. Van Eijk, UMC Utrecht, Utrecht University, Utrecht University Medical Center, Brain Ctr Rudolf Magnus, Human Neurogenet Unit
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  • Theo G. M. Van Erp, Univ Calif Irvine, University of California System, University of California Irvine, Dept Psychiat & Human Behav
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  • Daan Van Rooij, Univ Groningen, University of Groningen, Univ Med Ctr Groningen, Dept Psychiat
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  • Esther Walton, Georgia State Univ, Georgia State University, University System of Georgia, Dept Psychol
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  • Lars T. Westlye, Georgia State Univ, Georgia State University, University System of Georgia, Dept Psychol
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  • Christopher D. Whelan, Royal Coll Surgeons Ireland, Royal College of Surgeons - Ireland
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  • Beverly G. Windham, Univ Oslo, University of Oslo, Dept Psychol, NORMENT KG Jebsen Ctr
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  • Anderson M. Winkler, Univ Mississippi, University of Mississippi, University of Mississippi Medical Center, Med Ctr, Div Med Genet, Dept Pediat
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  • Katharina Wittfeld, Univ Oxford, University of Oxford, FMRIB Ctr
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  • Girma Woldehawariat, NIMH, National Institutes of Health (NIH) - USA, NIH National Institute of Mental Health (NIMH), Human Genet Branch, Intramural Res Program
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  • Christiane Wolf, German Ctr Neurodegenerat Dis DZNE Rostock Greifs, Helmholtz Association, German Center for Neurodegenerative Diseases (DZNE)
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  • Thomas Wolfers, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Inst Brain Cognit & Behav
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  • Lisa R. Yanek, Johns Hopkins Univ, Johns Hopkins University, Sch Med, Dept Med, GeneSTAR Res Ctr
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  • Jingyun Yang, Univ Wurzburg, University of Wurzburg, Dept Psychiat Psychosomat & Psychotherapy
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  • Alex Zijdenbos, Rush Univ, Rush University, Med Ctr, Dept Neurol Sci
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  • Marcel P. Zwiers, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Ctr Cognit Neuroimaging
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  • Ingrid Agartz, Biospective Inc
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  • Laura Almasy, Univ Penn, University of Pennsylvania, Dept Genet, Perelman Sch Med
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  • David Ames, Royal Melbourne Hosp, National Ageing Research Institute, Natl Ageing Res Inst
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  • Philippe Amouyel, Univ Lille, Universite Lille-Nord-de-France (ComUE), CHU Lille, Institut Pasteur Lille, University of Lille II, Le Reseau International des Instituts Pasteur (RIIP), Institut National de la Sante et de la Recherche Medicale (Inserm), CHU Lille, INSERM, Inst Pasteur Lille,RID AGE Risk Factors & Mol Det
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  • Ole A. Andreassen, Oslo Univ Hosp, University of Oslo, NORMENT KG Jebsen Ctr, Div Mental Hlth & Addict
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  • Sampath Arepalli, Univ Melbourne, University of Melbourne, Acad Unit Psychiat Old Age
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  • Amelia A. Assareh, Univ New South Wales, University of New South Wales Sydney, Ctr Healthy Brain Ageing, Sch Psychiat
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  • Sandra Barral, Columbia Univ, Columbia University, Med Ctr, Dept Neurol
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  • Mark E. Bastin, Univ Edinburgh, University of Edinburgh, Ctr Clin Brain Sci
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  • Diane M. Becker, Johns Hopkins Univ, Johns Hopkins University, Sch Med, Dept Med, GeneSTAR Res Ctr
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  • James T. Becker, NIA, National Institutes of Health (NIH) - USA, NIH National Institute on Aging (NIA), Neurogenet Lab, NIH
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  • David A. Bennett, Univ Wurzburg, University of Wurzburg, Dept Psychiat Psychosomat & Psychotherapy
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  • John Blangero, Karolinska Inst, Karolinska Institutet, Dept Clin Neurosci, Ctr Psychiat Res
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  • Hans van Bokhoven, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Inst Brain Cognit & Behav
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  • Dorret I. Boomsma, Vrije Universiteit Amsterdam
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  • Henry Brodaty, Univ Pittsburgh, Pennsylvania Commonwealth System of Higher Education (PCSHE), University of Pittsburgh, Dept Psychol
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  • Rachel M. Brouwer, UMC Utrecht, Utrecht University, Utrecht University Medical Center, Brain Ctr Rudolf Magnus, Dept Psychiat
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  • Han G. Brunner, Univ New South Wales, University of New South Wales Sydney, Dementia Collaborat Res Centre Assessment & Bette
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  • Randy L. Buckner, Maastricht Univ, Maastricht University, Med Ctr, GROW Sch Oncol & Dev Biol
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  • Jan K. Buitelaar, Karakter Child & Adolescent Psychiat Univ Ctr, Radboud University Nijmegen
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  • Wiepke Cahn, UMC Utrecht, Utrecht University, Utrecht University Medical Center, Brain Ctr Rudolf Magnus, Dept Psychiat
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  • Vince D. Calhoun, LBERI, Lovelace Respiratory Research Institute
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  • Dara M. Cannon, Univ New Mexico, University of New Mexico, Dept ECE
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  • Gianpiero L. Cavalleri, Royal Coll Surgeons Ireland, Royal College of Surgeons - Ireland
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  • Ching-Yu Cheng, Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom NICOG, Clin Neuroimaging Lab, NCBES Galway Neurosci Ctr,Coll Med Nursing & Hlth
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  • Sven Cichon, Univ Bonn, University of Bonn, Inst Human Genet
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  • Mark R. Cookson, Univ Melbourne, University of Melbourne, Acad Unit Psychiat Old Age
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  • Aiden Corvin, Trinity Coll Dublin, Trinity College Dublin, Trinity Translat Med Inst
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  • Benedicto Crespo-Facorro, CIBERSAM Ctr Invest Biomed Red Salud Mental
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  • Joanne E. Curran, Karolinska Inst, Karolinska Institutet, Dept Clin Neurosci, Ctr Psychiat Res
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  • Michael Czisch, Max Planck Inst Psychiat, Max Planck Society
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  • Anders M. Dale, Univ Calif San Diego, University of California San Diego, University of California System, Ctr Multimodal Imaging & Genet
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  • Gareth E. Davies, Univ Calif San Diego, University of California San Diego, University of California System, Dept Cognit Sci
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  • Anton J. M. De Craen, Avera Inst Human Genet
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  • Eco J. C. De Geus, Vrije Universiteit Amsterdam
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  • Philip L. De Jager, Broad Inst MIT & Harvard, Broad Institute, Massachusetts Institute of Technology (MIT), Harvard University, Program Med & Populat Genet
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  • Greig I. De Zubicaray, Broad Inst MIT & Harvard, Broad Institute, Massachusetts Institute of Technology (MIT), Harvard University, Stanley Ctr Psychiat Res
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  • Ian J. Deary, Univ Edinburgh, University of Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol
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  • Stephanie Debette, Queensland Univ Technol, Queensland University of Technology (QUT), Fac Hlth & Inst Hlth & Biomed Innovat
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  • Charles DeCarli, Bordeaux Univ Hosp, CHU Bordeaux, Dept Neurol
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  • Norman Delanty, Univ Calif Davis, University of California Davis, University of California System, Ctr Neurosci
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  • Chantal Depondt, Beaumont Hosp, Div Neurol
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  • Anita DeStefano, Framingham Heart Dis Epidemiol Study, Framingham Heart Study
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  • Allissa Dillman, Univ Melbourne, University of Melbourne, Acad Unit Psychiat Old Age
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  • Srdjan Djurovic, Univ Libre Bruxelles, Universite Libre de Bruxelles, Dept Neurol, Hop Erasme
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  • Gary Donohoe, Natl Univ Ireland Galway, Sch Psychol & Discipline Biochem, NCBES Galway Neurosci Ctr
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  • Wayne C. Drevets, Trinity Coll Dublin, Trinity College Dublin, Trinity Coll, Inst Psychiat
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  • Ravi Duggirala, Karolinska Inst, Karolinska Institutet, Dept Clin Neurosci, Ctr Psychiat Res
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  • Thomas D. Dyer, Karolinska Inst, Karolinska Institutet, Dept Clin Neurosci, Ctr Psychiat Res
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  • Christian Enzinger, Med Univ Graz, Medical University of Graz, Dept Neurol, Clin Div Neurogeriatr
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  • Susanne Erk, Janssen Res & Dev LLC, Janssen Biotech Inc, Johnson & Johnson USA, Johnson & Johnson
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  • Thomas Espeseth, Georgia State Univ, Georgia State University, University System of Georgia, Dept Psychol
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  • Guillen Fernandez, Radboud Univ Nijmegen, Radboud University Nijmegen, Donders Inst Brain Cognit & Behav
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  • Luigi Ferrucci, Charite, Free University of Berlin, Humboldt University of Berlin, Charite Medical University of Berlin, Charite Mitte Campus, Dept Psychiat & Psychotherapy
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  • Simon E. Fisher, Max Planck Inst Psycholinguist, Max Planck Society, Language & Genet Dept
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  • Debra A. Fleischman, NIA, National Institutes of Health (NIH) - USA, NIH National Institute on Aging (NIA), Intramural Res Program
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  • Ian Ford, Rush Univ, Rush University, Med Ctr, Dept Behav Sci
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  • Myriam Fornage, Univ Glasgow, University of Glasgow, Robertson Ctr Biostat
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  • Tatiana M. Foroud, Univ Texas Hlth Sci Ctr Houston, University of Texas Health Science Center Houston, University of Texas System, Inst Mol Med & Human Genet Ctr
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  • Peter T. Fox, Indiana Univ Sch Med, Indiana University-Purdue University Indianapolis, Indiana University System, Med & Mol Genet
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  • Clyde Francks, Max Planck Inst Psycholinguist, Max Planck Society, Language & Genet Dept
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  • Masaki Fukunaga, Univ Texas Hlth Sci Ctr San Antonio, University of Texas Health San Antonio, University of Texas System, Ctr Biomed Neurosci
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  • J. Raphael Gibbs, Univ Melbourne, University of Melbourne, Acad Unit Psychiat Old Age
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  • David C. Glahn, Olin Neuropsychiat Res Ctr
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  • Randy L. Gollub, Harvard Med Sch, Harvard University, Dept Hlth Care Policy
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  • Harald H. H. Goring, Karolinska Inst, Karolinska Institutet, Dept Clin Neurosci, Ctr Psychiat Res
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  • Robert C. Green, Natl Inst Physiol Sci, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS) - Japan, Div Cerebral Integrat
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  • Oliver Gruber, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging
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  • Vilmundur Gudnason, Univ Iceland, University of Iceland, BMC Biomed Ctr, Fac Med
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  • Sebastian Guelfi, UCL Inst Neurol, University of London, University College London, Dept Mol Neurosci
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  • Asta K. Haberg, Norwegian Univ Sci & Technol NTNU, Norwegian University of Science & Technology (NTNU), Fac Med, Dept Neurosci
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  • Narelle K. Hansell, Univ Queensland, University of Queensland, Queensland Brain Inst
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  • John Hardy, UCL Inst Neurol, University of London, University College London, Dept Mol Neurosci
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  • Catharina A. Hartman, Univ Groningen, University of Groningen, Univ Med Ctr Groningen, Dept Psychiat
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  • Ryota Hashimoto, Osaka Univ, Osaka University, Dept Psychiat, Grad Sch Med
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  • Katrin Hegenscheid, Osaka Univ, Osaka University, Mol Res Ctr Childrens Mental Dev, United Grad Sch Child Dev
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  • Andreas Heinz, Janssen Res & Dev LLC, Janssen Biotech Inc, Johnson & Johnson USA, Johnson & Johnson
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  • Stephanie Le Hellard, Haukeland Hosp, University of Bergen, Dr Einar Martens Res Grp Biol Psychiat, Ctr Med Genet & Mol Med
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  • Dena G. Hernandez, Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol
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  • Dirk J. Heslenfeld, German Ctr Neurodegenerat Dis DZNE, German Center for Neurodegenerative Diseases (DZNE), Eberhard Karls University of Tubingen, Helmholtz Association
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  • Beng-Choon Ho, Vrije Univ Amsterdam, Vrije Universiteit Amsterdam, Dept Psychol
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  • Pieter J. Hoekstra, Univ Groningen, University of Groningen, Univ Med Ctr Groningen, Dept Psychiat
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  • Wolfgang Hoffmann, Univ Oxford, University of Oxford, FMRIB Ctr
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  • Albert Hofman, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol
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  • Florian Holsboer, Univ Iowa, University of Iowa, Dept Psychiat
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  • Georg Homuth, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol
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  • Norbert Hosten, Osaka Univ, Osaka University, Mol Res Ctr Childrens Mental Dev, United Grad Sch Child Dev
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  • Jouke-Jan Hottenga, Vrije Universiteit Amsterdam
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  • Matthew Huentelman, HMNC Brain Hlth
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  • Hilleke E. Hulshoff Pol, UMC Utrecht, Utrecht University, Utrecht University Medical Center, Brain Ctr Rudolf Magnus, Dept Psychiat
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  • Masashi Ikeda, Univ Med Greifswald, Interfac Inst Genet & Funct Genom
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  • Clifford R. Jack, Translat Genom Res Inst, Translational Genomics Research Institute, Neurogen Div
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  • Mark Jenkinson, Univ Mississippi, University of Mississippi, University of Mississippi Medical Center, Med Ctr, Div Med Genet, Dept Pediat
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  • Robert Johnson, Fujita Hlth Univ, Fujita Health University, Sch Med, Dept Psychiat
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  • Erik G. Joensson, Biospective Inc
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  • J. Wouter Jukema, Leiden Univ, Leiden University, Med Ctr, Dept Cardiol
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  • Rene S. Kahn, UMC Utrecht, Utrecht University, Utrecht University Medical Center, Brain Ctr Rudolf Magnus, Dept Psychiat
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  • Ryota Kanai, Univ Sussex, University of Sussex, Sch Psychol
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  • Iwona Kloszewska, UCL, University of London, University College London, Inst Cognit Neurosci
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  • M. Arfan Ikram, NIA, National Institutes of Health (NIH) - USA, NIH National Institute on Aging (NIA), Intramural Res Program, NIH

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Original languageEnglish
Article number13624
JournalNature Communications
Volume8
Number of pages12
ISSN2041-1723
DOIs
Publication statusPublished - 18 Jan 2017

    Research areas

  • GENOME-WIDE ASSOCIATION, TEMPORAL-LOBE EPILEPSY, SUSCEPTIBILITY LOCI, ALZHEIMERS-DISEASE, BIPOLAR DISORDER, COMMON VARIANTS, BRAIN-REGIONS, MEMORY, SUBFIELDS, METAANALYSIS

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