Manuel Mattheisen

Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Ming Li
  • ,
  • Yi Wang
  • ,
  • Xue-bin Zheng
  • ,
  • Masashi Ikeda
  • ,
  • Nakao Iwata
  • ,
  • Xiong-jian Luo
  • ,
  • Siow-Ann Chong
  • ,
  • Jimmy Lee
  • ,
  • Marcella Rietschel
  • ,
  • Fengyu Zhang
  • ,
  • Bertram Müller-Myhsok
  • ,
  • Sven Cichon
  • ,
  • Daniel R Weinberger
  • ,
  • Manuel Mattheisen
  • Thomas G Schulze
  • ,
  • Nicholas G Martin
  • ,
  • Philip B Mitchell
  • ,
  • Peter R Schofield
  • ,
  • Jian-jun Liu
  • ,
  • Bing Su
  • ,
  • MooDS Consortium
Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
Original languageEnglish
JournalSchizophrenia research
Volume142
Issue1-3
Pages (from-to)200-5
Number of pages6
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

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