Manuel Mattheisen

Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Kari M Ersland
  • ,
  • Andrea Christoforou
  • ,
  • Christine Stansberg
  • ,
  • Thomas Espeseth
  • ,
  • Manuel Mattheisen
  • Morten Mattingsdal
  • ,
  • Gudmundur A Hardarson
  • ,
  • Thomas Hansen
  • ,
  • Carla P D Fernandes
  • ,
  • Sudheer Giddaluru
  • ,
  • René Breuer
  • ,
  • Jana Strohmaier
  • ,
  • Srdjan Djurovic
  • ,
  • Markus M Nöthen
  • ,
  • Marcella Rietschel
  • ,
  • Astri J Lundervold
  • ,
  • Thomas Werge
  • ,
  • Sven Cichon
  • ,
  • Ole A Andreassen
  • ,
  • Ivar Reinvang
  • ,
  • Vidar M Steen
  • ,
  • Stephanie Le Hellard
Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive functioning and impairment. Recently, we reported on sets of regionally enriched genes in three different cortical areas (frontomedial, temporal and occipital cortices) of the adult rat brain. It has been suggested that genes preferentially, or specifically, expressed in one region or organ reflect functional specialisation. Employing a gene-based approach to the analysis, we used the regionally enriched cortical genes to mine a genome-wide association study (GWAS) of the Norwegian Cognitive NeuroGenetics (NCNG) sample of healthy adults for association to nine psychometric tests measures. In addition, we explored GWAS data sets for the serious psychiatric disorders schizophrenia (SCZ) (n = 3 samples) and bipolar affective disorder (BP) (n = 3 samples), to which cognitive impairment is linked.
Original languageEnglish
JournalP L o S One
Volume7
Issue2
Pages (from-to)e31687
ISSN1932-6203
DOIs
Publication statusPublished - 2012
Externally publishedYes

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