Manuel Mattheisen

Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network. / Mohnke, Sebastian; Erk, Susanne; Schnell, Knut; Schütz, Claudia; Romanczuk-Seiferth, Nina; Grimm, Oliver; Haddad, Leila; Pöhland, Lydia; Garbusow, Maria; Schmitgen, Mike M; Kirsch, Peter; Esslinger, Christine; Rietschel, Marcella; Witt, Stephanie H; Nöthen, Markus M; Cichon, Sven; Mattheisen, Manuel; Mühleisen, Thomas; Jensen, Jimmy; Schott, Björn H; Maier, Wolfgang; Heinz, Andreas; Meyer-Lindenberg, Andreas; Walter, Henrik.

In: Neuropsychopharmacology, 19.11.2013.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Mohnke, S, Erk, S, Schnell, K, Schütz, C, Romanczuk-Seiferth, N, Grimm, O, Haddad, L, Pöhland, L, Garbusow, M, Schmitgen, MM, Kirsch, P, Esslinger, C, Rietschel, M, Witt, SH, Nöthen, MM, Cichon, S, Mattheisen, M, Mühleisen, T, Jensen, J, Schott, BH, Maier, W, Heinz, A, Meyer-Lindenberg, A & Walter, H 2013, 'Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network', Neuropsychopharmacology. https://doi.org/10.1038/npp.2013.321

APA

Mohnke, S., Erk, S., Schnell, K., Schütz, C., Romanczuk-Seiferth, N., Grimm, O., Haddad, L., Pöhland, L., Garbusow, M., Schmitgen, M. M., Kirsch, P., Esslinger, C., Rietschel, M., Witt, S. H., Nöthen, M. M., Cichon, S., Mattheisen, M., Mühleisen, T., Jensen, J., ... Walter, H. (2013). Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network. Neuropsychopharmacology. https://doi.org/10.1038/npp.2013.321

CBE

Mohnke S, Erk S, Schnell K, Schütz C, Romanczuk-Seiferth N, Grimm O, Haddad L, Pöhland L, Garbusow M, Schmitgen MM, Kirsch P, Esslinger C, Rietschel M, Witt SH, Nöthen MM, Cichon S, Mattheisen M, Mühleisen T, Jensen J, Schott BH, Maier W, Heinz A, Meyer-Lindenberg A, Walter H. 2013. Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network. Neuropsychopharmacology. https://doi.org/10.1038/npp.2013.321

MLA

Vancouver

Mohnke S, Erk S, Schnell K, Schütz C, Romanczuk-Seiferth N, Grimm O et al. Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network. Neuropsychopharmacology. 2013 Nov 19. https://doi.org/10.1038/npp.2013.321

Author

Mohnke, Sebastian ; Erk, Susanne ; Schnell, Knut ; Schütz, Claudia ; Romanczuk-Seiferth, Nina ; Grimm, Oliver ; Haddad, Leila ; Pöhland, Lydia ; Garbusow, Maria ; Schmitgen, Mike M ; Kirsch, Peter ; Esslinger, Christine ; Rietschel, Marcella ; Witt, Stephanie H ; Nöthen, Markus M ; Cichon, Sven ; Mattheisen, Manuel ; Mühleisen, Thomas ; Jensen, Jimmy ; Schott, Björn H ; Maier, Wolfgang ; Heinz, Andreas ; Meyer-Lindenberg, Andreas ; Walter, Henrik. / Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network. In: Neuropsychopharmacology. 2013.

Bibtex

@article{76a58cbb0cef4aa08f0cc57cf33e1760,
title = "Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network",
abstract = "The single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A is one of the best-supported risk variants for psychosis. We hypothesized that this SNP contributes to the development of schizophrenia by affecting the ability to understand other people's mental states. This skill, commonly referred to as Theory of Mind (ToM), has consistently been found to be impaired in schizophrenia. Using functional magnetic resonance imaging, we previously showed that in healthy individuals rs1344706 impacted on activity and connectivity of key areas of the ToM network, including the dorsomedial prefrontal cortex, temporo-parietal junction, and the posterior cingulate cortex, which show aberrant activity in schizophrenia patients, too. We aimed to replicate these results in an independent sample of 188 healthy German volunteers. In order to assess the reliability of brain activity elicited by the ToM task, 25 participants performed the task twice with an interval of 14 days showing excellent accordance in recruitment of key ToM areas. Confirming our previous results, we observed decreasing activity of the left temporo-parietal junction, dorsomedial prefrontal cortex, and the posterior cingulate cortex with increasing number of risk alleles during ToM. Complementing our replication sample with the discovery sample, analyzed in a previous report (total N=297), further revealed negative genotype effects in the left dorsomedial prefrontal cortex as well as in the temporal and parietal regions. In addition, as shown previously, rs1344706 risk allele dose positively predicted increased frontal-temporo-parietal connectivity. These findings confirm the effects of the psychosis risk variant in ZNF804A on the dysfunction of the ToM network.Neuropsychopharmacology advance online publication, 11 December 2013; doi:10.1038/npp.2013.321.",
author = "Sebastian Mohnke and Susanne Erk and Knut Schnell and Claudia Sch{\"u}tz and Nina Romanczuk-Seiferth and Oliver Grimm and Leila Haddad and Lydia P{\"o}hland and Maria Garbusow and Schmitgen, {Mike M} and Peter Kirsch and Christine Esslinger and Marcella Rietschel and Witt, {Stephanie H} and N{\"o}then, {Markus M} and Sven Cichon and Manuel Mattheisen and Thomas M{\"u}hleisen and Jimmy Jensen and Schott, {Bj{\"o}rn H} and Wolfgang Maier and Andreas Heinz and Andreas Meyer-Lindenberg and Henrik Walter",
year = "2013",
month = nov,
day = "19",
doi = "10.1038/npp.2013.321",
language = "English",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network

AU - Mohnke, Sebastian

AU - Erk, Susanne

AU - Schnell, Knut

AU - Schütz, Claudia

AU - Romanczuk-Seiferth, Nina

AU - Grimm, Oliver

AU - Haddad, Leila

AU - Pöhland, Lydia

AU - Garbusow, Maria

AU - Schmitgen, Mike M

AU - Kirsch, Peter

AU - Esslinger, Christine

AU - Rietschel, Marcella

AU - Witt, Stephanie H

AU - Nöthen, Markus M

AU - Cichon, Sven

AU - Mattheisen, Manuel

AU - Mühleisen, Thomas

AU - Jensen, Jimmy

AU - Schott, Björn H

AU - Maier, Wolfgang

AU - Heinz, Andreas

AU - Meyer-Lindenberg, Andreas

AU - Walter, Henrik

PY - 2013/11/19

Y1 - 2013/11/19

N2 - The single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A is one of the best-supported risk variants for psychosis. We hypothesized that this SNP contributes to the development of schizophrenia by affecting the ability to understand other people's mental states. This skill, commonly referred to as Theory of Mind (ToM), has consistently been found to be impaired in schizophrenia. Using functional magnetic resonance imaging, we previously showed that in healthy individuals rs1344706 impacted on activity and connectivity of key areas of the ToM network, including the dorsomedial prefrontal cortex, temporo-parietal junction, and the posterior cingulate cortex, which show aberrant activity in schizophrenia patients, too. We aimed to replicate these results in an independent sample of 188 healthy German volunteers. In order to assess the reliability of brain activity elicited by the ToM task, 25 participants performed the task twice with an interval of 14 days showing excellent accordance in recruitment of key ToM areas. Confirming our previous results, we observed decreasing activity of the left temporo-parietal junction, dorsomedial prefrontal cortex, and the posterior cingulate cortex with increasing number of risk alleles during ToM. Complementing our replication sample with the discovery sample, analyzed in a previous report (total N=297), further revealed negative genotype effects in the left dorsomedial prefrontal cortex as well as in the temporal and parietal regions. In addition, as shown previously, rs1344706 risk allele dose positively predicted increased frontal-temporo-parietal connectivity. These findings confirm the effects of the psychosis risk variant in ZNF804A on the dysfunction of the ToM network.Neuropsychopharmacology advance online publication, 11 December 2013; doi:10.1038/npp.2013.321.

AB - The single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A is one of the best-supported risk variants for psychosis. We hypothesized that this SNP contributes to the development of schizophrenia by affecting the ability to understand other people's mental states. This skill, commonly referred to as Theory of Mind (ToM), has consistently been found to be impaired in schizophrenia. Using functional magnetic resonance imaging, we previously showed that in healthy individuals rs1344706 impacted on activity and connectivity of key areas of the ToM network, including the dorsomedial prefrontal cortex, temporo-parietal junction, and the posterior cingulate cortex, which show aberrant activity in schizophrenia patients, too. We aimed to replicate these results in an independent sample of 188 healthy German volunteers. In order to assess the reliability of brain activity elicited by the ToM task, 25 participants performed the task twice with an interval of 14 days showing excellent accordance in recruitment of key ToM areas. Confirming our previous results, we observed decreasing activity of the left temporo-parietal junction, dorsomedial prefrontal cortex, and the posterior cingulate cortex with increasing number of risk alleles during ToM. Complementing our replication sample with the discovery sample, analyzed in a previous report (total N=297), further revealed negative genotype effects in the left dorsomedial prefrontal cortex as well as in the temporal and parietal regions. In addition, as shown previously, rs1344706 risk allele dose positively predicted increased frontal-temporo-parietal connectivity. These findings confirm the effects of the psychosis risk variant in ZNF804A on the dysfunction of the ToM network.Neuropsychopharmacology advance online publication, 11 December 2013; doi:10.1038/npp.2013.321.

U2 - 10.1038/npp.2013.321

DO - 10.1038/npp.2013.321

M3 - Journal article

C2 - 24247043

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

ER -