Department of Economics and Business Economics

Manuel Mattheisen

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. / Project MinE GWAS Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium.

In: Nature Communications, Vol. 8, 21.03.2017, p. 14774.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2017, 'Genetic correlation between amyotrophic lateral sclerosis and schizophrenia', Nature Communications, vol. 8, pp. 14774. https://doi.org/10.1038/ncomms14774

APA

Project MinE GWAS Consortium, & Schizophrenia Working Group of the Psychiatric Genomics Consortium (2017). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications, 8, 14774. https://doi.org/10.1038/ncomms14774

CBE

Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium. 2017. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications. 8:14774. https://doi.org/10.1038/ncomms14774

MLA

Project MinE GWAS Consortium and Schizophrenia Working Group of the Psychiatric Genomics Consortium. "Genetic correlation between amyotrophic lateral sclerosis and schizophrenia". Nature Communications. 2017, 8. 14774. https://doi.org/10.1038/ncomms14774

Vancouver

Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications. 2017 Mar 21;8:14774. https://doi.org/10.1038/ncomms14774

Author

Project MinE GWAS Consortium ; Schizophrenia Working Group of the Psychiatric Genomics Consortium. / Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. In: Nature Communications. 2017 ; Vol. 8. pp. 14774.

Bibtex

@article{f20e69cf949d43d1835957da0c20b420,
title = "Genetic correlation between amyotrophic lateral sclerosis and schizophrenia",
abstract = "We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.",
keywords = "Journal Article",
author = "McLaughlin, {Russell L} and Dick Schijven and {van Rheenen}, Wouter and {van Eijk}, {Kristel R} and Margaret O'Brien and Kahn, {Rene S} and Ophoff, {Roel A.} and An Goris and Bradley, {Daniel G} and Ammar Al-Chalabi and {van den Berg}, {Leonard H} and Luykx, {Jurjen J} and Orla Hardiman and Veldink, {Jan H} and {Project MinE GWAS Consortium} and {Schizophrenia Working Group of the Psychiatric Genomics Consortium} and Mortensen, {Preben Bo} and Ditte Demontis and Manuel Mattheisen and Anders B{\o}rglum",
year = "2017",
month = mar,
day = "21",
doi = "10.1038/ncomms14774",
language = "English",
volume = "8",
pages = "14774",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

AU - McLaughlin, Russell L

AU - Schijven, Dick

AU - van Rheenen, Wouter

AU - van Eijk, Kristel R

AU - O'Brien, Margaret

AU - Kahn, Rene S

AU - Ophoff, Roel A.

AU - Goris, An

AU - Bradley, Daniel G

AU - Al-Chalabi, Ammar

AU - van den Berg, Leonard H

AU - Luykx, Jurjen J

AU - Hardiman, Orla

AU - Veldink, Jan H

AU - Project MinE GWAS Consortium

AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium

AU - Mortensen, Preben Bo

AU - Demontis, Ditte

AU - Mattheisen, Manuel

AU - Børglum, Anders

PY - 2017/3/21

Y1 - 2017/3/21

N2 - We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

AB - We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

KW - Journal Article

U2 - 10.1038/ncomms14774

DO - 10.1038/ncomms14774

M3 - Journal article

C2 - 28322246

VL - 8

SP - 14774

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -