Mads Schak Toustrup-Jensen

  1. 2019
  2. Published

    Functional consequences of the CAPOS mutation E818K of Na+,K+-ATPase. / Roenn, Christian P; Li, Melody; Schack, Vivien R; Forster, Ian C; Holm, Rikke; Toustrup-Jensen, Mads S; Andersen, Jens P; Petrou, Steven; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 294, No. 1, 04.01.2019, p. 269-280.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. 2016
  4. Published

    Neurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function. / Holm, Rikke ; Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Andersen, Jens Peter; Vilsen, Bente.

    In: B B A - Bioenergetics, Vol. 1857, No. 11, 11.2016, p. 1807–1828.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  5. Published

    Importance of a potential protein kinase A phosphorylation site of Na+,K+-ATPase and its interaction network for Na+ binding. / Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 291, No. 20, 13.05.2016, p. 10934-47.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. 2015
  7. Published
  8. 2014
  9. Published

    Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Nielsen, Hang Nguyen; Holm, Rikke; Sobrido, Maria-Jesus; Andersen, Jens Peter; Clausen, Torben; Vilsen, Bente.

    2014. Poster session presented at 14th International ATPase Conference “Na,K‐ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease”, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  10. Published

    Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Nielsen, Hang Nguyen; Holm, Rikke; Sobrido, María-Jesús; Andersen, Jens Peter; Clausen, Torben; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 289(6), 07.02.2014, p. 3186-3197.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Elucidation of the functional role of a potential PKA site in Na+,K+-ATPase: Importance of Ser938 in binding of intracellular Na+. / Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    2014. Poster session presented at 14th International Conference Na,K-ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  12. Published

    Importance of Residues Outside the Cation Binding Pocket for Na+ and K+ Binding to the Na+/K+-ATPase. / Christiansen, Line; Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Vilsen, Bente.

    2014. Poster session presented at 14th International ATPase Conference “Na,K‐ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease”, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  13. 2012
  14. Published

    Na+,K+-ATPase amino acids involved in transport of the 3rd sodium ion. / Holm, Rikke; Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2012. Poster session presented at 3rd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy.

    Research output: Contribution to conferencePosterResearch

  15. Published
  16. Published
  17. 2011
  18. Published

    Na+,K+-ATPase amino acids involved in transport of the 3rd sodium ion. / Holm, Rikke; Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  19. Published

    The rapid-onset dystonia parkinsonism mutation D923N of the Na+,K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site and leads to a rise in intracellular Na+ in cell cultur. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  20. Published

    Two neurological disease mutations in the C-terminus of the Na+,K+-ATPase change the intracellular Na+ and K+ content in transfected mammalian COS-1 cell lines. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Clausen, Torben; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  21. 2010
  22. Published

    The rapid-onset dystonia Parkinsonism mutation D923N of the Na+,K+-ATPase alpha-3 isoform disrupts Na+interaction at the third Na+ site. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 285, No. 34, 20.08.2010, p. 26245-26254.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. 2009
  24. Published

    A C-terminal mutation of ATP1A3 underscores the crucial role of sodium affinity in the pathophysiology of rapid-onset dystonia-parkinsonism. / Blanco-Arias, Patricia; Einholm, Anja P.; Mamsa, Hafsa; Concheiro, Carla; Gutiérrez-de-Terán, Hugo; Romero, Jesús; Toustrup-Jensen, Mads Schak; Carracedo, Ángel; Jen, Joanna; Vilsen, Bente; Sobrido, María-Jesús.

    In: Human Molecular Genetics, Vol. 18, No. 13, 2009, p. 2370-2377.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    A new RDP mutation of ATP1A3 with an in-frame insertion of a tyrosine at the very C-terminus of the protein provides further evidence for a key regulatory role of the C-terminal tail of Na+,K+-ATPase. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Blanco-Arias, Patricia; Mamsa, Hafsa; Concheiro, Carla; Gutiérrez-Terán, Hugo; Romero, Jesús; Carracedo, Ángel; Jen, Joanna; Sorbrido, María-Jesús; Vilsen, Bente.

    2009. Poster session presented at 2nd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy.

    Research output: Contribution to conferencePosterResearch

  26. Published

    The C Terminus of Na+,K+-ATPase Controls Na+ Affinity on Both Sides of the Membrane through Arg935. / Toustrup-Jensen, Mads Schak; Holm, Rikke; Einholm, Anja P.; Schack, Vivien Rodacker; Morth, Jens Preben; Nissen, Poul; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 284, No. 28, 2009, p. 18715-18725.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations. / Morth, J Preben; Poulsen, Hanne; Toustrup-Jensen, Mads S; Schack, Vivien Rodacker; Egebjerg, Jan; Andersen, Jens Peter; Vilsen, Bente; Nissen, Poul.

    In: Royal Society of London. Philosophical Transactions. Biological Sciences, Vol. 364, No. 1514, 2009, p. 217-27.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. 2008
  29. Published

    Identification and function of a cytoplasmic K+ site of the Na+,K+-ATPase. / Schack, Vivien Rodacker; Morth, Jens Preben; Toustrup-Jensen, Mads Schak; Anthonisen, Anne Nyholm; Nissen, Poul; Andersen, Jens Peter; Vilsen, Bente.

    2008. Poster session presented at 12th International ATPase Conference:  Na,K-ATPase and Related Transport ATPases of P-type: Structures, Mechanisms, and Roles in Health and Disease, Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch

  30. Published

    Identification and function of a cytoplasmic K+ site of the Na+,K+ATPase. / Schack, Vivien Rodacker; Morth, Jens Preben; Toustrup-Jensen, Mads S; Anthonisen, Anne Nyholm; Nissen, Poul; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 283, No. 41, 2008, p. 27982-90.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Importance of Ser938 for Na+ binding to Na+,K+-ATPase. / Einholm, Anja P.; Jensen, Rikke Holm; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2008. Poster session presented at 12th International ATPase Conference: Na,K-ATPase and Related Transport ATPases of P-type: Structures, Mechanisms, and Roles in Health and Disease., Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch

  32. 2007
  33. Published

    Crystal structure of the sodium-potassium pump. / Morth, J Preben; Pedersen, Bjørn Panyella; Toustrup-Jensen, Mads S; Sørensen, Thomas L-M; Petersen, Janne; Andersen, Jens Peter; Vilsen, Bente; Nissen, Poul.

    In: Nature, Vol. 450, No. 7172, 2007, p. 1043-1049.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. Published

    Mutations Phe785Leu and Thr618Met in Na+, K+-ATPase, Associated with Familial Rapid-Onset Dystonia Parkinsonism, Interfere with Na+ Interaction by Distinct Mechanisms. / Schack, Vivien Rodacker; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    2007. Poster session presented at PhD day 2007, Faculty of Health Sciences, University of Aarhus, Århus, Denmark.

    Research output: Contribution to conferencePosterResearch

  35. Published

    Mutations Phe785Leu and Thr618Met in Na+, K+-ATPase, Associated with Familial Rapid-Onset Dystonia Parkinsonism, Interfere with Na+ Interaction by Distinct Mechanisms. / Schack, Vivien Rodacker; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    2007. Poster session presented at Membrane Protein Isolation, Crystallization and Structure Determination (TRAMP-6), Århus, Denmark.

    Research output: Contribution to conferencePosterResearch

  36. 2006
  37. Published

    Mutations Phe785Leu and Thr618Met in Na+,K+-ATPase, associated with Familial Rapid-onset Dystonia Parkinsonism, interfere with Na+ interaction by distinct mechanisms. / Rodacker, Vivien; Jensen, Mads Toustrup; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 281, No. 27, 2006, p. 18539-18548.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. 2005
  39. Published

    Interaction between the Catalytic Site and the A-M3 Linker Stabilizes E2/E2P Conformational States of Na+,K+-ATPase. / Jensen, Mads Toustrup; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 280, 2005, p. 10210-10218.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    Mutation Phe785-Leu, Associated with Rapid-onset Dystonia Parkinsonism, in the Na+, K+-ATPase, Interferes Severely with the Na+Binding Properties but not with the K+ Binding Properties. / Schack, Vivien Rodacker; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    2005. Poster session presented at 11th International Conference on the Na+/K+-ATPase and Related ATPases, Woods Hole, United States.

    Research output: Contribution to conferencePosterResearch

  41. Published

    Mutation of Gly-94 in transmembrane segment M1 of Na+, K+-ATPase interferes with Na+ and K+ binding in E2P conformation. / Einholm, Anja P.; Jensen, Mads Toustrup; Andersen, Jens Peter; Vilsen, Bente.

    In: Proceedings of the National Academy of Science, USA, Vol. 102, 2005, p. 11254-11259.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  42. 2003
  43. Published

    Functional consequences of alterations to Ile279, Ile283, Glu284, His285, Phe286, and His288, in the NH2-terminal part of transmembrane helix M3 of theNa+,K+-ATPase. / Toustrup-Jensen, Mads Schack; Vilsen, B.

    In: Journal of Biological Chemistry, Vol. 278, 2003, p. 38653-38664.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    Importance of Thr214 in the conserved TGES sequence of the Na+,K+-ATPase for vanadate binding and hydrolysis of E2P. / Toustrup-Jensen, Mads Schack; Vilsen, B.

    In: New York Academy of Sciences. Annals, Vol. 986, 2003, p. 267-269.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  45. Published

    Importance of conserved Thr214 in domain A of the Na+,K+-ATPase for stabilization of the phosphoryl transition state complex in E2P phosphorylation. / Toustrup-Jensen, Mads Schack; Vilsen, B.

    In: Journal of Biological Chemistry, Vol. 278, 2003, p. 11402-11410.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    Importance of transmembrane segment M3 of Na+,K+-ATPase for control of conformational changes and the cytoplasmic entry pathway for Na+. / Vilsen, B.; Toustrup-Jensen, Mads Schack.

    In: New York Academy of Sciences. Annals, Vol. 986, 2003, p. 50-57.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  47. Published

    Structure-function relationship of the A-M3 sector of Na+,K+-ATPase studied by site-directed mutagenesis. / Jensen, M.T.

    2003. 100 p.

    Research output: Book/anthology/dissertation/reportPh.D. thesisResearch

  48. 2002
  49. Published

    Importance of Glu282 in transmembrane segment M3 of the Na+,K+-ATPase for control of cation interaction and conformational changes. / Toustrup-Jensen, Mads Schack; Vilsen, B.

    In: Journal of Biological Chemistry, Vol. 277, 2002, p. 38607-38617.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. 2001
  51. Published

    Mutational effects on conformational changes of the dephospho-and phospho-forms of the Na+,K+-ATPase. / Toustrup-Jensen, Mads Schack; Hauge, M.; Vilsen, B.

    In: Biochemistry, Vol. 40, 2001, p. 5521-5532.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. 2000
  53. Published

    Mutations Gly263→Ala and Arg264→Ala in the small cytoplasmic domain of rat kidney Na+, K+-ATPase stabilize the E1 and E1P forms. / Jensen, M.T.; Hauge, M.; Vilsen, B.; Taniguchi, K. (Editor); Kaya, S. (Editor).

    Na/K-ATPase and Related ATPases. Pergamon Press, 2000. p. 225-228.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearch