Malene Flensborg Damholdt

In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography

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In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography. / Hansen, Allan K; Damholdt, Malene Flensborg; Fedorova, Tatyana D; Knudsen, Karoline; Parbo, Peter; Ismail, Rola; Østergaard, Karen; Brooks, David J; Borghammer, Per.

In: Movement Disorders, Vol. 32, No. 6, 06.2017, p. 922-927.

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@article{fdb23e534cd843549d3e1b924680d283,
title = "In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography",
abstract = "BACKGROUND: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction.OBJECTIVES: To describe tau aggregation in PD patients.METHODS: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment.RESULTS: Nine PD patients (35{\%}) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0.CONCLUSION: Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. {\circledC} 2017 International Parkinson and Movement Disorder Society.",
keywords = "Journal Article",
author = "Hansen, {Allan K} and Damholdt, {Malene Flensborg} and Fedorova, {Tatyana D} and Karoline Knudsen and Peter Parbo and Rola Ismail and Karen {\O}stergaard and Brooks, {David J} and Per Borghammer",
note = "{\circledC} 2017 International Parkinson and Movement Disorder Society.",
year = "2017",
month = "6",
doi = "10.1002/mds.26961",
language = "English",
volume = "32",
pages = "922--927",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "JohnWiley & Sons, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography

AU - Hansen, Allan K

AU - Damholdt, Malene Flensborg

AU - Fedorova, Tatyana D

AU - Knudsen, Karoline

AU - Parbo, Peter

AU - Ismail, Rola

AU - Østergaard, Karen

AU - Brooks, David J

AU - Borghammer, Per

N1 - © 2017 International Parkinson and Movement Disorder Society.

PY - 2017/6

Y1 - 2017/6

N2 - BACKGROUND: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction.OBJECTIVES: To describe tau aggregation in PD patients.METHODS: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment.RESULTS: Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0.CONCLUSION: Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. © 2017 International Parkinson and Movement Disorder Society.

AB - BACKGROUND: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction.OBJECTIVES: To describe tau aggregation in PD patients.METHODS: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment.RESULTS: Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0.CONCLUSION: Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. © 2017 International Parkinson and Movement Disorder Society.

KW - Journal Article

U2 - 10.1002/mds.26961

DO - 10.1002/mds.26961

M3 - Journal article

VL - 32

SP - 922

EP - 927

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 6

ER -