Manuel Mattheisen

Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support

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Standard

Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support. / Erk, S; Meyer-Lindenberg, A; Schmierer, P; Grimm, O; Tost, H; Mühleisen, T; Mattheisen, Manuel; Seiferth, N; Cichon, S; Rietschel, M; Nöthen, M M; Heinz, A; Walter, H.

In: Translational Psychiatry, Vol. 3, 2013, p. e287.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Erk, S, Meyer-Lindenberg, A, Schmierer, P, Grimm, O, Tost, H, Mühleisen, T, Mattheisen, M, Seiferth, N, Cichon, S, Rietschel, M, Nöthen, MM, Heinz, A & Walter, H 2013, 'Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support', Translational Psychiatry, vol. 3, pp. e287. https://doi.org/10.1038/tp.2013.57

APA

Erk, S., Meyer-Lindenberg, A., Schmierer, P., Grimm, O., Tost, H., Mühleisen, T., Mattheisen, M., Seiferth, N., Cichon, S., Rietschel, M., Nöthen, M. M., Heinz, A., & Walter, H. (2013). Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support. Translational Psychiatry, 3, e287. https://doi.org/10.1038/tp.2013.57

CBE

Erk S, Meyer-Lindenberg A, Schmierer P, Grimm O, Tost H, Mühleisen T, Mattheisen M, Seiferth N, Cichon S, Rietschel M, Nöthen MM, Heinz A, Walter H. 2013. Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support. Translational Psychiatry. 3:e287. https://doi.org/10.1038/tp.2013.57

MLA

Vancouver

Erk S, Meyer-Lindenberg A, Schmierer P, Grimm O, Tost H, Mühleisen T et al. Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support. Translational Psychiatry. 2013;3:e287. https://doi.org/10.1038/tp.2013.57

Author

Erk, S ; Meyer-Lindenberg, A ; Schmierer, P ; Grimm, O ; Tost, H ; Mühleisen, T ; Mattheisen, Manuel ; Seiferth, N ; Cichon, S ; Rietschel, M ; Nöthen, M M ; Heinz, A ; Walter, H. / Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support. In: Translational Psychiatry. 2013 ; Vol. 3. pp. e287.

Bibtex

@article{d241133e800b4497b9eeb4cc35454f17,
title = "Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support",
abstract = "In a large brain-imaging study, a multinational consortium has recently identified a common genetic variation in rs7294919 being associated with hippocampal volume. Here, we explored whether this quantitative trait locus also affects hippocampal function using a previously established reliable neuroimaging paradigm. We observed a significant effect of rs7294919 variation in the right hippocampus showing that hippocampal activation increased with the number of risk alleles. Furthermore, the risk allele was associated with decreased performance in a verbal learning and memory task. By showing that this single-nucleotide polymorphism also relates to behavioral difference and underlying brain activation in memory, our findings support the idea that rs7294919 may affect the individual capacity to resist disease in terms of diminishing or boosting hippocampal resources.",
author = "S Erk and A Meyer-Lindenberg and P Schmierer and O Grimm and H Tost and T M{\"u}hleisen and Manuel Mattheisen and N Seiferth and S Cichon and M Rietschel and N{\"o}then, {M M} and A Heinz and H Walter",
year = "2013",
doi = "10.1038/tp.2013.57",
language = "English",
volume = "3",
pages = "e287",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support

AU - Erk, S

AU - Meyer-Lindenberg, A

AU - Schmierer, P

AU - Grimm, O

AU - Tost, H

AU - Mühleisen, T

AU - Mattheisen, Manuel

AU - Seiferth, N

AU - Cichon, S

AU - Rietschel, M

AU - Nöthen, M M

AU - Heinz, A

AU - Walter, H

PY - 2013

Y1 - 2013

N2 - In a large brain-imaging study, a multinational consortium has recently identified a common genetic variation in rs7294919 being associated with hippocampal volume. Here, we explored whether this quantitative trait locus also affects hippocampal function using a previously established reliable neuroimaging paradigm. We observed a significant effect of rs7294919 variation in the right hippocampus showing that hippocampal activation increased with the number of risk alleles. Furthermore, the risk allele was associated with decreased performance in a verbal learning and memory task. By showing that this single-nucleotide polymorphism also relates to behavioral difference and underlying brain activation in memory, our findings support the idea that rs7294919 may affect the individual capacity to resist disease in terms of diminishing or boosting hippocampal resources.

AB - In a large brain-imaging study, a multinational consortium has recently identified a common genetic variation in rs7294919 being associated with hippocampal volume. Here, we explored whether this quantitative trait locus also affects hippocampal function using a previously established reliable neuroimaging paradigm. We observed a significant effect of rs7294919 variation in the right hippocampus showing that hippocampal activation increased with the number of risk alleles. Furthermore, the risk allele was associated with decreased performance in a verbal learning and memory task. By showing that this single-nucleotide polymorphism also relates to behavioral difference and underlying brain activation in memory, our findings support the idea that rs7294919 may affect the individual capacity to resist disease in terms of diminishing or boosting hippocampal resources.

U2 - 10.1038/tp.2013.57

DO - 10.1038/tp.2013.57

M3 - Journal article

C2 - 23880882

VL - 3

SP - e287

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

ER -