Manuel Mattheisen

Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene

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Standard

Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. / Luo, X-J; Li, Menxing; Huang, Liping; Steinberg, S; Mattheisen, Manuel; Liang, G; Donohoe, G; Shi, Y; Chen, Andrew C. N.; Yue, Wei; Alkelai, A; Lerer, B; Li, Z; Yi, Q; Rietschel, M; Cichon, S; Collier, D A; Tosato, S; Suvisaari, J; Rujescu, Dan; Golimbet, V; Silagadze, T; Durmishi, N; Milovancevic, M P; Stefansson, H; Schulze, T G; Nöthen, M M; Chen, Andrew C. N.; Lyne, R; Morris, D W; Gill, M; Corvin, A; Zhang, D; Dong, Q; Moyzis, R K; Stefansson, K; Sigurdsson, Eythor; Hu, F; Su, B; Gan, L; MooDS SCZ Consortium.

In: Molecular Psychiatry, 20.08.2013.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Luo, X-J, Li, M, Huang, L, Steinberg, S, Mattheisen, M, Liang, G, Donohoe, G, Shi, Y, Chen, ACN, Yue, W, Alkelai, A, Lerer, B, Li, Z, Yi, Q, Rietschel, M, Cichon, S, Collier, DA, Tosato, S, Suvisaari, J, Rujescu, D, Golimbet, V, Silagadze, T, Durmishi, N, Milovancevic, MP, Stefansson, H, Schulze, TG, Nöthen, MM, Chen, ACN, Lyne, R, Morris, DW, Gill, M, Corvin, A, Zhang, D, Dong, Q, Moyzis, RK, Stefansson, K, Sigurdsson, E, Hu, F, Su, B, Gan, L & MooDS SCZ Consortium 2013, 'Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene', Molecular Psychiatry. https://doi.org/10.1038/mp.2013.103

APA

Luo, X-J., Li, M., Huang, L., Steinberg, S., Mattheisen, M., Liang, G., Donohoe, G., Shi, Y., Chen, A. C. N., Yue, W., Alkelai, A., Lerer, B., Li, Z., Yi, Q., Rietschel, M., Cichon, S., Collier, D. A., Tosato, S., Suvisaari, J., ... MooDS SCZ Consortium (2013). Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. Molecular Psychiatry. https://doi.org/10.1038/mp.2013.103

CBE

Luo X-J, Li M, Huang L, Steinberg S, Mattheisen M, Liang G, Donohoe G, Shi Y, Chen ACN, Yue W, Alkelai A, Lerer B, Li Z, Yi Q, Rietschel M, Cichon S, Collier DA, Tosato S, Suvisaari J, Rujescu D, Golimbet V, Silagadze T, Durmishi N, Milovancevic MP, Stefansson H, Schulze TG, Nöthen MM, Chen ACN, Lyne R, Morris DW, Gill M, Corvin A, Zhang D, Dong Q, Moyzis RK, Stefansson K, Sigurdsson E, Hu F, Su B, Gan L, MooDS SCZ Consortium. 2013. Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. Molecular Psychiatry. https://doi.org/10.1038/mp.2013.103

MLA

Vancouver

Luo X-J, Li M, Huang L, Steinberg S, Mattheisen M, Liang G et al. Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. Molecular Psychiatry. 2013 Aug 20. https://doi.org/10.1038/mp.2013.103

Author

Luo, X-J ; Li, Menxing ; Huang, Liping ; Steinberg, S ; Mattheisen, Manuel ; Liang, G ; Donohoe, G ; Shi, Y ; Chen, Andrew C. N. ; Yue, Wei ; Alkelai, A ; Lerer, B ; Li, Z ; Yi, Q ; Rietschel, M ; Cichon, S ; Collier, D A ; Tosato, S ; Suvisaari, J ; Rujescu, Dan ; Golimbet, V ; Silagadze, T ; Durmishi, N ; Milovancevic, M P ; Stefansson, H ; Schulze, T G ; Nöthen, M M ; Chen, Andrew C. N. ; Lyne, R ; Morris, D W ; Gill, M ; Corvin, A ; Zhang, D ; Dong, Q ; Moyzis, R K ; Stefansson, K ; Sigurdsson, Eythor ; Hu, F ; Su, B ; Gan, L ; MooDS SCZ Consortium. / Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. In: Molecular Psychiatry. 2013.

Bibtex

@article{d5246bd84ad349c688377aa1b752bafc,
title = "Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene",
abstract = "Genes that are differentially expressed between schizophrenia patients and healthy controls may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale genome-wide expression studies, which examined changes in gene expression in schizophrenia patients and their matched controls. We found calcium/calmodulin (CAM)-dependent protein kinase kinase 2 (CAMKK2) is significantly downregulated in individuals with schizophrenia in both studies. To seek the potential genetic variants that may regulate the expression of CAMKK2, we investigated the association between single-nucleotide polymorphisms (SNPs) within CAMKK2 and the expression level of CAMKK2. We found one SNP, rs1063843, which is located in intron 17 of CAMKK2, is strongly associated with the expression level of CAMKK2 in human brains (P=1.1 × 10(-6)) and lymphoblastoid cell lines (the lowest P=8.4 × 10(-6)). We further investigated the association between rs1063843 and schizophrenia in multiple independent populations (a total of 130 623 subjects) and found rs1063843 is significantly associated with schizophrenia (P=5.17 × 10(-5)). Interestingly, we found the T allele of rs1063843, which is associated with lower expression level of CAMKK2, has a higher frequency in individuals with schizophrenia in all of the tested samples, suggesting rs1063843 may be a causal variant. We also found that rs1063843 is associated with cognitive function and personality in humans. In addition, protein-protein interaction (PPI) analysis revealed that CAMKK2 participates in a highly interconnected PPI network formed by top schizophrenia genes, which further supports the potential role of CAMKK2 in the pathogenesis of schizophrenia. Taken together, these converging lines of evidence strongly suggest that CAMKK2 may have pivotal roles in schizophrenia susceptibility.Molecular Psychiatry advance online publication, 20 August 2013; doi:10.1038/mp.2013.103.",
author = "X-J Luo and Menxing Li and Liping Huang and S Steinberg and Manuel Mattheisen and G Liang and G Donohoe and Y Shi and Chen, {Andrew C. N.} and Wei Yue and A Alkelai and B Lerer and Z Li and Q Yi and M Rietschel and S Cichon and Collier, {D A} and S Tosato and J Suvisaari and Dan Rujescu and V Golimbet and T Silagadze and N Durmishi and Milovancevic, {M P} and H Stefansson and Schulze, {T G} and N{\"o}then, {M M} and Chen, {Andrew C. N.} and R Lyne and Morris, {D W} and M Gill and A Corvin and D Zhang and Q Dong and Moyzis, {R K} and K Stefansson and Eythor Sigurdsson and F Hu and B Su and L Gan and {MooDS SCZ Consortium}",
year = "2013",
month = aug,
day = "20",
doi = "10.1038/mp.2013.103",
language = "English",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene

AU - Luo, X-J

AU - Li, Menxing

AU - Huang, Liping

AU - Steinberg, S

AU - Mattheisen, Manuel

AU - Liang, G

AU - Donohoe, G

AU - Shi, Y

AU - Chen, Andrew C. N.

AU - Yue, Wei

AU - Alkelai, A

AU - Lerer, B

AU - Li, Z

AU - Yi, Q

AU - Rietschel, M

AU - Cichon, S

AU - Collier, D A

AU - Tosato, S

AU - Suvisaari, J

AU - Rujescu, Dan

AU - Golimbet, V

AU - Silagadze, T

AU - Durmishi, N

AU - Milovancevic, M P

AU - Stefansson, H

AU - Schulze, T G

AU - Nöthen, M M

AU - Chen, Andrew C. N.

AU - Lyne, R

AU - Morris, D W

AU - Gill, M

AU - Corvin, A

AU - Zhang, D

AU - Dong, Q

AU - Moyzis, R K

AU - Stefansson, K

AU - Sigurdsson, Eythor

AU - Hu, F

AU - Su, B

AU - Gan, L

AU - MooDS SCZ Consortium

PY - 2013/8/20

Y1 - 2013/8/20

N2 - Genes that are differentially expressed between schizophrenia patients and healthy controls may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale genome-wide expression studies, which examined changes in gene expression in schizophrenia patients and their matched controls. We found calcium/calmodulin (CAM)-dependent protein kinase kinase 2 (CAMKK2) is significantly downregulated in individuals with schizophrenia in both studies. To seek the potential genetic variants that may regulate the expression of CAMKK2, we investigated the association between single-nucleotide polymorphisms (SNPs) within CAMKK2 and the expression level of CAMKK2. We found one SNP, rs1063843, which is located in intron 17 of CAMKK2, is strongly associated with the expression level of CAMKK2 in human brains (P=1.1 × 10(-6)) and lymphoblastoid cell lines (the lowest P=8.4 × 10(-6)). We further investigated the association between rs1063843 and schizophrenia in multiple independent populations (a total of 130 623 subjects) and found rs1063843 is significantly associated with schizophrenia (P=5.17 × 10(-5)). Interestingly, we found the T allele of rs1063843, which is associated with lower expression level of CAMKK2, has a higher frequency in individuals with schizophrenia in all of the tested samples, suggesting rs1063843 may be a causal variant. We also found that rs1063843 is associated with cognitive function and personality in humans. In addition, protein-protein interaction (PPI) analysis revealed that CAMKK2 participates in a highly interconnected PPI network formed by top schizophrenia genes, which further supports the potential role of CAMKK2 in the pathogenesis of schizophrenia. Taken together, these converging lines of evidence strongly suggest that CAMKK2 may have pivotal roles in schizophrenia susceptibility.Molecular Psychiatry advance online publication, 20 August 2013; doi:10.1038/mp.2013.103.

AB - Genes that are differentially expressed between schizophrenia patients and healthy controls may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale genome-wide expression studies, which examined changes in gene expression in schizophrenia patients and their matched controls. We found calcium/calmodulin (CAM)-dependent protein kinase kinase 2 (CAMKK2) is significantly downregulated in individuals with schizophrenia in both studies. To seek the potential genetic variants that may regulate the expression of CAMKK2, we investigated the association between single-nucleotide polymorphisms (SNPs) within CAMKK2 and the expression level of CAMKK2. We found one SNP, rs1063843, which is located in intron 17 of CAMKK2, is strongly associated with the expression level of CAMKK2 in human brains (P=1.1 × 10(-6)) and lymphoblastoid cell lines (the lowest P=8.4 × 10(-6)). We further investigated the association between rs1063843 and schizophrenia in multiple independent populations (a total of 130 623 subjects) and found rs1063843 is significantly associated with schizophrenia (P=5.17 × 10(-5)). Interestingly, we found the T allele of rs1063843, which is associated with lower expression level of CAMKK2, has a higher frequency in individuals with schizophrenia in all of the tested samples, suggesting rs1063843 may be a causal variant. We also found that rs1063843 is associated with cognitive function and personality in humans. In addition, protein-protein interaction (PPI) analysis revealed that CAMKK2 participates in a highly interconnected PPI network formed by top schizophrenia genes, which further supports the potential role of CAMKK2 in the pathogenesis of schizophrenia. Taken together, these converging lines of evidence strongly suggest that CAMKK2 may have pivotal roles in schizophrenia susceptibility.Molecular Psychiatry advance online publication, 20 August 2013; doi:10.1038/mp.2013.103.

U2 - 10.1038/mp.2013.103

DO - 10.1038/mp.2013.103

M3 - Journal article

C2 - 23958956

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -