Manuel Mattheisen

Genetic architecture of subcortical brain structures in 38,851 individuals

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Claudia L. Satizabal, University of Texas Health Science Center at San Antonio, National Heart Lung and Blood Institute’s Framingham Heart Study, Boston University School of Medicine
  • ,
  • Hieab H.H. Adams, Erasmus University Medical Center
  • ,
  • Derrek P. Hibar, University of Southern California
  • ,
  • Charles C. White, Broad Institute, Columbia University
  • ,
  • Maria J. Knol, Erasmus University Medical Center
  • ,
  • Jason L. Stein, University of Southern California, The University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, United States
  • ,
  • Markus Scholz, Leipzig University
  • ,
  • Muralidharan Sargurupremraj, Universite de Bordeaux
  • ,
  • Neda Jahanshad, University of Southern California
  • ,
  • Gennady V. Roshchupkin, Erasmus University Medical Center
  • ,
  • Albert V. Smith, University of Michigan School of Public Health, University of Iceland, Icelandic Heart Association
  • ,
  • Joshua C. Bis, University of Washington, Seattle
  • ,
  • Xueqiu Jian, McGovern Medical School at University of Texas Health Sciences Center at Houston
  • ,
  • Michelle Luciano, Edinburgh University
  • ,
  • Edith Hofer, Medical University of Graz
  • ,
  • Alexander Teumer, University Medicine Greifswald
  • ,
  • Sven J. van der Lee, Erasmus University Medical Center
  • ,
  • Jingyun Yang, Rush University
  • ,
  • Lisa R. Yanek, Johns Hopkins University
  • ,
  • Tom V. Lee, Baylor College of Medicine
  • ,
  • Shuo Li, Boston University School of Public Health
  • ,
  • Yanhui Hu, Harvard Medical School
  • ,
  • Jia Yu Koh, Singapore National Eye Center
  • ,
  • John D. Eicher, National Heart Lung and Blood Institute’s Framingham Heart Study
  • ,
  • Sylvane Desrivières, King's College London
  • ,
  • Alejandro Arias-Vasquez, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Ganesh Chauhan, Universite de Bordeaux, Indian Institute of Science
  • ,
  • Lavinia Athanasiu, University of Oslo, Universitetet i Oslo
  • ,
  • Miguel E. Rentería, QIMR Berghofer Medical Research Institute
  • ,
  • Sungeun Kim, Indiana University School of Medicine Indianapolis
  • ,
  • David Hoehn, Max Planck Institute of Psychiatry
  • ,
  • Nicola J. Armstrong, Murdoch University
  • ,
  • Qiang Chen, Lieber Institute for Brain Development
  • ,
  • Avram J. Holmes, Yale University, Massachusetts General Hospital, Boston
  • ,
  • Anouk den Braber, Vrije Universiteit Amsterdam, VU University Medical Center, Alzheimer Centre
  • ,
  • Iwona Kloszewska, Medical University of Lódz
  • ,
  • Micael Andersson, Clinical Sciences, Umea universitet, Klinisk vetenskap.
  • ,
  • Thomas Espeseth, University of Oslo, Universitetet i Oslo
  • ,
  • Oliver Grimm, University Medical Centre Mannheim
  • ,
  • Lucija Abramovic, Utrecht University
  • ,
  • Saud Alhusaini, Royal College of Surg. in Ireland, Yale School of Medicine
  • ,
  • Yuri Milaneschi, Vrije Universiteit Amsterdam
  • ,
  • Martina Papmeyer, Edinburgh University, University Hospital of Bern
  • ,
  • Tomas Axelsson, Uppsala University
  • ,
  • Stefan Ehrlich, Massachusetts General Hospital, Boston, Technische Universität Dresden
  • ,
  • Roberto Roiz-Santiañez, Hospital Universitario Marques de Valdecilla, Centro Investigación Biomédica en Red Salud Mental
  • ,
  • Bernd Kraemer, Universität Heidelberg
  • ,
  • Asta K. Håberg, Norwegian University of Science and Technology, St Olavs Hospital, Trondheim University Hospital
  • ,
  • Hannah J. Jones, University of Bristol, Faculty of Medicine and Dentistry, Bristol University
  • ,
  • G. Bruce Pike, University of Calgary
  • ,
  • Dan J. Stein, University of Cape Town, South African Medical Research Council
  • ,
  • Allison Stevens, Massachusetts General Hospital, Boston
  • ,
  • Janita Bralten, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Meike W. Vernooij, Erasmus University Medical Center
  • ,
  • Tamara B. Harris, National Institute on Aging
  • ,
  • Irina Filippi, Universite Paris-Saclay
  • ,
  • A. Veronica Witte, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig University
  • ,
  • Tulio Guadalupe, International Max Planck Research School for Language Sciences, Max Planck Institute for Psycholinguistics
  • ,
  • Katharina Wittfeld, University Medicine Greifswald, German Center for Neurodegenerative Diseases
  • ,
  • Thomas H. Mosley, University of Mississippi
  • ,
  • James T. Becker, University of Pittsburgh
  • ,
  • Nhat Trung Doan, Universitetet i Oslo
  • ,
  • Saskia P. Hagenaars, Edinburgh University
  • ,
  • Yasaman Saba, Medical University of Graz
  • ,
  • Gabriel Cuellar-Partida, QIMR Berghofer Medical Research Institute
  • ,
  • Najaf Amin, Erasmus University Medical Center
  • ,
  • Saima Hilal, National University of Singapore
  • ,
  • Kwangsik Nho, Indiana University School of Medicine Indianapolis
  • ,
  • Nazanin Mirza-Schreiber, Max Planck Institute of Psychiatry, Helmholtz Zentrum München - German Research Center for Environmental Health
  • ,
  • Konstantinos Arfanakis, Rush University, Illinois Institute of Technology
  • ,
  • Diane M. Becker, Johns Hopkins University
  • ,
  • David Ames, University of Melbourne, Royal Melbourne Hospital
  • ,
  • Aaron L. Goldman, Lieber Institute for Brain Development
  • ,
  • Phil H. Lee, Massachusetts General Hospital, Boston, Harvard Medical School, Broad Institute
  • ,
  • Dorret I. Boomsma, Vrije Universiteit Amsterdam, University of Amsterdam
  • ,
  • Simon Lovestone, Oxford University, Oxford, UK., King's College London
  • ,
  • Sudheer Giddaluru, University of Bergen
  • ,
  • Stephanie Le Hellard, University of Bergen
  • ,
  • Manuel Mattheisen
  • Marc M. Bohlken, Utrecht University
  • ,
  • Dalia Kasperaviciute, UCL, Chalfont Centre for Epilepsy
  • ,
  • Lianne Schmaal, The University of Melbourne, Orygen
  • ,
  • Stephen M. Lawrie, Edinburgh University
  • ,
  • Ingrid Agartz, Universitetet i Oslo, Karolinska Institutet, Diakonhjemmet Hospital
  • ,
  • Esther Walton, Technische Universität Dresden, Bath University
  • ,
  • Diana Tordesillas-Gutierrez, Centro Investigación Biomédica en Red Salud Mental, Valdecilla Biomedical Research Institute IDIVAL
  • ,
  • Gareth E. Davies, Avera Health
  • ,
  • Jean Shin, The Hospital for Sick Children
  • ,
  • Jonathan C. Ipser, University of Cape Town
  • ,
  • Louis N. Vinke, Boston University
  • ,
  • Martine Hoogman, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Tianye Jia, King's College London
  • ,
  • Ralph Burkhardt, Leipzig University, University of Regensburg
  • ,
  • Marieke Klein, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Fabrice Crivello, Universite Bordeaux
  • ,
  • Deborah Janowitz, University Medicine Greifswald
  • ,
  • Owen Carmichael, Pennington Biomedical Research Center
  • ,
  • Unn K. Haukvik, University of Oslo, Universitetet i Oslo
  • ,
  • Benjamin S. Aribisala, Edinburgh University, Lagos State University Ojo, Lagos
  • ,
  • Helena Schmidt, Medical University of Graz
  • ,
  • Lachlan T. Strike, QIMR Berghofer Medical Research Institute, University of Queensland
  • ,
  • Ching Yu Cheng, Singapore National Eye Center, National University of Singapore
  • ,
  • Shannon L. Risacher, Indiana University School of Medicine Indianapolis
  • ,
  • Benno Pütz, Max Planck Institute of Psychiatry
  • ,
  • Debra A. Fleischman, Rush University
  • ,
  • Amelia A. Assareh, University of New South Wales
  • ,
  • Venkata S. Mattay, Lieber Institute for Brain Development, Johns Hopkins University
  • ,
  • Randy L. Buckner, Massachusetts General Hospital, Boston, Harvard University
  • ,
  • Patrizia Mecocci, University of Perugia
  • ,
  • Anders M. Dale, University of California, San Diego, Department of Cognitive Science, Department of Psychiatry
  • ,
  • Sven Cichon, University of Basel, University Hospital Bonn, Jülich Research Centre
  • ,
  • Marco P. Boks, Utrecht University
  • ,
  • Mar Matarin, UCL, University College London
  • ,
  • Brenda W.J.H. Penninx, Vrije Universiteit Amsterdam
  • ,
  • Vince D. Calhoun, University of New Mexico, The Mind Research Network, Georgia State University
  • ,
  • M. Mallar Chakravarty, McGill University
  • ,
  • Andre F. Marquand, Radboud University Nijmegen
  • ,
  • Christine Macare, King's College London
  • ,
  • Shahrzad Kharabian Masouleh, Max Planck Institute for Human Cognitive and Brain Sciences, Jülich Research Centre
  • ,
  • Jaap Oosterlaan, Vrije Universiteit Amsterdam, University of Amsterdam
  • ,
  • Philippe Amouyel, Université of Lille, INSERM, University Hospital of Lille, Institut Pasteur de Lille
  • ,
  • Katrin Hegenscheid, University Medicine Greifswald
  • ,
  • Jerome I. Rotter, University of California at Los Angeles
  • ,
  • Andrew J. Schork, Mental Health Center Sct. Hans, The Translational Genomics Research Institute
  • ,
  • David C.M. Liewald, Edinburgh University
  • ,
  • Greig I. de Zubicaray, Queensland University of Technology
  • ,
  • Tien Yin Wong, Singapore National Eye Center, Duke-NUS Medical School
  • ,
  • Li Shen, University of Pennsylvania
  • ,
  • Philipp G. Sämann, Max Planck Institute of Psychiatry
  • ,
  • Henry Brodaty, University of New South Wales, University of New South Wales (UNSW) Australia
  • ,
  • Joshua L. Roffman, Massachusetts General Hospital, Boston
  • ,
  • Eco J.C. de Geus, Vrije Universiteit Amsterdam, University of Amsterdam
  • ,
  • Magda Tsolaki, Aristotle University of Thessaloniki
  • ,
  • Susanne Erk, Free University of Berlin
  • ,
  • Kristel R. van Eijk, Utrecht University
  • ,
  • Gianpiero L. Cavalleri, Royal College of Surg. in Ireland
  • ,
  • Nic J.A. van der Wee, Department of Human Genetics, Leiden University Medical Center (LUMC).
  • ,
  • Andrew M. McIntosh, Edinburgh University
  • ,
  • Randy L. Gollub, Massachusetts General Hospital, Boston, Harvard Medical School
  • ,
  • Kazima B. Bulayeva, Dagestan State University
  • ,
  • Manon Bernard, The Hospital for Sick Children
  • ,
  • Jennifer S. Richards, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen, University of Groningen
  • ,
  • Jayandra J. Himali, National Heart Lung and Blood Institute’s Framingham Heart Study, Boston University School of Medicine, Boston University School of Public Health
  • ,
  • Markus Loeffler, Leipzig University
  • ,
  • Nanda Rommelse, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Wolfgang Hoffmann, German Center for Neurodegenerative Diseases, University Medicine Greifswald
  • ,
  • Lars T. Westlye, University of Oslo, Universitetet i Oslo
  • ,
  • Maria C. Valdés Hernández, Edinburgh University
  • ,
  • Narelle K. Hansell, QIMR Berghofer Medical Research Institute, University of Queensland
  • ,
  • Theo G.M. van Erp, University of California at Irvine
  • ,
  • Christiane Wolf, Julius-Maximilians-Universitat Wurzburg
  • ,
  • John B.J. Kwok, University of Sydney, Neuroscience Research Australia, University of New South Wales (UNSW) Australia
  • ,
  • Bruno Vellas, Universite de Toulouse
  • ,
  • Andreas Heinz, Charité – Universitätsmedizin Berlin
  • ,
  • Loes M. Olde Loohuis, University of California Los Angeles
  • ,
  • Norman Delanty, Royal College of Surg. in Ireland, Beaumont Hospital, Dublin
  • ,
  • Beng Choon Ho, University of Iowa
  • ,
  • Christopher R.K. Ching, University of Southern California, University of California Los Angeles
  • ,
  • Elena Shumskaya, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Baljeet Singh, University of California at Davis
  • ,
  • Albert Hofman, Erasmus University Medical Center, Harvard School of Public Health
  • ,
  • Dennis van der Meer, University of Oslo, Universitetet i Oslo, Maastricht University
  • ,
  • Georg Homuth, University Medicine Greifswald
  • ,
  • Bruce M. Psaty, University of Washington, Seattle, Kaiser Permanent Washington Health Research Institute
  • ,
  • Mark E. Bastin, Edinburgh University
  • ,
  • Grant W. Montgomery, University of Queensland
  • ,
  • Tatiana M. Foroud, Indiana University School of Medicine Indianapolis
  • ,
  • Simone Reppermund, University of New South Wales
  • ,
  • Jouke Jan Hottenga, Vrije Universiteit Amsterdam, University of Amsterdam
  • ,
  • Andrew Simmons, King's College London, Karolinska Institutet
  • ,
  • Andreas Meyer-Lindenberg, University Medical Centre Mannheim
  • ,
  • Wiepke Cahn, Utrecht University
  • ,
  • Christopher D. Whelan, University of Southern California, Royal College of Surg. in Ireland
  • ,
  • Marjolein M.J. van Donkelaar, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Qiong Yang, Boston University School of Public Health
  • ,
  • Norbert Hosten, University Medicine Greifswald
  • ,
  • Robert C. Green, Harvard Medical School, Harvard University
  • ,
  • Anbupalam Thalamuthu, University of New South Wales
  • ,
  • Sebastian Mohnke, Free University of Berlin
  • ,
  • Hilleke E. Hulshoff Pol, Utrecht University
  • ,
  • Honghuang Lin, National Heart Lung and Blood Institute’s Framingham Heart Study, Boston University School of Medicine
  • ,
  • Clifford R. Jack, Mayo Clinic Rochester, MN
  • ,
  • Peter R. Schofield, Neuroscience Research Australia, University of New South Wales (UNSW) Australia
  • ,
  • Thomas W. Mühleisen, Jülich Research Centre, University of Basel, Heinrich Heine University Düsseldorf
  • ,
  • Pauline Maillard, University of California at Davis
  • ,
  • Steven G. Potkin, University of California at Irvine
  • ,
  • Wei Wen, University of New South Wales
  • ,
  • Evan Fletcher, University of California at Davis
  • ,
  • Arthur W. Toga, University of Southern California
  • ,
  • Oliver Gruber, Universität Heidelberg
  • ,
  • Matthew Huentelman, The Translational Genomics Research Institute
  • ,
  • George Davey Smith, University of Bristol, Faculty of Medicine and Dentistry
  • ,
  • Lenore J. Launer, National Institute on Aging
  • ,
  • Lars Nyberg, Clinical Sciences, Umea universitet, Klinisk vetenskap.
  • ,
  • Erik G. Jönsson, Universitetet i Oslo, Karolinska Institutet
  • ,
  • Benedicto Crespo-Facorro, Hospital Universitario Marques de Valdecilla, Centro Investigación Biomédica en Red Salud Mental
  • ,
  • Nastassja Koen, University of Cape Town, South African Medical Research Council
  • ,
  • Douglas N. Greve, Massachusetts General Hospital, Boston
  • ,
  • André G. Uitterlinden, Erasmus University Medical Center
  • ,
  • Daniel R. Weinberger, Lieber Institute for Brain Development, Johns Hopkins University
  • ,
  • Vidar M. Steen, University of Bergen
  • ,
  • Iryna O. Fedko, Vrije Universiteit Amsterdam, University of Amsterdam
  • ,
  • Nynke A. Groenewold, University of Cape Town
  • ,
  • Wiro J. Niessen, Erasmus University Medical Center, Delft University of Technology
  • ,
  • Roberto Toro, Institut Pasteur Paris
  • ,
  • Christophe Tzourio, CHU Hôpitaux de Bordeaux
  • ,
  • William T. Longstreth, University of Washington, Seattle
  • ,
  • M. Kamran Ikram, Erasmus University Medical Center
  • ,
  • Jordan W. Smoller, Massachusetts General Hospital, Boston, Harvard Medical School, Broad Institute
  • ,
  • Marie Jose van Tol, University of Groningen
  • ,
  • Jessika E. Sussmann, Edinburgh University
  • ,
  • Tomas Paus, University of Toronto
  • ,
  • Hervé Lemaître, Universite Paris-Saclay
  • ,
  • Matthias L. Schroeter, Leipzig University, Max Planck Institute for Human Cognitive and Brain Sciences, University Hospital Leipzig
  • ,
  • Bernard Mazoyer, Universite Bordeaux
  • ,
  • Ole A. Andreassen, University of Oslo, Universitetet i Oslo
  • ,
  • Florian Holsboer, Max Planck Institute of Psychiatry, HMNC Brain Health
  • ,
  • Chantal Depondt, Université Libre de Bruxelles
  • ,
  • Dick J. Veltman, Vrije Universiteit Amsterdam
  • ,
  • Jessica A. Turner, The Mind Research Network, Georgia State University
  • ,
  • Zdenka Pausova, The Hospital for Sick Children
  • ,
  • Gunter Schumann, King's College London
  • ,
  • Daan van Rooij, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen, University of Groningen
  • ,
  • Srdjan Djurovic, University of Bergen, University of Oslo
  • ,
  • Ian J. Deary, Edinburgh University
  • ,
  • Katie L. McMahon, Queensland University of Technology
  • ,
  • Bertram Müller-Myhsok, Max Planck Institute of Psychiatry, Munich Cluster for Systems Neurology (SyNergy), University of Liverpool
  • ,
  • Rachel M. Brouwer, Utrecht University
  • ,
  • Hilkka Soininen, University of Eastern Finland
  • ,
  • Massimo Pandolfo, Université Libre de Bruxelles
  • ,
  • Thomas H. Wassink, University of Iowa
  • ,
  • Joshua W. Cheung, University of Southern California
  • ,
  • Thomas Wolfers, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Jean Luc Martinot, Universite Paris-Saclay
  • ,
  • Marcel P. Zwiers, Radboud University Nijmegen
  • ,
  • Matthias Nauck, University Medicine Greifswald, German Center for Cardiovascular Research (partner site Greifswald)
  • ,
  • Ingrid Melle, University of Oslo, Universitetet i Oslo
  • ,
  • Nicholas G. Martin, QIMR Berghofer Medical Research Institute
  • ,
  • Ryota Kanai, Department of Neuroinformatics, Araya Brain Imaging, Tokyo, Araya Brain Imaging, Dept Neuroinformat, University College London, Sussex University
  • ,
  • Eric Westman, Karolinska Institutet
  • ,
  • René S. Kahn, Utrecht University, Icahn School of Medicine at Mount Sinai
  • ,
  • Sanjay M. Sisodiya, UCL, Chalfont Centre for Epilepsy
  • ,
  • Tonya White, Erasmus University Medical Center, Erasmus University Rotterdam
  • ,
  • Arvin Saremi, University of Southern California
  • ,
  • Hans van Bokhoven, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Han G. Brunner, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen, University Medical Centre Maastricht, GROW School of Oncology and Developmental Biology
  • ,
  • Henry Völzke, University Medicine Greifswald, German Center for Cardiovascular Research (partner site Greifswald)
  • ,
  • Margaret J. Wright, University of Queensland
  • ,
  • Dennis van ‘t Ent, Vrije Universiteit Amsterdam, University of Amsterdam
  • ,
  • Markus M. Nöthen, University Hospital Bonn, University of Bonn
  • ,
  • Roel A. Ophoff, University of California Los Angeles, Erasmus University Medical Center
  • ,
  • Jan K. Buitelaar, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Guillén Fernández, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • Perminder S. Sachdev, University of New South Wales, Prince of Wales Hospital
  • ,
  • Marcella Rietschel, University Medical Centre Mannheim
  • ,
  • Neeltje E.M. van Haren, Utrecht University, Erasmus University Rotterdam
  • ,
  • Simon E. Fisher, Radboud University Nijmegen, Max Planck Institute for Psycholinguistics
  • ,
  • Alexa S. Beiser, National Heart Lung and Blood Institute’s Framingham Heart Study, Boston University School of Medicine, Boston University School of Public Health
  • ,
  • Clyde Francks, Radboud University Nijmegen, Max Planck Institute for Psycholinguistics
  • ,
  • Andrew J. Saykin, Indiana University School of Medicine Indianapolis
  • ,
  • Karen A. Mather, University of New South Wales, Neuroscience Research Australia
  • ,
  • Nina Romanczuk-Seiferth, Charité – Universitätsmedizin Berlin
  • ,
  • Catharina A. Hartman, University of Groningen
  • ,
  • Anita L. DeStefano, National Heart Lung and Blood Institute’s Framingham Heart Study, Boston University School of Public Health
  • ,
  • Dirk J. Heslenfeld, Vrije Universiteit Amsterdam
  • ,
  • Michael W. Weiner, University of California, San Francisco
  • ,
  • Henrik Walter, Free University of Berlin
  • ,
  • Pieter J. Hoekstra, University of Groningen
  • ,
  • Paul A. Nyquist, Johns Hopkins University
  • ,
  • Barbara Franke, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen
  • ,
  • David A. Bennett, Rush University
  • ,
  • Hans J. Grabe, University Medicine Greifswald, German Center for Neurodegenerative Diseases
  • ,
  • Andrew D. Johnson, National Heart Lung and Blood Institute’s Framingham Heart Study
  • ,
  • Christopher Chen, National University of Singapore
  • ,
  • Cornelia M. van Duijn, Erasmus University Medical Center, Leiden University
  • ,
  • Oscar L. Lopez, University of Pittsburgh
  • ,
  • Myriam Fornage, McGovern Medical School at University of Texas Health Sciences Center at Houston
  • ,
  • Joanna M. Wardlaw, Edinburgh University
  • ,
  • Reinhold Schmidt, Medical University of Graz
  • ,
  • Charles DeCarli, University of California at Davis
  • ,
  • Philip L. De Jager, Broad Institute, Columbia University
  • ,
  • Arno Villringer, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig University
  • ,
  • Stéphanie Debette, Boston University School of Medicine, Universite de Bordeaux, CHU Hôpitaux de Bordeaux
  • ,
  • Vilmundur Gudnason, University of Iceland, Icelandic Heart Association
  • ,
  • Sarah E. Medland, QIMR Berghofer Medical Research Institute
  • ,
  • Joshua M. Shulman, Baylor College of Medicine
  • ,
  • Paul M. Thompson, University of Southern California
  • ,
  • Sudha Seshadri, National Heart Lung and Blood Institute’s Framingham Heart Study, Boston University School of Medicine
  • ,
  • M. Arfan Ikram, Erasmus University Medical Center

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

Original languageEnglish
JournalNature Genetics
Volume51
Issue11
Pages (from-to)1624-1636
Number of pages13
ISSN1061-4036
DOIs
Publication statusPublished - 2019

See relations at Aarhus University Citationformats

ID: 171582931