Manuel Mattheisen

Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Felix Schreiner
  • ,
  • Osman El-Maarri
  • ,
  • Bettina Gohlke
  • ,
  • Sonja Stutte
  • ,
  • Nicole Nuesgen
  • ,
  • Manuel Mattheisen
  • Rolf Fimmers
  • ,
  • Peter Bartmann
  • ,
  • Johannes Oldenburg
  • ,
  • Joachim Woelfle
Catechol-O-Methyltransferase (COMT) plays a key role in dopamine and estrogen metabolism. Recently, COMT haplotypes rather than the single polymorphism Val158Met have been reported to underlie differences in protein expression by modulating mRNA secondary structure. So far, studies investigating the epigenetic variability of the S-COMT (soluble COMT) promoter region mainly focused on phenotypical aspects, and results have been controversial.
Original languageEnglish
JournalB M C Medical Genetics
Pages (from-to)115
Publication statusPublished - 2011
Externally publishedYes

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