Manuel Mattheisen

Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Susanne Erk
  • ,
  • Andreas Meyer-Lindenberg
  • ,
  • Carola Opitz von Boberfeld
  • ,
  • Christine Esslinger
  • ,
  • Knut Schnell
  • ,
  • Peter Kirsch
  • ,
  • Manuel Mattheisen
  • Thomas W Mühleisen
  • ,
  • Sven Cichon
  • ,
  • Stephanie H Witt
  • ,
  • Marcella Rietschel
  • ,
  • Markus M Nöthen
  • ,
  • Henrik Walter
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.
Original languageEnglish
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Pages (from-to)18180-4
Number of pages5
Publication statusPublished - 7 Dec 2011
Externally publishedYes

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