Manuel Mattheisen

Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Mira M Wouters
  • ,
  • Diether Lambrechts
  • ,
  • Jessica Becker
  • ,
  • Isabelle Cleynen
  • ,
  • Jan Tack
  • ,
  • Ana G Vigo
  • ,
  • Antonio Ruiz de León
  • ,
  • Elena Urcelay
  • ,
  • Julio Pérez de la Serna
  • ,
  • Wout Rohof
  • ,
  • Vito Annese
  • ,
  • Anna Latiano
  • ,
  • Orazio Palmieri
  • ,
  • Manuel Mattheisen
  • Michaela Mueller
  • ,
  • Hauke Lang
  • ,
  • Uberto Fumagalli
  • ,
  • Luigi Laghi
  • ,
  • Giovanni Zaninotto
  • ,
  • Rosario Cuomo
  • ,
  • Giovanni Sarnelli
  • ,
  • Markus M Nöthen
  • ,
  • Séverine Vermeire
  • ,
  • Kolja Michael Knapp, 2012 Institut for Lægemiddeldesign og Farmakologi, Denmark
  • Ines Gockel
  • ,
  • Johannes Schumacher, 2012 Afd. for Skovdrift og Træprodukter, Denmark
  • Guy E Boeckxstaens
Idiopathic achalasia is a rare motor disorder of the oesophagus characterised by neuronal loss at the lower oesophageal sphincter. Achalasia is generally accepted as a multifactorial disorder with various genetic and environmental factors being risk-associated. Since genetic factors predisposing to achalasia have been poorly documented, we assessed whether single nucleotide polymorphisms (SNPs) in genes mediating immune response and neuronal function contribute to achalasia susceptibility.
Original languageEnglish
JournalGut
ISSN0017-5749
DOIs
Publication statusPublished - 20 Nov 2013

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