Manuel Mattheisen

Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. / McDonald, Merry-Lynn Noelle; Won, Sungho; Mattheisen, Manuel; Castaldi, Peter J.; Cho, Michael H.; Rutten, Erica; Hardin, Megan; Yip, Wai-Ki; Rennard, Stephen I.; Lomas, David A.; Wouters, Emiel F. M.; Agusti, Alvar; Casaburi, Richard; Lange, Christoph P.; O'Connor, George; Hersh, Craig P.; Silverman, Edwin K.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 8, No. 3, 06.2017, p. 428-436.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

McDonald, M-LN, Won, S, Mattheisen, M, Castaldi, PJ, Cho, MH, Rutten, E, Hardin, M, Yip, W-K, Rennard, SI, Lomas, DA, Wouters, EFM, Agusti, A, Casaburi, R, Lange, CP, O'Connor, G, Hersh, CP & Silverman, EK 2017, 'Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1', Journal of Cachexia, Sarcopenia and Muscle, vol. 8, no. 3, pp. 428-436. https://doi.org/10.1002/jcsm.12171

APA

McDonald, M-L. N., Won, S., Mattheisen, M., Castaldi, P. J., Cho, M. H., Rutten, E., Hardin, M., Yip, W-K., Rennard, S. I., Lomas, D. A., Wouters, E. F. M., Agusti, A., Casaburi, R., Lange, C. P., O'Connor, G., Hersh, C. P., & Silverman, E. K. (2017). Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Journal of Cachexia, Sarcopenia and Muscle, 8(3), 428-436. https://doi.org/10.1002/jcsm.12171

CBE

McDonald M-LN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip W-K, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK. 2017. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Journal of Cachexia, Sarcopenia and Muscle. 8(3):428-436. https://doi.org/10.1002/jcsm.12171

MLA

Vancouver

McDonald M-LN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E et al. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Journal of Cachexia, Sarcopenia and Muscle. 2017 Jun;8(3):428-436. https://doi.org/10.1002/jcsm.12171

Author

McDonald, Merry-Lynn Noelle ; Won, Sungho ; Mattheisen, Manuel ; Castaldi, Peter J. ; Cho, Michael H. ; Rutten, Erica ; Hardin, Megan ; Yip, Wai-Ki ; Rennard, Stephen I. ; Lomas, David A. ; Wouters, Emiel F. M. ; Agusti, Alvar ; Casaburi, Richard ; Lange, Christoph P. ; O'Connor, George ; Hersh, Craig P. ; Silverman, Edwin K. / Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. In: Journal of Cachexia, Sarcopenia and Muscle. 2017 ; Vol. 8, No. 3. pp. 428-436.

Bibtex

@article{44c40ef4ea89489ca83b55c43ade6974,
title = "Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1",
abstract = "Background There have been a number of candidate gene association studies of cancer cachexia-related traits, but no genome-wide association study (GWAS) has been published to date. Cachexia presents in patients with a number of complex traits, including both cancer and COPD. The objective of the current investigation was to search for a shared genetic aetiology for change in body mass index (Delta BMI) among cancer and COPD by using GWAS data in the Framingham Heart Study.Methods A linear mixed effects model accounting for age, sex, and change in smoking status was used to calculate Delta BMI in participants over 40 years of age with three consecutive BMI time points (n = 4162). Four GWAS of Delta BMI using generalized estimating equations were performed among 1085 participants with a cancer diagnosis, 204 with gastrointestinal (GI) cancer, 112 with lung cancer, and 237 with COPD to test for association with 418 365 single-nucleotide polymorphisms (SNPs).Results Two SNPs reached a level of genome-wide significance (P <5x10(-8)) with Delta BMI: (i) rs41526344 within the CNTN4 gene, among COPD cases (beta = 0.13, P = 4.3x10(-8)); and (ii) rs4751240 in the gene Dedicator of Cytokinesis 1 (DOCK1) among GI cancer cases (beta = 0.10, P = 1.9x10(-8)). The DOCK1 SNP association replicated in the Delta BMI GWAS among COPD cases (beta(meta-analyis)= 0.10, Pmeta-analyis = 9.3x10(-10)). The DOCK1 gene codes for the dedicator of cytokinesis 1 protein, which has a role in myoblast fusion.Conclusions In sum, one statistically significant common variant in the DOCK1 gene was associated with Delta BMI in GI cancer and COPD cases providing support for at least partially shared aetiology of Delta BMI in complex diseases.",
keywords = "GWAS, COPD, Cancer, Longitudinal, BMI, Cachexia, FTO GENE, EXTREME OBESITY, MYOBLAST FUSION, ADULT OBESITY, CACHEXIA, VARIANTS, POLYMORPHISMS, POPULATION, CONTACTINS, CHILDHOOD",
author = "McDonald, {Merry-Lynn Noelle} and Sungho Won and Manuel Mattheisen and Castaldi, {Peter J.} and Cho, {Michael H.} and Erica Rutten and Megan Hardin and Wai-Ki Yip and Rennard, {Stephen I.} and Lomas, {David A.} and Wouters, {Emiel F. M.} and Alvar Agusti and Richard Casaburi and Lange, {Christoph P.} and George O'Connor and Hersh, {Craig P.} and Silverman, {Edwin K.}",
year = "2017",
month = jun,
doi = "10.1002/jcsm.12171",
language = "English",
volume = "8",
pages = "428--436",
journal = "Journal of Cachexia, Sarcopenia and Muscle",
issn = "2190-5991",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1

AU - McDonald, Merry-Lynn Noelle

AU - Won, Sungho

AU - Mattheisen, Manuel

AU - Castaldi, Peter J.

AU - Cho, Michael H.

AU - Rutten, Erica

AU - Hardin, Megan

AU - Yip, Wai-Ki

AU - Rennard, Stephen I.

AU - Lomas, David A.

AU - Wouters, Emiel F. M.

AU - Agusti, Alvar

AU - Casaburi, Richard

AU - Lange, Christoph P.

AU - O'Connor, George

AU - Hersh, Craig P.

AU - Silverman, Edwin K.

PY - 2017/6

Y1 - 2017/6

N2 - Background There have been a number of candidate gene association studies of cancer cachexia-related traits, but no genome-wide association study (GWAS) has been published to date. Cachexia presents in patients with a number of complex traits, including both cancer and COPD. The objective of the current investigation was to search for a shared genetic aetiology for change in body mass index (Delta BMI) among cancer and COPD by using GWAS data in the Framingham Heart Study.Methods A linear mixed effects model accounting for age, sex, and change in smoking status was used to calculate Delta BMI in participants over 40 years of age with three consecutive BMI time points (n = 4162). Four GWAS of Delta BMI using generalized estimating equations were performed among 1085 participants with a cancer diagnosis, 204 with gastrointestinal (GI) cancer, 112 with lung cancer, and 237 with COPD to test for association with 418 365 single-nucleotide polymorphisms (SNPs).Results Two SNPs reached a level of genome-wide significance (P <5x10(-8)) with Delta BMI: (i) rs41526344 within the CNTN4 gene, among COPD cases (beta = 0.13, P = 4.3x10(-8)); and (ii) rs4751240 in the gene Dedicator of Cytokinesis 1 (DOCK1) among GI cancer cases (beta = 0.10, P = 1.9x10(-8)). The DOCK1 SNP association replicated in the Delta BMI GWAS among COPD cases (beta(meta-analyis)= 0.10, Pmeta-analyis = 9.3x10(-10)). The DOCK1 gene codes for the dedicator of cytokinesis 1 protein, which has a role in myoblast fusion.Conclusions In sum, one statistically significant common variant in the DOCK1 gene was associated with Delta BMI in GI cancer and COPD cases providing support for at least partially shared aetiology of Delta BMI in complex diseases.

AB - Background There have been a number of candidate gene association studies of cancer cachexia-related traits, but no genome-wide association study (GWAS) has been published to date. Cachexia presents in patients with a number of complex traits, including both cancer and COPD. The objective of the current investigation was to search for a shared genetic aetiology for change in body mass index (Delta BMI) among cancer and COPD by using GWAS data in the Framingham Heart Study.Methods A linear mixed effects model accounting for age, sex, and change in smoking status was used to calculate Delta BMI in participants over 40 years of age with three consecutive BMI time points (n = 4162). Four GWAS of Delta BMI using generalized estimating equations were performed among 1085 participants with a cancer diagnosis, 204 with gastrointestinal (GI) cancer, 112 with lung cancer, and 237 with COPD to test for association with 418 365 single-nucleotide polymorphisms (SNPs).Results Two SNPs reached a level of genome-wide significance (P <5x10(-8)) with Delta BMI: (i) rs41526344 within the CNTN4 gene, among COPD cases (beta = 0.13, P = 4.3x10(-8)); and (ii) rs4751240 in the gene Dedicator of Cytokinesis 1 (DOCK1) among GI cancer cases (beta = 0.10, P = 1.9x10(-8)). The DOCK1 SNP association replicated in the Delta BMI GWAS among COPD cases (beta(meta-analyis)= 0.10, Pmeta-analyis = 9.3x10(-10)). The DOCK1 gene codes for the dedicator of cytokinesis 1 protein, which has a role in myoblast fusion.Conclusions In sum, one statistically significant common variant in the DOCK1 gene was associated with Delta BMI in GI cancer and COPD cases providing support for at least partially shared aetiology of Delta BMI in complex diseases.

KW - GWAS

KW - COPD

KW - Cancer

KW - Longitudinal

KW - BMI

KW - Cachexia

KW - FTO GENE

KW - EXTREME OBESITY

KW - MYOBLAST FUSION

KW - ADULT OBESITY

KW - CACHEXIA

KW - VARIANTS

KW - POLYMORPHISMS

KW - POPULATION

KW - CONTACTINS

KW - CHILDHOOD

U2 - 10.1002/jcsm.12171

DO - 10.1002/jcsm.12171

M3 - Journal article

VL - 8

SP - 428

EP - 436

JO - Journal of Cachexia, Sarcopenia and Muscle

JF - Journal of Cachexia, Sarcopenia and Muscle

SN - 2190-5991

IS - 3

ER -