Research output per year
Research output per year
- 1 - 50 out of 53 results
Search results
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2024
Design of functional intrinsically disordered proteins
Garg, A., González-Foutel, N. S., Gielnik, M. B. & Kjaergaard, M., Mar 2024, In: Protein Engineering, Design and Selection. 37, gzae004.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
4 Citations (Scopus) -
Entering the Next Phase: Predicting Biological Effects of Biomolecular Condensates
Davis, M. C., André, A. A. M. & Kjaergaard, M., 1 Nov 2024, In: Journal of Molecular Biology. 436, 21, 168645.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
1 Citation (Scopus) -
Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers
Nielsen, J., Lauritsen, J., Pedersen, J. N., Nowak, J. S., Bendtsen, M. K., Kleijwegt, G., Lusser, K., Pitarch, L. C., Moreno, J. V., Schneider, M. M., Krainer, G., Goksøyr, L., Khalifé, P., Kaalund, S. S., Aznar, S., Kjærgaard, M., Sereikaité, V., Strømgaard, K., Knowles, T. P. J. & Nielsen, M. A. & 3 others, , Jun 2024, In: npj Parkinson's Disease . 10, 1, 139.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
2023
Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies
Bohr, F., Bohr, S. S. R., Mishra, N. K., González-Foutel, N. S., Pinholt, H. D., Wu, S., Nielsen, E. M., Zhang, M., Kjaergaard, M., Jensen, K. J. & Hatzakis, N. S., Dec 2023, In: Communications Biology. 6, 1, 178.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access5 Citations (Scopus) -
2022
A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL
Kjærgaard, M., Rasmussen, L. S., Vinther, J. N., Andersen, K. R., Andersen, E. S., Lorentzen, E., Thirup, S. S., Otzen, D. & Brodersen, D. E., Dec 2022, In: The Biophysicist. 3, 2, p. 106–114 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Estimation of Effective Concentrations Enforced by Complex Linker Architectures from Conformational Ensembles
Kjaergaard, M., Feb 2022, In: Biochemistry. 61, 3, p. 171-182 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
15 Citations (Scopus) -
The optimal docking strength for reversibly tethered kinases
Dyla, M., González Foutel, N. S., Otzen, D. E. & Kjaergaard, M., 21 Jun 2022, In: Proceedings of the National Academy of Sciences (PNAS). 119, 25, e2203098119.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile17 Citations (Scopus)39 Downloads (Pure) -
2021
Intrinsic disorder in protein kinase A anchoring proteins signaling complexes
Dyla, M. & Kjaergaard, M., Jan 2021, Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C. Uversky, V. N. & Uversky, V. N. (eds.). Amsterdam: Elsevier, p. 271-294 (Progress in Molecular Biology and Translational Science, Vol. 183).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
5 Citations (Scopus) -
Introducing the special issue on “Proteins and Circuits in Memory”
Kjaergaard, M., Petersen, N. C., Sørensen, J. B. & Takeuchi, T., Oct 2021, In: European Journal of Neuroscience. 54, 8, p. 6691-6695 5 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review
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Lagevrio: Hvordan virker de nye coronapiller?
Kjærgaard, M., 12 Dec 2021, ForskerzonenResearch output: Other contribution › Net publication - Internet publication › Communication
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Nanoscale spatial dependence of avidity in an IgG1 antibody
Jendroszek, A. & Kjaergaard, M., Jun 2021, In: Scientific Reports. 11, 12663.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access13 Citations (Scopus) -
Predicting the effect of disordered linkers on effective concentrations and avidity with the “Ceff calculator” app
Kjaergaard, M., Glavina, J. & Chemes, L. B., Jan 2021, Linkers in Biomacromolecules. Merkx, M. (ed.). Academic Press, p. 145-171 27 p. (Methods in Enzymology, Vol. 647).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
18 Citations (Scopus) -
The Crystal Structure of the Ca2+-ATPase 1 from Listeria monocytogenes reveals a Pump Primed for Dephosphorylation
Hansen, S. B., Dyla, M., Neumann, C., Quistgaard, E. M. H., Andersen, J. L., Kjaergaard, M. & Nissen, P., Aug 2021, In: Journal of Molecular Biology. 433, 16, 167015.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)70 Downloads (Pure) -
The C-terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease
Warnet, X. L., Bakke Krog, H., Sevillano-Quispe, O. G., Poulsen, H. & Kjaergaard, M., Oct 2021, In: European Journal of Neuroscience. 54, 8, p. 6713-6739 27 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
32 Citations (Scopus) -
2020
Identification of on- and off-pathway oligomers in amyloid fibril formation
Dear, A. J., Meisl, G., Saric, A., Michaels, T. C. T., Kjaergaard, M., Linse, S. & Knowles, T. P. J., 28 Jun 2020, In: Chemical Science. 11, 24, p. 6236-6247 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
81 Citations (Scopus) -
Intrinsically disordered linkers control tethered kinases via effective concentration
Dyla, M. & Kjaergaard, M., 1 Sept 2020, In: Proceedings of the National Academy of Sciences (PNAS). 117, 35, p. 21413-21419 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access44 Citations (Scopus) -
Measuring Effective Concentrations Enforced by Intrinsically Disordered Linkers
Sørensen, C. S. & Kjaergaard, M., 2020, Methods in Molecular Biology: Methods and protocols. Kragelund, B. B. & Skriver, K. (eds.). New York: Humana Press, p. 505-518 14 p. (Methods in Molecular Biology, Vol. 2141).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
4 Citations (Scopus) -
Structure and Mechanism of P-Type ATPase Ion Pumps
Dyla, M., Kjærgaard, M., Poulsen, H. & Nissen, P., Jun 2020, In: Annual Review of Biochemistry. 89, p. 583-603 21 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
114 Citations (Scopus) -
2019
Coupled Binding and Helix Formation Monitored by Synchrotron-Radiation Circular Dichroism
Karlsson, E., Andersson, E., Jones, N. C., Hoffmann, S. V., Jemth, P. & Kjærgaard, M., 20 Aug 2019, In: Biophysical Journal. 117, 4, p. 729-742 14 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
7 Citations (Scopus) -
Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics
Sørensen, C. S. & Kjaergaard, M., Nov 2019, In: Proceedings of the National Academy of Sciences (PNAS). 116, 46, p. 23124-23131 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access92 Citations (Scopus) -
Linker Dependence of Avidity in Multivalent Interactions between Disordered Proteins
Sørensen, C. S., Jendroszek, A. & Kjærgaard, M., 6 Dec 2019, In: Journal of Molecular Biology. 431, 24, p. 4784-4795 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
28 Citations (Scopus) -
Structural dynamics of P-type ATPase ion pumps
Dyla, M., Basse Hansen, S., Nissen, P. & Kjaergaard, M., 31 Oct 2019, In: Biochemical Society Transactions. 47, 5, p. 1247-1257 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
52 Citations (Scopus) -
2018
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity
Kundel, F., De, S., Flagmeier, P., Horrocks, M. H., Kjaergaard, M., Shammas, S. L., Jackson, S. E., Dobson, C. M. & Klenerman, D., 2018, In: ACS chemical biology. 13, 3, p. 636-646 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access81 Citations (Scopus) -
Naturens nanopumper fanget på film
Dyla, M. & Kjærgaard, M., Nov 2018, In: Dansk Kemi. 8, 99, p. 10-12 3 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication
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Oligomer diversity during the aggregation of the repeat-region of tau
Kjaergaard, M., Dear, A. J., Kundel, F., Qamar, S., Meisl, G., Knowles, T. P. J. & Klenerman, D., 2018, In: ACS Chemical Neuroscience. 9, 12, p. 3060-3071 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile55 Citations (Scopus)130 Downloads (Pure) -
2017
Dynamics of P-type ATPase transport cycle revealed by single-molecule FRET
Dyla, M., Terry, D., Kjærgaard, M., Sørensen, T.L.-M., Andersen, J. L., Andersen, J. P., Knudsen, C. R., Altman, R., Nissen, P. & Blanchard, S., 16 Nov 2017, In: Nature. 551, 7680, p. 346-351 18 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
68 Citations (Scopus) -
Functions of intrinsic disorder in transmembrane proteins
Kjaergaard, M. & Kragelund, B. B., 1 Sept 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3205-3224 20 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
63 Citations (Scopus) -
2016
Engineering a prototypic P-type ATPase Listeria Monocytogenes Ca(2+)-ATPase 1 for single-molecule FRET studies
Dyla, M., Andersen, J., Kjaergaard, M., Birkedal, V., Terry, D. S., Altman, R. B., Blanchard, S., Nissen, P. & Knudsen, C. R., 21 Sept 2016, In: Bioconjugate Chemistry. 27, 9, p. 2176-2187 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
11 Citations (Scopus) -
Single-molecule imaging of individual amyloid protein aggregates in human biofluids
Horrocks, M. H., Lee, S. F., Gandhi, S., Magdalinou, N. K., Chen, S. W., Devine, M. J., Tosatto, L., Kjaergaard, M., Beckwith, J. S., Zetterberg, H., Iljina, M., Cremades, N., Dobson, C. M., Wood, N. W. & Klenerman, D., 16 Mar 2016, In: ACS Chemical Neuroscience. 7, 3, p. 399–406 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access89 Citations (Scopus) -
2015
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
Shammas, S. L., Garcia, G. A., Kumar, S., Kjaergaard, M., Horrocks, M. H., Shivji, N., Mandelkow, E., Knowles, T. P. J., Mandelkow, E. & Klenerman, D., 2015, In: Nature Communications. 6, p. 7025Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
161 Citations (Scopus) -
Can proteins be intrinsically disordered inside a membrane?
Kjærgaard, M., 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-7 7 p., e984570.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
8 Citations (Scopus) -
2014
Helical propensity in an intrinsically disordered protein accelerates ligand binding
Iešmantavičius, V., Dogan, J., Jemth, P., Teilum, K. & Kjærgaard, M., 3 Feb 2014, In: Angewandte Chemie International Edition. 53, 6, p. 1548-51 4 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
135 Citations (Scopus) -
2013
A folded excited state of ligand-free nuclear coactivator binding domain (NCBD) underlies plasticity in ligand recognition
Kjærgaard, M., Andersen, L., Nielsen, L. D. & Teilum, K., 12 Mar 2013, In: Biochemistry. 52, 10, p. 1686-93 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
36 Citations (Scopus) -
Modulation of the intrinsic helix propensity of an intrinsically disordered protein reveals long-range helix-helix interactions
Iešmantavičius, V., Jensen, M. R., Ozenne, V., Blackledge, M., Poulsen, F. M. & Kjærgaard, M., 10 Jul 2013, In: Journal of the American Chemical Society. 135, 27, p. 10155-63 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
41 Citations (Scopus) -
Single-molecule measurements of transient biomolecular complexes through microfluidic dilution
Horrocks, M. H., Rajah, L., Jönsson, P., Kjærgaard, M., Vendruscolo, M., Knowles, T. P. J. & Klenerman, D., 16 Jul 2013, In: Analytical Chemistry. 85, 14, p. 6855-9 5 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
21 Citations (Scopus) -
2012
A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)
Mertens, H. D. T., Kjærgaard, M., Mysling, S., Gårdsvoll, H., Jørgensen, T. J. D., Svergun, D. I. & Ploug, M., 5 Oct 2012, In: Journal of Biological Chemistry. 287, 41, p. 34304-15 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
46 Citations (Scopus) -
Analyzing temperature-induced transitions in disordered proteins by NMR spectroscopy and secondary chemical shift analyses
Kjærgaard, M., Poulsen, F. M. & Kragelund, B. B., 2012, In: Methods in molecular biology (Clifton, N.J.). 896, p. 249-56 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Disordered proteins studied by chemical shifts
Kjærgaard, M. & Poulsen, F. M., Jan 2012, In: Progress in Nuclear Magnetic Resonance Spectroscopy. 60, p. 42-51 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
48 Citations (Scopus) -
Is a malleable protein necessarily highly dynamic? The hydrophobic core of the nuclear coactivator binding domain is well ordered
Kjærgaard, M., Poulsen, F. M. & Teilum, K., 4 Apr 2012, In: Biophysical Journal. 102, 7, p. 1627-35 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
18 Citations (Scopus) -
Temperature-induced transitions in disordered proteins probed by NMR spectroscopy
Kjærgaard, M., Poulsen, F. M. & Kragelund, B. B., 2012, In: Methods in molecular biology (Clifton, N.J.). 896, p. 233-47 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2 Citations (Scopus) -
2011
Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor
Gårdsvoll, H., Kjærgaard, M., Jacobsen, B., Kriegbaum, M. C., Huang, M. & Ploug, M., 16 Dec 2011, In: Journal of Biological Chemistry. 286, 50, p. 43515-26 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
28 Citations (Scopus) -
Random coil chemical shift for intrinsically disordered proteins: effects of temperature and pH
Kjærgaard, M., Brander, S. & Poulsen, F. M., Feb 2011, In: Journal of Biomolecular N M R. 49, 2, p. 139-49 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
236 Citations (Scopus) -
Sequence correction of random coil chemical shifts: correlation between neighbor correction factors and changes in the Ramachandran distribution
Kjærgaard, M. & Poulsen, F. M., Jun 2011, In: Journal of Biomolecular N M R. 50, 2, p. 157-65 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
225 Citations (Scopus) -
The interplay between transient α-helix formation and side chain rotamer distributions in disordered proteins probed by methyl chemical shifts
Kjærgaard, M., Iešmantavičius, V. & Poulsen, F. M., Dec 2011, In: Protein Science. 20, 12, p. 2023-34 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
10 Citations (Scopus) -
The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking
Nørholm, A.-B., Hendus-Altenburger, R., Bjerre, G. P., Kjærgaard, M., Pedersen, S. F. & Kragelund, B. B., 3 May 2011, In: Biochemistry. 50, 17, p. 3469-80 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
55 Citations (Scopus) -
The RelA nuclear localization signal folds upon binding to IκBα
Cervantes, C. F., Bergqvist, S., Kjærgaard, M., Kroon, G., Sue, S.-C., Dyson, H. J. & Komives, E. A., 21 Jan 2011, In: Journal of Molecular Biology. 405, 3, p. 754-64 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
29 Citations (Scopus) -
2010
Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP
Kjærgaard, M., Teilum, K. & Poulsen, F. M., 13 Jul 2010, In: Proceedings of the National Academy of Sciences (PNAS). 107, 28, p. 12535-40 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
137 Citations (Scopus) -
Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II?
Kjærgaard, M., Nørholm, A.-B., Hendus-Altenburger, R., Pedersen, S. F., Poulsen, F. M. & Kragelund, B. B., Aug 2010, In: Protein Science. 19, 8, p. 1555-64 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
187 Citations (Scopus) -
2008
Rapid mass spectrometric analysis of 15N-Leu incorporation fidelity during preparation of specifically labeled NMR samples
Truhlar, S. M. E., Cervantes, C. F., Torpey, J. W., Kjærgaard, M. & Komives, E. A., Sept 2008, In: Protein Science. 17, 9, p. 1636-9 4 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
6 Citations (Scopus) -
Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor
Jacobsen, B., Kjærgaard, M., Gårdsvoll, H. & Ploug, M., 2008, The Cancer Degradome. SpringerResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
1 Citation (Scopus)