Manuel Mattheisen

A novel locus for arterial hypertension on chromosome 1p36 maps to a metabolic syndrome trait cluster in the Sorbs, a Slavic population isolate in Germany

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Katrin Hoffmann
  • ,
  • Christian Planitz
  • ,
  • Franz Rüschendorf
  • ,
  • Bertram Müller-Myhsok
  • ,
  • Hans H Stassen
  • ,
  • Barbara Lucke
  • ,
  • Manuel Mattheisen
  • Michael Stumvoll
  • ,
  • Rolf Bochmann
  • ,
  • Martin Zschornack
  • ,
  • Thomas F Wienker
  • ,
  • Peter Nürnberg
  • ,
  • André Reis
  • ,
  • Friedrich C Luft
  • ,
  • Tom H Lindner
Genome-wide linkage studies and genome-wide association studies have not as yet identified major genes contributing to primary hypertension in the general population. This state-of-affairs suggests considerable heterogeneity with small contributing effects for primary hypertension, or other complex genetic traits, in outbred populations. Isolated populations, as recent data from Iceland and French Canada suggest, could offer a solution to this problem.
Original languageEnglish
JournalJournal of Hypertension
Volume27
Issue5
Pages (from-to)983-90
Number of pages8
DOIs
Publication statusPublished - May 2009

    Research areas

  • Adult, Aged, Chromosome Mapping, Chromosomes, Human, Pair 1, Female, Genetic Linkage, Genome-Wide Association Study, Germany, Humans, Hypertension, Lod Score, Male, Metabolic Syndrome X, Middle Aged, Multigene Family, Population Groups

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