Manuel Mattheisen

Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Johannes Dietter
  • ,
  • Manuel Mattheisen
  • Robert Fürst
  • ,
  • Franz Rüschendorf
  • ,
  • Thomas F Wienker
  • ,
  • Konstantin Strauch
Sex-specific marker maps have become increasingly available. We have implemented the usage of sex-specific recombination frequencies in the GENEHUNTER-MODSCORE program that performs multipoint linkage analysis. Furthermore, we have devised a consistent method to choose the combinations of male and female genetic positions at which linkage scores should be calculated. Marker coordinates can be read automatically from publicly available genetic maps.
Original languageEnglish
JournalBioinformatics (Online)
Volume23
Issue1
Pages (from-to)64-70
Number of pages7
ISSN1367-4811
DOIs
Publication statusPublished - 1 Jan 2007

    Research areas

  • Algorithms, Chromosome Mapping, Computer Simulation, Female, Gene Frequency, Humans, Lod Score, Male, Models, Genetic, Pedigree, Polymorphism, Single Nucleotide, Recombination, Genetic, Sex Factors, Software

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