Manuel Mattheisen

Genome-wide association data provide further support for an association between 5-HTTLPR and major depressive disorder

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Britta Haenisch
  • ,
  • Stefan Herms
  • ,
  • Manuel Mattheisen
  • Michael Steffens
  • ,
  • Rene Breuer
  • ,
  • Jana Strohmaier
  • ,
  • Franziska Degenhardt
  • ,
  • Christine Schmäl
  • ,
  • Susanne Lucae
  • ,
  • Wolfgang Maier
  • ,
  • Marcella Rietschel
  • ,
  • Markus M Nöthen
  • ,
  • Sven Cichon
Dysfunctions of serotonergic neurotransmission are supposed to be involved in the pathogenesis of psychiatric disorders such as major depressive disorder (MDD). The concentration of serotonin (5-hydroxytryptamine, 5-HT) in the synaptic cleft is essentially regulated by the 5-HT transporter (5-HTT). A length polymorphism repeat in the 5-HTT promoter region, termed 5-HTTLPR, has been commonly investigated for an association with psychiatric disorders.
Original languageEnglish
JournalJournal of Affective Disorders
Volume146
Issue3
Pages (from-to)438-40
Number of pages3
ISSN0165-0327
DOIs
Publication statusPublished - 25 Apr 2013
Externally publishedYes

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