Manuel Mattheisen

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Elisabeth Mangold
  • ,
  • Kerstin U Ludwig
  • ,
  • Stefanie Birnbaum
  • ,
  • Carlotta Baluardo
  • ,
  • Melissa Ferrian
  • ,
  • Stefan Herms
  • ,
  • Heiko Reutter
  • ,
  • Nilma Almeida de Assis
  • ,
  • Taofik Al Chawa
  • ,
  • Manuel Mattheisen
  • Michael Steffens
  • ,
  • Sandra Barth
  • ,
  • Nadine Kluck
  • ,
  • Anna Paul
  • ,
  • Jessica Becker
  • ,
  • Carola Lauster
  • ,
  • Gül Schmidt
  • ,
  • Bert Braumann
  • ,
  • Martin Scheer
  • ,
  • Rudolf H Reich
  • ,
  • Alexander Hemprich
  • ,
  • Simone Pötzsch
  • ,
  • Bettina Blaumeiser
  • ,
  • Susanne Moebus
  • ,
  • Michael Krawczak
  • ,
  • Stefan Schreiber
  • ,
  • Thomas Meitinger
  • ,
  • Hans-Erich Wichmann
  • ,
  • Regine P Steegers-Theunissen
  • ,
  • Franz-Josef Kramer
  • ,
  • Sven Cichon
  • ,
  • Peter Propping
  • ,
  • Thomas F Wienker
  • ,
  • Kolja Michael Knapp, 2012 Institut for Lægemiddeldesign og Farmakologi, Denmark
  • Michele Rubini
  • ,
  • Peter A Mossey
  • ,
  • Per Hoffmann
  • ,
  • Markus M Nöthen
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).
Original languageEnglish
JournalNature Genetics
Volume42
Issue1
Pages (from-to)24-6
Number of pages3
ISSN1061-4036
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

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