Manuel Mattheisen

GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THE AKR1C1 GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL EVIDENCE FOR THE IMPORTANCE OF NEUROSTEROIDS IN ANXIETY?

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Carina Quast, Max Planck Institute of Psychiatry, Munich, Germany.
  • ,
  • Andreas Reif
  • ,
  • Tanja Brückl
  • ,
  • Hildegard Pfister
  • ,
  • Heike Weber
  • ,
  • Manuel Mattheisen
  • Sven Cichon
  • ,
  • Thomas Lang
  • ,
  • Alfons Hamm
  • ,
  • Lydia Fehm
  • ,
  • Andreas Ströhle
  • ,
  • Volker Arolt
  • ,
  • Katharina Domschke
  • ,
  • Tilo Kircher
  • ,
  • Hans-Ulrich Wittchen
  • ,
  • Paul Pauli
  • ,
  • Alexander L Gerlach
  • ,
  • Georg W Alpers
  • ,
  • Jürgen Deckert
  • ,
  • Rainer Rupprecht
  • ,
  • Elisabeth B Binder
  • ,
  • Angelika Erhardt
Neurosteroids are synthesized both in brain and peripheral steroidogenic tissue from cholesterol or steroidal precursors. Neurosteroids have been shown to be implicated in neural proliferation, differentiation, and activity. Preclinical and clinical studies also suggest a modulatory role of neurosteroids in anxiety-related phenotypes. However, little is known about the contribution of genetic variants in genes relevant for the neurosteroidogenesis to anxiety disorders.
Original languageEnglish
JournalDepression and Anxiety
ISSN1091-4269
DOIs
Publication statusPublished - 3 Jan 2014

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